2002 Progress Report: Exposure Core

EPA Grant Number: R827355C008
Subproject: this is subproject number 008 , established and managed by the Center Director under grant R827355
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Airborne PM - Northwest Research Center for Particulate Air Pollution and Health
Center Director: Koenig, Jane Q.
Title: Exposure Core
Investigators: Larson, Timothy V. , Claiborn, Candis , Covert, David S. , Kalman, Dave , Lewtas, Joellen , Liu, Sally
Current Investigators: Larson, Timothy V. , Liu, Sally
Institution: University of Washington
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2004 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2001 through May 31, 2002
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air

Objective:

The objectives of this research project are to: (1) provide state-of-the-art particulate matter (PM) techniques for quantifying exposures and doses, and (2) facilitate cooperation between health and exposure studies.

Progress Summary:

Within Core Efforts

Source Apportionment Modeling. We successfully apportioned samples from personal, indoor, and outdoor samples taken from Year 2 of the project's panel study (PMF/UNMIX). We incorporated measurements of light absorption to perform the apportionment on a single teflon filter, and thus allow analysis of the personal samples.

We submitted a manuscript on the 1996-1999 Beacon Hill IMPROVE samples and are preparing a manuscript on the collaboration with Puget Sound Clean Air Agency in a PMF analysis of the 2000-2002 U.S. Environmental Protection Agency (EPA) STN samples. These latter two analyses are important benchmarks that will be compared with our panel study analyses.

We also submitted a PMF apportionment of the Phoenix data set as part of our participation in the upcoming PM Centers workshop on source apportionment.

Size Distribution Measurements. We completed the size distribution measurements at Beacon Hill. In conjunction with the data core, we also have analyzed the outdoor size distribution data from Beacon Hill for subsequent use in time series studies.

Instrument Testing. We have conducted additional field testing of the carbon foam denuder by incorporating it into the Harvard impactor/quartz filter samplers used in the Spring Agriculture burning study. We also began working on manuscripts on light scattering versus gravimetric methods comparisons.

Support of Center Projects

We supported the Autumn 2002 Agricultural Field Burning Study, and provided quality control (QC) assistance on the exposure data set.

Years 1 and 2 Panel Study. We contributed to data analysis and manuscript preparation with a focus on the personal exposure to outdoor PM.

Year 3 Panel Study. We worked closely with data core to provide QC on exposure data.

Winter 2002-2003 Panel Study. We supplemented the New York University (NYU) Center grant agreement for exposure assessment of 17 susceptible patients. Supplemental measures included filter weighing, indoor/outdoor PM using Radiance nephelometers, and exhaled breath samples for exhaled nitric oxide analysis.

Diesel Exposure Facility. We completed, tested, and turned over to trained operators the basic exposure system; installation and testing of the exposure measurement devices for exposure characterization are ongoing.

Animal Toxicology. We provided Teflon filter samples of PM2.5 from Beacon Hill for extraction and possible use in animal exposures.

Future Activities:

Year 5 of the project will focus on two areas: (1) manuscript preparation, and (2) further measurement and analysis of the Teflon panel study filters. We now know how to analyze them (light absorption and x-ray fluorescence [XRF]) to perform credible source apportionments. Relating source apportioned mass concentrations to health endpoints would give us a powerful bottom line. We would propose ranking the filters in some priority order, and also taking advantage of the offer from NYU to analyze some of the filters with their XRF facility.

We also will provide technical advice to the diesel exposure facility, particularly with respect to characterizing the exposure atmospheres. We also are prepared to support any new initiatives that require exposure expertise.


Journal Articles on this Report : 3 Displayed | Download in RIS Format

Other subproject views: All 21 publications 21 publications in selected types All 21 journal articles
Other center views: All 209 publications 113 publications in selected types All 109 journal articles
Type Citation Sub Project Document Sources
Journal Article Claiborn CS, Larson T, Sheppard L. Testing the metals hypothesis in Spokane, Washington. Environmental Health Perspectives 2002;110(Suppl 4):547-552. R827355 (2001)
R827355 (Final)
R827355C008 (2002)
R827355C008 (Final)
R828678C010 (2002)
R828678C010 (2003)
R828678C010 (2004)
R828678C010 (2005)
R828678C010 (2006)
R828678C010 (2007)
R828678C010 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ResearchGate - Abstract & Full Text PDF
    Exit
  • Journal Article Kim E, Larson TV, Hopke PK, Slaughter C, Sheppard LE, Claiborn C. Source identification of PM2.5 in an arid Northwest U.S. city by positive matrix factorization. Atmospheric Research 2003;66(4):291-305. R827355 (2004)
    R827355 (Final)
    R827355C008 (2002)
    R827355C008 (Final)
    R827355C009 (2003)
    R827354 (Final)
    R827354C001 (Final)
    R828678C010 (2003)
    R828678C010 (2004)
    R828678C010 (2005)
    R828678C010 (2006)
    R828678C010 (2007)
    R828678C010 (Final)
    R832415 (2010)
    R832415 (2011)
    R832415 (Final)
  • Full-text: ScienceDirect-Full Text PDF
    Exit
  • Abstract: ScienceDirect-Abstract and Full Text HTML
    Exit
  • Other: ResearchGate - Abstract & Full Text PDF
    Exit
  • Journal Article Kim E, Hopke PK, Larson TV, Covert DS. Analysis of ambient particle size distributions using Unmix and positive matrix factorization. Environmental Science & Technology 2004;38(1):202-209. R827355 (2004)
    R827355 (Final)
    R827355C004 (2003)
    R827355C008 (2002)
    R827355C008 (2003)
    R827355C008 (Final)
    R827354 (Final)
    R827354C001 (Final)
    R827354C002 (2004)
    R832415 (2010)
    R832415 (2011)
    R832415 (Final)
  • Abstract from PubMed
  • Full-text: ACS-Full Text HTML
    Exit
  • Abstract: ACS-Abstract
    Exit
  • Other: ACS-Full Text PDF
    Exit
  • Supplemental Keywords:

    air pollution, air pollutants, particulate matter, PM, fine particulates, PM2.5, personal exposure, indoor exposure, outdoor exposure, quantifying exposures, quantifying doses, health effects, aerosol characterization, source apportionment, PMF apportionment, agricultural burning, exposure assessment, exposure characterization, exhaled nitric oxide, exposure measurement devices., RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, ENVIRONMENTAL MANAGEMENT, Geographic Area, particulate matter, Toxicology, air toxics, Environmental Chemistry, Health Risk Assessment, Air Pollutants, Epidemiology, State, Air Pollution Effects, Northwest, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Biochemistry, Physical Processes, genetic susceptability, Atmospheric Sciences, Risk Assessment, biostatistics, health effects, ambient aerosol, particulates, sensitive populations, ambient air quality, morbidity, cardiopulmonary responses, human health effects, exposure and effects, health risks, acute cardiovascular effects, hazardous air pollutants, exposure, epidemelogy, dose-response, air pollution, particle exposure, Human Health Risk Assessment, atmospheric aerosols, ambient particle health effects, mortality studies, cardiopulmonary response, inhalation, human exposure, human susceptibility, PM, mortality, California (CA), air quality, particle transport, cardiovascular disease, human health risk, aerosols, atmospheric chemistry, exposure assessment, environmental hazard exposures

    Relevant Websites:

    http://depts.washington.edu/pmcenter/ Exit

    Progress and Final Reports:

    Original Abstract
  • 1999
  • 2000
  • 2001
  • 2003 Progress Report
  • 2004
  • Final Report

  • Main Center Abstract and Reports:

    R827355    Airborne PM - Northwest Research Center for Particulate Air Pollution and Health

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R827355C001 Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
    R827355C002 Health Effects
    R827355C003 Personal PM Exposure Assessment
    R827355C004 Characterization of Fine Particulate Matter
    R827355C005 Mechanisms of Toxicity of Particulate Matter Using Transgenic Mouse Strains
    R827355C006 Toxicology Project -- Controlled Exposure Facility
    R827355C007 Health Effects Research Core
    R827355C008 Exposure Core
    R827355C009 Statistics and Data Core
    R827355C010 Biomarker Core
    R827355C011 Oxidation Stress Makers