2004 Progress Report: Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans: The Role of Oxidative StressEPA Grant Number: R830954
Title: Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans: The Role of Oxidative Stress
Investigators: Kaufman, Joel D. , Chandler, Wayne , Gill, Edward , Koenig, Jane Q. , Larson, Timothy V. , Leotta, Daniel , Sheppard, Lianne (Elizabeth) A. , Sullivan, Jeff , Trenga, Carol , Yost, Michael
Institution: University of Washington
EPA Project Officer: Chung, Serena
Project Period: August 15, 2003 through August 14, 2006 (Extended to August 14, 2008)
Project Period Covered by this Report: August 15, 2003 through August 14, 2004
Project Amount: $1,036,972
RFA: Airborne Particulate Matter Health Effects: Cardiovascular Mechanisms (2002) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air , Health Effects
Diesel exhaust particles are a substantial and biologically active fraction of urban fine particulate air pollution, which is associated with increases in cardiovascular morbidity and mortality. This project addresses the overall hypothesis that ambient fine particulate matter exerts cardiovascular health effects via alteration of endothelial homeostasis, through a mechanism mediated by oxidative stress. The objectives of this research project are to determine if: (1) exposure to inhaled diesel exhaust (DE) particulate is associated with endothelial dysfunction in a concentration-related manner; (2) exposure to inhaled DE is associated with evidence of systemic oxidative stress; and (3) antioxidant supplementation blunts the DE effect on endothelial function. Controlled human inhalation exposure to diesel exhaust is used as a model to address the objectives.
The diesel exposure facility is functioning according to specifications. A pilot study was completed that demonstrated logistical success of study plans, as well as tolerability of exposures.
Experiments to evaluate concentration-related effects of DE on endothelial function and oxidative stress will be completed in Year 2 of the project.