2004 Progress Report: Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans: The Role of Oxidative Stress

EPA Grant Number: R830954
Title: Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans: The Role of Oxidative Stress
Investigators: Kaufman, Joel D. , Chandler, Wayne , Gill, Edward , Koenig, Jane Q. , Larson, Timothy V. , Leotta, Daniel , Sheppard, Lianne (Elizabeth) A. , Sullivan, Jeff , Trenga, Carol , Yost, Michael
Institution: University of Washington
EPA Project Officer: Chung, Serena
Project Period: August 15, 2003 through August 14, 2006 (Extended to August 14, 2008)
Project Period Covered by this Report: August 15, 2003 through August 14, 2004
Project Amount: $1,036,972
RFA: Airborne Particulate Matter Health Effects: Cardiovascular Mechanisms (2002) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air , Health Effects

Objective:

Diesel exhaust particles are a substantial and biologically active fraction of urban fine particulate air pollution, which is associated with increases in cardiovascular morbidity and mortality. This project addresses the overall hypothesis that ambient fine particulate matter exerts cardiovascular health effects via alteration of endothelial homeostasis, through a mechanism mediated by oxidative stress. The objectives of this research project are to determine if: (1) exposure to inhaled diesel exhaust (DE) particulate is associated with endothelial dysfunction in a concentration-related manner; (2) exposure to inhaled DE is associated with evidence of systemic oxidative stress; and (3) antioxidant supplementation blunts the DE effect on endothelial function. Controlled human inhalation exposure to diesel exhaust is used as a model to address the objectives.

Progress Summary:

The diesel exposure facility is functioning according to specifications. A pilot study was completed that demonstrated logistical success of study plans, as well as tolerability of exposures.

Future Activities:

Experiments to evaluate concentration-related effects of DE on endothelial function and oxidative stress will be completed in Year 2 of the project.

Journal Articles:

No journal articles submitted with this report: View all 33 publications for this project

Supplemental Keywords:

ambient air, human health, dose-response, mobile sources, diesel exhaust, particulate matter, PM, cardiovascular health, air pollution, health effects,, RFA, Health, Scientific Discipline, Air, HUMAN HEALTH, particulate matter, air toxics, Environmental Chemistry, Health Risk Assessment, Exposure, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, mobile sources, genetic susceptability, Biology, copollutant exposures, sensitive populations, atmospheric particulate matter, engine exhaust, airway epithelial cells, cardiopulmonary responses, fine particles, PM 2.5, inhaled pollutants, acute lung injury, morbidity, diesel engines, air pollution, susceptible subpopulations, endothelial function, diesel exhaust, automotive exhaust, chronic health effects, lung inflammation, oxidant gas, particulate exposure, cardiopulmonary response, heart rate, ambient particle pollution, Acute health effects, inhaled, chronic obstructive pulmonary disease, highrisk groups, human susceptibility, diesel exhaust particles, diesel exhaust particulate, cardiotoxicity, cardiopulmonary, mortality, DEP, concentrated particulate matter, air contaminant exposure, air quality, co-pollutants, environmental hazard exposures, toxics, airborne urban contaminants, biomarker, cardiovascular disease

Progress and Final Reports:

Original Abstract
  • 2005 Progress Report
  • 2006 Progress Report
  • 2007 Progress Report
  • Final Report