Final Report: Oxygenated Urban Air Toxics and Asthma Variability in Middle School Children: A Panel Study (ATAC–Air Toxics and Asthma in Children)

EPA Grant Number: R828678C005
Subproject: this is subproject number 005 , established and managed by the Center Director under grant R824834
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Mickey Leland National Urban Air Toxics Research Center (NUATRC)
Center Director: Beskid, Craig
Title: Oxygenated Urban Air Toxics and Asthma Variability in Middle School Children: A Panel Study (ATAC–Air Toxics and Asthma in Children)
Investigators: Delclos, George , Abramson, Stuart , Hanania, Nicola , Lai, Dejian , Morandi, Maria T. , Sockrider, Marianna , Stock, Tom
Institution: The University of Texas at Houston , Baylor College of Medicine
EPA Project Officer: Chung, Serena
Project Period: December 6, 2001 through December 6, 2004 (Extended to December 6, 2005)
RFA: Mickey Leland National Urban Air Toxics Research Center (NUATRC) (1997) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Targeted Research

Objective:

The goal of this study, “Oxygenated Urban Air Toxics and Asthma Variability in Middle-School Children: A Panel Study,” was to investigate the association between exposure to oxygenated air toxics (total carbonyl, or aldehyde concentration) and asthma health outcomes among labile, persistent asthmatic middle school children in Houston, using a prospective panel study with a repeated-measures design. Given the highly individual nature of asthma, as well as budget and time constraints, the most efficient study design is one of repeated measures of health outcomes and relevant exposure variables over time, in which each participant serves as her/his own control. Four separate 10-day measurement periods, for each of the main independent (exposure) and dependent (health outcome) variables were performed over a 20-month observation period. Consecutive 24-hour personal exposure measurements of airborne compounds were performed for the carbonyls using passive aldehyde samplers. Using data collected in a 25% subset of study homes, personal exposures to ozone and particulate matter were estimated from models, derived from the relationship between indoor/outdoor microenvironmental concentrations, fixed ambient central site values, and indoor/outdoor activity logs. Twice daily physiological (peak expiratory flow rate [PEFR] and forced expired volume in the first second [FEV1]) and daily clinical (asthma symptoms and rescue medication use) indicators of asthma variability were measured concurrently with the daily carbonyl measurements.

The primary study objectives were:

  • To evaluate the association between personal air concentrations of total carbonyls and variability of lung function (peak expiratory flow rate and forced expired volume in the first second) in a sample of middle school children with labile, persistent asthma.
  • To evaluate the association between personal air concentrations of total carbonyls and the variability of selected clinical indicators (asthma symptoms and medication use) in a sample of middle school children with labile, persistent asthma.

Results from the first-pass analysis of this pilot panel study suggest that exposure to total carbonyls at concentrations found in usual microenvironments does not adversely affect the short-term course of asthma in children, and is not as important as exposure to ozone and particulate matter in altering physiologic and clinical markers of asthma in children.

Summary/Accomplishments (Outputs/Outcomes):

This project was funded in response to RFA 2000-02: “Association Between Exposures to Oxygenated Air Toxics and Asthma: An Exposure and Health Effects Study of Houston Area School Children.” The study is in compliance with the Institutional Review Board of the University of Texas.  Human consent procedures met governmental guidelines. The study also is in compliance with appropriate quality control and quality assurance procedures as per NUATRC and EPA guidelines.

The study started in December 2001, and was scheduled to be completed in November 2004. A no-cost extension was granted through December 2005. A revised draft final report was received in October 2005. A draft final report was submitted in December 2005. The Center Research Report Number 11, “Oxygenated Urban Air Toxics and Asthma Variability in Middle-School Children: A Panel Study,” was published in 2007.

Journal Articles:

No journal articles submitted with this report: View all 2 publications for this subproject

Supplemental Keywords:

RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, INTERNATIONAL COOPERATION, ENVIRONMENTAL MANAGEMENT, POLLUTANTS/TOXICS, HUMAN HEALTH, particulate matter, air toxics, Environmental Chemistry, Health Risk Assessment, Exposure, Chemicals, Epidemiology, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Health Effects, Physical Processes, Children's Health, Atmospheric Sciences, Environmental Policy, Biology, Risk Assessment, asthma, copollutant exposures, sensitive populations, urban air, asthma triggers, atmospheric particulate matter, fine particles, PM 2.5, long term exposure, inhaled pollutants, acute lung injury, acute cardiovascular effects, airway disease, air pollution, children, susceptible subpopulations, cardiac arrest, chronic health effects, human exposure, lung inflammation, particulate exposure, assessment of exposure, Acute health effects, indoor air, inhaled, human susceptibility, children's environmental health, Volatile Organic Compounds (VOCs), acute exposure, air quality, exposure assessment, human health risk, toxics, environmental hazard exposures, air contaminant exposure, co-pollutants

Progress and Final Reports:

Original Abstract
  • 2002 Progress Report
  • 2003 Progress Report
  • 2004

  • Main Center Abstract and Reports:

    R824834    Mickey Leland National Urban Air Toxics Research Center (NUATRC)

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R824834C001 Air Toxics Exposures Among Teenagers in New York City and Los Angeles - A Columbia-Harvard Study (TEACH)
    R824834C002 Cardiopulmonary Response to Particulate Exposure
    R824834C003 VOC Exposure in an Industry Impacted Community
    R824834C004 A Study of Personal Exposure to Air Toxics Among a Subset of the Residential U.S. Population (VOC Project)
    R824834C005 Methods Development Project for a Study of Personal Exposures to Toxic Air Pollutants
    R824834C006 Relationship Between Indoor, Outdoor and Personal Air (RIOPA)
    R824834C007 Development of the "Leland Legacy" Air Sampling Pump
    R824834C008 Source Apportionment of Indoor Polycyclic Aromatic Hydrocarbons (PAHs) in Urban Residences
    R824834C009 Development of a Personal Cascade Impactor Sampler (PCIS)
    R824834C010 Testing the Metals Hypothesis in Spokane
    R828678C001 Air Toxics Exposures Among Teenagers in New York City and Los Angeles—A Columbia-Harvard Study (TEACH)
    R828678C002 Cardiopulmonary Effects of Metal-Containing Particulate Exposure
    R828678C003 VOC Exposure in an Industry Impacted Community
    R828678C004 A Study of Personal Exposure to Air Toxics Among a Subset of the Residential U.S. Population (VOC Project)
    R828678C005 Oxygenated Urban Air Toxics and Asthma Variability in Middle School Children: A Panel Study (ATAC–Air Toxics and Asthma in Children)
    R828678C006 Relationship between Indoor, Outdoor and Personal Air (RIOPA). Part II: Analyses of Concentrations of Particulate Matter Species
    R828678C007 Development of the “Leland Legacy” Air Sampling Pump
    R828678C008 Source Apportionment of Indoor PAHs in Urban Residences 98-03B
    R828678C009 Development of a Personal Cascade Impactor Sampler (PCIS)
    R828678C010 Testing the Metals Hypothesis in Spokane
    R828678C011 A Pilot Geospatial Analysis of Exposure to Air Pollutants (with Special Attention to Air Toxics) and Hospital Admissions in Harris County, Texas
    R828678C012 Impact of Exposure to Urban Air Toxics on Asthma Utilization for the Pediatric Medicaid Population in Dearborn, Michigan
    R828678C013 Field Validation of the Sioutas Sampler and Leland Legacy Pump – Joint Project with EPA’s Environmental Technology Validation Program (ETV)
    R828678C014 Performance Evaluation of the 3M Charcoal Vapor Monitor for Monitor Low Ambient Concentrations of VOCs
    R828678C015 RIOPA Database Development
    R828678C016 Contributions of Outdoor PM Sources to Indoor and Personal Exposures: Analysis of PM Species Concentrations” Focused on the PM Speciation and Apportioning of Sources
    R828678C017 The Short and Long-Term Respiratory Effects of Exposure to PAHs from Traffic in a Cohort of Asthmatic Children