2003 Progress Report: Endocrine Disrupting Chemicals and Thyroid OutcomesEPA Grant Number: R830254
Title: Endocrine Disrupting Chemicals and Thyroid Outcomes
Investigators: Anderson, Henry A.
Institution: Wisconsin Department of Health and Family Services
EPA Project Officer: Hunt, Sherri
Project Period: March 1, 2003 through February 28, 2007 (Extended to February 28, 2009)
Project Period Covered by this Report: March 1, 2003 through February 28, 2004
Project Amount: $2,288,208
RFA: Endocrine Disruptors: Epidemiologic Approaches (2001) RFA Text | Recipients Lists
Research Category: Economics and Decision Sciences , Endocrine Disruptors , Health , Safer Chemicals
The overall objective of this research project is to measure polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) levels, thyroid parameters, reproductive hormone levels, urinary iodine and hormone concentrations, and hemoglobin A1C in 500 frequent and infrequent sport fish consumers. Based on the study findings, the specific objective of this research project is to determine whether there is an interaction between fish consumption and endocrine function.
Our progress to date includes completing the U.S. Environmental Protection Agency Quality Assurance Project Plan for all data and laboratory components, confirming the mailing addresses of our cohort members, and developing the survey instruments that will be used to collect health and fish consumption data. These surveys, along with a cover letter and consent form, have been submitted to our local Internal Review Board for approval. The laboratory also has completed validation of PBDE analytic methods, and has refined model sensitivity.
We will begin mailing surveys to 3,600 individuals in the spring of 2004; biological sample collection will begin in the spring/summer of 2004. We will recruit at least 500 participants to donate blood and urine specimens. We will continue to measure PCB and PBDE levels, thyroid parameters, reproductive hormone levels, urinary iodine and hormone concentrations, and hemoglobin A1C in 500 frequent and infrequent sport fish consumers. We also will use survey and laboratory data to publish peer-reviewed scientific articles and revise state fish advisories.