2003 Progress Report: X-ray CT-based Assessment of Variations in Human Airway Geometry: Implications for Evaluation of Particle Deposition and Dose to Different Populations

EPA Grant Number: R827351C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R827351
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: EPA NYU PM Center: Health Risks of PM Components
Center Director: N/A
Title: X-ray CT-based Assessment of Variations in Human Airway Geometry: Implications for Evaluation of Particle Deposition and Dose to Different Populations
Investigators: Cohen, Beverly S. , Hoffman, Eric
Institution: New York University School of Medicine , University of Iowa
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2003 through May 31, 2004
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air

Objective:

The objective of this research project is to address the paucity of data regarding particulate matter (PM) deposition in the lungs of people with preexisting pulmonary disease and the normal elderly; subpopulations which may be at special risk. This project is investigating the potential for retrieval of morphometric data from three-dimensional images of tracheobronchial airways obtained in vivo by x-ray computerized tomography (CT). The study also is exploring the potential for the use of stereolithography (STL) to produce hollow airway casts of normal and abnormal lung airways for the experimental determination of site-specific deposition and for experimental verification of particle deposition models. We are using these tools to compare inhaled particle deposition pattern and efficiency in sheep in vivo with the deposition measured in a hollow airway cast prepared from the same animal’s three-dimensional image for a variety of breathing patterns and when particles are inhaled at different points in the respiratory cycle. We also plan to: (1) select representative lungs of patients with clinically diagnosed lung diseases using the extensive database being established at the University of Iowa; (2) prepare hollow airway casts; and (3) test deposition in these casts. These data will test and validate theoretical and empirical models used to predict detailed particle deposition in living individuals, including those representative of various potentially susceptible subgroups. The ultimate goal of the project is to quantify the impact of the airway variability on PM deposition and dose. This research project is a collaboration between the extensive imaging expertise at the University of Iowa and New York University (NYU) PM Center particle deposition expertise.

This is one of the projects funded by the New York University (NYU) PM Center. The progress for the other projects is reported separately (see reports for R827351C001 and R827351C003 through R827351C016).

Progress Summary:

The research project has been completed as a verification of the fidelity of the hollow airway cast to the in vivo CT images, and a publication has been submitted for peer review. Developmental work has been suspended temporarily.

Future Activities:

Colleagues at the University of Texas Health Science Center at Houston have submitted a research proposal for use of the casts in particle deposition studies. Dr. Cohen is a consultant on that proposal, and, if it is funded, we will resume development and production of the airway casts and proceed with further validation of quantitative deposition models.

Journal Articles:

No journal articles submitted with this report: View all 1 publications for this subproject

Supplemental Keywords:

thoracic particles, PM10, fine particles, PM2.5, ultrafine particles, PM 0.1, lung dosimetry models, human exposure models, pulmonary responses, cardiovascular responses, immunological responses, criteria air pollutants, concentrated ambient aerosols, aerosol, air pollutants, air pollution, airborne pollutants, airway disease, airway inflammation, airway variability, allergen, ambient air, ambient air quality, analytical chemistry, assessment of exposure, asthma, asthma morbidity, atmospheric monitoring, biological markers, childhood respiratory disease, children, combustion, combustion contaminants, combustion emissions, compliance monitoring, dosimetry, epidemiology, exposure, exposure and effects, health effects, heart rate variability, human exposure, human health, human health effects, incineration, lead, lung, mercury, morbidity, particulates, pulmonary, pulmonary disease, respiratory,, RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, ENVIRONMENTAL MANAGEMENT, particulate matter, Environmental Chemistry, Health Risk Assessment, Risk Assessments, Environmental Monitoring, Physical Processes, Atmospheric Sciences, Risk Assessment, ambient air quality, atmospheric particulate matter, particulates, air toxics, atmospheric particles, chemical characteristics, toxicology, ambient air monitoring, acute lung injury, airborne particulate matter, environmental risks, exposure, epidemelogy, air pollution, aerosol composition, atmospheric aerosol particles, human exposure, PM, X-ray tomagraphy, airway contractile properties, exposure assessment

Relevant Websites:

http://www.med.nyu.edu/environmental/centers/epa/ Exit

Progress and Final Reports:

Original Abstract
  • 1999 Progress Report
  • 2000 Progress Report
  • 2001 Progress Report
  • 2002 Progress Report
  • 2004
  • Final Report

  • Main Center Abstract and Reports:

    R827351    EPA NYU PM Center: Health Risks of PM Components

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R827351C001 Exposure Characterization Error
    R827351C002 X-ray CT-based Assessment of Variations in Human Airway Geometry: Implications for Evaluation of Particle Deposition and Dose to Different Populations
    R827351C003 Asthma Susceptibility to PM2.5
    R827351C004 Health Effects of Ambient Air PM in Controlled Human Exposures
    R827351C005 Physicochemical Parameters of Combustion Generated Atmospheres as Determinants of PM Toxicity
    R827351C006 Effects of Particle-Associated Irritants on the Cardiovascular System
    R827351C007 Role of PM-Associated Transition Metals in Exacerbating Infectious Pneumoniae in Exposed Rats
    R827351C008 Immunomodulation by PM: Role of Metal Composition and Pulmonary Phagocyte Iron Status
    R827351C009 Health Risks of Particulate Matter Components: Center Service Core
    R827351C010 Lung Hypoxia as Potential Mechanisms for PM-Induced Health Effects
    R827351C011 Urban PM2.5 Surface Chemistry and Interactions with Bronchoalveolar Lavage Fluid (BALF)
    R827351C012 Subchronic PM2.5 Exposure Study at the NYU PM Center
    R827351C013 Long Term Health Effects of Concentrated Ambient PM2.5
    R827351C014 PM Components and NYC Respiratory and Cardiovascular Morbidity
    R827351C015 Development of a Real-Time Monitoring System for Acidity and Soluble Components in Airborne Particulate Matter
    R827351C016 Automated Real-Time Ambient Fine PM Monitoring System