1999 Progress Report: Asthma Susceptibility to PM2.5EPA Grant Number: R827351C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R827351
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: EPA NYU PM Center: Health Risks of PM Components
Center Director: N/A
Title: Asthma Susceptibility to PM2.5
Investigators: Thurston, George D. , Reibman, Joan
Institution: New York University School of Medicine
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 1999 through May 31, 2000
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air
The objectives of this research project are to: (1) investigate which particulate matter (PM) component(s) and PM mechanisms affect asthmatics most strongly; and (2) follow prospectively a cohort of asthmatics and evaluate PM effects on their health status.
An initial group of 12 Bellevue Hospital Primary Care Asthma Clinic mild-moderate asthmatic subjects were recruited into the study and followed during the summer of 1999. It was found that the prior day’s PM10 and PM2.5 mass concentration was negatively associated with peak expiratory flow rate (PEFR). Reported decrements were 3.7 percent per 50 μg/m3 PM10 increase and 2.3 percent per 40 μg/m3 PM2.5 increase. Followup analyses have found that ozone exposure also is associated with PEFR decrements, and we are investigating the relative roles of these copollutants on the reported acute air pollution exposure lung function effects.
Throughout the summer, fall, and winter of 1999, we successfully developed a sputum induction procedure based on the U.S. Environmental Protection Agency’s (EPA) methods. We sent a research associate to learn the sputum induction procedure, and we have now implemented this sputum induction capability into our Center resources for this and other funded studies.
In the winter of 1999, our recruitment continued of patients for our cohort of 30 adult, nonsmoking, asthmatic subjects willing to be followed by prospective monitoring (on days following low versus high PM2.5 concentrations) of their serum and sputum levels of proinflammatory mediators (IL-6, IL-8), as well as of Th1- and Th2-induced cells (interferon-gamma and IL-4, respectively) that are thought to mediate asthma responses. A limitation to this recruitment has been the inability of many moderate to severe asthmatics to produce a useful sputum sample without having asthma exacerbation symptoms. As of the spring of 2000, we had screened dozens of candidates and successfully recruited 14 patients for this cohort.
We will continue recruitment of patients for our cohort of adult non-smoking asthmatic subjects willing to be followed by prospective monitoring, on days following low versus high PM2.5 concentrations . We also will improve our induced sputum technique.
Journal Articles:No journal articles submitted with this report: View all 4 publications for this subproject
Supplemental Keywords:thoracic particles, particulate matter, PM, PM10, fine particles, PM2.5, ultrafine particles, PM0.1, lung dosimetry models, human exposure models, pulmonary responses, cardiovascular responses, immunological responses, criteria air pollutants, concentrated ambient aerosols, air, health, waste, biochemistry, biology, chemical engineering, chemistry, children’s health, civil engineering, environmental engineering, environmental chemistry, physics, analytical chemistry, epidemiology, health risk assessment, immunology, incineration, combustion, combustion contaminants, combustion emissions, air toxics, tropospheric ozone, aerosol, air pollutants, air pollution, airborne pollutants, airway disease, airway inflammation, airway variability, allergen, ambient air, ambient air quality, assessment of exposure, asthma, asthma morbidity, atmospheric monitoring, biological markers, childhood respiratory disease, children, compliance monitoring, dosimetry, exposure, exposure and effects, health effects, heart rate variability, human exposure, human health, human health effects, lead, lung, mercury, morbidity, pulmonary, pulmonary disease, respiratory, clinical, toxicology, smoker, nonsmoker, sputum, genetic susceptibility, aerosol composition, airborne particulate matter, allergic response, ambient air monitoring, asthma indices, asthma triggers, atmospheric aerosol particles, atmospheric particles, atmospheric particulate matter, chemical characteristics, environmental risks, exposure assessment, health risks, human health risk, human susceptibility, inhalation, ozone, ozone monitoring, particulates, secondhand smoke, sensitive populations, tobacco smoke, peak expiratory flow rate, PEFR,, RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, ENVIRONMENTAL MANAGEMENT, HUMAN HEALTH, particulate matter, Environmental Chemistry, Health Risk Assessment, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Allergens/Asthma, Environmental Monitoring, Health Effects, Physical Processes, genetic susceptability, Atmosphere, Risk Assessment, ambient air quality, atmospheric particulate matter, particulates, asthma, asthma triggers, sensitive populations, air toxics, atmospheric particles, chemical characteristics, toxicology, ambient air monitoring, health risks, airborne particulate matter, ozone, asthma indices, environmental risks, exposure, second hand smoke, airway disease, airway inflammation, air pollution, aerosol composition, atmospheric aerosol particles, human exposure, airborne pollutants, inhalation, ozone monitoring, human susceptibility, allergic response, tobacco smoke, exposure assessment
Progress and Final Reports:Original Abstract
Main Center Abstract and Reports:R827351 EPA NYU PM Center: Health Risks of PM Components
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827351C001 Exposure Characterization Error
R827351C002 X-ray CT-based Assessment of Variations in Human Airway Geometry: Implications for Evaluation of Particle Deposition and Dose to Different Populations
R827351C003 Asthma Susceptibility to PM2.5
R827351C004 Health Effects of Ambient Air PM in Controlled Human Exposures
R827351C005 Physicochemical Parameters of Combustion Generated Atmospheres as Determinants of PM Toxicity
R827351C006 Effects of Particle-Associated Irritants on the Cardiovascular System
R827351C007 Role of PM-Associated Transition Metals in Exacerbating Infectious Pneumoniae in Exposed Rats
R827351C008 Immunomodulation by PM: Role of Metal Composition and Pulmonary Phagocyte Iron Status
R827351C009 Health Risks of Particulate Matter Components: Center Service Core
R827351C010 Lung Hypoxia as Potential Mechanisms for PM-Induced Health Effects
R827351C011 Urban PM2.5 Surface Chemistry and Interactions with Bronchoalveolar Lavage Fluid (BALF)
R827351C012 Subchronic PM2.5 Exposure Study at the NYU PM Center
R827351C013 Long Term Health Effects of Concentrated Ambient PM2.5
R827351C014 PM Components and NYC Respiratory and Cardiovascular Morbidity
R827351C015 Development of a Real-Time Monitoring System for Acidity and Soluble Components in Airborne Particulate Matter
R827351C016 Automated Real-Time Ambient Fine PM Monitoring System