CECEHDPR - University of Michigan

EPA Grant Number: R826710
Center: Michigan Center for the Environment and Children’s Health
Center Director: Israel, Barbara A.
Title: CECEHDPR - University of Michigan
Investigators: Israel, Barbara A.
Institution: University of Michigan
EPA Project Officer: Fields, Nigel
Project Period: September 1, 1998 through August 31, 2003 (Extended to August 31, 2005)
Project Amount: $2,830,746
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text |  Recipients Lists
Research Category: Human Health , Health , Children's Health , Health Effects

Objective:

Childhood asthma is one of the most common chronic pediatric diseases and poses a serious public health problem.  The prevalence of the disease in the city of Detroit is particularly high, reflecting the trends found elsewhere among urban populations and communities of color.  The Michigan Center for the Environment and Children's Health (MCECH) will engage in coordinated interdisciplinary research aimed at: 1) identifying children with asthma and assess their household, school, and neighborhood environment, 2) increasing knowledge and behavior to reduce environmental hazards in households and neighborhoods, thereby improving asthma-related health status, 3) examining the effects of daily and seasonal fluctuations in indoor and outdoor ambient air quality on pulmonary function and severity of asthma symptoms, 4) determining the effects of allergen-induced local, excessive production of chemokines on redox status and innervation of the bronchial tree, and 5) developing specific mechanisms for communication and translation of laboratory and community-based research across disciplines and to community partners. The Center will include three research cores, Asthma Intervention (Core 1), Asthma Exposure (Core 2) and Asthma Chemokines (Core 3), supported by two Facility Cores (Biostatistics and Exposure Assessment) and an Administrative Core,  and two new Center Scientists.

The Center is a partnership involving the University of Michigan Schools of Public Health and Medicine, the Detroit Health Department, Henry Ford Health System, community-based organizations based on the southwest and east sides of Detroit, including Butzel Family Center, Community Health and Social Services Center (CHASS), Detroiters Working for Environmental Justice, Friends of Parkside, Kettering/Butzel Health Initiative, Latino Family Services, United Community Housing Coalition, and Warren/Conner Development Coalition, and the Centers for Disease Control and Prevention (CDC.)  The Center builds on a partnership established in 1995 by the Detroit Community-Academic Urban Research Center (URC), one of three "Urban Centers for Applied Research" funded by the CDC.  The Detroit URC seeks to develop and implement prevention research that improves the health of children and families in selected communities in southwest and east side Detroit.  The Detroit URC Board, comprised of representatives of many of the same partners currently participating in the new Center, adopted a set of "Community-Based Research Principles" to guide the development of research projects carried out in conjunction with the URC.  These research principles include an emphasis on: the local relevance of public health problems; the involvement of community, practitioner, and academic partners in all major phases of the research process; the conduct of research that is beneficial to the community involved; and the dissemination of research findings to community members in ways that are understandable and useful.   In 1996 the URC Board, after a review of relevant data and discussion of interests and needs of partner organizations, identified three overall priority areas for developing new community-based prevention research projects.  One of these priorities was the area of environmental health and in particular housing and air quality as it relates to asthma in children.  The URC Board enthusiastically and unanimously decided to be involved in submitting a proposal for the new Center that would focus on identifying and reducing environmental exposures considered to be associated with asthma health status in children.


Journal Articles: 22 Displayed | Download in RIS Format

Other center views: All 45 publications 24 publications in selected types All 22 journal articles
Type Citation Sub Project Document Sources
Journal Article Clark NM, Brown RW, Parker E, Robins TG, Remick Jr. DG, Philbert MA, Keeler GJ, Israel BA. Childhood asthma. Environmental Health Perspectives 1999;107(Suppl 3):421-429. R826710 (Final)
R826710C001 (1999)
R826710C002 (1999)
R826710C003 (1999)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: EHP - Full Text PDF
  • Abstract: EHP
  • Journal Article Dvonch JT, Marsik FJ, Keeler GJ, Robins TG, Yip F, Morishita M. Field comparison of PM2.5 teom and PM2.5 manual filter-based measurement methods in urban atmospheres. Journal of Aerosol Science 2000;31(Suppl 1):190-191. R826710 (Final)
  • Full-text: ScienceDirect - PDF
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  • Abstract: ScienceDirect
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  • Journal Article Edgren KK, Parker EA, Israel BA, Lewis TC, Salinas MA, Robins TG, Hill YR. Community involvement in the conduct of a health education intervention and research project: Community Action Against Asthma. Health Promotion Practice 2005;6(3):263-269. R826710 (Final)
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  • Abstract: Sage Publications-Abstract
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  • Journal Article Eggleston PA, Diette G, Lipsett M, Lewis T, Tager I, McConnell R, Chrischilles E, Lanphear B, Miller R, Krishnan J. Lessons learned for the study of childhood asthma from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1430-1436. R826710 (Final)
    R827027 (2002)
    R829389 (2003)
    R829389 (2004)
    R829389 (2005)
    R829389 (Final)
    R831710 (2004)
    R831710 (2005)
    R831710 (Final)
    R831861 (2005)
    R831861 (2006)
    R831861C001 (2006)
    R832139 (2004)
    R832139 (2005)
    R832139 (2006)
    R832139C002 (2005)
    R832139C003 (2005)
    R832141 (2006)
    R832141 (2007)
    R832141 (Final)
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  • Journal Article Farquhar SA, Parker EA, Schulz AJ, Israel BA. In their words: how Detroit residents perceive the effects of their physical environment. Local Environment: The International Journal of Justice and Sustainability 2005;10(3):259-274. R826710 (Final)
  • Abstract: Taylor & Francis Online-Abstract
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  • Journal Article Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1447-1454. R826710 (Final)
    R826708 (2000)
    R826708 (2001)
    R826708 (2002)
    R826708 (Final)
    R827027 (2002)
    R831845 (2005)
    R831861 (2004)
    R831861 (2005)
    R831861 (2006)
    R831861 (Final)
    R831861C001 (2006)
    R831861C001 (Final)
    R831861C002 (Final)
    R831861C003 (2006)
    R831861C003 (Final)
    R832139 (2006)
    R832141 (2006)
    R832141 (2007)
    R832141 (Final)
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  • Journal Article Israel BA, Parker EA, Rowe Z, Salvatore A, Minkler M, Lopez J, Butz A, Mosley A, Coates L, Lambert G, Potito PA, Brenner B, Rivera M, Romero H, Thompson B, Coronado G, Halstead S. Community-based participatory research: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1463-1471. R826710 (Final)
    R829391 (2004)
    R829391 (2005)
    R829391 (2006)
    R829391C005 (2006)
    R831709 (2005)
    R831709 (2007)
    R831709C003 (2005)
    R831709C003 (2006)
    R831710 (2004)
    R831710 (2005)
    R831710 (Final)
    R831710C001 (2006)
    R831710C002 (2006)
    R831710C004 (2006)
    R831711 (2005)
    R831711 (2006)
    R831711 (2007)
    R831711 (Final)
    R831711C001 (2006)
    R831711C002 (2006)
    R831711C003 (2006)
    R832139 (2006)
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  • Journal Article Keeler GJ, Dvonch T, Yip FY, Parker EA, Isreal BA, Marsik FJ, Morishita M, Barres JA, Robins TG, Brakefield-Caldwell W, Sam M. Assessment of personal and community-level exposures to particulate matter among children with asthma in Detroit, Michigan, as part of Community Action Against Asthma (CAAA). Environmental Health Perspectives 2002;110(Suppl 2):173-181. R826710 (2002)
    R826710 (Final)
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  • Abstract from PubMed
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  • Full-text: EHP - full text PDF
  • Abstract: EHP
  • Journal Article Kim J, Merry AC, Nemzek JA, Bolgos GL, Siddiqui J, Remick DG. Eotaxin represents the principal eosinophil chemoattractant in a novel murine asthma model induced by house dust containing cockroach allergens. Journal of Immunology 2001;167(5):2808-2815. R826710 (2002)
    R826710 (Final)
  • Abstract from PubMed
  • Full-text: Journal of Immunology-Full Text HTML
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  • Abstract: Journal of Immunology-Abstract
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  • Other: Journal of Immunology-PDF
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  • Journal Article Kim J, McKinley L, Siddiqui J, Bolgos GL, Remick DG. Prevention and reversal of pulmonary inflammation and airway hyperresponsiveness by dexamethasone treatment in a murine model of asthma induced by house dust. American Journal of Physiology-Lung Cellular and Molecular Physiology 2004;287(3):L503-L509. R826710 (2002)
    R826710 (Final)
  • Abstract from PubMed
  • Full-text: American Physiological Society-Full Text HTML
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  • Abstract: American Physiological Society-Abstract
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  • Other: American Physiological Society-PDF
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  • Journal Article Kim J, McKinley L, Natarajan S, Bolgos GL, Siddiqui J, Copeland S, Remick DG. Anti-tumor necrosis factor-α antibody treatment reduces pulmonary inflammation and methacholine hyper-responsiveness in a murine asthma model induced by house dust. Clinical and Experimental Allergy 2006;36(1):122-132. R826710 (Final)
  • Abstract from PubMed
  • Abstract: Wiley Online-Abstract
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  • Journal Article Lewis TC, Robins TG, Joseph CLM, Parker EA, Israel BA, Rowe Z, Edgren KK, Salinas MA, Martinez ME, Brown RW. Identification of gaps in the diagnosis and treatment of childhood asthma using a community-based participatory research approach. Journal of Urban Health 2004;81(3):472-488. R826710 (Final)
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  • Abstract: Springer Link - Abstract
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  • Journal Article Lewis TC, Robins TG, Dvonch JT, Keeler GJ, Yip FY, Mentz GB, Lin X, Parker EA, Israel BA, Gonzalez L, Hill Y. Air pollution-associated changes in lung function among asthmatic children in Detroit. Environmental Health Perspectives 2005;113(8):1068-1075. R826710 (Final)
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  • Abstract: Environmental Health Perspectives
  • Journal Article Lopez ED, Parker EA, Edgren KK, Brakefield-Caldwell W. Disseminating research findings back to partnering communities: lessons learned from a community-based participatory research approach. Metropolitan Universities Journal 2005;16(1):57-76. R826710 (Final)
  • Abstract: CUMU-Abstract
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  • Journal Article McKinley L, Kim J, Bolgos GL, Siddiqui J, Remick DG. Reproducibility of a novel model of murine asthma-like pulmonary inflammation. Clinical & Experimental Immunology 2004;136(2):224-231. R826710 (Final)
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  • Abstract: Wiley Online Library - Abstract
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  • Journal Article McKinley L, Kim J, Bolgos GL, Siddiqui J, Remick DG. CXC chemokines modulate IgE secretion and pulmonary inflammation in a model of allergic asthma. Cytokine 2005;32(3-4):178-185. R826710 (2002)
    R826710 (Final)
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  • Abstract: ScienceDirect-Abstract
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  • Journal Article McKinley L, Kim J, Bolgos GL, Siddiqui J, Remick DG. Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice. Respiratory Research 2006;7(1):129. R826710 (Final)
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  • Full-text: Respiratory Research - Full Text HTML
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  • Abstract: Respiratory Research
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  • Other: Respiratory Research - Full Text PDF
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  • Journal Article Parker EA, Israel BA, Williams M, Brakefield-Caldwell W, Lewis TC, Robins T, Ramirez E, Rowe Z, Keeler G. Community action against asthma: examining the partnership process of a community-based participatory research project. Journal of General Internal Medicine 2003;18(7):558-567. R826710 (Final)
  • Full-text from PubMed
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  • Abstract: Springerlink
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  • Journal Article Parker EA, Baldwin GT, Israel B, Salinas MA. Application of health promotion theories and models for environmental health. Health Education & Behavior 2004;31(4):491-509. R826710 (Final)
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  • Abstract: Sage Journals - Abstract
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  • Journal Article Parker EA, Israel BA, Robins TG, Mentz G, Lin X, Brakefield-Caldwell W, Ramirez E, Edgren KK, Salinas M, Lewis TC. Evaluation of Community Action Against Asthma: a community health worker intervention to improve children's asthma-related health by reducing household environmental triggers for asthma. Health Education & Behavior 2008;35(3):376-395. R826710 (Final)
  • Abstract from PubMed
  • Abstract: Sage Journal - Abstract
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  • Journal Article Trout D, Weissman DN, Lewis D, Brundage RA, Franzblau A, Remick D. Evaluation of hypersensitivity pneumonitis among workers exposed to metal removal fluids. Applied Occupational and Environmental Hygiene 2003;18(11):953-960. R826710 (Final)
  • Abstract from PubMed
  • Abstract: Taylor & Francis Online
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  • Journal Article Yip FY, Keeler GJ, Dvonch JT, Robins TG, Parker EA, Israel BA, Brakefield-Caldwell W. Personal exposures to particulate matter among children with asthma in Detroit, Michigan. Atmospheric Environment 2004;38(31):5227-5236. R826710 (Final)
  • Full-text: ScienceDirect - Full Text HTML
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  • Abstract: ScienceDirect
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  • Other: University of Michigan - Full Text PDF
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  • Supplemental Keywords:

    RFA, Health, Scientific Discipline, Air, Geographic Area, HUMAN HEALTH, Environmental Chemistry, Health Risk Assessment, State, Indoor Air Pollution, Risk Assessments, Allergens/Asthma, Health Effects, Children's Health, indoor air, Molecular Biology/Genetics, asthma, asthma triggers, acute lung injury, airway disease, exposure, respiratory problems, second hand smoke, asthma indices, respiratory disease, air pollution, children, Human Health Risk Assessment, airway inflammation, indoor air chemistry, airborne pollutants, human exposure, inhalation, susceptibility, children's vulnerablity, assessment of exposure, childhood respiratory disease, asthmatic children, cigarette smoke, children's environmental health, environmental tobacco smoke, allergic response, air quality, allergen, exposure assessment, human health risk, Michigan (MI), cockroaches

    Progress and Final Reports:

    2000 Progress Report
    2002 Progress Report
    Final Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R826710C001 Indoor and Outdoor Air Contaminant Exposures and Asthma Aggravation Among Children (Asthma Exposure)
    R826710C002 Chemokines in the Pathogenesis of Asthma (Asthma Chemokines)
    R826710C003 A Community-Based Intervention to Reduce Environmental Triggers for Asthma Among Children (Asthma Intervention)