2001 Progress Report: CECEHDPR - University of Southern California

EPA Grant Number: R826708
Center: CECEHDPR - University of Southern California
Center Director: Gong, Henry
Title: CECEHDPR - University of Southern California
Investigators: Gong, Henry
Current Investigators: Gong, Henry , Avol, Edward L. , Diaz-Sanchez, David , Gauderman, William , Gilliland, Frank D. , Hinds, William C. , Jones, Craig , McConnell, Rob Scot , Peters, John M.
Institution: University of California - Los Angeles
EPA Project Officer: Louie, Nica
Project Period: August 1, 1998 through July 31, 2003
Project Period Covered by this Report: August 1, 2000 through July 31, 2001
Project Amount: $2,895,926
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text |  Recipients Lists
Research Category: Children's Health , Health Effects , Human Health , Health

Objective:

The objective of the University of Southern California (USC) Children’s Environmental Health Center (CEHC) is to develop a better understanding of how host susceptibility and environmental exposures contribute to children’s respiratory disease.  This research will provide health and environmental officials with a variety of useful intervention tools.  USC is investigating the relationship between environmental tobacco smoke (ETS) and asthma in children.  This Center is determining the biological mechanisms by which ETS alters normal allergic responses in children.

The Administrative Core of the CEHC , located at the Keck School of Medicine of USC , supervises and coordinates a multi disciplinary and multi-institutional effort for the research and outreach in children’s environmental health issues, in particular, as they relate to air pollution and respiratory disease and prevention.

The Community Outreach and Education Program (COEP) of CEHC connects an interdisciplinary team of scientists from USC and the University of California at Los Angeles (UCLA) with other researchers studying issues of children’s environmental health, as well as with community-based organizations and others interested in children’s environmental health issues.  The COEP program at the Keck School of Medicine of USC began when the National Institute of Environmental Health Sciences (NIEHS) funded the Southern California Environmental Health Sciences Center (SCEHSC) in 1996.  The CEHC has allowed an expansion of partnerships with community-based and public health organizations, as well as with health care providers and schools, particularly around issues of asthma.

The primary objectives of CEHC’s COEP activities are to:  (1) create awareness of new problems and research opportunities in children’s environmental health that are relevant to the community; (2) collaborate with community-based organizations and community-focused institutions on projects involving children’s environmental health issues; (3) provide support to Center members by linking their research efforts with interested community organizations; (4) identify and respond to programmatic needs and requests concerning environmental health issues that affect children that are raised within the community; and (5) promote education about children and environmental health issues in kindergarten to grade 12 (K-12) school programs.

Progress Summary:

Administrative Core

The CEHC developed new and ongoing collaborations and accomplishments both within its structure and with USC, UCLA, and the community as part of its research and outreach missions. The research and community outreach accomplishments are described in a subsequent section. Specifically, the Administrative Core was involved in the following activities: 

  • Drs. Henry Gong and David Diaz-Sanchez attended the third annual meeting of the Directors of the Children’ s Environmental Health Centers in Berkeley, California , in October 2000.
  • The principal investigators (PIs) of the three research projects and the Internal Advisory Committee met on a regular and ad hoc basis to review research progress.
  • The New Scientist Program was re directed to a search for a full-time faculty member who would be spending a significant proportion of his/her time in children’s respiratory epidemiology.  We have interviewed several excellent candidates and offered a position to one candidate; ultimately, however, that candidate declined.  We are continuing with the search process.
  • The CEHC Web Site (http://www.usc.edu/medicine/cehc Exit ) was finalized under the able leadership of Andrea Hricko and Carrie van Doren.  We plan to revise the Web site on an annual basis or more frequently if necessary.
  • Ana Miranda, who was awarded an NIEHS supplemental training grant for under represented minority students, was recruited and trained.
  • Interactions between the CEHC and the NIEHS-supported SCEHSC continue to occur:  (1) several CEHC investigators presented their research in the SCEHSC’s established research seminar series and other CEHC presentations are planned; and (2) the CEHC investigators made use of the SCEHSC’s Facility Cores, such as storing buccal samples (by Dr. Frank Gilliland) in the Biological Sample/Processing Core, accessing advice about environmental tobacco smoke generation and monitoring (by Dr. Diaz-Sanchez) from the Analytical Chemistry Core, and obtaining statistical advice (by all PIs) from the Biostatistics Core.

Significance.  The CEHC has allowed expansion and synergism of research and community interactions that heretofore were not present in our institutions and communities.

Community Outreach and Education Program

The COEP has developed a number of significant ongoing collaborations that facilitate CEHC’s research and outreach on issues involving children and environmental health issues. Ongoing collaborations include: 

Asthma and Children.  The CEHC is actively involved in outreach activities and faculty serve as advisers in two asthma intervention projects funded by the State of California Proposition 10 (tobacco) money and another funded by the Robert Wood Johnson Foundation (RWJF).  One project is a partnership led by the Asthma and Allergy Foundation of America (AAFA) in Los Angeles County; the second is a partnership led by Latino Health Access in Orange County; and the third is a partnership of many groups in Long Beach (the latter funded by RWJF).  

KICK Asthma LA.  Ms. Hricko, t he COEP director, continues to work on Keep Improving Control of Kids’ Asthma in Los Angeles (KICK Asthma LA), which is nearing completion.  This project includes the following collaborators:  Mothers of East Los Angeles—Santa Isabel; American Lung Association of Los Angeles County; City of Los Angeles Environmental Affairs Department; Environmental Protection Agency—Child Health Champion Program; Francisco Bravo Medical Magnet High School; Murchison Elementary School; school nurses at nine elementary schools in El Sereno; various health clinics and hospitals; and local businesses.

Environmental Justice Issues and Children:  Environmental Health Coalition (EHC), San Diego.  The CEHC faculty and staff are working with this group on issues dealing with children and air pollution.  Ed Avol has been working with the EHC on evaluation of air monitoring results in Barrio Logan, a low- income community of San Diego; Dr. Rob McConnell is working on burden of disease issues, utilizing asthma data from a community clinic; and Ms. Hricko has been working with EHC staff to develop and teach a high school curriculum on air pollution.  These efforts are part of a joint grant between EHC and USC, facilitated by the COEP.

Boyle Heights Mejoramiento.  Ms. Hricko has worked closely with this group on its concerns about the effect of truck exhaust and noise pollution on school children’s respiratory health in an area of dense diesel truck traffic.  She has advised an Occidental College student who compared a noisy school in Boyle Heights and a quiet school with regard to sound levels as part of her senior project, utilizing equipment purchased by the COEP.

Communities for a Better Environment (CBE).  The COEP Director is working with CBE in developing a section of its environmental leadership training manual to include asthma issues, as part of the collaboration of the asthma intervention study directed by Drs. Craig Jones and Rob McConnell.

Highlights of Year 3 of the project include the following:

  • The CEHC partnership led by AAFA in Los Angeles County involves three of the community partner organizations for our asthma intervention study (AAFA, Esperanza Community Housing Corp. , and Hathaway Children and Family Services).  For the partnership led by Latino Health Access in Orange County, CEHC faculty members have provided assistance as members of the partnership’ s external advisory committee and with materials developed by the CEHC.  The RWJF-funded partnership has CEHC faculty serving as advisors for the development of a plan to address environmental factors in asthma severity.
  • The involvement of the CEHC in a Los Angeles County community asthma program is an excellent example of how the expertise developed by Dr. McConnell as part of his CEHC asthma intervention study is reaching the broader community.  A major expenditure of CEHC community outreach effort has been focused on the “Community Asthma Intervention Project” led by AAFA.  A s part of this project, Dr. McConnell, his study coordinator Judith Cahero, and COEP Director Ms. Hricko, organized and participated in a 2-day training of grassroots community health workers in intervention strategies for control of indoor asthma triggers .  Ms. Cahero conducted the bulk of the 2-day training, with additional lectures by Dr. McConnell and Ms. Hricko, as well as by the lay health workers/staff of the CEHC asthma intervention project.  Materials used by the CEHC asthma study were distributed to the attendees, who learned about environmental triggers and controls during their 2-day session.
  • An ongoing in-service training program has been developed jointly for staff from the CEHC asthma intervention study and the new community initiative.  This new intervention service project is focusing on children with asthma in downtown and South Central Los Angeles, a geographic area containing nearly one-half of Los Angeles County’ s African American population aged 17 and under, an ethnic group with significantly higher rates of asthma prevalence and asthma hospitalization than either Hispanic or non-Hispanic whites.  Under discussion is CEHC participation in developing an evaluation component for this new project, as discussed under the asthma intervention project.

Future Activities:

During Year 4 of the project, the Administrative Core will encourage further progress of research projects, continue recruitment for a New Scientist (faculty), and continue development of the CEHC Web Site.

The COEP anticipates continuing its asthma-related work in the community and its assistance to local groups concerned about environmental health problems. It has broadened its environmental justice activities through the recent funding of an NIEHS Environmental Justice Partnerships in Communication grant to the EHC, in which Andrea Hricko, Rob McConnell, and Ed Avol are partners.

The CEHC is a cosponsor of a major Town Hall Meeting taking place in December 2001:  Voices for Healthy Environments, Healthy Communities, Healthy Jobs. Center faculty will be involved in the meeting as leaders of panels and workshops.


Journal Articles: 61 Displayed | Download in RIS Format

Other center views: All 92 publications 63 publications in selected types All 61 journal articles
Type Citation Sub Project Document Sources
Journal Article American Lung Association. Urban air pollution and health inequities: a workshop report. Environmental Health Perspectives 2001;109(Suppl 3):357-374. R826708 (2000)
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  • Journal Article Avol EL, Gauderman WJ, Tan SM, London SJ, Peters JM. Respiratory effects of relocating to areas of differing air pollution levels. American Journal of Respiratory and Critical Care Medicine 2001;164(11):2067-2072. R826708 (Final)
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  • Journal Article Berhane K, McConnell R, Gilliland F, Islam T, Gauderman WJ, Avol E, London SJ, Rappaport E, Margolis HG, Peters JM. Sex-specific effects of asthma on pulmonary function in children. American Journal of Respiratory and Critical Care Medicine 2000;162(5):1723-1730. R826708 (2000)
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  • Journal Article Berhane K, Thomas DC. Combining evidence on air pollution and daily mortality from the 20 largest US cities: a hierarchical modeling strategy-Discussion. Journal of the Royal Statistical Society, Series A, Statistics in Society 2000;163(3):292. R826708 (Final)
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    Journal Article Chang MC, Sioutas C, Kim S, Gong Jr. H, Linn WS. Reduction of nitrate losses from filter and impactor samplers by means of concentration enrichment. Atmospheric Environment 2000;34(1):85-98. R826708 (2000)
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  • Journal Article Corren J, Diaz-Sanchez D, Saxon A, Deniz Y, Reimann J, Sinclair D, Davancaze T, Adelman D. Effects of omalizumab, a humanized monoclonal anti-IgE antibody, on nasal reactivity to allergen and local IgE synthesis. Annals of Allergy, Asthma and Immunology 2004;93(3):243-248. R826708 (2000)
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  • Journal Article Diaz-Sanchez D, Proietti L, Polosa R. Diesel fumes and the rising prevalence of atopy: an urban legend? Current Allergy and Asthma Reports 2003;3(2):146-152. R826708 (2000)
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  • Journal Article Diaz-Sanchez D, Riedl M. Diesel effects on human health: a question of stress? American Journal of Physiology—Lung Cellular and Molecular Physiology 2005;289(5):L722-L723. R826708 (2000)
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  • Journal Article Enright PL, Linn WS, Avol EL, Margolis HG, Gong Jr. H, Peters JM. Quality of spirometry test performance in children and adolescents: experience in a large field study. Chest 2000;118(3):665-671. R826708 (2000)
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  • Journal Article Finkelman FD, Yang M, Orekhova T, Clyne E, Bernstein J, Whitekus M, Diaz-Sanchez D, Morris SC. Diesel exhaust particles suppress in vivo IFN-γ production by inhibiting cytokine effects on NK and NKT cells. Journal of Immunology 2004;172(6):3808-3813. R826708 (2000)
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  • Journal Article Gauderman WJ, McConnell R, Gilliland F, London S, Thomas D, Avol E, Vora H, Berhane K, Rappaport EB, Lurmann F, Margolis HG, Peters J. Association between air pollution and lung function growth in southern California children. American Journal of Respiratory and Critical Care Medicine 2000;162(4 Pt 1):1383-1390. R826708 (2000)
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  • Journal Article Gauderman WJ, Gilliland GF, Vora H, Avol E, Stram D, McConnell R, Thomas D, Lurmann F, Margolis HG, Rappaport EB, Berhane K, Peters JM. Association between air pollution and lung function growth in southern California children: results from a second cohort. American Journal of Respiratory and Critical Care Medicine 2002;166(1):76-84. R826708 (Final)
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  • Journal Article Gilliland FD, McConnell R, Peters J, Gong Jr. H. A theoretical basis for investigating ambient air pollution and children's respiratory health. Environmental Health Perspectives 1999;107(Suppl 3):403-407. R826708 (2000)
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  • Journal Article Gilliland FD, Linn W, Rappaport E, Avol E, Gong H, Peters J. Effect of spirometer temperature on FEV1 in a longitudinal epidemiological study. Occupational and Environmental Medicine 1999;56(10):718-720. R826708 (2000)
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  • Journal Article Gilliland FD, Berhane K, McConnell R, Gauderman WJ, Vora H, Rappaport EB, Avol E, Peters JM. Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function. Thorax 2000;55(4):271-276. R826708 (2000)
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  • Journal Article Gilliland FD, Li YF, Peters JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. American Journal of Respiratory and Critical Care Medicine 2001;163(2):429-436. R826708 (2000)
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  • Journal Article Gilliland FD, Berhane K, Rappaport EB, Thomas DC, Avol E, Gauderman WJ, London SJ, Margolis HG, McConnell R, Islam KT, Peters JM. The effects of ambient air pollution on school absenteeism due to respiratory illnesses. Epidemiology 2001;12(1):43-54. R826708 (2000)
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  • Journal Article Gilliland FD, Rappaport EB, Berhane K, Islam T, Dubeau L, Gauderman WJ, McConnell R. Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children. American Journal of Respiratory and Critical Care Medicine 2002;166(3):346-351. R826708 (Final)
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  • Journal Article Gilliland FD, Li YF, Dubeau L, Berhane K, Avol E, McConnell R, Gauderman WJ, Peters JM. Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children. American Journal of Respiratory and Critical Care Medicine 2002;166(4):457-463. R826708 (Final)
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  • Journal Article Gilliland FD, Berhane KT, Li YF, Kim DH, Margolis HG. Dietary magnesium, potassium, sodium, and children's lung function. American Journal of Epidemiology 2002;155(2):125-131. R826708 (2000)
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  • Journal Article Gilliland FD, Gauderman WJ, Vora H, Rappaport E, Dubeau L. Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growth. American Journal of Respiratory and Critical Care Medicine 2002;166(5):710-716. R826708 (Final)
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  • Journal Article Gilliland FD, Berhane K, Islam T, McConnell R, Gauderman WJ, Gilliland SS, Avol E, Peters JM. Obesity and the risk of newly diagnosed asthma in school-age children. American Journal of Epidemiology 2003;158(5):406-415. R826708 (2000)
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  • Journal Article Gilliland FD, Berhane KT, Li Y-F, Gauderman WJ, McConnell R, Peters J. Children's lung function and antioxidant vitamin, fruit, juice, and vegetable intake. American Journal of Epidemiology 2003;158(6):576-584. R826708 (2000)
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  • Journal Article Gilliland FD, Li Y-F, Saxon A, Diaz-Sanchez D. Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study. Lancet 2004;363(9403):119-125. R826708 (2000)
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  • Journal Article Gilliland FD, Li Y-F, Saxon A, Diaz-Sanchez D. Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study. Lancet 2004;363(9403):119-125. R826708 (2002)
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  • Journal Article Gilliland FD, Li Y-F, Saxon A, Diaz-Sanchez D. Glutathione-S-Transferase M1 and P1 genotypes protect against xenobiotic enhancement of allergic responses. Lancet 2004;363:119-125. R826708C002 (Final)
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  • Journal Article Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1447-1454. R826708 (2000)
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  • Journal Article Gong Jr. H, Sioutas C, Linn WS, Clark KW, Terrell SL, Terrell LL, Anderson KR, Kim S, Chang M-C. Controlled human exposures to concentrated ambient fine particles in metropolitan Los Angeles:methodology and preliminary health-effect findings. Inhalation Toxicology 2000;12(Suppl 1):107-119. R826708 (2000)
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  • Journal Article Gong Jr. H, Linn WS, Terrell SL, Anderson KR, Clark KW. Anti-inflammatory and lung function effects of montelukast in asthmatic volunteers exposed to sulfur dioxide. Chest 2001;119(2):402-408. R826708 (2000)
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  • Journal Article Gong Jr. H, Linn WS, Clark KW, Anderson KR, Geller MD, Sioutas C. Respiratory responses to exposures with fine particulates and nitrogen dioxide in the elderly with and without COPD. Inhalation Toxicology 2005;17(3):123-132. R826708 (Final)
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  • Journal Article Harrington-Brock K, Cabrera M, Collard DD, Doerr CL, McConnell R, Moore MM, Sandoval H, Fuscoe JC. Effects of arsenic exposure on the frequency of HPRT-mutant lymphocytes in a population of copper roasters in Antofagasta, Chile:a pilot study. Mutation Research--Fundamental and Molecular Mechanisms of Mutagenesis 1999;431(2):247-257. R826708 (2000)
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  • Journal Article Kim S, Sioutas C, Chang M-C, Gong Jr. H. Factors affecting the stability of the performance of ambient fine-particle concentrators. Inhalation Toxicology 2000;12(Suppl 4):281-298. R826708 (2000)
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  • Journal Article Kuenzli N, McConnell R, Bates D, Bastain TM, Hricko A, Lurmann F, Avol E, Gilliland FD, Peters JM. Breathless in Los Angeles: the exhausting search for clean air. American Journal of Public Health 2003;93(9):1494-1499. R826708 (2000)
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  • Journal Article Li Y-F, Gilliland FD, Berhane K, McConnell R, Gauderman WJ, Rappaport EB, Peters JM. Effects of in utero and environmental tobacco smoke exposure on lung function in boys and girls with and without asthma. American Journal of Respiratory and Critical Care Medicine 2000;162(6):2097-2104. R826708 (2000)
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  • Journal Article Li Y-F, Langholz B, Salam MT, Gilliland FD. Maternal and grandmaternal smoking patterns are associated with early childhood asthma. Chest 2005;127(4):1232-1241. R826708 (2000)
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  • Abstract from PubMed
  • Full-text: Chest-Full Text HTML
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  • Abstract: Chest-Abstract
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  • Journal Article Li Y-F, Tsao YH, Gauderman WJ, Conti DV, Avol E, Dubeau L, Gilliland FD. Intercellular adhesion molecule-1 and childhood asthma. Human Genetics 2005;117(5):476-484. R826708 (2000)
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  • Abstract: SpringerLink-Abstract
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  • Journal Article Li Y-F, Gauderman WJ, Avol E, Dubeau L, Gilliland FD. Associations of tumor necrosis factor G-308A with childhood asthma and wheezing. American Journal of Respiratory and Critical Care Medicine 2006;173(9):970-976. R826708 (2000)
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  • Journal Article Linn WS, Gong Jr. H, Clark KW, Anderson KR. Day-to-day particulate exposures and health changes in Los Angeles area residents with severe lung disease. Journal of the Air & Waste Management Association 1999;49(9 Spec No):108-115. R826708 (2000)
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  • Journal Article Linn WS, Adkins RH, Gong Jr. H, Waters RL. Pulmonary function in chronic spinal cord injury: a cross-sectional survey of 222 Southern California adult outpatients. Archives of Physical Medicine and Rehabilitation 2000;81(6):757-763. R826708 (2000)
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  • Abstract: APMR-Abstract
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  • Journal Article Linn WS, Szlachcic Y, Gong Jr. H, Kinney PL, Berhane KT. Air pollution and daily hospital admissions in metropolitan Los Angeles. Environmental Health Perspectives 2000;108(5):427-434. R826708 (2000)
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  • Journal Article McConnell R, Berhane K, Gilliland F, London SJ, Vora H, Avol E, Gauderman WJ, Margolis HG, Lurmann F, Thomas DC, Peters JM. Air pollution and bronchitic symptoms in Southern California children with asthma. Environmental Health Perspectives 1999;107(9):757-760. R826708 (2000)
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  • Journal Article McConnell R, Berhane K, Gilliland F, London SJ, Islam T, Gauderman WJ, Avol E, Margolis HG, Peters JM. Asthma in exercising children exposed to ozone: a cohort study. Lancet 2002;359(9304):386-391. R826708 (2000)
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  • Full-text: Lancet-Full Text PDF
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  • Abstract: Lancet-Abstract and Full Text HTML
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  • Journal Article McConnell R, Berhane K, Gilliland F, Molitor J, Thomas D, Lurmann F, Avol E, Gauderman WJ, Peters JM. Prospective study of air pollution and bronchitic symptoms in children with asthma. American Journal of Respiratory and Critical Care Medicine 2003;168(7):790-797. R826708 (2000)
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  • Journal Article McConnell R, Milam J, Richardson J, Galvan J, Jones C, Thorne PS, Berhane K. Educational intervention to control cockroach allergen exposure in the homes of hispanic children in Los Angeles: results of the La Casa study. Clinical & Experimental Allergy 2005;35(4):426-433. R826708 (2000)
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  • Journal Article McConnell R, Berhane K, Molitor J, Gilliland F, Kunzli N, Thorne PS, Thomas D, Gauderman WJ, Avol E, Lurmann F, Rappaport E, Jerrett M, Peters JM. Dog ownership enhances symptomatic responses to air pollution in children with asthma. Environmental Health Perspectives 2006;114(12):1910-1915. R826708 (Final)
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  • Journal Article McConnell R, Berhane K, Yao L, Jerrett M, Lurmann F, Gilliland F, Kunzli N, Gauderman J, Avol E, Thomas D, Peters J. Traffic, susceptibility, and childhood asthma. Environmental Health Perspectives 2006;114(5):766-772. R826708 (Final)
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  • Journal Article Peters JM, Avol E, Navidi W, London SJ, Gauderman WJ, Lurmann F, Linn WS, Margolis H, Rappaport E, Gong Jr. H, Thomas DC. A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. American Journal of Respiratory and Critical Care Medicine 1999;159(3):760-767. R826708 (2000)
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  • Full-text: ATS-Full Text HTML
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  • Journal Article Peters JM, Avol E, Gauderman WJ, Linn WS, Navidi W, London SJ, Margolis H, Rappaport E, Vora H, Gong Jr. H, Thomas DC. A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. American Journal of Respiratory and Critical Care Medicine 1999;159(3):768-775. R826708 (2000)
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  • Journal Article Richardson JL, Milam JE, Galvan J, Jones C, McConnell R. Knowledge of skin test results among parents of asthmatic children. Journal of Asthma 2004;41(2):199-204. R826708 (2000)
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  • Abstract: Taylor and Francis-Abstract
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  • Journal Article Riedl MA, Landaw EM, Saxon A, Diaz-Sanchez D. Initial high-dose nasal allergen exposure prevents allergic sensitization to a neoantigen. Journal of Immunology 2005;174(11):7440-7445. R826708 (2000)
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  • Abstract from PubMed
  • Full-text: Journal of Immunology-Full Text HTML
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  • Journal Article Riedl M, Diaz-Sanchez D. Biology of diesel exhaust effects on respiratory function. Journal of Allergy and Clinical Immunology 2005;115(2):221-228. R826708 (2000)
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  • Journal Article Rumold R, Jyrala M, Diaz-Sanchez D. Secondhand smoke induces allergic sensitization in mice. Journal of Immunology 2001;167(8):4765-4770. R826708 (2000)
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  • Full-text: Journal of Immunology-Full Text HTML
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  • Journal Article Salam MT, Li Y-F, Langholz B, Gilliland FD. Early-life environmental risk factors for asthma:findings from the Children's Health Study. Environmental Health Perspectives 2004;112(6):760-765. R826708 (2000)
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  • Journal Article Salam MT, Li Y-F, Langholz B, Gilliland FD. Maternal fish consumption during pregnancy and risk of childhood asthma. Journal of Asthma 2005;42(6):513-518. R826708 (2000)
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  • Abstract: Taylor and Francis-Abstract
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  • Journal Article Saxon A, Diaz-Sanchez D. Air pollution and allergy: you are what you breathe. Nature Immunology 2005;6(3):223-226. R826708 (2000)
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  • Full-text: USC-Full Text PDF
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  • Abstract: Nature Immunology-Abstract
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  • Journal Article Sioutas C, Kim S, Chang M, Terrell LL, Gong Jr. H. Field evaluation of a modified DataRAM MIE scattering monitor for real-time PM2.5 mass concentration measurements. Atmospheric Environment 2000;34(28):4829-4838. R826708 (2000)
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  • Full-text: ScienceDirect-Full Text HTML
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  • Journal Article Thorne PS, Metwali N, Avol E, McConnell RS. Surface sampling for endotoxin assessment using electrostatic wiping cloths. Annals of Occupational Hygiene 2005;49(5):401-406. R826708 (2000)
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  • Full-text: Oxford Journals-Full Text HTML
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  • Journal Article Wan J, Diaz-Sanchez D. Phase II enzymes induction blocks the enhanced IgE production in B cells by diesel exhaust particles. Journal of Immunology 2006;177(5):3477-3483. R826708 (2000)
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  • Full-text: Journal of Immunology-Full Text HTML
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  • Journal Article Wenten M, Berhane K, Rappaport EB, Avol E, Tsai WW, Gauderman WJ, McConnell R, Dubeau L, Gilliland FD. TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences. American Journal of Respiratory and Critical Care Medicine 2005;172(12):1563-1568. R826708 (2000)
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  • Abstract: ATS Journals-Abstract
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  • Journal Article Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, Horwitz LD, Brechun N, Diaz-Sanchez D, Nel AE. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. Journal of Immunology 2002;168(5):2560-2567. R826708 (2000)
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  • Abstract from PubMed
  • Full-text: Journal of Immunology-Full Text PDF
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  • Abstract: Journal of Immunology-Abstract and Full Text HTML
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  • Journal Article Xie B, Gilliland FD, Li Y-F, Rockett HRH. Effects of ethnicity, family income, and education on dietary intake among adolescents. Preventive Medicine 2003;36(1):30-40. R826708 (2000)
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  • Supplemental Keywords:

    health, children’s health, epidemiology, health risk assessment, risk assessments, California, acute lung injury, air pollution, airborne pollutants, airway disease, airway inflammation, allergen, allergic response, asthma, asthma indices, asthma triggers, asthmatic children, childhood respiratory disease, children, children’s environmental health, children’s vulnerability, cigarette smoke, exposure, human exposure, human health risk, respiratory disease, respiratory problems, secondhand smoke, susceptibility,, RFA, Health, Scientific Discipline, Geographic Area, Health Risk Assessment, Epidemiology, State, Risk Assessments, Allergens/Asthma, Children's Health, asthma, asthma triggers, acute lung injury, airway disease, respiratory problems, asthma indices, second hand smoke, exposure, respiratory disease, air pollution, children, airway inflammation, childhood respiratory disease, children's vulnerablity, susceptibility, airborne pollutants, asthmatic children, human exposure, children's environmental health, cigarette smoke, tobacco smoke, California (CA), allergic response, allergen

    Relevant Websites:

    http://www.usc.edu/schools/medicine/research/centers_programs/cehc Exit
    http://www.usc.edu/schools/medicine/departments/preventive_medicine/divisions/occupational/occ_environmental/cehc/index.html Exit

    Progress and Final Reports:

    Original Abstract
  • 1999
  • 2000 Progress Report
  • 2002 Progress Report
  • Final Report
  • Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R826708C001 Asthma in Children: A Community-based Intervention Project
    R826708C002 Children's Exposure to Environmental Tobacco Smoke: Changes in Allergic Response
    R826708C003 Respiratory Disease and Prevention Center