2002 Progress Report: Centers of Excellence in Children's Environmental Health and Disease Prevention Research

EPA Grant Number: R827027
Center: CECEHDPR - Columbia University School of Public Health
Center Director: Perera, Frederica P.
Title: Centers of Excellence in Children's Environmental Health and Disease Prevention Research
Investigators: Perera, Frederica P.
Institution: Columbia University in the City of New York
EPA Project Officer: Callan, Richard
Project Period: August 1, 1998 through July 31, 2003 (Extended to October 31, 2004)
Project Period Covered by this Report: August 1, 2001 through July 31, 2002
Project Amount: $3,136,357
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text |  Recipients Lists
Research Category: Human Health , Health , Children's Health , Health Effects

Objective:

The mission of the Columbia Center for Children's Environmental Health (CCCEH) is to undertake a comprehensive community-based assessment of environmental risks to infants and children, and to develop strategies for reducing, and ultimately preventing, those risks. The Center is responsive to the urgent health needs of the minority communities in Northern Manhattan and the South Bronx, which suffer uniquely high rates of asthma, adverse birth outcomes, impaired development, and other diseases. These communities also have disproportionately heavy exposure to environmental pollutants, which may contribute to these adverse health outcomes.

Community participation is an integral component of both the Center's organizational structure and its research projects. We anticipate that research results will aid the development of community-based strategies to reduce and ultimately prevent asthma and developmental impairment in the target population, and will have implications for the control of these health risks in other inner-city, minority communities. Thus, the Center is responsive to the need for environmental justice.

The Center utilizes an innovative approach -molecular epidemiology - to answer questions regarding environmental impacts on children's health. Biomarkers will be used in conjunction with questionnaires, individual exposure assessment, clinical evaluations, and quantitative measures of community-level risk factors to evaluate exposure, susceptibility, and risk from the environmental toxicants of concern, and to monitor the efficacy of intervention. The main hypotheses of the Center are that: 1) prenatal and postnatal environmental exposures to airborne particulate matter (PM), polycyclic aromatic hydrocarbons (PAH), environmental tobacco smoke (ETS), and home allergens (cockroach, house dust mite and rodent) increase the risk of asthma and/or developmental impairment in these disadvantaged communities; 2) inadequate nutritional status exacerbates the impact of these environmental toxicants; and 3) a community-based intervention to reduce these toxic exposures and improve nutritional status can reduce the risk of disease. To test these hypotheses and meet its objective, the Center is undertaking three interrelated research studies, all of which build on a prospective cohort of 400 African American and Dominican mothers and their newborn infants living in Washington Heights, Harlem and the South Bronx. The research studies (described in detail below) include projects that investigate the impact of environmental pollutants and allergens on: 1) growth and development; and 2) asthma. The third research study investigates the impact of community and home-based interventions to reduce toxicant and allergen exposure, as well as risk of asthma.

Progress Summary:

The Columbia Center for Children's Environmental Health (CCCEH) has sponsored three projects. The progress on these projects is detailed below:

Project 1: Growth and Development: Prenatal Exposure PAH

The objectives of the Growth and Development research remain unchanged. They are to test hypotheses that: 1) prenatal and/or early postnatal exposure to polycyclic aromatic hydrocarbons (PAH), environmental tobacco smoke (ETS) and pesticides are significant contributors to impaired fetal and early childhood growth and neurobehavioral development, after controlling for the effects of known neurodevelopmental toxicants and other potential confounding variables; and 2) impaired nutritional status (inadequate levels of micronutrients) and social stressors act as susceptibility factors to increase the effects of the environmental exposures and biomarkers on these adverse outcomes. The aim of the project on the evaluation of carcinogenic risk is to test the hypotheses that: 1) exposure to PAH and other aromatic pollutants is associated with procarcinogenic genetic damage in cord blood; and 2) effects are modulated by the nutritional factors. Another aim is to estimate exposure to pesticides with carcinogenic potential. The number of biomarkers has been expanded as described previously to include non-persistent pesticides (NPP), and additional metals.

STUDIES AND RESULTS:
See individual Progress Reports for details (R827027C003 – 2002 Progress Report)

Project 2: Research on Asthma

The objective of the Research Project on Asthma remains unchanged. It is designed to test the hypotheses a) that prenatal and/or postnatal exposure to home allergens (cockroach, house dust mite, and rodent) and ETS, as well as postnatal exposure to PM2.5 and diesel exhaust particulate (DEP), are significant contributors to risk of asthma, as indicated by related biomarkers and persistent wheezing, b) that the risk from home allergens is increased by co-exposure to the air pollutants (ETS, PM2.5 and DEP); and c) that impaired nutritional status (inadequate levels of antioxidants) heightens susceptibility to the pollutants.
Project investigators will conduct an etioloic study of environmental and susceptibility factors in the same cohort of 400 infants and will also contribute to the intervention study. The Project will make use of all of the questionnaire data as well as the biomarker data on cotinine and antioxidants collected by the G&D Project. Additional exposures of interest (home allergens, PM2.5 and DEP, and N02 as a potential confounder) will be monitored and modeled. In addition, the Project will obtain measurements of infants' IgE (total and allergen specific) at birth and at 24 months, as well as measurements of lymphocyte proliferation and cytokines at birth. Mothers will be interviewed at serial time points to obtain information on their children's respiratory symptoms.

STUDIES AND RESULTS:
See individual Progress Reports for details (R827027C002 – 2002 Progress Report)

Project 3: Community-Based Intervention: Reducing Risks of Asthma

The Community-based Intervention project has two objectives, one focused on educating women living in Northern Manhattan about environmental risks to children's health, and the other focused on integrated pest management to reduce pests and allergens in the home. The specific aims of the first project, the Community Education Intervention (CEI), remain unchanged. They are to: (1) determine community knowledge and attitudes about environmental health hazards and what can be done to prevent or reduce them; (2) develop and implement strategies to teach community residents and organizations in Northern Manhattan about environmental hazards and what can be done to prevent or reduce them; and (3) assess the degree to which the intervention reaches members of the community and changes the behavior of those exposed. The aim of the second project, the Indoor Pollution and Allergen Control Intervention (IPAC) is to evaluate the impact of a building-wide Integrated Pest Management (IPM) program that represents a collaboration between the New York City Department of Health (NYCDOH), the NYC Housing Authority (NYCHA), and the Columbia Center for Children's Environmental Health (CCCEH).

STUDIES AND RESULTS:
See individual Progress Reports for details (R827027 – 2002 Progress Report)

Future Activities:

Project 1: Growth and Development: Prenatal Exposure PAH

Investigators will continue enrollment, monitoring, interviewing, extraction of medical record data and analysis of pollutants in air samples and analysis of biologic markers in maternal and infant blood samples. Analyses of the association between exposures, biomarkers and infant growth, and neurocognitive development is ongoing. Funds have been obtained to continue follow-up through the children's 5th birthdays.

Project 2: Research on Asthma

Investigators plan to continue expanding data collection and analysis. Evaluation of the relationship between birth biomarkers and findings at age two and three is ongoing (i.e., associations between sensitization patterns at birth and development of total and allergen-specific IgE levels at age two years and frequency of respiratory symptoms/diagnosis of asthma are reevaluated). Relationships between outcomes and PAH/diesel and pyrene exposure prenatally and early postnatally are being assessed, again both at birth and early childhood. Evaluation of the contribution of nutritional status to onset of asthma is underway.

Project 3: Community-Based Intervention: Reducing Risks of Asthma

The CEI Healthy Home, Healthy Child Campaign will continue to be implemented throughout the year with evaluation occurring simultaneously. The IPAC study evaluating IPM in public housing will continue to enroll families.


Journal Articles: 43 Displayed | Download in RIS Format

Other center views: All 60 publications 43 publications in selected types All 43 journal articles
Type Citation Sub Project Document Sources
Journal Article Barr DB, Barr JR, Maggio VL, Whitehead RD Jr., Sadowski MA, Whyatt RM, Needham LL. A multi-analyte method for the quantification of contemporary pesticides in human serum and plasma using high resolution mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2002;778(1-2):99-111. R827027 (2002)
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  • Journal Article Bocskay KA, Tang D, Orjuela MA, Liu X, Warburton DP, Perera FP. Chromosomal aberrations in cord blood are associated with prenatal exposure to carcinogenic polycyclic aromatic hydrocarbons. Cancer Epidemiology, Biomarkers & Prevention 2005;14(2):506-511. R827027 (2002)
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  • Journal Article Bradman A, Whyatt RM. Characterizing exposures to nonpersistent pesticides during pregnancy and early childhood in the National Children's Study: a review of monitoring and measurement methodologies. Environmental Health Perspectives 2005;113(8):1092-1099. R827027 (2002)
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  • Journal Article Carlton EJ, Moats HL, Feinberg M, Shepard P, Garfinkel R, Whyatt R, Evans D. Pesticide sales in low-income, minority neighborhoods. Journal of Community Health 2004;29(3):231-244. R827027 (2002)
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  • Journal Article Chew GL, Perzanowski MS, Miller RL, Correa JC, Hoepner LA, Jusino CM, Becker MG, Kinney PL. Distribution and determinants of mouse allergen exposure in low-income New York City apartments. Environmental Health Perspectives 2003;111(10):1348-1351. R827027 (2002)
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  • Journal Article Chow JC, Watson JG, Chen L-WA, Ho SSH, Koracin D, Zielinska B, Tang D, Perera F, Cao J, Lee SC. Exposure to PM2.5 and PAHs from the Tong Liang, China epidemiological study. Journal of Environmental Science and Health Part A, Toxic/Hazardous Substances and Environmental Engineering 2006;41(4):517-542. R827027 (2002)
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  • Journal Article Dietrich KN, Eskenazi B, Schantz S, Yolton K, Rauh VA, Johnson CB, Alkon A, Canfield RL, Pessah IN, Berman RF. Principles and practices of neurodevelopmental assessment in children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1437-1446. R827027 (2002)
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  • Journal Article Eggleston PA, Diette G, Lipsett M, Lewis T, Tager I, McConnell R, Chrischilles E, Lanphear B, Miller R, Krishnan J. Lessons learned for the study of childhood asthma from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1430-1436. R827027 (2002)
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  • Journal Article Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. R827027 (2002)
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  • Journal Article Evans DT, Fullilove MT, Green L, Levison M. Awareness of environmental risks and protective actions among minority women in Northern Manhattan. Environmental Health Perspectives 2002;110(S2):271-275. R827027 (2002)
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  • Journal Article Fenske RA, Bradman A, Whyatt RM, Wolff MS, Barr DB. Lessons learned for the assessment of children's pesticide exposure: critical sampling and analytical issues for future studies. Environmental Health Perspectives 2005;113(10):1455-1462. R827027 (2002)
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  • Journal Article Fullilove MT. Links between the social and physical environments. Pediatric Clinics of North America, Review 2001;48(5):1253-1266. R827027 (2002)
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  • Journal Article Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1447-1454. R827027 (2002)
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  • Journal Article Goldstein IF, Perzanowski MS, Lendor C, Garfinkel RS, Hoepner LA, Chew GL, Perera FP, Miller RL. Prevalence of allergy symptoms and total IgE in a New York City cohort and their association with birth order. International Archives of Allergy and Immunology 2005;137(3):249-257. R827027 (2002)
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  • Journal Article Green L, Fullilove M, Evans D, Shepard P. “Hey, Mom, thanks!”: use of focus groups in the development of place-specific materials for a community environmental action campaign. Environmental Health Perspectives 2002;110(Suppl 2):265-269. R827027 (2002)
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  • Journal Article Kinney PL, Northridge ME, Correa JC, Gronning E, Joseph E, Prakash S, Goldstein I. On the front lines: an environmental asthma intervention in New York City. American Journal of Public Health 2002;92(1):24-26. R827027 (2002)
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  • Journal Article Meyer IH, Whyatt RM, Perera FP, Ford JG. Risk for asthma in 1-year-old infants residing in New York City high-risk neighborhoods. Journal of Asthma 2003;40(5):545-550. R827027 (2002)
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  • Journal Article Miller RL, Chew GL, Bell CA, Biedermann SA, Aggarwal M, Kinney PL, Tsai W-Y, Whyatt RM, Perera FP, Ford JG. Prenatal exposure, maternal sensitization, and sensitization in utero to indoor allergens in an inner-city cohort. American Journal of Respiratory and Critical Care Medicine 2001;164(6):995-1001. R827027 (2002)
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  • Journal Article Miller RL, Garfinkel R, Horton M, Camann D, Perera FP, Whyatt RM, Kinney PL. Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort. Chest 2004;126(4):1071-1078. R827027 (2002)
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  • Journal Article Perera FP, Whyatt RM, Jedrychowski W, Rauh V, Manchester D, Santella RM, Ottman R. Recent developments in molecular epidemiology: a study of the effects of environmental polycyclic aromatic hydrocarbons on birth outcomes in Poland. American Journal of Epidemiology 1998;147(3):309-314. R827027 (2002)
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  • Journal Article Perera FP, Jedrychowski W, Rauh V, Whyatt RM. Molecular epidemiologic research on the effects of environmental pollutants on the fetus. Environmental Health Perspectives 1999;107(S3):451-460. R827027 (2002)
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  • Journal Article Perera FP. Molecular epidemiology: on the path to prevention? Journal of the National Cancer Institute 2000;92(8):602-612. R827027 (2002)
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  • Journal Article Perera FP, Weinstein IB. Molecular epidemiology: recent advances and future directions. Carcinogenesis 2000;21(3):517-524. R827027 (2002)
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  • Journal Article Perera FP, Illman SM, Kinney PL, Whyatt RM, Kelvin EA, Shepard P, Evans D, Fullilove M, Ford JG, Miller RL, Meyer IH, Rauh VA. The challenge of preventing environmentally related disease in young children: community-based research in New York City. Environmental Health Perspectives 2002;110(2):197-204. R827027 (2002)
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  • Journal Article Perera FP, Rauh V, Tsai W-Y, Kinney P, Camann D, Barr D, Bernert T, Garfinkel R, Tu Y-H, Diaz D, Dietrich J, Whyatt RM. Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population. Environmental Health Perspectives 2003;111(2):201-205. R827027 (2002)
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  • Journal Article Perera FP, Tang D, Tu Y-H, Cruz LA, Borjas M, Bernert T, Whyatt RM. Biomarkers in maternal and newborn blood indicate heightened fetal susceptibility to procarcinogenic DNA damage. Environmental Health Perspectives 2004;112(10):1133-1136. R827027 (2002)
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  • Journal Article Perera FP, Rauh V, Whyatt RM, Tang D, Tsai WY, Bernert JT, Tu YH, Andrews H, Barr DB, Camann DE, Diaz D, Dietrich J, Reyes A, Kinney PL. A summary of recent findings on birth outcomes and developmental effects of prenatal ETS, PAH, and pesticide exposures. NeuroToxicology 2005;26(4):573-587. R827027 (2002)
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  • Journal Article Perera FP, Tang D, Rauh VA, Lester K, Tsai WY, Tu YH, Weiss L, Hoepner L, King J, Del Priore G, Lederman SA. Relationships among polycyclic aromatic hydrocarbon-DNA adducts, proximity to the World Trade Center, and effects on fetal growth. Environmental Health Perspectives 2005;113(8):1062-1067. R827027 (2002)
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  • Journal Article Perera FP, Rauh V, Whyatt RM, Tsai W-Y, Tang D, Diaz D, Hoepner L, Barr D, Tu Y-H, Camann D, Kinney P. Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children. Environmental Health Perspectives 2006;114(8):1287-1292. R827027 (2002)
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  • Journal Article Perera F, Tang D, Whyatt R, Lederman SA, Jedrychowski W. DNA damage from polycyclic aromatic hydrocarbons measured by benzo[a]pyrene-DNA adducts in mothers and newborns from Northern Manhattan, the World Trade Center area, Poland, and China. Cancer Epidemiology, Biomarkers & Prevention 2005;14(3):709-714. R827027 (2002)
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  • Journal Article Perzanowski MS, Miller RL, Thorne PS, Barr RG, Divjan A, Sheares BJ, Garfinkel RS, Perera FP, Goldstein IF, Chew GL. Endotoxin in inner-city homes: associations with wheeze and eczema in early childhood. Journal of Allergy and Clinical Immunology 2006;117(5):1082-1089. R827027 (2002)
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  • Journal Article Rauh VA, Andrews HF, Garfinkel RS. The contribution of maternal age to racial disparities in birthweight: a multilevel perspective. American Journal of Public Health 2001;91(11):1815-1824. R827027 (2002)
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  • Journal Article Rauh VA, Chew GL, Garfinkel RS. Deteriorated housing contributes to high cockroach allergen level in inner-city households. Environmental Health Perspectives 2002;110(S2):323-327. R827027 (2002)
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  • Journal Article Rauh VA, Whyatt RM, Garfinkel R, Andrews H, Hoepner L, Reyes A, Diaz D, Camann D, Perera FP. Developmental effects of exposure to environmental tobacco smoke and material hardship among inner-city children. Neurotoxicology and Teratology 2004;26(3):373-385. R827027 (2002)
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  • Journal Article Strunk RC, Ford JG, Taggart V. Reducing disparities in asthma care: priorities for research--National Heart, Lung, and Blood Institute workshop report. Journal of Allergy and Clinical Immunology 2002;109(2):229-237. R827027 (2002)
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  • Journal Article Tonne CC, Whyatt RM, Camann DE, Perera FP, Kinney PL. Predictors of personal polycyclic aromatic hydrocarbon exposures among pregnant minority women in New York City. Environmental Health Perspectives 2004;112(6):754-759. R827027 (2002)
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  • Journal Article Wallace D, Wallace R, Rauh V. Community stress, demoralization and body mass index: evidence for social signal transduction. Social Science and Medicine 2003;56(12):2467-2478. R827027 (2002)
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  • Journal Article Wallace R, Wallace RG. Adaptive chronic infection, structured stress, and medical magic bullets: do reductionist cures select for holistic diseases? Biosystems 2004;77(1-3):93-108. R827027 (2002)
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  • Journal Article Whyatt RM, Perera FP, Jedrychowski W, Santella RM, Garte SJ, Bell DA. Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and Glutathione S-Transferase P1 and CYP1A1 polymorphisms. Cancer Epidemiology, Biomarkers & Prevention 2000;9(2):207-212. R827027 (2002)
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  • Journal Article Whyatt RM, Barr DB. Measurement of organophosphate metabolites in postpartum meconium as a potential biomarker of prenatal exposure: a validation study. Environmental Health Perspectives 2001;109(4):417-420. R827027 (2002)
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  • Journal Article Whyatt RM, Jedrychowski W, Hemminki K, Santella RM, Tsai WY, Yong K, Perera FP. Biomarkers of polycyclic aromatic hydrocarbon-DNA damage and cigarette smoke exposures in paired maternal and newborn blood samples as a measure of differential susceptibility. Cancer Epidemiology Biomarkers and Prevention 2001;10(6):581-588. R827027 (2002)
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  • Journal Article Whyatt RM, Barr DB, Camann DE, Kinney PL, Barr JR, Andrews HF, Hoepner LA, Garfinkel R, Hazi Y, Reyes A, Ramirez J, Cosme Y, Perera FP. Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns. Environmental Health Perspectives 2003;111(5):749-756. R827027 (2002)
    R828609 (2002)
    R828609 (2004)
    R828609 (Final)
    R832141 (2005)
    R832141 (2006)
    R832141 (2007)
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  • Abstract from PubMed
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  • Journal Article Whyatt RM, Camann D, Perera FP, Rauh VA, Tang D, Kinney PL, Garfinkel R, Andrews H, Hoepner L, Barr DB. Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth. Toxicology and Applied Pharmacology 2005;206(2):246-254. R827027 (2002)
    R828609 (2004)
    R828609 (Final)
    R832141 (2005)
    R832141 (2006)
    R832141 (2007)
    R832141 (Final)
  • Abstract from PubMed
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  • Supplemental Keywords:

    Allergens/Asthma, Biochemistry, Children's Health, Disease and Cumulative Effects, Ecological Risk Assessment, Human Health Risk Assessment, age-related differences, air pollutants, air toxics, airborne pollutants, airborne urban contaminants, airway disease, airway inflammation, ambient particulates, asthma, asthma morbidity, children's environmental health, community-based intervention, disease, environmental health, epidemiology, human exposure, indoor air quality., RFA, Health, Scientific Discipline, Economic, Social, & Behavioral Science Research Program, Air, Geographic Area, particulate matter, Health Risk Assessment, State, environmental justice, Epidemiology, Risk Assessments, Allergens/Asthma, Disease & Cumulative Effects, Biochemistry, Children's Health, Ecological Risk Assessment, asthma, sensitive populations, environmental health, particulates, ambient air quality, air toxics, community-based intervention, air pollutants, lung disease, human health effects, hazardous environmental exposures, second hand smoke, airway disease, environmental risks, age-related differences, developmental toxicity, pulmonary disease, exposure, airway inflammation, children, air pollution, environmental health effects, airborne pollutants, childhood respiratory disease, inner city toxicants, human exposure, particulate exposure, children's environmental health, epidemeology, ambient particulates, environmental toxicant, harmful environmental agents, Acute health effects, epidemiological studies, environmental toxicants, PM, tobacco smoke, aersol particles, indoor air quality, community based intervention, urban environmental exposure, indoor environment, disease, New York (NY), risk and vulnerability

    Relevant Websites:

    "Community-Based Intervention: Reducing Risks of Asthma"
    https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/1078/report/2002

    "Research on Asthma"
    https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/1079/report/2002

    "Growth and Development: Prenatal Exposure PAH"
    https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/1080/report/2002

    Progress and Final Reports:

    Original Abstract
  • 1999
  • 2000
  • 2001
  • 2003
  • 2004
  • Final
  • Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R827027C001 Community-Based Intervention: Reducing Risks of Asthma
    R827027C002 Growth and Development/Evaluation of Carcinogenic Risks
    R827027C003 Research Project on Asthma