Longitudinal Study of Children's Exposure to Permethrin

EPA Grant Number: R829397
Title: Longitudinal Study of Children's Exposure to Permethrin
Investigators: Hu, Ye A. , Akland, Gerald G. , Raymer, James H.
Current Investigators: Raymer, James H. , Hu, Ye A. , Michael, L. C. , Studabaker, W.
Institution: Dessert Research Institute
EPA Project Officer: Deener, Kacee
Project Period: February 18, 2002 through February 17, 2005 (Extended to July 17, 2006)
Project Amount: $754,664
RFA: Children's Vulnerability to Toxic Substances in the Environment (2001) RFA Text |  Recipients Lists
Research Category: Economics and Decision Sciences , Human Health , Health Effects , Children's Health , Health

Description:

The specific aims for the proposed research program are to: (1) investigate the time course of the redistribution of permethrin in various media following application and factors affecting the redistribution; (2) investigate the functional relationships across time between environmental media, personal measurements and biological media; (3) estimate aggregate exposure after application and the importance of each exposure pathway; and (4) investigate the difference between the time course of permethrin metabolism between adults and children.

Approach:

We will investigate 15 homes that uses permethrin indoors and with stay home children younger than 3 years old. Each of the homes will be followed intensively for 7 days after application. Then they will be followed once a week in the first month after application and every other a month in the following 11 months. Environmental samples, food samples, personal samples (hand wipes, whole body dosimeter) and urine samples will be collected from children and one stay-home parent. The samples will be analyzed in our laboratory following stand operating procedures and analysis protocols. Data will be analyzed to meet the objectives.

Expected Results:

The anticipated results of this study include: (1) a longitudinal characterization of permethrin concentrations in a multipathway study of young children;(2) an information base from which to develop a relationship of within and across home variation; (3) field testing of new sample collection methods, including whole body dosimeter, urine collection technique for children, and baby wipes for collecting surface samples; (4) development of a time series statistical model which can be used to describe the temporal characteristics of the permethrin decay pattern, as well as the age-specific exposure related behavior patterns observed over the study period; and (5) development of adult-child urinary metabolite profiles over time. The relationship between these profiles over time may improve our understanding of permethrin exposures and behaviors affecting these exposures.

Publications and Presentations:

Publications have been submitted on this project: View all 9 publications for this project

Journal Articles:

Journal Articles have been submitted on this project: View all 4 journal articles for this project

Supplemental Keywords:

multi-media exposure analysis; longitudinal exposure; urinary pesticide metabolite., RFA, Health, Scientific Discipline, Health Risk Assessment, Chemistry, Risk Assessments, Disease & Cumulative Effects, Children's Health, Biology, multi-pathway study, permethrin, exposure, pesticides, functional relationships, urinary metabolite, children, longitudinal study, human exposure, body dosimeter, exposure pathways, metabolism, exposure assessment

Progress and Final Reports:

2002 Progress Report
2003 Progress Report
2004 Progress Report
2005 Progress Report
Final Report