Developmental Neurotoxicity of Chlorpyrifos: Mechanisms and Consequences

EPA Grant Number: U915425
Title: Developmental Neurotoxicity of Chlorpyrifos: Mechanisms and Consequences
Investigators: Dam, Kristina
Institution: Duke University Medical Center
EPA Project Officer: Lee, Sonja
Project Period: September 1, 1998 through August 1, 2001
Project Amount: $45,432
RFA: STAR Graduate Fellowships (1998) RFA Text |  Recipients Lists
Research Category: Fellowship - Toxicology , Health Effects , Academic Fellowships


The objective of this research project is to examine the adverse effects of chlorpyrifos (CPF) exposure on brain development.


For our studies, we use a neonatal rat model because the early postnatal period in rats (postnatal days 1-20) roughly corresponds to the neurodevelopment from the third trimester to the first postnatal year in humans. The treatment paradigm involves repeated CPF exposure during two developmental periods, PN1-4 (examined on PN5 or 10) or PN11-14 (examined PN15 or 20). Doses of CPF are used that are well below the threshold for systemic toxicity, producing no mortality or weight deficits. Likewise, levels of cholinesterase inhibition are well below those that produce acute toxicity.

Supplemental Keywords:

fellowship, pesticide, development, neurotoxicity, chlorpyrifos, CPF, systemic toxicity, cholinesterase inhibition, toxicity., RFA, Health, Scientific Discipline, Toxics, Toxicology, Genetics, Health Risk Assessment, Chemistry, pesticides, Susceptibility/Sensitive Population/Genetic Susceptibility, Disease & Cumulative Effects, Biochemistry, genetic susceptability, Molecular Biology/Genetics, Biology, chlorpyrifos (Dursban (r)), insecticide exposure, developmental toxicity, susceptability to pesticides, neurodevelopmental, neurotoxicity, insecticides

Progress and Final Reports:

  • 1999
  • 2000
  • Final