1999 Progress Report: Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality

EPA Grant Number: R827355C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R827355
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Airborne PM - Northwest Research Center for Particulate Air Pollution and Health
Center Director: Koenig, Jane Q.
Title: Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
Investigators: Kaufman, Joel D. , Checkoway, Harvey , Koenig, Jane Q. , Sheppard, Lianne (Elizabeth) A. , Siscovick, David
Current Investigators: Kaufman, Joel D. , Ishikawa, Naomi , Karr, Catharine J. , Miller, Kristine , Schreuder, Astrid , Shepherd, Kristine , Sheppard, Lianne (Elizabeth) A. , Siscovick, David , Sullivan, Jeff
Institution: University of Washington
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2004 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 1999 through May 31, 2000
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air


This project consists of two related study designs addressing associations between ambient PM exposure and cardiorespiratory disease risks. The first is a time-series analysis of cause-specific mortality in Seattle that relates daily mortality with changes in PM and co-pollutant levels. Its emphasis is cardiovascular and respiratory disease mortality. In parallel with this analysis, we also are performing similar time-series analyses of mortality in Spokane, Washington, and Anchorage, Alaska. The contrasts of results between Seattle, Spokane, and Anchorage, which have different PM compositions, should add significant new information about the relative contributions of particle count, size, and chemical composition to cardiorespiratory mortality. The second design is a "case-crossover" study of roughly 1,100 out-of-hospital sudden cardiac arrest (SCA) cases in Seattle. This design compares PM levels in the days immediately preceding SCA events with levels at previous reference time points.

Progress Summary:

The relationship between sudden cardiac death in King County with daily air pollution was evaluated. The title of this project is "A Case Cross-Over Study of Particulate Matter Air Pollution and Out-of Hospital Primary Cardiac Arrest in King County, Washington." There were 362 cases. This analysis did not find an association between any PM parameters and sudden cardiac death. One possible explanation is that the cases were highly selected and not very susceptible. Three additional analyses relating to the cases-crossover study were undertaken as part of the EPA PM Center and/or the National Research Center for Statistics and the Environment at the University of Washington.

Future Activities:

Project 1 plans to extend this analysis to a new cohort of sudden cardiac death cases totaling more than 1,000 individuals. To assess the role of susceptibility, Project 1 investigators also plan to conduct similar case-crossover analyses of asthma, respiratory diseases, and other cardiovascular endpoints. An effort will be made to use data from personal exposure assessments from Project 2 to reduce exposure error.

Journal Articles on this Report : 1 Displayed | Download in RIS Format

Other subproject views: All 21 publications 14 publications in selected types All 14 journal articles
Other center views: All 209 publications 113 publications in selected types All 109 journal articles
Type Citation Sub Project Document Sources
Journal Article Sheppard L, Kaufman J. Sorting out the role of air pollutants in asthma initiation. Epidemiology 2000;11(2):100-101. R827355 (2004)
R827355 (Final)
R827355C001 (1999)
R827355C001 (2001)
R827355C009 (Final)
  • Abstract from PubMed
  • Abstract: LWW-Abstract and Full Text HTML
  • Supplemental Keywords:

    ambient particles, fine particles, combustion, health, exposure, biostatistics, susceptibility., RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, Geographic Area, particulate matter, Toxicology, air toxics, Environmental Chemistry, Health Risk Assessment, Epidemiology, State, Northwest, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Allergens/Asthma, Biochemistry, Physical Processes, Children's Health, genetic susceptability, indoor air, Atmospheric Sciences, Incineration/Combustion, ambient aerosol, ambient air quality, asthma, biostatistics, health effects, particulates, risk assessment, sensitive populations, air pollutants, cardiopulmonary responses, health risks, human health effects, morbidity, exposure and effects, acute cardiovascular effects, airway disease, ambient air, exposure, hazardous air pollutants, animal model, epidemelogy, combustion emissions, biological response, air pollution, children, Human Health Risk Assessment, airway inflammation, particle exposure, airborne pollutants, cardiopulmonary response, human exposure, inhalation, PAHs, atmospheric aerosols, children's vulnerablity, assessment of exposure, ambient particle health effects, mortality studies, combustion, harmful environmental agents, hydrocarbons, epidemeology, human susceptibility, biological markers, incineration, indoor air quality, mortality, California (CA), allergens, aerosols, air quality, allergen, atmospheric chemistry, cardiovascular disease, combustion contaminants, exposure assessment, human health risk, indoor environment, particle transport, toxics

    Relevant Websites:

    http://depts.washington.edu/pmcenter/ Exit EPA icon

    Progress and Final Reports:

    Original Abstract
  • 2000 Progress Report
  • 2001 Progress Report
  • 2002 Progress Report
  • 2003 Progress Report
  • 2004
  • Final Report

  • Main Center Abstract and Reports:

    R827355    Airborne PM - Northwest Research Center for Particulate Air Pollution and Health

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R827355C001 Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
    R827355C002 Health Effects
    R827355C003 Personal PM Exposure Assessment
    R827355C004 Characterization of Fine Particulate Matter
    R827355C005 Mechanisms of Toxicity of Particulate Matter Using Transgenic Mouse Strains
    R827355C006 Toxicology Project -- Controlled Exposure Facility
    R827355C007 Health Effects Research Core
    R827355C008 Exposure Core
    R827355C009 Statistics and Data Core
    R827355C010 Biomarker Core
    R827355C011 Oxidation Stress Makers