Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality

EPA Grant Number: R827355C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R827355
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Airborne PM - Northwest Research Center for Particulate Air Pollution and Health
Center Director: Koenig, Jane Q.
Title: Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
Investigators: Kaufman, Joel D. , Checkoway, Harvey , Koenig, Jane Q. , Sheppard, Lianne (Elizabeth) A. , Siscovick, David
Current Investigators: Kaufman, Joel D. , Ishikawa, Naomi , Karr, Catharine J. , Miller, Kristine , Schreuder, Astrid , Shepherd, Kristine , Sheppard, Lianne (Elizabeth) A. , Siscovick, David , Sullivan, Jeff
Institution: University of Washington
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2004 (Extended to May 31, 2006)
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air

Objective:

This project consists of two related study designs addressing associations between ambient PM exposure and cardiorespiratory disease risks. The first is a time-series analysis of cause-specific mortality in Seattle that relates daily mortality with changes in PM and co-pollutant levels. Its emphasis is cardiovascular and respiratory disease mortality. In parallel with this analysis, we also are performing similar time-series analyses of mortality in Spokane, Washington, and Anchorage, Alaska. The contrasts of results between Seattle, Spokane, and Anchorage, which have different PM compositions, should add significant new information about the relative contributions of particle count, size, and chemical composition to cardiorespiratory mortality. The second design is a "case-crossover" study of roughly 1,100 out-of-hospital sudden cardiac arrest (SCA) cases in Seattle. This design compares PM levels in the days immediately preceding SCA events with levels at previous reference time points.

Publications and Presentations:

Publications have been submitted on this subproject: View all 21 publications for this subprojectView all 209 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 14 journal articles for this subprojectView all 109 journal articles for this center

Supplemental Keywords:

ambient particles, fine particles, combustion, health, exposure, biostatistics, susceptibility., RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, Geographic Area, particulate matter, Toxicology, air toxics, Environmental Chemistry, Health Risk Assessment, Epidemiology, State, Northwest, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Allergens/Asthma, Biochemistry, Physical Processes, Children's Health, genetic susceptability, indoor air, Atmospheric Sciences, Incineration/Combustion, ambient air quality, health effects, risk assessment, particulates, biostatistics, asthma, ambient aerosol, sensitive populations, exposure and effects, health risks, air pollutants, morbidity, cardiopulmonary responses, human health effects, acute cardiovascular effects, animal model, airway disease, hazardous air pollutants, biological response, ambient air, exposure, combustion emissions, epidemelogy, air pollution, children, Human Health Risk Assessment, particle exposure, airway inflammation, human exposure, PAHs, atmospheric aerosols, ambient particle health effects, mortality studies, cardiopulmonary response, inhalation, children's vulnerablity, assessment of exposure, airborne pollutants, combustion, hydrocarbons, harmful environmental agents, epidemeology, human susceptibility, biological markers, incineration, mortality, California (CA), allergens, indoor air quality, aerosols, atmospheric chemistry, exposure assessment, environmental hazard exposures, toxics, air quality, particle transport, allergen, cardiovascular disease, human health risk, combustion contaminants

Progress and Final Reports:

  • 1999 Progress Report
  • 2000 Progress Report
  • 2001 Progress Report
  • 2002 Progress Report
  • 2003 Progress Report
  • 2004
  • Final Report

  • Main Center Abstract and Reports:

    R827355    Airborne PM - Northwest Research Center for Particulate Air Pollution and Health

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R827355C001 Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
    R827355C002 Health Effects
    R827355C003 Personal PM Exposure Assessment
    R827355C004 Characterization of Fine Particulate Matter
    R827355C005 Mechanisms of Toxicity of Particulate Matter Using Transgenic Mouse Strains
    R827355C006 Toxicology Project -- Controlled Exposure Facility
    R827355C007 Health Effects Research Core
    R827355C008 Exposure Core
    R827355C009 Statistics and Data Core
    R827355C010 Biomarker Core
    R827355C011 Oxidation Stress Makers