2000 Progress Report: Investigating Chronic Effects of Exposure to Particulate MatterEPA Grant Number: R827353C006
Subproject: this is subproject number 006 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: EPA Harvard Center for Ambient Particle Health Effects
Center Director: Koutrakis, Petros
Title: Investigating Chronic Effects of Exposure to Particulate Matter
Investigators: Dockery, Douglas W.
Current Investigators: Dockery, Douglas W. , Laden, Francine , Schwartz, Joel
Institution: Harvard University
Current Institution: Harvard University , Harvard T.H. Chan School of Public Health
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 1999 through May 31, 2000
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air
Objective:This project is one of four projects under Theme II: Identifying Populations Susceptible to the Health Effects of Particulate Air Pollution of our proposal. As part of this project we will follow up the Six Cities Study cohort up to 24 years in an effort to assess the cumulative effect of long-term exposures on the incidence of lung cancer, nonmalignant respiratory disease, cardiovascular disease, and cause-specific mortality. Another objective of this project is to estimate the years lost associated with particulate exposure.
Progress Summary:Vital status was determined for the 8111 participants in the Harvard Six Cities adult cohort for an additional 9 years of follow-up (1990-1998). We identified 1430 additional deaths, bringing the total to 2737 deaths. Survival analyses of all-cause mortality shows that life expectancy continues to be reduced in the more polluted cities, with the relative ranking of the survival the same as in the original published analyses. We also are investigating how the risk varies with the baseline age of the members of the cohort.
Future Activities:In the coming year, we will construct an air pollution timeline for each city, analyze cause-specific mortality, and estimate the net years of life lost attributable to particulate air pollution.
Journal Articles:No journal articles submitted with this report: View all 4 publications for this subproject
Supplemental Keywords:particulate matter, PM2.5, PM10, air pollutants, particulates, health effects, exposure, ambient particles, susceptibility, metals, public policy, biology, engineering, epidemiology, toxicology, environmental chemistry, monitoring., RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, ENVIRONMENTAL MANAGEMENT, particulate matter, Toxicology, air toxics, Environmental Chemistry, Epidemiology, Risk Assessments, Microbiology, Susceptibility/Sensitive Population/Genetic Susceptibility, Environmental Microbiology, Environmental Monitoring, Physical Processes, Children's Health, genetic susceptability, tropospheric ozone, Atmospheric Sciences, Molecular Biology/Genetics, Biology, Environmental Engineering, Risk Assessment, ambient air quality, health effects, interindividual variability, molecular epidemiology, monitoring, particle size, particulates, sensitive populations, chemical exposure, air pollutants, cardiopulmonary responses, health risks, human health effects, indoor exposure, lung, stratospheric ozone, ambient air monitoring, exposure and effects, ambient air, ambient measurement methods, exposure, pulmonary disease, developmental effects, epidemelogy, biological response, respiratory disease, air pollution, ambient monitoring, children, Human Health Risk Assessment, particle exposure, lung cancer, biological mechanism , cardiopulmonary response, chronic effects, human exposure, inhalation, pulmonary, susceptibility, particulate exposure, assessment of exposure, ambient particle health effects, elderly, indoor air, inhaled, atmospheric monitoring, epidemeology, human susceptibility, environmental health hazard, inhalation toxicology, cardiopulmonary, indoor air quality, inhaled particles, human health, measurement methods , air quality, cardiovascular disease, dosimetry, exposure assessment, human health risk, respiratory, measurement methods, genetic susceptibility
Progress and Final Reports:Original Abstract
Main Center Abstract and Reports:R827353 EPA Harvard Center for Ambient Particle Health Effects
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core