2005 Progress Report: FRIENDS Children's Environmental Health Center

EPA Grant Number: R829390
Center: CECEHDPR - University of Illinois FRIENDS Children’s Environmental Health Center
Center Director: Schantz, Susan L.
Title: FRIENDS Children's Environmental Health Center
Investigators: Schantz, Susan L.
Institution: University of Illinois at Urbana
EPA Project Officer: Louie, Nica
Project Period: November 1, 2001 through October 31, 2006 (Extended to October 31, 2008)
Project Period Covered by this Report: November 1, 2004 through October 31, 2005
Project Amount: $5,568,992
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001) RFA Text |  Recipients Lists
Research Category: Children's Health , Health Effects , Human Health , Health

Objective:

The Fox River Environment and Diet Study (FRIENDS) Children’s Environmental Health Center was established to investigate the health effects of combined exposure to PCBs and MeHg in Hmong and Lao refugees consuming contaminated fish from the Fox River in northeastern Wisconsin. The objectives of the FRIENDS Center are to: (1) study the impact of PCB and MeHg exposure on women’s reproductive health and child development; (2) develop effective educational strategies to reduce exposure; and (3) conduct laboratory studies aimed at understanding the mechanisms through which these contaminants induce neurological deficits in children.

Progress Summary:

The accomplishments of the Center are described in the individual 2005 Annual Reports for the FRIENDS Center projects:

R829390C001: Neurobehavioral Effects of PCBs and Methylmercury in Rats.

R829390C002: Perinatal PCB Exposure and Neurophysical/Auditing Function.

R829390C003: FRIENDS Analytical Toxicology Core Facility.

R829390C004: Development Effects of PCB and Methylmercury.

Future Activities:

See the individual 2005 Annual Reports for R829390C001 through R829390C004 for future activities.


Journal Articles: 21 Displayed | Download in RIS Format

Other center views: All 38 publications 22 publications in selected types All 21 journal articles
Type Citation Sub Project Document Sources
Journal Article Bemis JC, Seegal RF. Polychlorinated biphenyls and methylmercury act synergistically to reduce rat brain dopamine content in vitro. Environmental Health Perspectives 1999;107(11):879-885. R829390 (2005)
R829390 (Final)
R825812 (1999)
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  • Journal Article Bemis JC, Seegal RF. Polychlorinated biphenyls and methylmercury alter intracellular calcium concentrations in rat cerebellar granule cells. NeuroToxicology 2000;21(6):1123-1134. R829390 (2005)
    R829390 (Final)
    R825812 (1999)
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  • Journal Article Bemis JC, Seegal RF. PCB-induced inhibition of the vesicular monoamine transporter predicts reductions in synaptosomal dopamine content. Toxicological Sciences 2004;80(2):288-295. R829390 (2005)
    R829390 (Final)
    R829390C004 (2004)
    R825812 (1999)
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  • Journal Article Dietrich KN, Eskenazi B, Schantz S, Yolton K, Rauh VA, Johnson CB, Alkon A, Canfield RL, Pessah IN, Berman RF. Principles and practices of neurodevelopmental assessment in children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1437-1446. R829390 (2005)
    R829390 (Final)
    R829390C002 (2005)
    R827027 (2002)
    R829388 (2006)
    R829388 (Final)
    R829388C006 (2005)
    R829389 (2005)
    R829389 (Final)
    R831710 (2005)
    R831710 (Final)
    R831711 (2005)
    R832141 (2006)
    R832141 (2007)
    R832141 (Final)
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  • Journal Article Dreiem A, Gertz CC, Seegal RF. The effects of methylmercury on mitochondrial function and reactive oxygen species formation in rat striatal synaptosomes are age-dependent. Toxicological Sciences 2005;87(1):156-162. R829390 (2005)
    R829390 (Final)
    R829390C004 (2005)
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  • Journal Article Dreiem A, Seegal RF. Methylmercury-induced changes in mitochondrial function in striatal synaptosomes are calcium-dependent and ROS-independent. NeuroToxicology 2007;28(4):720-726. R829390 (2005)
    R829390 (Final)
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  • Journal Article Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. R829390 (2005)
    R829390 (Final)
    R829390C002 (2005)
    R827027 (2002)
    R829389 (2003)
    R829389 (2004)
    R829389 (2005)
    R829389 (Final)
    R831709 (2005)
    R831709C001 (2004)
    R831710 (2005)
    R831710 (Final)
    R831710C001 (2006)
    R831710C002 (2006)
    R831711 (2005)
    R831711 (2006)
    R831711 (2007)
    R831711 (Final)
    R831711C001 (2006)
    R831711C002 (2004)
    R831711C002 (2006)
    R831711C003 (2006)
    R832141 (2005)
    R832141 (2007)
    R832141 (Final)
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  • Journal Article Kornosky JL, Peck JD, Sweeney AM, Adelson PL, Schantz SL. Reproductive characteristics of Southeast Asian immigrants before and after migration. Journal of Immigrant and Minority Health 2008;10(2):135-143. R829390 (2005)
    R829390 (Final)
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  • Journal Article Kostyniak PJ, Hansen LG, Widholm JJ, Fitzpatrick RD, Olson JR, Helferich JL, Kim KH, Sable HJ, Seegal RF, Pessah IN, Schantz SL. Formulation and characterization of an experimental PCB mixture designed to mimic human exposure from contaminated fish. Toxicological Sciences 2005;88(2):400-411. R829390 (2005)
    R829390 (Final)
    R829388 (2006)
    R829388 (Final)
    R829388C006 (2005)
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  • Journal Article Lyng GD, Synder-Keller A, Seegal RF. Dopaminergic development of prenatal ventral mesencephalon and striatum in organotypic co-cultures. Brain Research 2007;1133(1):1-9. R829390 (2005)
    R829390 (Final)
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  • Journal Article Lyng GD, Synder-Keller A, Seegal RF. Polychlorinated biphenyl-induced neurotoxicity in organotypic co-cultures of developing rat ventral mesencephalon and striatum. Toxicological Sciences 2007;97(1):128-139. R829390 (2005)
    R829390 (Final)
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  • Journal Article Lyng GD, Seegal RF. Polychlorinated biphenyl-induced oxidative stress in organotypic co-cultures: experimental dopamine depletion prevents reductions in GABA. NeuroToxicology 2008;29(2):301-308. R829390 (2005)
    R829390 (Final)
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  • Journal Article Powers BE, Widholm JJ, Lasky RE, Schantz SL. Auditory deficits in rats exposed to an environmental PCB mixture during development. Toxicological Sciences 2006;89(2):415-422. R829390 (2005)
    R829390 (Final)
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  • Journal Article Roegge CS, Wang VC, Powers BE, Klintsova AY, Villareal S, Greenough WT, Schantz SL. Motor impairment in rats exposed to PCBs and methylmercury during early development. Toxicological Sciences 2004;77(2):315-324. R829390 (2005)
    R829390 (Final)
    R829390C001 (2004)
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  • Journal Article Roegge CS, Morris JR, Villareal S, Wang VC, Powers BE, Klintsova AY, Greenough WT, Pessah IN, Schantz SL. Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHg. Neurotoxicology and Teratology 2006;28(1):74-85. R829390 (2005)
    R829390 (Final)
    R829390C001 (2005)
    R829388 (2006)
    R829388 (Final)
    R829388C006 (2005)
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  • Journal Article Roegge CS, Schantz SL. Motor function following developmental exposure to PCBS and/or MEHG. Neurotoxicology and Teratology 2006;28(2):260-277. R829390 (2005)
    R829390 (Final)
    R829390C001 (2005)
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  • Journal Article Roegge CS, Wang VC, Powers BE, Klintsova A, Villareal S, Greenough WT, Schantz SL. Motor functions in rats exposed to PCBs and methylmercury during early development. Neurotoxicology and Teratology 2002;24(3):424-425. R829390C001 (2002)
    R829390C001 (2003)
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    Journal Article Sable HJK, Powers BE, Wang VC, Widholm JJ, Schantz SL. Alterations in DRH and DRL performance in rats developmentally exposed to an environmental PCB mixture. Neurotoxicology and Teratology 2006;28(5):548-556. R829390 (2005)
    R829390 (Final)
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  • Journal Article Seegal RF, Brosch KO, Okoniewski RJ. Coplanar PCB congeners increase uterine weight and frontal cortical dopamine in the developing rat: implications for developmental neurotoxicity. Toxicological Sciences 2005;86(1):125-131. R829390 (2005)
    R829390 (Final)
    R829390C004 (2005)
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  • Journal Article Sweeney AM, Peck JD, Gasior DM, Gardiner J, Schantz SL. Perinatal PCBs and mercury exposure and neurodevelopmental effects. Epidemiology 2004;15(4):S147-S148. R829390 (Final)
    R829390C002 (2004)
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  • Journal Article Widholm JJ, Villareal S, Seegal RF, Schantz SL. Spatial alternation deficits following developmental exposure to Aroclor 1254 and/or methylmercury in rats. Toxicological Sciences 2004;82(2):577-589. R829390 (2002)
    R829390 (2005)
    R829390 (Final)
    R829390C001 (2004)
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  • Supplemental Keywords:

    children’s health, disease and cumulative effects, ecological risk assessment, susceptibility, sensitive population, toxicology, Fox River, PCBs, exposure assessment, heavy metals, methylmercury, pesticides, fish consumption,, RFA, Health, Scientific Discipline, Geographic Area, Midwest, Toxicology, Health Risk Assessment, Chemistry, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Disease & Cumulative Effects, Children's Health, Ecological Risk Assessment, Molecular Biology/Genetics, genetic susceptability, neurotoxic, human data, Fox River, PCBs, pesticides, behavioral assessment, children, neurotoxicity, motor development, methylmercury, PCB, behavioral deficits, cognitive development, Wisconsin (WI), reproductive health, animal studies, biomedical research, exposure assessment

    Progress and Final Reports:

    Original Abstract
  • 2002 Progress Report
  • 2003 Progress Report
  • 2004 Progress Report
  • 2006
  • 2007
  • Final Report
  • Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R829390C001 Neurobehavioral Effects of PCBs and Methylmercury in Rats
    R829390C002 Perinatal PCB Exposure and Neuropsychological/Auditory Function
    R829390C003 FRIENDS Analytical Toxicology Core Facility
    R829390C004 Developmental Effects of PCBs and Methylmercury