FRIENDS Children's Environmental Health Center

EPA Grant Number: R829390
Center: CECEHDPR - University of Illinois FRIENDS Children’s Environmental Health Center
Center Director: Schantz, Susan L.
Title: FRIENDS Children's Environmental Health Center
Investigators: Schantz, Susan L.
Institution: University of Illinois at Urbana
EPA Project Officer: Fields, Nigel
Project Period: November 1, 2001 through October 31, 2006 (Extended to October 31, 2008)
Project Amount: $5,568,992
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001) RFA Text |  Recipients Lists
Research Category: Children's Health , Health Effects , Human Health , Health

Objective:

The overall research objectives of the Friends Children's Environmental Health Center are to: (1) study the impact of exposure to polychlorinated bipbenyls (PCBs) and methy1mercury (MeHg) on cognitive, sensory and motor development of children, (2) develop effective educational strategies to reduce exposure to these neurotoxic contaminants, and (3) undertake laboratory studies to better understand the mechanisms by which these contaminants induce neurological deficits in children. The Center will build on several long-standing research collaborations and will be organized around an exposure cohort that is already being recruited. The cohort consists of Hmong, and Laotian refugees who are consuming PCB and MeHg contaminated fish from the Fox River in northeastern Wisconsin. The Center includes an administrative core, a community-based project, two biomedical research projects and an analytical toxicology core. The two primary goals of the community-based project are: (1) to evaluate the impact of PCB and MeHg exposure on reproductive health and child development and (2) to provide families with practical information that will help them to reduce their exposure to PCBs and MeHg. The assessments of the children will focus on specific aspects of behavioral and sensory function that have not been adequately addressed in previous human studies. These goals will be accomplished in partnership with community resource groups in the area. The biomedical research projects will complement the community based project by characterizing the cognitive, sensory, motor and neurochemical effects of exposure to PCBs alone, MeHg alone or PCBs and McHg combined in a rodent model. Both projects will use a mixture of PCBs that models the PCB congener profile in Fox River fish, and a ratio of PCBs to MeHg similar to that found in -the fish. The findings from the animal studies mill guide the selection of additional behavioral and sensory endpoints for use in the children exposed to PCBs and MeHg via maternal consumption of Fox River fish. The analytical toxicology, core will formulate the PCB mixture to be used in the animal studies and provide congener specific PCB- analysis, heavy metal analysis, and pesticide analysis in human and animal samples from the three research projects. The administrative core will provide oversight, coordination and integration of all Center activities.


Journal Articles: 22 Displayed | Download in RIS Format

Other center views: All 38 publications 23 publications in selected types All 22 journal articles
Type Citation Sub Project Document Sources
Journal Article Bemis JC, Seegal RF. Polychlorinated biphenyls and methylmercury act synergistically to reduce rat brain dopamine content in vitro. Environmental Health Perspectives 1999;107(11):879-885. R829390 (2005)
R825812 (1999)
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  • Journal Article Bemis JC, Seegal RF. Polychlorinated biphenyls and methylmercury alter intracellular calcium concentrations in rat cerebellar granule cells. Neurotoxicology 2000;21(6):1123-1134. R829390 (2005)
    R825812 (1999)
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  • Journal Article Bemis JC, Seegal RF. PCB-induced inhibition of the vesicular monoamine transporter predicts reductions in synaptosomal dopamine content. Toxicological Sciences 2004;80(2):288-295. R829390 (2005)
    R829390C004 (2004)
    R825812 (1999)
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  • Journal Article Dietrich KN, Eskenazi B, Schantz S, Yolton K, Rauh VA, Johnson CB, Alkon A, Canfield RL, Pessah IN, Berman RF. Principles and practices of neurodevelopmental assessment in children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1437-1446. R829390 (2005)
    R829390 (Final)
    R829390C002 (2005)
    R827027 (2002)
    R829388 (2006)
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    R829388C006 (2005)
    R829389 (2005)
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    R831710 (2005)
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    R831711 (2005)
    R832141 (2006)
    R832141 (2007)
    R832141 (Final)
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  • Journal Article Dreiem A, Gertz CC, Seegal RF. The effects of methylmercury on mitochondrial function and reactive oxygen species formation in rat striatal synaptosomes are age-dependent. Toxicological Sciences 2005;87(1):156-162. R829390 (2005)
    R829390C004 (2005)
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  • Journal Article Dreiem A, Seegal RF. Methylmercury-induced changes in mitochondrial function in striatal synaptosomes are calcium-dependent and ROS-independent. NeuroToxicology 2007;28(4):720-726. R829390 (2005)
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  • Journal Article Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. R829390 (2005)
    R829390 (Final)
    R829390C002 (2005)
    R827027 (2002)
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    R831709 (2005)
    R831709C001 (2004)
    R831710 (2005)
    R831710 (Final)
    R831710C001 (2006)
    R831710C002 (2006)
    R831711 (2005)
    R831711 (2006)
    R831711 (2007)
    R831711 (Final)
    R831711C001 (2006)
    R831711C002 (2004)
    R831711C002 (2006)
    R831711C003 (2006)
    R832141 (2005)
    R832141 (2007)
    R832141 (Final)
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  • Journal Article Kornosky JL, Peck JD, Sweeney AM, Adelson PL, Schantz SL. Reproductive characteristics of Southeast Asian immigrants pre and post migration. Journal of Immigrant and Minority Health 2008;10(2):135-143. R829390 (2005)
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  • Journal Article Kostyniak PJ, Hansen LG, Widholm JJ, Fitzpatrick RD, Olson JR, Helferich JL, Kim KH, Sable HJ, Seegal RF, Pessah IN, Schantz SL. Formulation and characterization of an experimental PCB mixture designed to mimic human exposure from contaminated fish. Toxicological Sciences 2005;88(2):400-411. R829390 (2005)
    R829388 (2006)
    R829388 (Final)
    R829388C006 (2005)
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  • Journal Article Lyng GD, Synder-Keller A, Seegal RF. Dopaminergic development of prenatal ventral mesencephalon and striatum in organotypic co-cultures. Brain Research 2007;1133(1):1-9. R829390 (2005)
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  • Journal Article Lyng GD, Synder-Keller A, Seegal RF. Polychlorinated biphenyl-induced neurotoxicity in organotypic co-cultures of developing rat ventral mesencephalon and striatum. Toxicological Sciences 2007;97(1):128-139. R829390 (2005)
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  • Journal Article Lyng GD, Seegal RF. Polychlorinated biphenyl-induced oxidative stress in organotypic co-cultures: experimental dopamine depletion prevents reductions in GABA. NeuroToxicology 2008;29(2):301-308. R829390 (2005)
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  • Journal Article Powers BE, Widholm JJ, Lasky RE, Schantz SL. Auditory deficits in rats exposed to an environmental PCB mixture during development. Toxicology Science 2006;89(2):415-422. R829390 (2005)
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  • Journal Article Roegge CS, Wang VC, Powers BE, Klintsova AY, Villareal S, Greenough WT, Schantz SL. Motor impairment in rats exposed to PCBs and methylmercury during early development. Toxicological Sciences 2004;77(2):315-324. R829390 (2005)
    R829390C001 (2004)
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  • Journal Article Roegge CS, Morris JR, Villareal S, Wang VC, Powers BE, Klintsova AY, Greenough WT, Pessah IN, Schantz SL. Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHg. Neurotoxicology and Teratology 2006;28(1):74-85. R829390 (2005)
    R829390C001 (2005)
    R829388 (2006)
    R829388 (Final)
    R829388C006 (2005)
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  • Journal Article Roegge CS, Schantz SL. Motor function following developmental exposure to PCBS and/or MEHG. Neurotoxicology and Teratology 2006;28(2):260-277. R829390 (2005)
    R829390C001 (2005)
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  • Journal Article Roegge CS, Wang VC, Powers BE, Klintsova A, Villareal S, Greenough WT, Schantz SL. Motor functions in rats exposed to PCBs and methylmercury during early development. Neurotoxicology and Teratology 2002;24(3):424-425. R829390C001 (2002)
    R829390C001 (2003)
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    Journal Article Sable HJK, Powers BE, Wang VC, Widholm JJ, Schantz SL. Alterations in DRH and DRL performance in rats developmentally exposed to an environmental PCB mixture. Neurotoxicology and Teratology 2006;28(5):548-556. R829390 (2005)
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  • Journal Article Seegal RF, Brosch KO, Okoniewski RJ. Coplanar PCB congeners increase uterine weight and frontal cortical dopamine in the developing rat: implications for developmental neurotoxicity. Toxicological Sciences 2005;86(1):125-131. R829390 (2005)
    R829390C004 (2005)
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  • Journal Article Sweeney AM, Peck JD, Gasior DM, Gardiner J, Schantz SL. Perinatal PCBs and mercury exposure and neurodevelopmental outcomes. Epidemiology 2004;15(4):S147. R829390C002 (2004)
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    Journal Article Widholm JJ, Villareal S, Seegal RF, Schantz SL. Spatial alternation deficits following developmental exposure to Aroclor 1254 and/or methylmercury in rats. Toxicological Sciences 2004;82(2):577-589. R829390 (2002)
    R829390 (2005)
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  • Journal Article Widholm, J., Villareal, S., Seegal, R., and Schantz, S. (2002). Impaired spatial alternation following developmental exposure to PCBs and methylmercury in rats. The Toxicologist, 66(1S): LB128. R829390C001 (2002)
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    Supplemental Keywords:

    RFA, Health, Scientific Discipline, Geographic Area, Midwest, Toxicology, Health Risk Assessment, Chemistry, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Disease & Cumulative Effects, Children's Health, genetic susceptability, Ecological Risk Assessment, Molecular Biology/Genetics, neurotoxic, human data, Fox River, PCBs, pesticides, behavioral assessment, children, neurotoxicity, motor development, methylmercury, PCB, behavioral deficits, cognitive development, Wisconsin (WI), reproductive health, animal studies, biomedical research, exposure assessment

    Progress and Final Reports:

    2002 Progress Report
    2003 Progress Report
    2004 Progress Report
    2005 Progress Report
    Final Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R829390C001 Neurobehavioral Effects of PCBs and Methylmercury in Rats
    R829390C002 Perinatal PCB Exposure and Neuropsychological/Auditory Function
    R829390C003 FRIENDS Analytical Toxicology Core Facility
    R829390C004 Developmental Effects of PCBs and Methylmercury