Center for the Study of Environmental Factors in the Etiology of Autism

EPA Grant Number: R829388
Center: CECEHDPR - University of California at Davis Center for the Study of Environmental Factors in the Etiology of Autism
Center Director: Pessah, Isaac N.
Title: Center for the Study of Environmental Factors in the Etiology of Autism
Investigators: Pessah, Isaac N.
Institution: University of California - Davis
EPA Project Officer: Fields, Nigel
Project Period: November 1, 2001 through October 31, 2006
Project Amount: $7,325,232
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001) RFA Text |  Recipients Lists
Research Category: Children's Health , Health Effects , Human Health , Health

Objective:

We intend to establish a Center for the Study of Environmental Factors in the Etiology of Autism at U.C. Davis that will investigate environmental risk factors contributing to the incidence and severity of childhood autism. Autism is a neurodevelopmental disorder defined by deficiencies of social reciprocity and communication, and by repetitive behavior. The majority of cases seem likely to arise from a -multiplicity of yet unidentified genetic and environmental factors. Surveys in California have indicated an apparent 210% increase in the cases of profound autism in children diagnosed over the last 10 years. Recent estimates indicate the frequency of mild to severe autism may be as high as 1:150 (Lord et al 2000). Thus there is growing concern from both parents and health professionals that prenatal and postnatal exposure to xenobiotic (e.g. mercurials, halogenated aromatics, and pesticides) and biotic (e.g. vaccine antigens) factors may act synergistically with unidentified susceptibility-genetic factors to produce autistic spectrum disorders.. To understand how the interaction of susceptibility genes with exposure to "environmental" chemicals may increase the risk and severity of autism and to identify which combination of chemical exposures confer the greatest threat, we propose to establish an interdisciplinary Center that addresses this complex problem at several levels. Project I proposes the first case-controlled epidemiological study of environmental factors in the etiology of autism. Tissue samples and exhaustive information will be collected from geographically distinct areas of California. Project two proposes to identify for the first time how known neurotoxicants of concern to children's health influence the development of social behavior and mediating brain regions such as the amygdala. Project III integrates elements of Projects I and 11 in order to examine molecular mechanisms underlying neurodevelopmental disorders associated with human autism and animal models of autism. The three research project are integrated within a center framework that provides extensive facility core capabilities in xenobiotic/lipid analysis (Core 1), cell activation biomarkers (Core 11), and molecular biomarkers (Core III). Our ultimate goal is to understand common patterns of dysfunction in autism and elucidate mechanisms by which chemicals known to be toxic to the nervous system contribute to abnormal development of social behavior in children so that rational strategies for treatment and prevention can be undertaken.


Journal Articles: 132 Displayed | Download in RIS Format

Other center views: All 145 publications 133 publications in selected types All 132 journal articles
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Journal Article Ahn KC, Zhao B, Chen J, Cherednichenko G, Sanmarti E, Denison MS, Lasley B, Pessah IN, Kultz D, Chang DPY, Gee SJ, Hammock BD. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens:receptor-based bioassay screens. Environmental Health Perspectives 2008;116(9):1203-1210. R829388 (Final)
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  • Journal Article Aleman M, Riehl J, Aldridge BM, Lecouteur RA, Stott JL, Pessah IN. Association of a mutation in the ryanodine receptor 1 gene with equine malignant hyperthermia. Muscle & Nerve 2004;30(3):356-365. R829388 (2006)
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  • Journal Article Anderson PJ, Lango J, Carkeet C, Britten A, Krautler B, Hammock BD, Roth JR. One pathway can incorporate either adenine or dimethylbenzimidazole as an α-axial ligand of B12 cofactors in Salmonella enterica. Journal of Bacteriology 2008;190(4):1160-1171. R829388 (Final)
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  • Journal Article Aronov PA, Dettmer K, Hammock BD, Christiansen JA, Cornel AJ. Development of a HPLC/tandem-MS method for the analysis of the larvicides methoprene, hydroprene, and kinoprene at trace levels using Diels-Alder derivatization. Journal of Agricultural and Food Chemistry 2005;53(9):3306-3312. R829388 (2006)
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  • Journal Article Aronov PA, Hall LM , Dettmer K, Stephensen CB, Hammock BD. Metabolic profiling of major vitamin D metabolites using Diels-Alder derivatization and ultra-performance liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry 2008;391(5):1917-1930. R829388 (Final)
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  • Journal Article Ashwood P, Van de Water J. A review of autism and the immune response. Clinical & Developmental Immunology 2004;11(2):165-174. R829388 (Final)
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  • Journal Article Ashwood P, Van de Water J. Is autism an autoimmune disease? Autoimmunity Reviews 2004;3(7-8):557-562. R829388 (2006)
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  • Journal Article Ashwood P, Wills S, Van de Water J. The immune response in autism: a new frontier for autism research. Journal of Leukocyte Biology 2006;80(1):1-15. R829388 (2006)
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  • Journal Article Ashwood P, Kwong C, Hansen R, Hertz-Picciotto I, Croen L, Krakowiak P, Walker W, Pessah IN, Van de Water J. Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? Journal of Autism and Developmental Disorders 2008;38(1):169-175. R829388 (2006)
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  • Journal Article Baron CA, Tepper CG, Liu SY, Davis RR, Wang NJ, Schanen NC, Gregg JP.
 Genomic and functional profiling of duplicated chromosome 15 cell lines reveal regulatory alterations in UBE3A-associated ubiquitin-proteasome pathway processes. Human Molecular Genetics 2006;15(6):853-869. R829388 (2006)
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  • Journal Article Baron CA, Liu SY, Hicks C, Gregg JP. Utilization of lymphoblastoid cell lines as a system for the molecular modeling of autism. Journal of Autism and Developmental Disorders 2006;36(8):973-982. R829388 (2006)
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  • Journal Article Bauman MD, Lavenex P, Mason WA, Capitanio JP, Amaral DG. The development of social behavior following neonatal amygdala lesions in rhesus monkeys. Journal of Cognitive Neuroscience 2004;16(8):1388-1411. R829388 (2006)
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  • Journal Article Berman RF, Pessah IN, Mouton PR, Mav D, Harry J. Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice. Toxicological Sciences 2008;101(2):294-309. R829388 (Final)
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  • Journal Article Berman RF, Pessah IN, Mouton PR, Mav D, Harry GJ. Modeling neonatal thimerosal exposure in mice. Toxicological Sciences 2008;103(2):416. R829388 (Final)
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  • Journal Article Braunschweig D, Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen LA, Pessah IN, Van de Water J. Autism: maternally derived antibodies specific for fetal brain proteins. NeuroToxicology 2008;29(2):226-231. R829388 (Final)
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  • Journal Article Bu B, Ashwood P, Harvey D, King IB, Water JV, Jin LW.
 Fatty acid compositions of red blood cell phospholipids in children with autism.
 Prostaglandins, Leukotrienes and Essential Fatty Acids 2006;74(4):215-221. R829388 (Final)
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  • Journal Article Burke K, Cheng Y, Li B, Petrov A, Joshi P, Berman RF, Reuhl KR, DiCicco-Bloom E. Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E. NeuroToxicology 2006;27(6):970-981. R829388 (2006)
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  • Journal Article Cabanlit M, Wills S, Goines P, Ashwood P, Van de Water J. 
Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. 
Annals of the New York Academy of Sciences 2007;1107:92-103. R829388 (Final)
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  • Journal Article Carkeet C, Dueker SR, Lango J, Buchholz BA, Miller JW, Green R, Hammock BD, Roth JR, Anderson PJ. Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled 14C-cobalamin. Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5694-5699. R829388 (2006)
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  • Journal Article Chelu MG, Goonasekera SA, Durham WJ, Tang W, Lueck JD, Riehl J, Pessah IN, Zhang P, Bhattacharjee MB, Dirksen RT, Hamilton SL. Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse. FASEB Journal 2006;20(2):329-330. R829388 (2006)
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  • Journal Article Chen L, Esteve E, Sabatier J-M, Ronjat M, De Waard M, Allen PD, Pessah IN. Maurocalcine and peptide A stabilize distinct subconductance states of ryanodine receptor type 1, revealing a proportional gating mechanism. Journal of Biological Chemistry 2003;278(18):16095-16106. R829388 (2006)
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  • Journal Article Cherednichenko G, Zima AV, Feng W, Schaefer S, Blatter LA, Pessah IN. NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. Circulation Research 2004;94(4):478-486. R829388 (2006)
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  • Journal Article Cherednichenko G, Hurne AM, Fessenden JD, Lee EH, Allen PD, Beam KG, Pessah IN. Conformational activation of Ca2+ entry by depolarization of skeletal myotubes. Proceedings of the National Academy of Sciences of the United States of America 2004;101(44):15793-15798. R829388 (2006)
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  • Journal Article Croen LA, Grether JK, Yoshida CK, Odouli R, Van de Water J. Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case-control study. Archives of Pediatrics and Adolescent Medicine 2005;159(2):151-157. R829388 (2006)
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  • Journal Article Dai JJ, Lieu L, Rocke D.
 Dimension reduction for classification with gene expression microarray data.
 Statistical Applications in Genetics and Molecular Biology 2006;5(1):Article 6. R829388 (2006)
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  • Journal Article Davis BB, Thompson DA, Howard LL, Morisseau C, Hammock BD, Weiss RH. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2222-2227. R829388 (2006)
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  • Journal Article Davis BB, Morisseau C, Newman JW, Pedersen TL, Hammock BD, Weiss RH. Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition. Journal of Pharmacology and Experimental Therapeutics 2006;316(2):815-821. R829388 (2006)
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  • Journal Article Denning L, Anderson JA, Davis R, Gregg JP, Kuzdenyi J, Maselli RA.
 High throughput genetic analysis of congenital myasthenic syndromes using resequencing microarrays. PLoS One 2007;2(9):e918. R829388 (Final)
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  • Journal Article Dettmer K, Hanna D, Whetstone P, Hansen R, Hammock BD. 
Autism and urinary exogenous neuropeptides: development of an on-line SPE-HPLC-tandem mass spectrometry method to test the opioid excess theory.
 Analytical and Bioanalytical Chemistry 2007;388(8):1643-1651. R829388 (Final)
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  • Journal Article Dettmer K, Aronov PA, Hammock BD. 
Mass spectrometry-based metabolomics.
 Mass Spectrometry Reviews 2007;26(1):51-78. R829388 (Final)
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  • Journal Article Dey A, Williams RS, Pollock DM, Stepp DW, Newman JW, Hammock BD, Imig JD. Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. Obesity Research 2004;12(8):1278-1289. R829388 (2006)
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  • Journal Article Dietrich KN, Eskenazi B, Schantz S, Yolton K, Rauh VA, Johnson CB, Alkon A, Canfield RL, Pessah IN, Berman RF. Principles and practices of neurodevelopmental assessment in children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1437-1446. R829388 (2006)
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  • Journal Article Dodds ED, German JB, Lebrilla CB. Enabling MALDI-FTICR-MS/MS for high-performance proteomics through combination of infrared and collisional activation. Analytical Chemistry 2007;79(24):9547-9556. R829388 (Final)
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  • Journal Article Du X, Tang Y, Xu H, Lit L, Walker W, Ashwood P, Gregg JP, Sharp FR. Genomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndrome. Genomics 2006;87(6):693-703. R829388 (2006)
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  • Journal Article DuTeaux SB, Newman JW, Morisseau C, Fairbairn EA, Jelks K, Hammock BD, Miller MG. Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism. Toxicological Sciences 2004;78(2):187-195. R829388 (2006)
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  • Journal Article Enstrom A, Onore C, Hertz-Picciotto I, Hansen R, Croen L, Van de Water J, Ashwood P. Detection of IL-17 and IL-23 in plasma samples of children with autism. American Journal of Biochemistry and Biotechnology 2008;4(2):114-120. R829388 (2007)
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  • Journal Article Enstrom A, Onore C, Tarver A, Hertz-Picciotto I, Hansen R, Croen L, Van de Water J, Ashwood P. Peripheral blood leukocyte production of BDNF following mitogen stimulation in early onset and regressive autism. American Journal of Biochemistry and Biotechnology 2008;4(2):121-129. R829388 (2007)
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  • Journal Article Esteve E, Smida-Rezgui S, Sarkozi S, Szegedi C, Regaya I, Chen L, Altafaj X, Rochat H, Allen P, Pessah IN, Marty I, Sabatier JM, Jona I, De Waard M, Ronjat M. Critical amino acid residues determine the binding affinity and the Ca2+ release efficacy of maurocalcine in skeletal muscle cells. Journal of Biological Chemistry 2003;278(39):37822-37831. R829388 (2006)
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  • Journal Article Fang X, Weintraub NL, Oltman CL, Stoll LL, Kaduce TL, Harmon S, Dellsperger KC, Morisseau C, Hammock BD, Spector AA. Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide. American Journal of Physiology-Heart and Circulatory Physiology 2002;283(6):H2306-H2314. R829388 (2006)
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  • Journal Article Fang X, Weintraub NL, McCaw RB, Hu S, Harmon SD, Rice JB, Hammock BD, Spector AA. Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. American Journal of Physiology-Heart and Circulatory Physiology 2004;287(6):H2412-H2420. R829388 (2006)
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  • Journal Article Fang X, Hu S, Watanabe T, Weintraub NL, Snyder GD, Yao J, Liu Y, Shyy JY-J, Hammock BD, Spector AA. Activation of peroxisome proliferator-activated receptor α by substituted urea-derived soluble epoxide hydrolase inhibitors. Journal of Pharmacology and Experimental Therapeutics 2005;314(1):260-270. R829388 (2006)
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  • Journal Article Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN. Homer regulates gain of ryanodine receptor type 1 channel complex. Journal of Biological Chemistry 2002;277(47):44722-44730. R829388 (2006)
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  • Journal Article Feng W, Tu J, Pouliquin P, Cabrales E, Shen X, Dulhunty A, Worley PF, Allen PD, Pessah IN. Dynamic regulation of ryanodine receptor type 1 (RyR1) channel activity by Homer 1. Cell Calcium 2008;43(3):307-314. R829388 (Final)
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  • Journal Article Fleming EJ, Mack EE, Green PG, Nelson DC. Mercury methylation from unexpected sources: molybdate-inhibited freshwater sediments and an iron-reducing bacterium. Applied and Environmental Microbiology 2006;72(1):457-464. R829388 (Final)
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  • Journal Article Folkerts MM, Parks EA, Dedman JR, Kaetzel MA, Lyeth BG, Berman RF. Phosphorylation of calcium calmodulin-dependent protein kinase II following lateral fluid percussion brain injury in rats.
 Journal of Neurotrauma 2007;24(4):638-650. R829388 (Final)
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  • Journal Article Gafni J, Wong PW, Pessah IN. Non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95) amplifies ionotropic glutamate receptor signaling in embryonic cerebellar granule neurons by a mechanism involving ryanodine receptors. Toxicological Sciences 2004;77(1):72-82. R829388 (2006)
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  • Journal Article Gao J, Voss AA, Pessah IN, Lauer FT, Penning TM, Burchiel SW. Ryanodine receptor-mediated rapid increase in intracellular calcium induced by 7,8-benzo(a)pyrene quinone in human and murine leukocytes. Toxicological Sciences 2005;87(2):419-426. R829388 (2006)
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  • Journal Article Geller SC, Gregg JP, Hagerman P, Rocke DM. Transformation and normalization of oligonucleotide microarray data. Bioinformatics 2003;19(14):1817-1823. R829388 (2006)
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  • Journal Article German JB, Hammock BD, Watkins SM. Metabolomics: building on a century of biochemistry to guide human health. Metabolomics 2005;1(1):3-9. R829388 (2006)
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  • Journal Article German JB, Watkins SM, Fay LB. Metabolomics in practice: emerging knowledge to guide future dietetic advice toward individualized health. Journal of the American Dietetic Association 2005;105(9):1425-1432. R829388 (2006)
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  • Journal Article German JB, Gillies LA, Smilowitz JT, Zivkovic AM, Watkins SM. Lipidomics and lipid profiling in metabolomics.
 Current Opinion in Lipidology 2007;18(1):66-71. R829388 (Final)
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  • Abstract: Current Opinion in Lipidology-Abstract
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  • Journal Article Gibney MJ, Walsh M, Brennan L, Roche HM, German B, van Ommen B. Metabolomics in human nutrition: opportunities and challenges. American Journal of Clinical Nutrition 2005;82(3):497-503. R829388 (2006)
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  • Journal Article Goines P, Schauer J, Heuer L, Ashwood P, Van de Water J. Beta-2-microglobulin in autism spectrum disorders. American Journal of Biochemistry and Biotechnology 2007;3(2):87-91. R829388 (Final)
    R833292 (2007)
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  • Journal Article Goth SR, Chu RA, Pessah IN. Oxygen tension regulates the in vitro maturation of GM-CSF expanded murine bone marrow dendritic cells by modulating class II MHC expression. Journal of Immunological Methods 2006;308(1-2):179-191. R829388 (2006)
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    R833292 (2007)
    R833292 (2009)
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  • Journal Article Goth SR, Chu RA, Gregg JP, Cherednichenko G, Pessah IN. Uncoupling of ATP-mediated calcium signaling and dysregulated interleukin-6 secretion in dendritic cells by nanomolar thimerosal. Environmental Health Perspectives 2006;114(7):1083-1091. R829388 (2006)
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    R833292 (Final)
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  • Journal Article Greco CM, Berman RF, Martin RM, Tassone F, Schwartz PH, Chang A, Trapp BD, Iwahashi C, Brunberg J, Grigsby J, Hessl D, Becker EJ, Papazian J, Leehey MA, Hagerman RJ, Hagerman PJ. Neuropathology of fragile X-associated tremor/ataxia syndrome (FXTAS). Brain 2006;129(1):243-255. R829388 (2006)
    R829388 (Final)
    R829388C005 (2005)
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  • Journal Article Gregg JP, Lit L, Baron CA, Hertz-Picciotto I, Walker W, Davis RA, Croen LA, Ozonoff S, Hansen R, Pessah IN, Sharp FR. Gene expression changes in children with autism. Genomics 2008;91(1):22-29. R829388 (Final)
    R833292 (2008)
    R833292 (2009)
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  • Journal Article Hansen ME, Pessah IN, Matsumura F. Heptachlor epoxide induces a non-capacitative type of Ca2+ entry and immediate early gene expression in mouse hepatoma cells. Toxicology 2006;220(2-3):218-231. R829388 (2006)
    R829388 (Final)
    R829388C006 (2005)
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  • Journal Article Hansen RL, Ozonoff S, Krakowiak P, Angkustsiri K, Jones C, Deprey LJ, Le D-N, Croen LA, Hertz-Picciotto I. Regression in autism: prevalence and associated factors in the CHARGE Study. Ambulatory Pediatrics 2008;8(1):25-31. R829388 (2007)
    R829388 (Final)
    R833292 (2008)
    R833292 (2009)
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  • Journal Article Hertz-Picciotto I, Charles MJ, James RA, Keller JA, Willman E, Teplin S. In utero polychlorinated biphenyl exposures in relation to fetal and early childhood growth. Epidemiology 2005;16(5):648-656. R829388 (2006)
    R829388 (2007)
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    R833292 (2007)
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  • Abstract: Epidemiology-Abstract
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  • Journal Article Hertz-Picciotto I, Croen LA, Hansen R, Jones CR, van de Water J, Pessah IN. The CHARGE Study: an epidemiologic investigation of genetic and environmental factors contributing to autism. Environmental Health Perspectives 2006;114(7):1119-1125. R829388 (2006)
    R829388 (Final)
    R829388C004 (2005)
    R833292 (2007)
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  • Journal Article Hertz-Picciotto I, Baker RJ, Yap PS, Dostal M, Joad JP, Lipsett M, Greenfield T, Herr CE, Benes I, Shumway RH, Pinkerton KE, Sram R. Early childhood lower respiratory illness and air pollution. Environmental Health Perspectives 2007;115(10):1510-1518. R829388 (2007)
    R829388 (Final)
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  • Journal Article Hertz-Picciotto I, Park H-Y, Dostal M, Kocan A, Trnovec T, Sram R. Prenatal exposures to persistent and non-persistent organic compounds and effects on immune system development. Basic & Clinical Pharmacology and Toxicology 2008;102(2):146-154. R829388 (Final)
    R833292 (2008)
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  • Journal Article Hertz-Picciotto I, Jusko TA, Willman EJ, Baker RJ, Keller JA, Teplin SW, Charles MJ. A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio. Environmental Health 2008;7:37. R829388 (Final)
    R833292 (2009)
    R833292 (Final)
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  • Full-text: Environmental Health-Full Text HTML
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  • Journal Article Hillyard SL, German JB. Non-essential dietary factors: from test tube to lifespan. Journal of the Science of Food and Agriculture 2007;87(10):1802-1805. R829388 (Final)
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  • Journal Article Howard AS, Fitzpatrick R, Pessah I, Kostyniak P, Lein PJ. Polychlorinated biphenyls induce caspase-dependent cell death in cultured embryonic rat hippocampal but not cortical neurons via activation of the ryanodine receptor. Toxicology and Applied Pharmacology 2003;190(1):72-86. R829388 (2006)
    R829388 (Final)
    R829388C006 (2003)
    R829388C006 (2005)
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  • Journal Article Howards PP, Hertz-Picciotto I. Invited commentary: Disinfection by-products and pregnancy loss—lessons. American Journal of Epidemiology 2006;164(11):1052-1055. R829388 (2007)
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    R833292 (2007)
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  • Journal Article Huang H, Stok JE, Stoutamire DW, Gee SJ, Hammock BD. Development of optically pure pyrethroid-like fluorescent substrates for carboxylesterases. Chemical Research in Toxicology 2005;18(3):516-527. R829388 (Final)
    R829388C001 (2005)
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  • Journal Article Huang H, Nishi K, Gee SJ, Hammock BD. Evaluation of chiral α-cyanoesters as general fluorescent substrates for screening enantioselective esterases. Journal of Agricultural and Food Chemistry 2006;54(3):694-699. R829388 (2006)
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  • Journal Article Hurne AM, O'Brien JJ, Wingrove D, Cherednichenko G, Allen PD, Beam KG, Pessah IN. Ryanodine receptor type 1 (RyR1) mutations C4958S and C4961S reveal excitation-coupled calcium entry (ECCE) is independent of sarcoplasmic reticulum store depletion. Journal of Biological Chemistry 2005;280(44):36994-37004. R829388 (2006)
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    R829388C006 (2005)
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  • Journal Article Inceoglu B, Lango J, Jing J, Chen L, Doymaz F, Pessah IN, Hammock BD. One scorpion, two venoms: prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action. Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):922-927. R829388 (2006)
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  • Journal Article Inceoglu B, Lango J, Pessah IN, Hammock BD. Three structurally related, highly potent, peptides from the venom of Parabuthus transvaalicus possess divergent biological activity. Toxicon 2005;45(6):727-733. R829388 (Final)
    R829388C001 (2005)
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  • Journal Article Inceoglu B, Schmelzer KR, Morisseau C, Jinks SL, Hammock BD.
 Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). 
Prostaglandins & Other Lipid Mediators 2007;82(1-4):42-49. R829388 (Final)
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  • Journal Article Jaubert PJ, Golub MS, Lo YY, Germann SL, Dehoff MH, Worley PF, Kang SH, Schwarz MK, Seeburg PH, Berman RF. Complex, multimodal behavioral profile of the Homer1 knockout mouse. Genes, Brain and Behavior 2007;6(2):141-154. R829388 (2006)
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    R829388C005 (2005)
    R833292 (2007)
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  • Journal Article Jusko TA, Koepsell TD, Baker RJ, Greenfield TA, Willman EJ, Charles MJ, Teplin SW, Checkoway H, Hertz-Picciotto I. Maternal DDT exposures in relation to fetal and 5-year growth. Epidemiology 2006;17(6):692-700. R829388 (2007)
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  • Journal Article Kenet T, Froemke RC, Schreiner CE, Pessah IN, Merzenich MM. Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex.
 Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7646-7651. R829388 (2006)
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  • Journal Article Kim H-J, Ahn KC, Ma SJ, Gee SJ, Hammock BD.
 Development of sensitive immunoassays for the detection of the glucuronide conjugate of 3-phenoxybenzyl alcohol, a putative human urinary biomarker for pyrethroid exposure. Journal of Agricultural and Food Chemistry 2007;55(10):3750-3757. R829388 (Final)
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  • Journal Article Kim I-H, Morisseau C, Watanabe T, Hammock BD. Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility. Journal of Medicinal Chemistry 2004;47(8):2110-2122. R829388 (2006)
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    R829388C001 (2005)
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  • Journal Article Kim I-H, Heirtzler FR, Morisseau C, Nishi K, Tsai H-J, Hammock BD. Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. Journal of Medicinal Chemistry 2005;48(10):3621-3629. R829388 (2006)
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    R829388C001 (2005)
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  • Journal Article Kim KH, Inan SY, Berman RF, Pessah IN. Excitatory and inhibitory synaptic transmission is differentially influenced by two ortho-substituted polychlorinated biphenyls in the hippocampal slice preparation. Toxicology and Applied Pharmacology 2009;237(2):168-177. R829388 (Final)
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  • Journal Article Kim KH, Bose DD, Ghogha A, Riehl J, Zhang R, Barnhart CD, Lein PJ, Pessah IN. Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity. Environmental Health Perspectives 2011;119(4):519-526. R829388 (2006)
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  • Journal Article Kostyniak PJ, Hansen LG, Widholm JJ, Fitzpatrick RD, Olson JR, Helferich JL, Kim KH, Sable HJ, Seegal RF, Pessah IN, Schantz SL. Formulation and characterization of an experimental PCB mixture designed to mimic human exposure from contaminated fish. Toxicological Sciences 2005;88(2):400-411. R829388 (2006)
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  • Journal Article Krakowiak P, Goodlin-Jones B, Hertz-Picciotto I, Croen LA, Hansen RL.
Sleep problems in children with autism spectrum disorders, developmental delays, and typical development: a population-based study. 
Journal of Sleep Research 2008;17(2):197-206. R829388 (Final)
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  • Journal Article Lange MC, Lemay DG, German JB. A multi-ontology framework to guide agriculture and food towards diet and health. Journal of the Science of Food and Agriculture 2007;87(8):1427-1434. R829388 (Final)
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  • Journal Article Lawler CP, Croen LA, Grether JK, Van de Water J. Identifying environmental contributions to autism: provocative clues and false leads. Mental Retardation & Developmental Disabilities Research Reviews 2004;10(4):292-302. R829388 (2006)
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    R829388C002 (2005)
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  • Journal Article Lemay DG, Neville MC, Rudolph MC, Pollard KS, German JB.
 Gene regulatory networks in lactation: identification of global principles using bioinformatics. BMC Systems Biology 2007;1:56 (24 pp.). R829388 (Final)
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  • Journal Article Lemay DG, Zivkovic AM, German JB.
 Building the bridges to bioinformatics in nutrition research. American Journal of Clinical Nutrition 2007;86(5):1261-1269. R829388 (Final)
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  • Journal Article Li L, Li H. Dimension reduction methods for microarrays with application to censored survival data. Bioinformatics 2004;20(18):3406-3412. R829388 (2006)
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    R829388C003 (2005)
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  • Journal Article Li L. Survival prediction of diffuse large-B-cell lymphoma based on both clinical and gene expression information. Bioinformatics 2006;22(4):466-471. R829388 (2006)
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  • Journal Article Martin LA, Ashwood P, Braunschweig D, Cabanlit M, Van de Water J, Amaral DG. Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain, Behavior, and Immunity 2008;22(6):806-816. R829388 (Final)
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  • Journal Article Masuno MN, Pessah IN, Olmstead MM, Molinski TF. Simplified cyclic analogues of bastadin-5. Structure-activity relationships for modulation of the RyR1/FKBP12 Ca2+ channel complex. Journal of Medicinal Chemistry 2006;49(15):4497-4511. R829388 (2006)
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  • Abstract: Journal of Medicinal Chemistry-Abstract
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  • Journal Article Merin N, Young GS, Ozonoff S, Rogers SJ. Visual fixation patterns during reciprocal social interaction distinguish a subgroup of 6-month-old infants at-risk for autism from comparison infants. Journal of Autism and Developmental Disorders 2007;37(1):108-121. R829388 (2007)
    R829388 (Final)
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  • Journal Article Nadig AS, Ozonoff S, Young GS, Rozga A, Sigman M, Rogers SJ. A prospective study of response to name in infants at risk for autism. Archives of Pediatrics & Adolescent Medicine 2007;161(4):378-383. R829388 (2007)
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  • Full-text: Archives of Pediatrics & Adolescent Medicine-Full Text
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  • Journal Article Newman JW, Watanabe T, Hammock BD. The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. Journal of Lipid Research 2002;43(9):1563-1578. R829388 (2006)
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    R829388C001 (2003)
    R829388C001 (2005)
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  • Journal Article Newman JW, Morisseau C, Harris TR, Hammock BD. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1558-1563. R829388 (2006)
    R829388 (Final)
    R829388C001 (2003)
    R829388C001 (2005)
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  • Journal Article Newman JW, Morisseau C, Hammock BD. Epoxide hydrolases: their roles and interactions with lipid metabolism. Progress in Lipid Research 2005;44(1):1-51. R829388 (2006)
    R829388 (Final)
    R829388C001 (2005)
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  • Journal Article Newman JW, Kaysen GA, Hammock BD, Shearer GC. Proteinuria increases oxylipid concentrations in VLDL and HDL, but not LDL particles in the rat. Journal of Lipid Research 2007;48(8):1792-1800. R829388 (Final)
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  • Journal Article Nguyen DV, Senturk D. Distortion diagnostics for covariate-adjusted regression: graphical techniques based on local linear modeling.
 Journal of Data Science 2007;5(4):471-490. R829388 (Final)
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  • Journal Article Nguyen DV, Senturk D. 
Multicovariate-adjusted regression models.
 Journal of Statistical Computation and Simulation 2008;78(9):813-827. R829388 (Final)
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  • Journal Article Ninonuevo MR, Park Y, Yin H, Zhang J, Ward RE, Clowers BH, German JB, Freeman SL, Killeen K, Grimm R, Lebrilla CB. A strategy for annotating the human milk glycome.
 Journal of Agricultural and Food Chemistry 2006;54(20):7471-7480. R829388 (Final)
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  • Journal Article Ninonuevo MR, Ward RE, LoCascio RG, German JB, Freeman SL, Barboza M, Mills DA, Lebrilla CB. 
Methods for the quantitation of human milk oligosaccharides in bacterial fermentation by mass spectometry.
 Analytical Biochemistry 2007;361(1):15-23. R829388 (Final)
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  • Journal Article Ninonuevo MR, Perkins PD, Francis J, Lamotte LM, LoCascio RG, Freeman SL, Mills DA, German JB, Grimm R, Lebrilla CB. Daily variations in oligosaccharides of human milk determined by microfluidic chips and mass spectrometry. 
Journal of Agricultural and Food Chemistry 2008;56(2):618-626. R829388 (Final)
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  • Journal Article Ostrovskaya O, Goyal R, Osman N, McAllister CE, Pessah IN, Hume JR, Wilson SM. 
Inhibition of ryanodine receptors by 4-(2-aminopropyl)-3,5-dichloro-N,N-dimethylaniline (FLA 365) in canine pulmonary arterial smooth muscle cells.
 Journal of Pharmacology and Experimental Therapeutics 2007;323(1):381-390. R829388 (Final)
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  • Journal Article Ozonoff S, Young GS, Goldring S, Greiss-Hess L, Herrera AM, Steele J, Macari S, Hepburn S, Rogers SJ. Gross motor development, movement abnormalities, and early identification of autism. Journal of Autism and Developmental Disorders 2008;38(4):644-656. R829388 (2007)
    R829388 (Final)
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  • Journal Article Palkovicova L, Ursinyova M, Masanova V, Yu Z, Hertz-Picciotto I. Maternal amalgam dental fillings as the source of mercury exposure in developing fetus and newborn. Journal of Exposure Science & Environmental Epidemiology 2008;18(3):326-331. R829388 (2007)
    R829388 (Final)
    R833292 (2007)
    R833292 (2008)
    R833292 (2009)
  • Abstract from PubMed
  • Full-text: JESEE - Full Text HTML
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  • Abstract: JESEE - Abstract
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  • Other: JESEE - Full Text PDF
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  • Journal Article Paolini C, Fessenden JD, Pessah IN, Franzini-Armstrong C. Evidence for conformational coupling between two calcium channels. Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12748-12752. R829388 (Final)
    R829388C006 (2005)
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  • Abstract: PNAS-Abstract
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  • Journal Article Park H-Y, Hertz-Picciotto I, Petrik J, Palkovicova L, Kocan A, Trnovec T.
 Prenatal PCB exposure and thymus size at birth in neonates in Eastern Slovakia.
 Environmental Health Perspectives 2008;116(1):104-109. R829388 (Final)
    R833292 (Final)
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  • Journal Article Pessah IN, Hansen LG, Albertson TE, Garner CE, Ta TA, Do Z, Kim KH, Wong PW. Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1). Chemical Research in Toxicology 2006;19(1):92-101. R829388 (2006)
    R829388 (Final)
    R829388C006 (2005)
    R833292 (2007)
    R833292 (2009)
    R833292 (Final)
  • Abstract from PubMed
  • Full-text: University of California, Davis-PDF
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  • Abstract: ACS Publications-Abstract
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  • Journal Article Pessah IN, Seegal RF, Lein PJ, LaSalle J, Yee BK, Van de Water J, Berman RF. Immunologic and neurodevelopmental susceptibilities of autism. NeuroToxicology 2008;29(3):532-545. R829388 (Final)
    R833292 (2008)
    R833292 (Final)
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  • Full-text: ScienceDirect-Full Text HTML
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  • Abstract: ScienceDirect-Abstract
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  • Other: ScienceDirect-Full Text PDF
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  • Journal Article Phimister AJ, Lango J, Lee EH, Ernst-Russell MA, Takeshima H, Ma J, Allen PD, Pessah IN.
 Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols.
 Journal of Biological Chemistry 2007;282(12):8667-8677. R829388 (Final)
    R833292 (2007)
    R833292 (Final)
  • Abstract from PubMed
  • Full-text: Journal of Biological Chemistry-Full Text HTML
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  • Abstract: Journal of Biological Chemistry-Abstract
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  • Other: Journal of Biological Chemistry-Full Text PDF
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  • Journal Article Ran R, Pan R, Lu A, Xu H, Davis RR, Sharp FR. 
A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosis. 
Molecular and Cellular Neuroscience 2007;36(3):392-407. R829388 (Final)
  • Abstract from PubMed
  • Abstract: Science Direct-Abstract
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  • Journal Article Roegge CS, Morris JR, Villareal S, Wang VC, Powers BE, Klintsova AY, Greenough WT, Pessah IN, Schantz SL. Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHg. Neurotoxicology and Teratology 2006;28(1):74-85. R829388 (2006)
    R829388 (Final)
    R829388C006 (2005)
    R829390 (2005)
    R829390C001 (2005)
  • Abstract from PubMed
  • Full-text: Science Direct-Full Text HTML
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  • Abstract: Science Direct
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  • Other: Science Direct-Full Text PDF
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  • Journal Article Sakimura JN, Dang MT, Ballard KB, Hansen RL. Cognitive and temperament clusters in 3- to 5-year-old children with aggressive behavior. Journal of School Health 2008;78(1):38-45. R829388 (Final)
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  • Abstract: Journal of School Health-Abstract
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  • Journal Article Schmelzer KR, Kubala L, Newman JW, Kim I-H, Eiserich JP, Hammock BD.
 Soluble epoxide hydrolase is a therapeutic target for acute inflammation.
 Proceedings of the National Academy of Sciences of the United States of America 2005;102(28):9772-9777. R829388 (Final)
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  • Associated PubMed link
  • Full-text: PNAS Full Text
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  • Abstract: PNAS
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  • Journal Article Schmelzer KR, Inceoglu B, Kubala L, Kim IH, Jinks SL, Eiserich JP, Hammock BD. Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors. Proceedings of the National Academy of Sciences of the United States of America 2006;103(37):13646-13651. R829388 (Final)
    R833292 (Final)
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  • Abstract: PNAS-Abstract
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  • Other: PNAS-Full Text PDF
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  • Journal Article Schmelzer KR, Wheelock AM, Dettmer K, Morin D, Hammock BD. The role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airways.
 Environmental Health Perspectives 2006;114(9):1354-1360. R829388 (Final)
    R833292 (Final)
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  • Journal Article Shearer GC, Newman JW, Hammock BD, Kaysen GA. Graded effects of proteinuria on HDL structure in nephrotic rats. Journal of the American Society of Nephrology 2005;16(5):1309-1319. R829388 (2006)
    R829388 (Final)
    R833292 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Journal of the American Society of Nephrology-Full Text HTML
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  • Abstract: Journal of the American Society of Nephrology-Abstract
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  • Other: Journal of the American Society of Nephrology-Full Text PDF
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  • Journal Article Smilowitz JT, Dillard CJ, German JB. Milk beyond essential nutrients: the metabolic food.
 Australian Journal of Dairy Technology 2005;60(2):77-83. R829388 (Final)
    R833292 (Final)
  • Abstract: Dairy Industry Association of Australia-Abstract
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  • Other: ProQuest-Abstract
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  • Journal Article Smith KR, Pinkerton KE, Watanabe T, Pedersen TL, Ma SJ, Hammock BD. Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor. Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):2186-2191. R829388 (2006)
    R829388 (Final)
    R829388C001 (2005)
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  • Full-text: PNAS-Full Text HTML
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  • Abstract: PNAS
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  • Other: PNAS-Full Text PDF
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  • Journal Article Sonneborn D, Park H-Y, Petrik J, Kocan A, Palkovicova L, Trnovec T, Nguyen D, Hertz-Picciotto I. Prenatal polychlorinated biphenyl exposures in eastern Slovakia modify effects of social factors on birthweight. Paediatric and Perinatal Epidemiology 2008;22(3):202-213. R829388 (Final)
    R833292 (Final)
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  • Abstract: Wiley Online-Abstract
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  • Journal Article Ta TA, Feng W, Molinski TF, Pessah IN. Hydroxylated xestospongins block inositol-1,4,5-trisphosphate-induced Ca2+ release and sensitize Ca2+-induced Ca2+ release mediated by ryanodine receptors. Molecular Pharmacology 2006;69(2):532-538. R829388 (2006)
    R829388 (Final)
    R829388C006 (2005)
    R833292 (Final)
  • Abstract from PubMed
  • Full-text: Molecular Pharmacology-Full Text HTML
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  • Abstract: Molecular Pharmacology-Abstract
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  • Other: Molecular Pharmacology-Full Text PDF
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  • Journal Article Ta TA, Pessah IN. Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95). NeuroToxicology 2007;28(4):770-779. R829388 (2006)
    R829388 (Final)
    R833292 (2007)
    R833292 (2008)
    R833292 (2009)
    R833292 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
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  • Full-text: ScienceDirect - Full Text HTML
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  • Abstract: ScienceDirect - Abstract
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  • Journal Article Viswanathan S, Hammock BD, Newman JW, Meerarani P, Toborek M, Hennig B. Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cells. Journal of the American College of Nutrition 2003;22(6):502-510. R829388 (2006)
    R829388 (Final)
    R829388C001 (2005)
  • Abstract from PubMed
  • Full-text: Journal of the American College of Nutrition-Full Text HTML
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  • Abstract: Journal of the American College of Nutrition
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  • Other: Journal of the American College of Nutrition-Full Text PDF
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  • Journal Article Voss AA, Lango J, Ernst-Russell M, Morin D, Pessah IN. Identification of hyperreactive cysteines within ryanodine receptor type 1 by mass spectrometry. Journal of Biological Chemistry 2004;279(33):34514-34520. R829388 (2006)
    R829388 (Final)
    R829388C006 (2005)
  • Abstract from PubMed
  • Full-text: Journal of Biological Chemistry
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  • Abstract: Journal of Biological Chemistry
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  • Other: Journal of Biological Chemistry PDF
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  • Journal Article Ward CW, Feng W, Tu J, Pessah IN, Worley PK, Schneider MF. Homer protein increases activation of Ca2+ sparks in permeabilized skeletal muscle. Journal of Biological Chemistry 2004;279(7):5781-5787. R829388 (Final)
    R829388C006 (2005)
  • Abstract from PubMed
  • Full-text: Journal of Biological Chemistry
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  • Abstract: Journal of Biological Chemistry
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  • Other: Journal of Biological Chemistry PDF
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  • Journal Article Ward RE, Ninonuevo M, Mills DA, Lebrilla CB, German JB. In vitro fermentation of breast milk oligosaccharides by Bifidobacterium infantis and Lactobacillus gasseri. Applied and Environmental Microbiology 2006;72(6):4497-4499. R829388 (Final)
    R833292 (Final)
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  • Full-text: AEM-Full Text HTML
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  • Abstract: AEM-Abstract
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  • Other: AEM-Full Text PDF
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  • Journal Article Ward RE, Ninonuevo M, Mills DA, Lebrilla CB, German JB. In vitro fermentability of human milk oligosaccharides by several strains of bifidobacteria. Molecular Nutrition & Food Research 2007;51(11):1398-1405. R829388 (Final)
    R833292 (Final)
  • Abstract from PubMed
  • Abstract: Wiley Online-Abstract
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  • Journal Article Wills S, Cabanlit M, Bennett J, Ashwood P, Amaral D, Van de Water J. Autoantibodies in autism spectrum disorders (ASD).
 Annals of the New York Academy of Sciences 2007;1107:79-91. R829388 (Final)
    R833292 (2007)
    R833292 (Final)
  • Abstract from PubMed
  • Full-text: University of Texas-Dallas-Full Text PDF
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  • Abstract: Wiley Online-Abstract
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  • Journal Article Yang T, Riehl J, Esteve E, Matthaei KI, Goth S, Allen PD, Pessah IN, Lopez JR. Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse. Anesthesiology 2006;105(6):1164-1175. R829388 (Final)
    R833292 (2007)
    R833292 (Final)
  • Abstract from PubMed
  • Abstract: Anesthesiology
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  • Journal Article Yang T, Allen PD, Pessah IN, Lopez JR. Enhanced excitation-coupled calcium entry in myotubes is associated with expression of RyR1 malignant hyperthermia mutations. 
Journal of Biological Chemistry 2007;282(52):37471-37478. R829388 (Final)
    R833292 (2007)
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  • Full-text: Journal of Biological Chemistry-Full Text HTML
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  • Abstract: Journal of Biological Chemistry-Abstract
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  • Other: Journal of Biological Chemistry-Full Text PDF
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  • Journal Article Yang W, Yaoi T, Huang S, Yang Q, Hatcher S, Seet H, Gregg JP. Detecting the C282Y and H63D mutations of the HFE gene by Holliday Junction-based allele-specific genotyping methods. Clinical Chemistry 2005;51(1):210-213. R829388 (2006)
    R829388 (Final)
  • Abstract from PubMed
  • Full-text: Clinical Chemistry-Full Text HTML
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  • Abstract: Clinical Chemistry
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  • Other: Clinical Chemistry-Full Text PDF
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  • Journal Article Zhao X, Yamamoto T, Newman JW, Kim I-H, Watanabe T, Hammock BD, Stewart J, Pollock JS, Pollock DM, Imig JD. Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage. Journal of the American Society of Nephrology 2004;15(5):1244-1253. R829388 (2006)
    R829388 (Final)
    R829388C001 (2005)
  • Abstract from PubMed
  • Full-text: JASN Full Text
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  • Abstract: JASN
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  • Other: JASN PDF
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  • Supplemental Keywords:

    RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, Toxics, Toxicology, Health Risk Assessment, pesticides, Chemistry, Epidemiology, climate change, Air Pollution Effects, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Disease & Cumulative Effects, Physical Processes, Children's Health, genetic susceptability, Biology, Atmosphere, pesticide exposure, chemical exposure, neurotoxic, environmental monitoring, xenobiotics, biomarkers, gene-environment interaction, neurodevelopment, exposure, halogenated aromatics, children, neurobehavioral, neurodevelopmental, neurotoxicity, etiology, susceptibility, human exposure, neurobehavioral effects, autism, biological markers, mechanisms, exposure assessment, neurological development, biomarker, halogenated aromatic hydrocarbons, synergistic interactions, mercurials

    Progress and Final Reports:

    2006 Progress Report
    2007 Progress Report
    Final Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R829388C001 Environmental Factors in the Etiology of Autism; Analytic Biomakers (xenobiotic) Core
    R829388C002 Environmental Factors in the Etiology of Autism; Cell Activation/Signaling Core
    R829388C003 Environmental Factors in the Etiology of Autism; Molecular Biomakers Core
    R829388C004 Environmental Factors in the Etiology of Autism; Childhood Autism Risks from Genetics and the Environment (The CHARGE Study)
    R829388C005 Environmental Factors in the Etiology of Autism; Animal Models of Autism
    R829388C006 Environmental Factors in the Etiology of Autism; Molecular and Cellular Mechanisms of Autism