2003 Progress Report: St. Louis Bus, Steubenville and Atlanta Studies

EPA Grant Number: R827353C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: EPA Harvard Center for Ambient Particle Health Effects
Center Director: Koutrakis, Petros
Title: St. Louis Bus, Steubenville and Atlanta Studies
Investigators: Gold, Diane R.
Current Investigators: Gold, Diane R. , Adamkiewicz, Gary , Coull, Brent , Dockery, Douglas W. , Dubowsky, S. , Luttmann-Gibson, Heike , Sarnat, Jeremy , Schwartz, Joel , Stone, Peter , Suh, Helen H. , Wheeler, A. , Zanobetti, Antonella
Institution: Harvard T.H. Chan School of Public Health , Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2003 through May 31, 2004
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air


The main objective of this research project is to investigate the joint and individual effects of outdoor and indoor particles on heart rate and heart rate variability.

This is one of 10 projects funded by the Center. The progress for the other nine projects is reported separately (see reports for R827353C001, R827353C002, and R827353C004 through R827353C011).

Progress Summary:

We completed laboratory analysis and data processing of collected exposure and health data from three exposure and cardiovascular health studies conducted in Atlanta, GA, Steubenville, OH, and St. Louis, MO, all of which were cosponsored by the Center. Analyses of the data currently are being finalized, with papers for these studies being drafted and revised. For the Atlanta and Steubenville studies, papers on the ability of ambient concentrations to reflect exposures currently are undergoing internal review. Similarly, a paper on the association between ambient pollutant exposures and heart rate variability is being prepared for the Atlanta study, whereas a paper on the association between ambient air pollution and arrhythmias currently is being prepared for the Steubenville cohort. For the St. Louis study, analysis of the effect of ambient and microenvironmental exposures on exhaled NO currently is underway. We expect these papers to be submitted to a peer-reviewed journal by the end of this summer.

We are repeating the analysis of indoor and outdoor particle toxicity performed by Long, et al. (2001) using data collected inside and outside 16 homes located in Atlanta, GA. As before, toxicity was assessed using in vitro bioassays of tumor necrosis factor-alpha (TNF-a) production. Sample collection, laboratory analysis, and data processing have been completed, with data analysis currently underway.

Journal Articles:

No journal articles submitted with this report: View all 8 publications for this subproject

Supplemental Keywords:

exposure, health effects, susceptibility, biology, engineering, epidemiology, toxicology, environmental chemistry, monitoring, air pollutants, air pollution, air quality, ambient air, ambient air monitoring, ambient air quality, ambient measurement methods, ambient monitoring, ambient particle health effects, ambient particles, indoor particles, outdoor particles, exposure assessment, biological mechanism, biological response, heart rate, heart rate variability, arrhythmias, cardiopulmonary, cardiopulmonary response, cardiovascular disease, chemical exposure, dosimetry, environmental health hazard, exposure and effects, , health risks, human exposure, human health, human health effects, human health risk, human susceptibility, indoor air quality, indoor exposure, outdoor exposure, inhalation, inhalation toxicology, inhaled particles, measurement methods, particle exposure, particulate exposure, particulates, risk assessment, , Atlanta, Georgia, GA, Steubenville, Ohio, OH, St. Louis, Missouri, MO., RFA, Health, Scientific Discipline, Air, particulate matter, Toxicology, air toxics, Environmental Chemistry, Epidemiology, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, genetic susceptability, indoor air, tropospheric ozone, Biology, ambient air quality, health effects, monitoring, risk assessment, sensitive populations, particulates, chemical exposure, interindividual variability, molecular epidemiology, air pollutants, exposure and effects, stratospheric ozone, ambient air monitoring, health risks, cardiopulmonary responses, indoor exposure, human health effects, ambient air, developmental effects, epidemelogy, respiratory disease, exposure, pulmonary disease, ambient measurement methods, ambient monitoring, air pollution, particle exposure, biological mechanism , Human Health Risk Assessment, human exposure, inhalation, pulmonary, ambient particle health effects, cardiopulmonary response, particulate exposure, inhaled, inhalation toxicology, human susceptibility, differentiating outdoor and indoor sources, atmospheric monitoring, cardiopulmonary, human health, indoor air quality, inhaled particles, measurement methods , metals, respiratory, genetic susceptibility, air quality, dosimetry, cardiovascular disease, human health risk

Relevant Websites:

https://cfserver.hsph.harvard.edu/cfdocs/eer/epa/ Exit

Progress and Final Reports:

Original Abstract
  • 1999 Progress Report
  • 2000 Progress Report
  • 2001 Progress Report
  • 2002 Progress Report
  • 2004 Progress Report
  • Final Report

  • Main Center Abstract and Reports:

    R827353    EPA Harvard Center for Ambient Particle Health Effects

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
    R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
    R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
    R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
    R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
    R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
    R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
    R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
    R827353C009 Assessing Deposition of Ambient Particles in the Lung
    R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
    R827353C011 Studies of Oxidant Mechanisms
    R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
    R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
    R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
    R827353C015 Research Coordination Core
    R827353C016 Analytical and Facilities Core
    R827353C017 Technology Development and Transfer Core