2001 Progress Report: Assessing Deposition of Ambient Particles in the LungEPA Grant Number: R827353C009
Subproject: this is subproject number 009 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: EPA Harvard Center for Ambient Particle Health Effects
Center Director: Koutrakis, Petros
Title: Assessing Deposition of Ambient Particles in the Lung
Investigators: Tsuda, Akira
Current Investigators: Godleski, John J. , Tsuda, Akira
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2001 through May 31, 2002
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air
This is one of three projects under Theme III: Biological Mechanisms and Dosimetry. The objective of this research project is to conduct and analyze in situ continuous measurements of ambient particle deposition.
We have collected several measurements of ambient particle deposition. The total deposition fraction of fine and ultra-fine aerosols was measured in a group of six healthy adults exposed to Boston ambient particles. During these exposures particle mass and number concentration ranged from 7 to 32 µg/m3 and from 16,100 to 64,100 lb/cm3, respectively. Fifteen repeated inhalation-exhalation cycles were conducted during a given exposure session. The deposition efficiency of particles ranging from 40 to 2,045 nm was determined using the average concentration of inhaled and exhaled particles measured during these cycles. Deposition efficiencies ranged between 7.3 ± 18.7 percent (for particles 168 to 195 nm) and 98.6 ± 28.1 percent (for particles 1,545 to 2,045 nm). Subjects exhibited similar deposition patterns with a minimum efficiency in the size range of 100 to 200 nm. Results from ANOVA and mixed model regression analyses, suggested that deposition efficiency varied with individual and particle size. Deposition efficiencies varied mostly among subjects for particles in the size range between 100 to 1,000 nm. Measured deposition efficiencies were compared to those reported by the International Commission on Radiological Protection (ICRP) model. For this comparison, the ICRP deposition efficiencies for a sitting female subject were used. The minimum deposition estimated by the model was at 400 to 500 nm, while our results show a minimum at about 100 nm. The ICRP model deposition efficiencies were lower for particles <150 nm, about 20 percent, and higher for particles >676 nm by about 20 percent. Inter-subject variability in airway morphology, differences in breathing patterns used in the model and, particle composition may account for the observed differences. Finally, over the last two years, we have continued working on the development of particle deposition models (Tsuda, Rogers, et al., 2002).
We are planning to submit a manuscript for publication during the next reporting period (Montoya, et al.).
Journal Articles:No journal articles submitted with this report: View all 4 publications for this subproject
Supplemental Keywords:particulate matter, PM, ambient particle, inhalation, exhalation, lung, Boston., RFA, Health, Scientific Discipline, Air, particulate matter, Toxicology, air toxics, Environmental Chemistry, Epidemiology, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Environmental Microbiology, genetic susceptability, indoor air, Molecular Biology/Genetics, Biology, ambient air quality, health effects, monitoring, risk assessment, sensitive populations, particulates, chemical exposure, interindividual variability, molecular epidemiology, air pollutants, exposure and effects, stratospheric ozone, ambient air monitoring, health risks, cardiopulmonary responses, indoor exposure, human health effects, COPD, ambient air, developmental effects, epidemelogy, respiratory disease, exposure, pulmonary disease, ambient measurement methods, ambient monitoring, air pollution, particle exposure, biological mechanism , Human Health Risk Assessment, human exposure, heart rate, inhalation, pulmonary, ambient particle health effects, cardiopulmonary response, particulate exposure, inhaled, inhalation toxicology, human susceptibility, PM, cardiopulmonary, human health, indoor air quality, inhaled particles, toxics, metals, respiratory, genetic susceptibility, air quality, dosimetry, cardiovascular disease, human health risk
Progress and Final Reports:Original Abstract
Main Center Abstract and Reports:R827353 EPA Harvard Center for Ambient Particle Health Effects
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core