Genetic Susceptibility to Pesticides (Paraoxonase Polymorphism or PON1 Study)

EPA Grant Number: R826886C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R826886
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: University of Washington
Center Director: Faustman, Elaine
Title: Genetic Susceptibility to Pesticides (Paraoxonase Polymorphism or PON1 Study)
Investigators: Faustman, Elaine , Thompson, Engelberta
Current Investigators: Faustman, Elaine
Institution: University of Washington
EPA Project Officer: Callan, Richard
Project Period: August 1, 1998 through December 31, 2003
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text |  Recipients Lists
Research Category: Children's Health , Health Effects , Health


This is a the Community Intervention Study that will utilize the results of the Pesticide Exposure Study and will evaluate the impact of modifying the occupational take-home exposure pathway on children's exposure to pesticides. These two studies together will evaluate pesticide exposures in children of farmworkers with the overall aim to reduce pesticide exposures in children. Given the complexity of children's exposure to pesticides, the Pesticide Exposure Pathways Study will estimate the relative' contribution of major pesticide exposure pathways for children of farmworkers. As a long-term objective, they will prioritize efforts to prevent childhood pesticide associated illness. The Exposure Assessment Facility Core will be critical to this project as they will develop source attribution models for the major exposure pathways.

In previous studies by our researchers the worker take-home exposure pathway has been identified as an important pesticide exposure pathway for children; the Community Intervention Study will evaluate the effect of breaking this pathway. Information on what intervention strategies work in agricultural communities to reduce children's exposure to pesticides is critical for our national child health promotion goals. The UW CHC is poised to apply its extensive experience in basic and field based research, and its vast experience working with the public on public health issues, to meet the challenge of improving children's health.

Publications and Presentations:

Publications have been submitted on this subproject: View all 14 publications for this subprojectView all 87 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 11 journal articles for this subprojectView all 73 journal articles for this center

Supplemental Keywords:

children, health, pesticide, exposure., RFA, Health, Scientific Discipline, Toxics, Geographic Area, Environmental Chemistry, Health Risk Assessment, pesticides, State, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Biochemistry, Children's Health, genetic susceptability, farmworkers, health effects, pesticide exposure, dermal exposure, sensitive populations, community-based intervention, biological response, environmental risks, exposure, Washington (WA), children, Human Health Risk Assessment, assessment of exposure, children's vulnerablity, public health, human exposure, insecticides, pesticide residues, environmental health hazard, environmental toxicant, exposure pathways, harmful environmental agents, take home exposure, agricultural community, exposure assessment, intervention, environmental hazard exposures

Progress and Final Reports:

  • 1999
  • 2000 Progress Report
  • 2001 Progress Report
  • 2002 Progress Report
  • 2003
  • Final

  • Main Center Abstract and Reports:

    R826886    University of Washington

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R826886C001 Molecular Mechanisms of Pesticide-Induced Developmental Toxicity
    R826886C002 Genetic Susceptibility to Pesticides (Paraoxonase Polymorphism or PON1 Study)
    R826886C003 Community-Based Participatory Research Project
    R826886C004 Pesticide Exposure Pathways Research Project