2003 Progress Report: NYU-EPA PM Center: Health Risks of PM Components

EPA Grant Number: R827351
Center: EPA NYU PM Center: Health Risks of PM Components
Center Director: N/A
Title: NYU-EPA PM Center: Health Risks of PM Components
Investigators: Lippmann, Morton , Thurston, George D.
Current Investigators: Lippmann, Morton , Chen, Lung Chi , Cohen, Beverly S. , Cohen, Mitchell , Gordon, Terry , Hoffman, Eric , Ito, Kazuhiko , Kendall, Michaela , Nadziejko, Christine , Reibman, Joan , Salnikow, Konstantin , Thurston, George D. , Zelikoff, Judith T.
Institution: New York University School of Medicine
Current Institution: New York University School of Medicine , University of Iowa
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2002 through May 31, 2003
Project Amount: $8,076,438
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air

Objective:

The overall objective of the New York University (NYU) Particulate Matter (PM) Center’s research is to develop and conduct a comprehensive research program focused on the identification and characterization of the physical and chemical properties of PM that adversely impact human health. The focal hypothesis of this PM Center is that specific chemical species within PM and within certain particle size ranges are primarily responsible for the mortality, morbidity, and functional effects of PM.

Progress Summary:

This report summarizes some activities of the PM Center, but most of the research and related activities at the NYU PM Center are described in separate reports for the various projects directly supported with PM Center funding awards (see reports for R827351C001 through R827351C016).

Under the auspices of the PM Centers, Drs. Thurston (NYU Center), Suh (Harvard Center), and Hopke (Rochester Center) organized a workshop to evaluate PM source apportionment and its usefulness for epidemiological time-series analyses. The workshop was hosted by the NYU PM Center in May 2003. The specific objectives of the workshop were to: (1) inter-compare variations in results of separate research teams’ independent analyses of reference PM databases; (2) use the research teams’ respective PM source apportionments and evaluate the variation in the associated source-specific effects estimated using a single standardized health effects model of mortality; and (3) identify key research needs for source apportionment health effects evaluation. Eight research groups participated in the workshop, including representatives from five PM Centers and the U.S. Environmental Protection Agency (EPA). Two sets of PM2.5 speciated data (Phoenix, AZ and Washington, DC) were analyzed using various source apportionment techniques by the participants in advance of the workshop, and results were intercompared at the meeting. Despite the variety of source apportionment methods, many similar sources were identified, and good agreement was seen in predicted concentrations across investigators by source class, when identified. Mortality most often was associated with secondary aerosols and traffic combustion particles. These also are the dominant contributors of combustion-related sources. Other sources were less consistently associated. The range of mortality risk estimates obtained for the major source types was comparable across groups. Overall, the workshop indicated the usefulness and reliability of PM source apportionment methods in evaluating source-related PM associations, while also identifying areas of further research needed in the area of PM source apportionment epidemiology. The Workshop Report will be available in the summer of 2004.

Hosting of Visiting Scientists

Dr. Jing-Shiang Hwang has completed his 1-year visit and returned to his positions as a Research Fellow at the Institute of Statistical Science, Academia Sinica in Taipei, and as an Adjunct Associate Professor at National Taiwan University. He received his Ph.D. in Statistics from Harvard in 1992. Since his tenure at the NYU PM Center, he continued development of a novel and efficient method for processing and analyzing electrocardiogram data recorded for animals exposed to concentrated ambient air particles (CAPs). This work has led to two publications (Hwang, et al., 2004a,b).

Dritan Xhillari, who arrived in February 2003 as a visiting scientist from the National Institute for Public Health and Environment (RIVM) in Bilthoven, The Netherlands, became actively involved in our subchronic mouse exposures to CAPs and in our air pollution compositional characterizations using our Center’s mobile laboratory resource in the South Bronx region of New York City. He will continue his research career at NYU for several more years.

Additional manuscripts describing the accomplishments of NYU PM Center members’ contributions to the characterization of exposures and health risks resulting from the collapse of the World Trade Center buildings on September 11, 2001, have been completed. The capabilities developed for the PM Center enabled us to rapidly and effectively help EPA, New York, and the nation respond to this emergency situation.

The presence of the PM Health Effects Research Center at NYU has facilitated the completion of other PM-related research studies that were supported primarily by other research sponsors. This includes access to facilities supported by the PM Center, such as the XRF spectrometer and the mobile laboratory, and the intellectual stimulation and periodic consultations provided by Center investigators.


Journal Articles: 88 Displayed | Download in RIS Format

Other center views: All 111 publications 100 publications in selected types All 88 journal articles
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Journal Article Chen LC, Thurston G. World Trade Center cough. Lancet 2002;360(Suppl 1):S37-S38. R827351 (2001)
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  • Journal Article Chen LC, Hwang JS. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. IV. Characterization of acute and chronic effects of ambient air fine particulate matter exposures on heart-rate variability. Inhalation Toxicology 2005;17(4-5):209-216. R827351 (Final)
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  • Journal Article Chen LC, Nadziejko C. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: V. CAPs exacerbate aortic plaque development in hyperlipidemic mice. Inhalation Toxicology 2005;17(4-5):217-224. R827351 (2003)
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  • Journal Article Cifuentes L, Borja-Aburto VH, Gouveia N, Thurston G, Davis DL. Assessing the health benefits of urban air pollution reductions associated with climate change mitigation (2000-2020): Santiago, Sao Paulo, Mexico City, and New York City. Environmental Health Perspectives 2001;109(Suppl 3):419-425. R827351 (2003)
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  • Journal Article Cifuentes L, Borja-Aburto VH, Gouveia N, Thurston G, Davis DL. Climate change. Hidden health benefits of greenhouse gas mitigation. Science 2001;293(5533):1257-1259. R827351 (2001)
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  • Journal Article Cohen BS, Li W, Xiong JQ, Lippmann M. Detecting H+ in ultrafine ambient aerosol using iron nano-film detectors and scanning probe microscopy. Applied Occupational and Environmental Hygiene 2000;15(1):80-89. R827351 (2003)
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  • Journal Article Cohen BS, Heikkinen MSA, Hazi Y. Airborne fine and ultrafine particles near the World Trade Center disaster site. Aerosol Science and Technology 2004;38(4):338-348. R827351 (2003)
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  • Journal Article Cohen MD, Sisco M, Baker K, Chen L-C, Schlesinger RB. Effect of inhaled chromium on pulmonary A1AT. Inhalation Toxicology 2002;14(7):765-771. R827351 (2001)
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  • Journal Article Cohen MD. Pulmonary immunotoxicology of select metals: aluminum, arsenic, cadmium, chromium, copper, manganese, nickel, vanadium, and zinc. Journal of Immunotoxicology 2004;1(1):39-69. R827351 (2003)
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  • Journal Article Cohen MD, Prophete C, Sisco M, Chen LC, Zelikoff JT, Smee JJ, Holder AA, Crans DC. Pulmonary immunotoxic potentials of metals are governed by select physicochemical properties: chromium agents. Journal of Immunotoxicology 2006;3(2):69-81. R827351 (Final)
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  • Journal Article Cohen MD, Sisco M, Prophete C, Chen LC, Zelikoff JT, Ghio AJ, Stonehuerner JD, Smee JJ, Holder AA, Crans DC. Pulmonary immunotoxic potentials of metals are governed by select physicochemical properties: vanadium agents. Journal of Immunotoxicology 2007;4(1):49-60. R827351 (Final)
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  • Journal Article De Leon SF, Thurston GD, Ito K. Contribution of respiratory disease to nonrespiratory mortality associations with air pollution. American Journal of Respiratory and Critical Care Medicine 2003;167(8):1117-1123. R827351 (2002)
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  • Journal Article Doherty SP, Prophete C, Maciejczyk P, Salnikow K, Gould T, Larson T, Koenig J, Jaques P, Sioutas C, Zelikoff JT, Lippmann M, Cohen MD. Detection of changes in alveolar macrophage iron status induced by select PM2.5-associated components using iron-response protein binding activity. Inhalation Toxicology 2007;19(6-7):553-562. R827351 (Final)
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  • Journal Article Duvall RM, Norris GA, Dailey LA, Burke JM, Mcgee JK, Gilmour MI, Gordon T, Devlin RB. Source apportionment of particulate matter in the U.S. and associations with lung inflammatory markers. Inhalation Toxicology 2008;20(7):671-683. R827351 (Final)
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  • Journal Article Fanning EW, Froines JR, Utell MJ, Lippmann M, Oberdorster G, Frampton M, Godleski J, Larson TV. Particulate Matter (PM) Research Centers (1999-2005) and the role of interdisciplinary center-based research. Environmental Health Perspectives 2009;117(2):167-174. R827351 (Final)
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  • Journal Article Gavett SH, Haykal-Coates N, Highfill JW, Ledbetter AD, Chen LC, Cohen MD, Harkema JR, Wagner JG, Costa DL. World Trade Center fine particulate matter causes respiratory tract hyperresponsiveness in mice. Environmental Health Perspectives 2003;111(7):981-991. R827351 (2002)
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  • Journal Article Ghio AJ, Cohen MD. Disruption of iron homeostasis as a mechanism of biologic effect by ambient air pollution particles. Inhalation Toxicology 2005;17(13):709-716. R827351 (Final)
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  • Journal Article Gillespie P, Tajuba J, Lippmann M, Chen LC, Veronesi B. Particulate matter neurotoxicity in culture is size-dependent. NeuroToxicology 2013;36:112-117. R827351 (Final)
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  • Journal Article Gilmour MI, McGee J, Duvall RM, Dailey L, Daniels M, Boykin E, Cho SH, Doerfler D, Gordon T, Devlin RB. Comparative toxicity of size-fractionated airborne particulate matter obtained from different cities in the United States. Inhalation Toxicology 2007;19(Suppl 1):7-16. R827351 (Final)
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  • Journal Article Gordon T, Reibman J. Cardiovascular toxicity of inhaled ambient particulate matter. Toxicological Sciences 2000;56(1):2-4. R827351 (Final)
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  • Journal Article Gunnison A, Chen LC. Effects of subchronic exposures to concentrated ambient particles in mice: VI. Gene expression in heart and lung tissue. Inhalation Toxicology 2005;17(4-5):225-233. R827351 (Final)
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  • Journal Article Gwynn RC, Thurston GD. The burden of air pollution: impacts among racial minorities. Environmental Health Perspectives 2001;109(Suppl 4):501-506. R827351 (2001)
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  • Journal Article Hazi Y, Heikkinen MSA, Cohen BS. Size distribution of acidic sulfate ions in fine ambient particulate matter and assessment of source region effect. Atmospheric Environment 2003;37(38):5403-5413. R827351 (2001)
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  • Journal Article Hopke PK, Ito K, Mar T, Christiansen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Liu H, Neas L, Pinto J, Stolzel M, Suh H, Paatero P, Thurston GD. PM source apportionment and health effects:1. Intercomparison of source apportionment results. Journal of Exposure Science & Environmental Epidemiology 2006;16(3):275-286. R827351 (Final)
    R827351C001 (Final)
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  • Journal Article Hwang J-S, Nadziejko C, Chen LC. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: III. Acute and chronic effects of CAPs on heart rate, heart-rate fluctuation, and body temperature. Inhalation Toxicology 2005;17(4-5):199-207. R827351 (2003)
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  • Journal Article Ito K, Thurston GD, Nadas A, Lippmann M. Monitor-to-monitor temporal correlation of air pollution and weather variables in the North-Central U.S. Journal of Exposure Analysis & Environmental Epidemiology 2001;11(1):21-32. R827351 (Final)
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  • Journal Article Ito K, Xue N, Thurston G. Spatial variation of PM2.5 chemical species and source-apportioned mass concentrations in New York City. Atmospheric Environment 2004;38(31):5269-5282. R827351 (2003)
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  • Journal Article Ito K, De Leon SF, Thurston GD, Nadas A, Lippmann M. Monitor-to-monitor temporal correlation of air pollution in the contiguous US. Journal of Exposure Analysis and Environmental Epidemiology 2005;15(2):172-184. R827351 (2003)
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  • Journal Article Ito K, Christensen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Neas L, Hopke PK, Thurston GD. PM source apportionment and health effects: 2. An investigation of intermethod variability in associations between source-apportioned fine particle mass and daily mortality in Washington, DC. Journal of Exposure Science & Environmental Epidemiology 2006;16(4):300-310. R827351 (Final)
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  • Journal Article Kendall M, Brown L, Trought K. Molecular adsorption at particle surfaces: a PM toxicity mediation mechanism. Inhalation Toxicology 2004;16(Suppl 1):99-105. R827351 (2003)
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  • Journal Article Kendall M, Guntern J, Lockyer NP, Jones FH, Hutton BM, Lippmann M, Tetley TD. Urban PM2.5 surface chemistry and interactions with bronchoalveolar lavage fluid. Inhalation Toxicology 2004;16(Suppl 1):115-128. R827351 (2003)
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  • Journal Article Lall R, Kendall M, Ito K, Thurston GD. Estimation of historical annual PM2.5 exposures for health effects assessment. Atmospheric Environment 2004;38(31):5217-5226. R827351 (2003)
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  • Journal Article Lall R, Thurston GD. Identifying and quantifying transported vs. local sources of New York City PM2.5 fine particulate matter air pollution. Atmospheric Environment 2006;40(Suppl 2):333-346. R827351 (Final)
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  • Journal Article Lall R, Ito K, Thurston GD. Distributed lag analyses of daily hospital admissions and source-apportioned fine particle air pollution. Environmental Health Perspectives 2011;119(4):455-460. R827351 (Final)
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  • Journal Article Landrigan PJ, Lioy PJ, Thurston G, Berkowitz G, Chen LC, Chillrud SN, Gavett SH, Georgopoulos PG, Geyh AS, Levin S, Perera F, Rappaport SM, Small C, NIEHS World Trade Center Working Group. Health and environmental consequences of the World Trade Center disaster. Environmental Health Perspectives 2004;112(6):731-739. R827351 (2003)
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  • Journal Article Lioy PJ, Weisel CP, Millette JR, Eisenreich S, Vallero D, Offenberg J, Buckley B, Turpin B, Zhong M, Cohen MD, Prophete C, Yang I, Stiles R, Chee G, Johnson W, Porcja R, Alimokhtari S, Hale RC, Weschler C, Chen LC. Characterization of the dust/smoke aerosol that settled east of the World Trade Center (WTC) in lower Manhattan after the collapse of the WTC 11 September 2001. Environmental Health Perspectives 2002;110(7):703-714. R827351 (2001)
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  • Journal Article Lippmann M, Frampton M, Schwartz J, Dockery D, Schlesinger R, Koutrakis P, Froines J, Nel A, Finkelstein J, Godleski J, Kaufman J, Koenig J, Larson T, Luchtel D, Liu L-JS, Oberdorster G, Peters A, Sarnat J, Sioutas C, Suh H, Sullivan J, Utell M, Wichmann E, Zelikoff J. The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plans. Environmental Health Perspectives 2003;111(8):1074-1092. R827351 (2002)
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  • Journal Article Lippmann M. Winter air pollution and respiratory function. Occupational and Environmental Medicine 2003;60(2):81. R827351 (2003)
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  • Journal Article Lippmann M, Gordon T, Chen LC. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: I. Introduction, objectives, and experimental plan. Inhalation Toxicology 2005;17(4-5):177-187. R827351 (Final)
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  • Journal Article Lippmann M, Gordon T, Chen LC. Effects of subchronic exposures to concentrated ambient particles in mice: IX. Integral assessment and human health implications of subchronic exposures of mice to CAPs. Inhalation Toxicology 2005;17(4-5):255-261. R827351 (2003)
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  • Journal Article Lippmann M, Cassee FR, Costa DL, Costantini M, van Erp AM, Gordon T. International workshop on the design and analysis of experimental studies using PM concentrator technologies, Boston, May 5, 2004. Inhalation Toxicology 2005;17(14):839-850. R827351 (Final)
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  • Journal Article Lippmann M. The search for non-linear exposure-response relationships at ambient levels in environmental epidemiology. Nonlinearity in Biology, Toxicology, and Medicine 2005;3(1):125-144. R827351 (Final)
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  • Journal Article Lippmann M, Hwang JS, Maciejczyk P, Chen LC. PM source apportionment for short-term cardiac function changes in ApoE-/- mice. Environmental Health Perspectives 2005;113(11):1575-1579. R827351 (Final)
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  • Journal Article Lippmann M, Ito K, Hwang JS, Maciejczyk P, Chen LC. Cardiovascular effects of nickel in ambient air. Environmental Health Perspectives 2006;114(11):1662-1669. R827351 (Final)
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  • Journal Article Lippmann M. Semi-continuous speciation analyses for ambient air particulate matter: an urgent need for health effects studies. Journal of Exposure Science and Environmental Epidemiology 2009;19(3):235-247. R827351 (Final)
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  • Journal Article Maciejczyk PB, Offenberg JH, Clemente J, Blaustein M, Thurston GD, Chen LC. Ambient pollutant concentrations measured by a mobile laboratory in South Bronx, NY. Atmospheric Environment 2004;38(31):5283-5294. R827351 (2003)
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  • Journal Article Maciejczyk P, Zhong MH, Li Q, Xiong J, Nadziejko C, Chen LC. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: II. The design of a CAPs exposure system for biometric telemetry monitoring. Inhalation Toxicology 2005;17(4-5):189-197. R827351 (2003)
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  • Journal Article Maciejczyk P, Chen LC. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: VIII. Source-related daily variations in in vitro responses to CAPs. Inhalation Toxicology 2005;17(4-5):243-253. R827351 (Final)
    R827351C013 (2003)
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  • Journal Article Maciejczyk P, Zhong M, Lippmann M, Chen LC. Oxidant generation capacity of source-apportioned PM2.5. Inhalation Toxicology 2010;22(Suppl 2):29-36. R827351 (Final)
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  • Journal Article Mar TF, Ito K, Koenig JQ, Larson TV, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Neas L, Stolzel M, Paatero P, Hopke PK, Thurston GD. PM source apportionment and health effects. 3. Investigation of inter-method variations in associations between estimated source contributions of PM2.5 and daily mortality in Phoenix, AZ. Journal of Exposure Science & Environmental Epidemiology 2006;16(4):311-320. R827351 (Final)
    R827353 (Final)
    R827353C015 (Final)
    R827354 (Final)
    R827354C001 (Final)
    R827355 (Final)
    R827355C002 (Final)
    R827355C008 (Final)
    R832415 (2010)
    R832415 (2011)
    R832415 (Final)
  • Abstract from PubMed
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  • Journal Article McGee JK, Chen LC, Cohen MD, Chee GR, Prophete CM, Haykal-Coates N, Wasson SJ, Conner TL, Costa DL, Gavett SH. Chemical analysis of World Trade Center fine particulate matter for use in toxicologic assessment. Environmental Health Perspectives 2003;111(7):972-980. R827351 (2001)
    R827351 (2002)
    R827351 (Final)
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  • Journal Article Mehta M, Chen LC, Gordon T, Rom W, Tang MS. Particulate matter inhibits DNA repair and enhances mutagenesis. Mutation Research-Genetic Toxicology and Environmental Mutagenesis 2008;657(2):116-121. R827351 (Final)
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  • Journal Article Nadziejko C, Fang K, Nadziejko E, Narciso SP, Zhong M, Chen LC. Immediate effects of particulate air pollutants on heart rate and respiratory rate in hypertensive rats. Cardiovascular Toxicology 2002;2(4):245-252. R827351 (2003)
    R827351 (Final)
    R827351C005 (2001)
    R827351C005 (2002)
    R827351C005 (Final)
    R827351C006 (2003)
    R827351C006 (Final)
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  • Abstract: SpringerLink-Abstract
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  • Journal Article Nadziejko C, Fang K, Chen LC, Gordon T, Nadas A. Quantitative analysis of cardiac data from rats monitored by telemetry: reducing within-and between-animal variability. Cardiovascular Toxicology 2002;2(4):237-244. R827351 (2003)
    R827351 (Final)
    R827351C005 (2002)
    R827351C005 (Final)
    R827351C006 (2003)
    R827351C006 (Final)
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  • Journal Article Nadziejko C, Fang K, Narciso S, Zhong M, Su WC, Gordon T, Nadas A, Chen LC. Effect of particulate and gaseous pollutants on spontaneous arrhythmias in aged rats. Inhalation Toxicology 2004;16(6-7):373-380. R827351 (2003)
    R827351 (Final)
    R827351C005 (Final)
    R827351C006 (2003)
    R827351C006 (Final)
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  • Abstract: Taylor and Francis-Abstract
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  • Journal Article Nadziejko C, Chen LC, Nadas A, Hwang JS. The 'Fishing License' method for analysing the time course of effects in repeated measurements. Statistics in Medicine 2004;23(9):1399-1411. R827351 (2003)
    R827351 (Final)
    R827351C005 (Final)
    R827351C006 (2003)
    R827351C006 (Final)
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  • Abstract: Wiley Online - Abstract
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  • Journal Article Narciso SP, Nadziejko E, Chen LC, Gordon T, Nadziejko C. Adaptation to stress induced by restraining rats and mice in nose-only inhalation holders. Inhalation Toxicology 2003;15(11):1133-1143. R827351 (2001)
    R827351 (Final)
    R827351C005 (2002)
    R827351C005 (Final)
    R827351C006 (2003)
    R827351C006 (Final)
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  • Journal Article Ng SP, Dimitroulopoulou C, Grossinho A, Chen LC, Kendall M. PM2.5 exposure assessment of the population in Lower Manhattan area of New York City after the World Trade Center disaster. Atmospheric Environment 2005;39(11):1979-1992. R827351 (Final)
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  • Journal Article Offenberg JH, Eisenreich SJ, Chen LC, Cohen MD, Chee G, Prophete C, Weisel C, Lioy PJ. Persistent organic pollutants in the dusts that settled across lower Manhattan after September 11, 2001. Environmental Science & Technology 2003;37(3):502-508. R827351 (2001)
    R827351 (2003)
    R827351 (Final)
  • Abstract from PubMed
  • Full-text: ACS-Full Text HTML
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  • Journal Article Offenberg JH, Eisenreich SJ, Gigliotti CL, Chen LC, Xiong JQ, Quan C, Lou X, Zhong M, Gorczynski J, Yiin L-M, Illacqua V, Lioy PJ. Persistent organic pollutants in dusts that settled indoors in lower Manhattan after September 11, 2001. Journal of Exposure Analysis & Environmental Epidemiology 2004;14(2):164-172. R827351 (Final)
  • Abstract from PubMed
  • Full-text: Nature-Full Text HTML
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  • Journal Article Payne JP, Kemp SJ, Dewar A, Goldstraw P, Kendall M, Chen LC, Tetley TD. Effects of airborne World Trade Center dust on cytokine release by primary human lung cells in vitro. Journal of Occupational and Environmental Medicine 2004;46(5):420-427. R827351 (2003)
    R827351 (Final)
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  • Abstract: Journal of Occupational and Environmental Medicine-Abstract
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  • Journal Article Peltier RE, Hsu SI, Lall R, Lippmann M. Residual oil combustion: a major source of airborne nickel in New York City. Journal of Exposure Science and Environmental Epidemiology 2008;19(6):603-612. R827351 (Final)
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  • Journal Article Pope III CA, Burnett RT, Thun MJ, Calle EE, Krewski D, Ito K, Thurston GD. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA-Journal of the American Medical Association 2002;287(9):1132-1141. R827351 (2001)
    R827351 (Final)
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  • Journal Article Pope III CA, Burnett RT, Thurston GD, Thun MJ, Calle EE, Krewski D, Godleski JJ. Cardiovascular mortality and long-term exposure to particulate air pollution:epidemiological evidence of general pathophysiological pathways of disease. Circulation 2004;109(1):71-77. R827351 (2003)
    R827351 (Final)
  • Abstract from PubMed
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  • Journal Article Prophete C, Maciejczyk P, Salnikow K, Gould T, Larson T, Koenig J, Jaques P, Sioutas C, Lippmann M, Cohen M. Effects of select PM-associated metals on alveolar macrophage phosphorylated ERK1 and-2 and iNOS expression during ongoing alteration in iron homeostasis. Journal of Toxicology and Environmental Health, Part A:Current Issues 2006;69(10):935-951. R827351 (Final)
    R827351C008 (Final)
    R827351C010 (Final)
    R827352 (Final)
    R827352C014 (Final)
    R827355 (Final)
    R827355C008 (Final)
    R832413C001 (Final)
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  • Journal Article Rajagopalan S, Sun Q, Chen LC. Particulate pollution and endothelial function: deja vu all over again in the air. Circulation 2005;111(22):2869-2871 (editorial). R827351 (Final)
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  • Journal Article Reibman J, Hsu Y, Chen LC, Kumar A, Su WC, Choy W, Talbot A, Gordon T. Size fractions of ambient particulate matter induce granulocyte macrophage colony-stimulating factor in human bronchial epithelial cells by mitogen-activated protein kinase pathways. American Journal of Respiratory Cell and Molecular Biology 2002;27(4):455-462. R827351 (2003)
    R827351 (Final)
    R827351C004 (2002)
    R827351C004 (Final)
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  • Journal Article Reibman J, Hsu Y, Chen LC, Bleck B, Gordon T. Airway epithelial cells release MIP-3α/CCL20 in response to cytokines and ambient particulate matter. American Journal of Respiratory Cell and Molecular Biology 2003;28(6):648-654. R827351 (2003)
    R827351 (Final)
    R827351C003 (2003)
    R827351C003 (Final)
    R827351C004 (2002)
    R827351C004 (Final)
  • Abstract from PubMed
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  • Journal Article Restrepo C, Zimmerman R, Thurston G, Clemente J, Gorczynski J, Zhong M, Blaustein M, Chen LC. A comparison of ground-level air quality data with New York State Department of Environmental Conservation monitoring stations data in South Bronx, New York. Atmospheric Environment 2004;38(31):5295-5304. R827351 (2003)
    R827351 (Final)
  • Full-text: Science Direct-Full Text HTML
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  • Journal Article Salnikow K, Davidson T, Zhang Q, Chen LC, Su W, Costa M. The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis. Cancer Research 2003;63(13):3524-3530. R827351 (Final)
    R827351C010 (Final)
  • Abstract from PubMed
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  • Journal Article Salnikow K, Li X, Lippmann M. Effect of nickel and iron co-exposure on human lung cells. Toxicology and Applied Pharmacology 2004;196(2):258-265. R827351 (2003)
    R827351 (Final)
    R827351C010 (2003)
    R827351C010 (Final)
  • Abstract from PubMed
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  • Journal Article Sama P, Long TC, Hester S, Tajuba J, Parker J, Chen LC, Veronesi B. The cellular and genomic response of an immortalized microglia cell line (BV2) to concentrated ambient particulate matter. Inhalation Toxicology 2007;19(13):1079-1087. R827351 (Final)
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  • Journal Article Schlesinger RB. Properties of ambient PM responsible for human health effects: coherence between epidemiology and toxicology. Inhalation Toxicology 2000;12(Suppl 1):23-25. R827351 (2003)
    R827351 (Final)
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  • Journal Article Spira-Cohen A, Chen LC, Kendall M, Sheesley R, Thurston GD. Personal exposures to traffic-related particle pollution among children with asthma in the South Bronx, NY. Journal of Exposure Science & Environmental Epidemiology 2010;20(5):446-456. R827351 (Final)
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  • Journal Article Spira-Cohen A, Chen LC, Kendall M, Lall R, Thurston GD. Personal exposures to traffic-related air pollution and acute respiratory health among Bronx schoolchildren with asthma. Environmental Health Perspectives 2011;119(4):559-565. R827351 (Final)
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  • Journal Article Sun Q, Wang A, Jin X, Natanzon A, Duquaine D, Brook RD, Aquinaldo JG, Fayad ZA, Fuster V, Lippmann M, Chen LC, Rajagopalan S. Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model. JAMA-Journal of the American Medical Association 2005;294(23):3003-3010. R827351 (Final)
    R827351C013 (Final)
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  • Journal Article Sun Q, Yue P, Kirk RI, Wang A, Moatti D, Jin X, Lu B, Schecter AD, Lippmann M, Gordon T, Chen LC, Rajagopalan S. Ambient air particulate matter exposure and tissue factor expression in atherosclerosis. Inhalation Toxicology 2008;20(2):127-137. R827351 (Final)
  • Abstract from PubMed
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  • Abstract: Taylor&Francis-Abstract
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  • Journal Article Sun Q, Yue P, Ying Z, Cardounel AJ, Brook RD, Devlin R, Hwang J-S, Zweier JL, Chen LC, Rajagopalan S. Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK. Arteriosclerosis Thrombosis and Vascular Biology 2008;28(10):1760-1766. R827351 (Final)
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  • Journal Article Thurston GD, Chen LC. Risk communication in the aftermath of the World Trade Center disaster. American Journal of Industrial Medicine 2002;42(6):543-544. R827351 (2001)
    R827351 (Final)
  • Abstract from PubMed
  • Full-text: Impact-Full Text PDF
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  • Abstract: Wiley Online Library
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  • Journal Article Thurston GD, Bates DV. Air pollution as an underappreciated cause of asthma symptoms. JAMA-Journal of the American Medical Association 2003;290(14):1915-1917 (editorial). R827351 (2003)
    R827351 (Final)
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  • Journal Article Thurston GD, Ito K, Mar T, Christensen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Liu H, Neas L, Pinto J, Stolzel M, Suh H, Hopke PK. Workgroup report: Workshop on source apportionment of particulate matter health effects—intercomparison of results and implications. Environmental Health Perspectives 2005;113(12):1768-1774. R827351 (Final)
    R827351C001 (Final)
    R827353 (Final)
    R827353C015 (Final)
    R827354 (Final)
    R827354C001 (Final)
    R827355 (Final)
    R827355C008 (Final)
    R832415 (2010)
    R832415 (2011)
    R832415 (Final)
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  • Journal Article Trasande L, Thurston GD. The role of air pollution in asthma and other pediatric morbidities. Journal of Allergy and Clinical Immunology 2005;115(4):689-699. R827351 (Final)
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  • Journal Article Veronesi B, Makwana O, Pooler M, Chen LC. Effects of subchronic exposure to concentrated ambient particles: VII. Degeneration of dopaminergic neurons in Apo E-/-mice. Inhalation Toxicology 2005;17(4-5):235-241. R827351 (Final)
    R827351C013 (2003)
    R827351C013 (Final)
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  • Abstract: Informa healthcare-Abstract
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  • Journal Article Wesselkamper SC, Chen LC, Kleeberger SR, Gordon T. Genetic variability in the development of pulmonary tolerance to inhaled pollutants in inbred mice. American Journal of Physiology-Lung Cellular and Molecular Physiology 2001;281(5):L1200-L1209. R827351 (2001)
    R827351 (Final)
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  • Journal Article Yiin L-M, Millette JR, Vette A, Ilacqua V, Quan C, Gorczynski J, Kendall M, Chen LC, Weisel CP, Buckley B, Yang I, Lioy PJ. Comparisons of the dust/smoke particulate that settled inside the surrounding buildings and outside on the streets of southern New York City after the collapse of the World Trade Center, September 11, 2001. Journal of the Air & Waste Management Association 2004;54(5):515-528. R827351 (2003)
    R827351 (Final)
  • Abstract from PubMed
  • Full-text: Taylor Francis Online-Full Text PDF
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  • Abstract: Taylor Francis Online-Abstract
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  • Journal Article Zelikoff JT, Chen LC, Cohen MD, Schlesinger RB. The toxicology of inhaled woodsmoke. Journal of Toxicology and Environmental Health-Part B-Critical Reviews 2002;5(3):269-282. R827351 (2001)
    R827351 (Final)
  • Abstract from PubMed
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  • Abstract: Taylor Francis Online-Abstract
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  • Journal Article Zelikoff JT, Schermerhorn KR, Fang K, Cohen MD, Schlesinger RB. A role for associated transition metals in the immunotoxicity of inhaled ambient particulate matter. Environmental Health Perspectives 2002;110(Suppl 5):871-875. R827351 (Final)
    R827351C007 (2001)
    R827351C007 (2002)
    R827351C007 (Final)
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  • Journal Article Zelikoff JT, Chen LC, Cohen MD, Fang K, Gordon T, Li Y, Nadziejko C, Schlesinger RB. Effects of inhaled ambient particulate matter on pulmonary antimicrobial immune defense. Inhalation Toxicology 2003;15(2):131-150. R827351 (Final)
    R827351C007 (2003)
    R827351C007 (Final)
  • Abstract from PubMed
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  • Abstract: Taylor and Francis-Abstract
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  • Supplemental Keywords:

    thoracic particles, PM10, fine particles, PM2.5, ultrafine particles, PM 0.1, lung dosimetry models, human exposure models, pulmonary responses, cardiovascular responses, immunological responses, criteria air pollutants, concentrated ambient aerosols, aerosol, air pollutants, air pollution, airborne pollutants, airway disease, airway inflammation, airway variability, allergen, ambient air, ambient air quality, analytical chemistry, assessment of exposure, asthma, asthma morbidity, atmospheric monitoring, biological markers, childhood respiratory disease, children, combustion, combustion contaminants, combustion emissions, compliance monitoring, dosimetry, epidemiology, exposure, exposure and effects, health effects, heart rate variability, human exposure, human health, human health effects, incineration, lead, lung, mercury, morbidity, particulates, pulmonary, pulmonary disease, respiratory,, RFA, Health, Scientific Discipline, Air, Waste, particulate matter, Environmental Chemistry, air toxics, Health Risk Assessment, Epidemiology, climate change, Air Pollution Effects, Risk Assessments, Allergens/Asthma, Biochemistry, Children's Health, tropospheric ozone, Incineration/Combustion, Environmental Engineering, Biology, Atmosphere, asthma, particulates, ambient air quality, criteria air pollutants, health effects, environmental monitoring, morbidity, airway variablity, compliance monitoring, human health effects, air pollutants, exposure and effects, lung, stratospheric ozone, mercury, airway disease, exposure, combustion emissions, heart rate variability, pulmonary disease, ambient air, lead, airway inflammation, air pollution, children, Human Health Risk Assessment, airborne pollutants, assessment of exposure, childhood respiratory disease, human exposure, complinace monitoring, pulmonary, combustion, epidemeology, atmospheric monitoring, PM, biological markers, incineration, allergens, aerosol, human health, asthma morbidity, allergen, dosimetry, combustion contaminants, aerosols, respiratory, human health risk

    Relevant Websites:

    http://www.med.nyu.edu/environmental/centers/epa/ Exit

    Progress and Final Reports:

    Original Abstract
  • 1999
  • 2000
  • 2001 Progress Report
  • 2002 Progress Report
  • 2004
  • Final Report
  • Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R827351C001 Exposure Characterization Error
    R827351C002 X-ray CT-based Assessment of Variations in Human Airway Geometry: Implications for Evaluation of Particle Deposition and Dose to Different Populations
    R827351C003 Asthma Susceptibility to PM2.5
    R827351C004 Health Effects of Ambient Air PM in Controlled Human Exposures
    R827351C005 Physicochemical Parameters of Combustion Generated Atmospheres as Determinants of PM Toxicity
    R827351C006 Effects of Particle-Associated Irritants on the Cardiovascular System
    R827351C007 Role of PM-Associated Transition Metals in Exacerbating Infectious Pneumoniae in Exposed Rats
    R827351C008 Immunomodulation by PM: Role of Metal Composition and Pulmonary Phagocyte Iron Status
    R827351C009 Health Risks of Particulate Matter Components: Center Service Core
    R827351C010 Lung Hypoxia as Potential Mechanisms for PM-Induced Health Effects
    R827351C011 Urban PM2.5 Surface Chemistry and Interactions with Bronchoalveolar Lavage Fluid (BALF)
    R827351C012 Subchronic PM2.5 Exposure Study at the NYU PM Center
    R827351C013 Long Term Health Effects of Concentrated Ambient PM2.5
    R827351C014 PM Components and NYC Respiratory and Cardiovascular Morbidity
    R827351C015 Development of a Real-Time Monitoring System for Acidity and Soluble Components in Airborne Particulate Matter
    R827351C016 Automated Real-Time Ambient Fine PM Monitoring System