2004 Progress Report: Research Center for Particulate Air Pollution and Health

EPA Grant Number: R827355
Center: Airborne PM - Northwest Research Center for Particulate Air Pollution and Health
Center Director: Koenig, Jane Q.
Title: Research Center for Particulate Air Pollution and Health
Investigators: Koenig, Jane Q.
Institution: University of Washington
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 30, 2004 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2003 through May 30, 2004
Project Amount: $8,288,977
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air

Objective:

The Northwest (NW) Research Center for Particulate Air Pollution and Health integrates the efforts of a multidisciplinary team of scientists with expertise in environmental exposure assessment, toxicology, epidemiology, and biostatistics to address critical aspects of the health effects related to particulate matter (PM) air pollution. The theme of this Center is combustion-derived fine particulate composition, exposures, and health effects. Atmospheric fine particulate components vary regionally as a result of climate, industry, and resources. Elucidation of relationships among ambient air quality, population exposures, and population health (and study of these regional differences as a strategic approach to uncovering causative agents and mechanisms of effect) will provide crucial information for understanding and preventing PM-associated health effects.

The Northwest PM Center is well positioned to advance the understanding of population exposures to atmospheric PM and resulting health effects by linking and building on the following aspects of Northwest PM activity: (1) the innovative programs of PM measurement in Northwest states conducted by the University of Washington (UW), Washington State University, and local air agencies, together with ongoing and anticipated enhancements such as the PM2.5 network; (2) the expertise and progress to date by academic and local air agencies in characterization of sources, atmospheric transport and transformation models, ambient impacts, and personal or community exposures to fine PM; (3) the University and affiliated resources for research in related biomedical areas such as toxicology, epidemiology, biostatistics, and biomarkers. The Center will accomplish its aims by providing administrative infrastructure, research funding, and technical support to help focus and link studies of PM that address aerosol characterization for exposure assessment, population studies aimed at establishing the role of PM exposures in cardiopulmonary morbidity and mortality, and toxicological studies that seek to establish causative agents and physiological processes. The research projects are focused on epidemiology, exposure assessment, health effects, dosimetry, and toxicology. Center research and related research are assisted by three resource service cores: health, exposure, and biostatistics. These cores provide expertise, services, and resources to assist projects and to maximize the cross-project benefits of shared data and methods.

Progress Summary:

Highlights of Year 6 for the NW PM Center

The highlights and accomplishments of the NW PM Center were presented at an all day symposium on January 24, 2005, which was the first day of the 2-day external Science Advisory Committee (eSAC). This was the sixth meeting with the Center’s eSAC. Highlights included the following: (1) characterization of exposure and sources; (2) development of a model for estimating source-specific health effects and case-crossover studies of cardiac effects in Seattle; (3) study of associations between bronchiolitis and PM in Southern California; (4) description of associations between cardiac outcomes and chronic exposure in the Women’s Health Initiative cohort; (5) use of exhaled nitric oxide as a model for health outcomes by exploring short-term effects and partitioning exposure into ambient-generated versus indoor-generated particles; (6) construction of a diesel exposure chamber; (7) development and validation of the apo-E deficient mouse model for use in air pollution studies; and (8) new developments in statistical methods.

Future Activities:

Future projects are described separately for the projects that are continuing.


Journal Articles: 109 Displayed | Download in RIS Format

Other center views: All 209 publications 113 publications in selected types All 109 journal articles
Type Citation Sub Project Document Sources
Journal Article Allen J, Trenga CA, Peretz A, Sullivan JH, Carlsten CC, Kaufman JD. Effect of diesel exhaust inhalation on antioxidant and oxidative stress responses in adults with metabolic syndrome. Inhalation Toxicology 2009;21(13):1061-1067. R827355 (Final)
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  • Journal Article Allen RW, Mar T, Koenig J, Liu LJ, Gould T, Simpson C, Larson T. Changes in lung function and airway inflammation among asthmatic children residing in a woodsmoke-impacted urban area. Inhalation Toxicology 2008;20(4):423-433. R827355 (Final)
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  • Journal Article Allen R, Box M, Liu L-JS, Larson TV. A cost-effective weighing chamber for particulate matter filters. Journal of the Air & Waste Management Association 2001;51(12):1650-1653. R827355 (2001)
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  • Journal Article Allen R, Larson T, Sheppard L, Wallace L, Liu L-JS. Use of real-time light scattering data to estimate the contribution of infiltrated and indoor-generated particles to indoor air. Environmental Science & Technology 2003;37(16):3484-3492. R827355 (2004)
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  • Journal Article Allen R, Wallace L, Larson T, Sheppard L, Liu L-JS. Estimated hourly personal exposures to ambient and nonambient particulate matter among sensitive populations in Seattle, Washington. Journal of the Air & Waste Management Association 2004;54(9):1197-1211. R827355 (2004)
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  • Journal Article Allen R, Wallace L, Sheppard L, Larson T, Liu L-JS. Evaluation of the recursive model approach for estimating particulate matter infiltration efficiencies using continuous light scattering data. Journal of Exposure Science & Environmental Epidemiology 2007;17(5):468-477. R827355 (Final)
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  • Journal Article Bayer-Oglesby L, Schindler C, Hazenkamp-von Arx ME, Braun-Fahrlander C, Keidel D, Rapp R, Kunzli N, Braendli O, Burdet L, Liu L-JS, Leuenberger P, Ackermann-Liebrich U, SAPALDIA Team. Living near main streets and respiratory symptoms in adults:the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults. American Journal of Epidemiology 2006;164(12):1190-1198. R827355 (Final)
    R827355C003 (Final)
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  • Journal Article Claiborn CS, Finn D, Larson TV, Koenig JQ. Windblown dust contributes to high PM2.5 concentrations. Journal of the Air & Waste Management Association 2000;50(8):1440-1445. R827355 (2004)
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  • Journal Article Claiborn CS, Larson T, Sheppard L. Testing the metals hypothesis in Spokane, Washington. Environmental Health Perspectives 2002;110(Suppl 4):547-552. R827355 (2001)
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  • Journal Article Clark M, Paulsen M, Smith KR, Canuz E, Simpson CD. Urinary methoxyphenol biomarkers and woodsmoke exposure: comparisons in rural Guatemala with personal CO and kitchen CO, levoglucosan, and PM2.5. Environmental Science & Technology 2007;41(10):3481-3487. R827355 (Final)
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  • Journal Article Corey LM, Baker C, Luchtel DL. Heart-rate variability in the apolipoprotein E knockout transgenic mouse following exposure to Seattle particulate matter. Journal of Toxicology and Environmental Health-Part A-Current Issues 2006;69(10):953-965. R827355 (Final)
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  • Journal Article Cosselman KE, Krishnan RM, Oron AP, Jansen K, Peretz A, Sullivan JH, Larson TV, Kaufman JD. Blood pressure response to controlled diesel exhaust exposure in human subjects. Hypertension 2012;59(5):943-948. R827355 (Final)
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  • Journal Article Delfino RJ, Quintana PJE, Floro J, Gastanaga VM, Samimi BS, Kleinman MT, Liu L-JS, Bufalino C, Wu C-F, McLaren CE. Association of FEV1 in asthmatic children with personal and microenvironmental exposure to airborne particulate matter. Environmental Health Perspectives 2004;112(8):932-941. R827355 (2004)
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  • Journal Article Dhammapala R, Claiborn C, Corkill J, Gullett B. Particulate emissions from wheat and Kentucky bluegrass stubble burning in eastern Washington and northern Idaho. Atmospheric Environment 2006;40(6):1007-1015. R827355 (Final)
    R827355C003 (Final)
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  • Journal Article Dhammapala R, Claiborn C, Jimenez J, Corkill J, Gullet B, Simpson C, Paulsen M. Emission factors of PAHs, methoxyphenols, levoglucosan, elemental carbon and organic carbon from simulated wheat and Kentucky bluegrass stubble burns. Atmospheric Environment 2007;41(12):2660-2669. R827355 (Final)
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  • Journal Article Dhammapala R, Claiborn C, Simpson C, Jiminez J. Emission factors from wheat and Kentucky bluegrass stubble burning:comparison of field and simulated burn experiments. Atmospheric Environment 2007;41(7):1512-1520. R827355 (Final)
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  • Journal Article Dillner AM, Schauer JJ, Christensen WF, Cass GR. A quantitative method for clustering size distributions of elements. Atmospheric Environment 2005;39(8):1525-1537. R827355 (Final)
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  • Journal Article Dills RL, Zhu X, Kalman DA. Measurement of urinary methoxyphenols and their use for biological monitoring of wood smoke exposure. Environmental Research 2001;85(2):145-158. R827355 (2001)
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  • Journal Article Dills RL, Paulsen M, Ahmad J, Kalman DA, Elias FN, Simpson CD. Evaluation of urinary methoxyphenols as biomarkers of woodsmoke exposure. Environmental Science & Technology 2006;40(7):2163-2170. (Erratum in Environmental Science & Technology 2007;41(8):3030. R827355 (Final)
    R827355C010 (Final)
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  • Journal Article Doherty SP, Prophete C, Maciejczyk P, Salnikow K, Gould T, Larson T, Koenig J, Jaques P, Sioutas C, Zelikoff JT, Lippmann M, Cohen MD. Detection of changes in alveolar macrophage iron status induced by select PM2.5-associated components using iron-response protein binding activity. Inhalation Toxicology 2007;19(6-7):553-562. R827355 (2004)
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  • Journal Article Dominici F, Sheppard L, Clyde M. Health effects of air pollution: a statistical review. International Statistical Review 2003;71(2):243-276. R827355 (2004)
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  • Journal Article Elleman RA, Covert DS. Aerosol size distribution modeling with the Community Multiscale Air Quality modeling system in the Pacific Northwest: 1. Model comparison to observation. Journal of Geophysical Research-Atmospheres 2009;114(D11):D11206 (16 pp.). R827355 (Final)
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  • Journal Article Elleman RA, Covert DS. Aerosol size distribution modeling with the Community Multiscale Air Quality modeling system in the Pacific Northwest: 2. Parameterizations for ternary nucleation and nucleation mode processes. Journal of Geophysical Research-Atmospheres 2009;114(D11):D11207 (16 pp.). R827355 (Final)
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  • Journal Article Elleman RA, Covert DS. Aerosol size distribution modeling with the Community Multiscale Air Quality modeling system in the Pacific Northwest: 3. Size distribution of particles emitted into a mesoscale model. Journal of Geophysical Research-Atmospheres 2010;115(D3):D03204 (14 pp.). R827355 (Final)
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  • Journal Article Fanning EW, Froines JR, Utell MJ, Lippmann M, Oberdorster G, Frampton M, Godleski J, Larson TV. Particulate Matter (PM) Research Centers (1999-2005) and the role of interdisciplinary center-based research. Environmental Health Perspectives 2009;117(2):167-174. R827355 (Final)
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  • Journal Article Goss CH, Newsom SA, Schildcrout JS, Sheppard L, Kaufman JD. Effect of ambient air pollution on pulmonary exacerbations and lung function in cystic fibrosis. American Journal of Respiratory and Critical Care Medicine 2004;169(7):816-821. R827355 (2004)
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  • Journal Article Goswami E, Larson T, Lumley T, Liu L-J. Spatial characteristics of fine particulate matter:identifying representative monitoring locations in Seattle, Washington. Journal of the Air & Waste Management Association 2002;52(3):324-333. R827355 (2004)
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  • Journal Article Gould T, Larson T, Stewart J, Kaufman JD, Slater D, McEwen N. A controlled inhalation diesel exhaust exposure facility with dynamic feedback control of PM concentration. Inhalation Toxicology 2008;20(1):49-52. R827355 (Final)
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  • Journal Article Haneuse S, Wakefield J, Sheppard L. The interpretation of exposure effect estimates in chronic air pollution studies. Statistics in Medicine 2007;26(16):3172-3187. R827355 (Final)
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  • Journal Article Hopke PK, Ito K, Mar T, Christiansen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Liu H, Neas L, Pinto J, Stolzel M, Suh H, Paatero P, Thurston GD. PM source apportionment and health effects:1. Intercomparison of source apportionment results. Journal of Exposure Science & Environmental Epidemiology 2006;16(3):275-286. R827355 (Final)
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  • Journal Article Hsu SO-I, Ito K, Lippmann M. Effects of thoracic and fine PM and their components on heart rate and pulmonary function in COPD patients. Journal of Exposure Science and Environmental Epidemiology 2011;21(5):464-472. R827355 (Final)
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  • Journal Article Ito K, Christensen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Neas L, Hopke PK, Thurston GD. PM source apportionment and health effects: 2. An investigation of intermethod variability in associations between source-apportioned fine particle mass and daily mortality in Washington, DC. Journal of Exposure Science & Environmental Epidemiology 2006;16(4):300-310. R827355 (Final)
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  • Journal Article Janes H, Sheppard L, Lumley T. Overlap bias in the case-crossover design, with application to air pollution exposures. Statistics in Medicine 2005;24(2):285-300. R827355 (2004)
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  • Journal Article Janes H, Sheppard L, Lumley T. Do subject characteristics modify the effects of particulate air pollution on daily mortality among the elderly? Journal of Occupational and Environmental Medicine 2005;47(6):543-545. (This publication is a comment on Journal of Occupational and Environmental Medicine 2004;46(11):1115-1122.). R827355 (Final)
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  • Journal Article Janes H, Sheppard L, Lumley T. Case-crossover analyses of air pollution exposure data:referent selection strategies and their implication for bias. Epidemiology 2005;16(6):717-726. R827355 (Final)
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  • Journal Article Jansen KL, Larson TV, Koenig JQ, Mar TF, Fields C, Stewart J, Lippmann M. Associations between health effects and particulate matter and black carbon in subjects with respiratory disease. Environmental Health Perspectives 2005;113(12):1741-1746. R827355 (Final)
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  • Journal Article Jimenez JR, Claiborn CS, Dhammapala RS, Simpson CD. Methoxyphenols and levoglucosan ratios in PM2.5 from wheat and Kentucky bluegrass stubble burning in eastern Washington and northern Idaho. Environmental Science & Technology 2007;41(22):7824-7829. R827355 (Final)
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  • Journal Article Jimenez J, Wu C-F, Claiborn C, Gould T, Simpson CD, Larson T, Liu L-JS. Agricultural burning smoke in Eastern Washington—Part I: atmospheric characterization. Atmospheric Environment 2006;40(4):639-650. R827355 (Final)
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  • Journal Article Jimenez J, Claiborn C, Larson T, Gould T, Kirchstetter TW, Gundel L. Loading effect correction for real-time aethalometer measurements of fresh diesel soot. Journal of the Air & Waste Management Association 2007;57(7):868-873. R827355 (Final)
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  • Journal Article Karr C. Bronchiolitis poses significant public health burden. Pediatric Annals 2004;33(7):454-459. R827355 (2004)
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  • Journal Article Karr C, Lumley T, Shepherd K, Davis R, Larson T, Ritz B, Kaufman J. A case crossover study of wintertime ambient air pollution and infant bronchiolitis. Environmental Health Perspectives 2006;114(2):277-281. R827355 (Final)
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  • Journal Article Karr C, Lumley T, Schreuder A, Davis R, Larson T, Ritz B, Kaufman J. Effects of subchronic and chronic exposure to ambient air pollutants on infant bronchiolitis. American Journal of Epidemiology 2007;165(5):553-560. R827355 (Final)
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  • Journal Article Kim E, Larson TV, Hopke PK, Slaughter C, Sheppard LE, Claiborn C. Source identification of PM2.5 in an arid Northwest U.S. city by positive matrix factorization. Atmospheric Research 2003;66(4):291-305. R827355 (2004)
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  • Journal Article Kim E, Hopke PK, Larson TV, Maykut NN, Lewtas J. Factor analysis of Seattle fine particles. Aerosol Science and Technology 2004;38(7):724-738. R827355 (2004)
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  • Journal Article Kim E, Hopke PK, Larson TV, Covert DS. Analysis of ambient particle size distributions using Unmix and positive matrix factorization. Environmental Science & Technology 2004;38(1):202-209. R827355 (2004)
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  • Journal Article Koenig JQ, Jansen K, Mar TF, Lumley T, Kaufman J, Trenga CA, Sullivan J, Liu L-JS, Shapiro GG, Larson TV. Measurement of offline exhaled nitric oxide in a study of community exposure to air pollution. Environmental Health Perspectives 2003;111(13):1625-1629. R827355 (2004)
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  • Journal Article Koenig JQ, Mar TF, Allen RW, Jansen K, Lumley T, Sullivan JH, Trenga CA, Larson TV, Liu L-JS. Pulmonary effects of indoor-and outdoor-generated particles in children with asthma. Environmental Health Perspectives 2005;113(4):499-503. R827355 (2004)
    R827355 (Final)
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  • Journal Article Larson TV, Covert DS, Kim E, Elleman R, Schreuder AB, Lumley T. Combining size distribution and chemical species measurements into a multivariate receptor model of PM2.5. Journal of Geophysical Research-Atmospheres 2006;111(D10):D10S09 (10 pp.). R827355 (Final)
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  • Full-text: AGU-Full Text HTML
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  • Journal Article Larson T, Gould T, Simpson C, Liu L-JS, Claiborn C, Lewtas J. Source apportionment of indoor, outdoor, and personal PM2.5 in Seattle, Washington, using positive matrix factorization. Journal of the Air & Waste Management Association 2004;54(9):1175-1187. R827355 (2004)
    R827355 (Final)
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  • Journal Article Levy D, Sheppard L, Checkoway H, Kaufman J, Lumley T, Koenig J, Siscovick D. A case-crossover analysis of particulate matter air pollution and out-of-hospital primary cardiac arrest. Epidemiology 2001;12(2):193-199. R827355 (2004)
    R827355 (Final)
    R827355C001 (2000)
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  • Journal Article Levy D, Lumley T, Sheppard L, Kaufman J, Checkoway H. Referent selection in case-crossover analyses of acute health effects of air pollution. Epidemiology 2001;12(2):186-192. R827355 (2004)
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  • Journal Article Lippmann M, Frampton M, Schwartz J, Dockery D, Schlesinger R, Koutrakis P, Froines J, Nel A, Finkelstein J, Godleski J, Kaufman J, Koenig J, Larson T, Luchtel D, Liu L-JS, Oberdorster G, Peters A, Sarnat J, Sioutas C, Suh H, Sullivan J, Utell M, Wichmann E, Zelikoff J. The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plans. Environmental Health Perspectives 2003;111(8):1074-1092. R827355 (Final)
    R827351 (2002)
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    R827353C015 (Final)
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    R832415 (2010)
    R832415 (2011)
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    R832415C003 (2011)
    R832415C004 (2011)
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  • Journal Article Liu L-JS, Slaughter JC, Larson TV. Comparison of light scattering devices and impactors for particulate measurements in indoor, outdoor, and personal environments. Environmental Science & Technology 2002;36(13):2977-2986. R827355 (2004)
    R827355 (Final)
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  • Journal Article Liu L-JS, Box M, Kalman D, Kaufman J, Koenig J, Larson T, Lumley T, Sheppard L, Wallace L. Exposure assessment of particulate matter for susceptible populations in Seattle. Environmental Health Perspectives 2003;111(7):909-918. R827355 (2004)
    R827355 (Final)
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    R827355C009 (2002)
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  • Journal Article Lumley T, Sheppard L. Assessing seasonal confounding and model selection bias in air pollution epidemiology using positive and negative control analyses. Environmetrics 2000;11(6):705-717. R827355 (2001)
    R827355 (Final)
    R827355C001 (2000)
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    R825173 (1999)
  • Abstract: Wiley-Abstract
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  • Other: University of Washington-Prepublication paper
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  • Journal Article Lumley T, Levy D. Bias in the case-crossover design: implications for studies of air pollution. Environmetrics 2000;11(6):689-704. R827355 (2001)
    R827355 (Final)
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    R825173 (1999)
  • Abstract: Wiley-Abstract
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  • Journal Article Lumley T, Sheppard L. Time series analyses of air pollution and health: straining at gnats and swallowing camels? Epidemiology 2003;14(1):13-14. R827355 (2004)
    R827355 (Final)
    R827355C009 (2002)
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  • Journal Article Mar TF, Norris GA, Koenig JQ, Larson TV. Associations between air pollution and mortality in Phoenix, 1995-1997. Environmental Health Perspectives 2000;108(4):347-353. R827355 (2004)
    R827355 (Final)
    R827355C002 (1999)
    R827355C002 (2001)
    R827355C002 (Final)
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  • Journal Article Mar TF, Larson TV, Stier RA, Claiborn C, Koenig JQ. An analysis of the association between respiratory symptoms in subjects with asthma and daily air pollution in Spokane, Washington. Inhalation Toxicology 2004;16(13):809-815. R827355 (2004)
    R827355 (Final)
    R827355C002 (2003)
    R827355C002 (2004)
    R827355C002 (Final)
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  • Abstract: Taylor and Francis-Abstract
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  • Journal Article Mar TF, Jansen K, Shepherd K, Lumley T, Larson TV, Koenig JQ. Exhaled nitric oxide in children with asthma and short-term PM2.5 exposure in Seattle. Environmental Health Perspectives 2005;113(12):1791-1794. R827355 (Final)
    R827355C002 (2004)
    R827355C002 (Final)
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  • Journal Article Mar TF, Koenig JQ, Jansen K, Sullivan J, Kaufman J, Trenga CA, Siahpush SH, Liu LJ, Neas L. Fine particulate air pollution and cardiorespiratory effects in the elderly. Epidemiology 2005;16(5):681-687. R827355 (Final)
    R827355C002 (2004)
    R827355C002 (Final)
  • Abstract from PubMed
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  • Journal Article Mar TF, Ito K, Koenig JQ, Larson TV, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Neas L, Stolzel M, Paatero P, Hopke PK, Thurston GD. PM source apportionment and health effects. 3. Investigation of inter-method variations in associations between estimated source contributions of PM2.5 and daily mortality in Phoenix, AZ. Journal of Exposure Science & Environmental Epidemiology 2006;16(4):311-320. R827355 (Final)
    R827355C002 (Final)
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    R832415 (2010)
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  • Journal Article Maykut NN, Lewtas J, Kim E, Larson TV. Source apportionment of PM2.5 at an urban IMPROVE site in Seattle, Washington. Environmental Science & Technology 2003;37(22):5135-5142. R827355 (2004)
    R827355 (Final)
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  • Journal Article Maynard D, Coull BA, Gryparis A, Schwartz J. Mortality risk associated with short-term exposure to traffic particles and sulfates. Environmental Health Perspectives 2007;115(5):751-755. R827355 (Final)
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    R832416 (2008)
    R832416 (2009)
    R832416C001 (2009)
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  • Journal Article Miller KA, Siscovick DS, Sheppard L, Shepherd K, Sullivan JH, Anderson GL, Kaufman JD. Long-term exposure to air pollution and incidence of cardiovascular events in women. New England Journal of Medicine 2007;356(5):447-458. R827355 (Final)
    R827355C001 (Final)
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  • Journal Article Moolgavkar SH, Hazelton W, Leubeck G, Levy D, Sheppard L. Air pollution, pollens, and admissions for chronic respiratory disease in King County, Washington. Inhalation Toxicology 2000;12(Suppl 1):157-171. R827355 (2001)
    R827355 (Final)
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    R825266 (Final)
  • Abstract: Taylor and Francis-Abstract
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  • Journal Article Needham LL, Ozkaynak H, Whyatt RM, Barr DB, Wang RY, Naeher L, Akland G, Bahadori T, Bradman A, Fortmann R, Liu L-JS, Morandi M, O'Rourke MK, Thomas K, Quackenboss J, Ryan PB, Zartarian V. Exposure assessment in the National Children's Study: Introduction. Environmental Health Perspectives 2005;113(8):1076-1082. R827355 (Final)
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    R831710 (2005)
    R831710 (Final)
    R832141 (2006)
    R832141 (2007)
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  • Journal Article Neitzel R, Naeher LP, Paulsen M, Dunn K, Stock A, Simpson CD. Biological monitoring of smoke exposure among wildland firefighters:a pilot study comparing urinary methoxyphenols with personal exposures to carbon monoxide, particular matter, and levoglucosan. Journal of Exposure Science & Environmental Epidemiology 2008;19(4):349-358. R827355 (Final)
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  • Journal Article Norris G, Larson T, Koenig J, Claiborn C, Sheppard L, Finn D. Asthma aggravation, combustion, and stagnant air. Thorax 2000;55(6):466-470. R827355 (2004)
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  • Journal Article Pang Y, Gundel LA, Larson T, Finn D, Liu L-JS, Claiborn CS. Development and evaluation of a personal particulate organic and mass sampler. Environmental Science & Technology 2002;36(23):5205-5210. R827355 (2004)
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    R827355C003 (2002)
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  • Journal Article Pang Y, Eatough NL, Modey WK, Eatough DJ. Evaluation of the RAMS continuous monitor for determination of PM2.5 mass including semi-volatile material in Philadelphia, PA. Journal of the Air & Waste Management Association 2002;52(5):563-572. R827355 (2001)
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  • Full-text: Taylor&Francis-Full Text PDF
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  • Journal Article Peretz A, Leotta DF, Sullivan JH, Trenga CA, Sands FN, Aulet MR, Paun M, Gill EA, Kaufman JD. Flow mediated dilation of the brachial artery: an investigation of methods requiring further standardization. BMC Cardiovascular Disorders 2007;7:11 (8 pp.). R827355 (Final)
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  • Journal Article Peretz A, Peck EC, Bammler TK, Beyer RP, Sullivan JH, Trenga CA, Srinouanprachnah S, Farin FM, Kaufman JD. Diesel exhaust inhalation and assessment of peripheral blood mononuclear cell gene transcription effects: an exploratory study of healthy human volunteers. Inhalation Toxicology 2007;19(14):1107-1119. R827355 (Final)
    R830954 (2007)
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  • Journal Article Peretz A, Sullivan JH, Leotta DF, Trenga CA, Sands FN, Allen J, Carlsten C, Wilkinson CW, Gill EA, Kaufman JD. Diesel exhaust inhalation elicits acute vasoconstriction in vivo. Environmental Health Perspectives 2008;116(7):937-942. R827355 (Final)
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  • Journal Article Peretz A, Kaufman JD, Trenga CA, Allen J, Carlsten C, Aulet MR, Adar SD, Sullivan JH. Effects of diesel exhaust inhalation on heart rate variability in human volunteers. Environmental Research 2008;107(2):178-184. R827355 (Final)
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  • Journal Article Prophete C, Maciejczyk P, Salnikow K, Gould T, Larson T, Koenig J, Jaques P, Sioutas C, Lippmann M, Cohen M. Effects of select PM-associated metals on alveolar macrophage phosphorylated ERK1 and-2 and iNOS expression during ongoing alteration in iron homeostasis. Journal of Toxicology and Environmental Health, Part A:Current Issues 2006;69(10):935-951. R827355 (Final)
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  • Journal Article Quintana PJE, Valenzia JR, Delfino RJ, Liu L-JS. Monitoring of 1-min personal particulate matter exposures in relation to voice-recorded time-activity data. Environmental Research 2001;87(3):199-213. R827355 (2004)
    R827355 (Final)
    R827355C003 (2001)
    R827355C003 (Final)
  • Abstract from PubMed
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  • Journal Article Schildcrout JS, Sheppard L, Lumley T, Slaughter JC, Koenig JQ, Shapiro GG. Ambient air pollution and asthma exacerbations in children: an eight-city analysis. American Journal of Epidemiology 2006;164(6):505-517. R827355 (Final)
    R827355C002 (Final)
  • Abstract from PubMed
  • Full-text: Oxford-Full Text PDF
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  • Journal Article Schreuder AB, Larson TV, Sheppard L, Claiborn CS. Ambient woodsmoke and associated respiratory emergency department visits in Spokane, Washington. International Journal of Occupational and Environmental Health 2006;12(2):147-153. R827355 (Final)
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    R828678C010 (2007)
    R828678C010 (Final)
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  • Journal Article Sheppard L, Lumley T. Comment in: Dominici F, Samet JM, Zeger SL. Combining evidence on air pollution and daily mortality from the 20 largest U.S. cities: a hierarchical modelling strategy. Journal of the Royal Statistical Society Series A-Statistics in Society 2000;163(3):297. R827355 (2001)
    R827355 (Final)
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  • Journal Article Sheppard L, Kaufman J. Sorting out the role of air pollutants in asthma initiation. Epidemiology 2000;11(2):100-101. R827355 (2004)
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    R827355C001 (1999)
    R827355C001 (2001)
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  • Abstract: LWW-Abstract and Full Text HTML
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  • Journal Article Sheppard L, Damian D. Estimating short-term PM effects accounting for surrogate exposure measurements from ambient monitors. Environmetrics 2000;11(6):675-687. R827355 (2001)
    R827355 (Final)
    R827355C009 (Final)
  • Abstract: Wiley-Abstract
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  • Journal Article Sheppard L, Levy D, Checkoway H. Correcting for the effects of location and atmospheric conditions on air pollution exposures in a case-crossover study. Journal of Exposure Analysis and Environmental Epidemiology 2001;11(2):86-96. R827355 (2004)
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    R825173 (1999)
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  • Journal Article Sheppard L. Insights on bias and information in group-level studies. Biostatistics 2003;4(2):265-278. R827355 (2004)
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  • Journal Article Sheppard L, Wakefield JC. Comment: "Statistical issues in studies of the long-term effects of air pollution: the Southern California Children's Health Study" by Berhane K, Gauderman WF, Stram DO, Thomas DC. Statistical Science 2004;19(3):438-441. R827355 (2004)
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  • Journal Article Sheppard L. Acute air pollution effects:consequences of exposure distribution and measurements. Journal of Toxicology and Environmental Health-Part A-Current Issues 2005;68(13-14):1127-1135. R827355 (2004)
    R827355 (Final)
    R827355C009 (2003)
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  • Abstract: Taylor Francis Online
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  • Journal Article Sheppard L, Slaughter JC, Schildcrout J, Liu L-JS, Lumley T. Exposure and measurement contributions to estimates of acute air pollution effects. Journal of Exposure Analysis and Environmental Epidemiology 2005;15(4):366-376. R827355 (2004)
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    R827355C009 (Final)
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  • Journal Article Simpson CD, Dills RL, Katz BS, Kalman DA. Determination of levoglucosan in atmospheric fine particulate matter. Journal of the Air & Waste Management Association 2004;54(6):689-694. R827355 (2004)
    R827355 (Final)
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  • Abstract from PubMed
  • Full-text: Taylor and Francis-Full Text PDF
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  • Abstract: ResearchGate-Abstract and Full Text PDF
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  • Journal Article Simpson CD, Paulsen M, Dills RL, Liu L-JS, Kalman DA. Determination of methoxyphenols in ambient atmospheric particulate matter:tracers for wood combustion. Environmental Science & Technology 2005;39(2):631-637. R827355 (2004)
    R827355 (Final)
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    R829584 (2004)
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  • Journal Article Slaughter JC, Lumley T, Sheppard L, Koenig JQ, Shapiro GG. Effects of ambient air pollution on symptom severity and medication use in children with asthma. Annals of Allergy Asthma & Immunology 2003;91(4):346-353. R827355 (Final)
    R827355C002 (2003)
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  • Abstract: Annals of Allergy Asthma & Immunology
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  • Journal Article Slaughter JC, Koenig JQ, Reinhardt TE. Association between lung function and exposure to smoke among firefighters at prescribed burns. Journal of Occupational and Environmental Hygiene 2004;1(1):45-49. R827355 (Final)
    R827355C002 (2004)
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  • Abstract: Taylor and Francis-Abstract
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  • Journal Article Slaughter JC, Kim E, Sheppard L, Sullivan JH, Larson TV, Claiborn C. Association between particulate matter and emergency room visits, hospital admissions and mortality in Spokane, Washington. Journal of Exposure Analysis and Environmental Epidemiology 2005;15(2):153-159. R827355 (Final)
    R827355C008 (Final)
    R827355C009 (2002)
    R827355C009 (2003)
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    R828678C010 (2003)
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    R828678C010 (2005)
    R828678C010 (2006)
    R828678C010 (2007)
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  • Journal Article Su JG, Buzzelli M, Brauer M, Gould T, Larson TV. Modeling spatial variability of airborne levoglucosan in Seattle, Washington. Atmospheric Environment 2008;42(22):5519-5525. R827355 (Final)
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  • Journal Article Sullivan JH, Schreuder AB, Trenga CA, Liu SL, Larson TV, Koenig JQ, Kaufman JD. Association between short term exposure to fine particulate matter and heart rate variability in older subjects with and without heart disease. Thorax 2005;60(6):462-466. R827355 (Final)
    R827355C001 (Final)
    R827355C009 (2003)
    R827355C009 (Final)
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  • Journal Article Sullivan JH, Hubbard R, Liu SL-J, Shepherd K, Trenga CA, Koenig JQ, Chandler WL, Kaufman JD. A community study of the effect of particulate matter on blood measures of inflammation and thrombosis in an elderly population. Environmental Health 2007;6:3 (7 pp.). R827355 (Final)
    R827355C001 (Final)
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  • Journal Article Sullivan J, Ishikawa N, Sheppard L, Siscovick D, Checkoway H, Kaufman J. Exposure to ambient fine particulate matter and primary cardiac arrest among persons with and without clinically recognized heart disease. American Journal of Epidemiology 2003;157(6):501-509. R827355 (Final)
    R827355C001 (2002)
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  • Journal Article Sullivan J, Sheppard L, Schreuder A, Ishikawa N, Siscovick D, Kaufman J. Relation between short-term fine-particulate matter exposure and onset of myocardial infarction. Epidemiology 2005;16(1):41-48. R827355 (Final)
    R827355C001 (2003)
    R827355C001 (Final)
    R827355C009 (2003)
    R827355C009 (Final)
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  • Journal Article Thurston GD, Ito K, Mar T, Christensen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Liu H, Neas L, Pinto J, Stolzel M, Suh H, Hopke PK. Workgroup report: Workshop on source apportionment of particulate matter health effects—intercomparison of results and implications. Environmental Health Perspectives 2005;113(12):1768-1774. R827355 (Final)
    R827355C008 (Final)
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    R832415 (2010)
    R832415 (2011)
    R832415 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ResearchGate - Abstract & Full Text
    Exit
  • Journal Article Trenga CA, Koenig JQ, Williams PV. Dietary antioxidants and ozone-induced bronchial hyperresponsiveness in adults with asthma. Archives of Environmental Health 2001;56(3):242-249. R827355 (Final)
    R827355C002 (2001)
  • Abstract from PubMed
  • Abstract: Taylor & Francis - Abstract
    Exit
  • Journal Article Trenga CA, Sullivan JH, Schildcrout JS, Shepherd KP, Shapiro GG, Liu LJ, Kaufman JD, Koenig JQ. Effect of particulate air pollution on lung function in adult and pediatric subjects in a Seattle panel study. Chest 2006;129(6):1614-1622. R827355 (Final)
    R827355C002 (Final)
    R827355C009 (Final)
  • Abstract from PubMed
  • Full-text: Chest Full Text HTML
    Exit
  • Abstract: Chest-Abstract
    Exit
  • Other: Chest-Full Text PDF
    Exit
  • Journal Article Wallace LA, Mitchell H, O'Connor GT, Neas L, Lippmann M, Kattan M, Koenig J, Stout JW, Vaughn BJ, Wallace D, Walter M, Adams K, Liu L-JS. Particle concentrations in inner-city homes of children with asthma:the effect of smoking, cooking, and outdoor pollution. Environmental Health Perspectives 2003;111(9):1265-1272. R827355 (Final)
    R827355C002 (2002)
    R827355C003 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ResearchGate - Abstract & Full Text PDF
    Exit
  • Journal Article Ward TJ, Hamilton Jr RF, Dixon RW, Paulsen M, Simpson CD. Characterization and evaluation of smoke tracers in PM: results from the 2003 Montana wildfire season. Atmospheric Environment 2006;40(36):7005-7017. R827355 (Final)
    R827355C010 (Final)
  • Full-text: Science Direct-Full Text HTML
    Exit
  • Abstract: Science Direct-Abstract
    Exit
  • Other: Science Direct-Full Text PDF
    Exit
  • Journal Article Wu C-F, Wu S-Y, Wu Y-H, Cullen AC, Larson TV, Williamson J, Liu L-JS. Cancer risk assessment of selected hazardous air pollutants in Seattle. Environment International 2009;35(3):516-522. R827355 (Final)
  • Abstract from PubMed
  • Full-text: Science Direct-Full Text HTML
    Exit
  • Abstract: Science Direct-Abstract
    Exit
  • Other: Science Direct-Full Text PDF
    Exit
  • Journal Article Wu C-F, Liu L-JS, Cullen A, Westberg H, Williamson J. Spatial-temporal and cancer risk assessment of selected hazardous air pollutants in Seattle. Environment International 2011;37(1):11-17. R827355 (Final)
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Wu C-F, Delfino RJ, Floro JN, Samimi BS, Quintana PJE, Kleinman MT, Liu L-JS. Evaluation and quality control of personal nephelometers in indoor, outdoor and personal environments. Journal of Exposure Analysis and Environmental Epidemiology 2005;15(1):99-110. R827355 (Final)
    R827355C003 (2003)
    R827355C003 (Final)
  • Abstract from PubMed
  • Full-text: NATURE-Full Text PDF
    Exit
  • Abstract: NATURE-Abstract & Full Text HTML
    Exit
  • Other: ResearchGate - Abstract & Full Text PDF
    Exit
  • Journal Article Wu C-F, Delfino RJ, Floro JN, Quintana PJE, Samimi BS, Kleinman MT, Allen RW, Liu L-JS. Exposure assessment and modeling of particulate matter for asthmatic children using personal nephelometers. Atmospheric Environment 2005;39(19):3457-3469. R827355 (Final)
    R827355C003 (2004)
    R827355C003 (Final)
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Wu C-F, Jimenez J, Claiborn C, Gould T, Simpson CD, Larson T, Liu L-JS. Agricultural burning smoke in Eastern Washington:Part II. Exposure assessment. Atmospheric Environment 2006;40(28):5379-5392. R827355 (Final)
    R827355C003 (Final)
    R827355C010 (Final)
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Wu C-F, Larson TV, Wu S-Y, Williamson J, Westberg HH, Liu L-JS. Source apportionment of PM2.5 and selected hazardous air pollutants in Seattle. Science of the Total Environment 2007;386(1-3):42-52. R827355 (Final)
    R827355C003 (Final)
  • Abstract from PubMed
  • Full-text: ScienceDirect-Full Text PDF
    Exit
  • Abstract: ScienceDirect-Abstract and Full Text HTML
    Exit
  • Other: ResearchGate - Abstract & Full Text PDF
    Exit
  • Journal Article Yu O, Sheppard L, Lumley T, Koenig JQ, Shapiro GG. Effects of ambient air pollution on symptoms of asthma in Seattle-area children enrolled in the CAMP study. Environmental Health Perspectives 2000;108(12):1209-1214. R827355 (Final)
    R827355C002 (2001)
    R827355C002 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Supplemental Keywords:

    ambient particles, fine particles, combustion, health, exposure, biostatistics, susceptibility, human susceptibility, sensitive populations, air toxics, genetic susceptibility, indoor air, indoor air quality, indoor environment, tropospheric ozone, California, CA, polyaromatic hydrocarbons, PAHs, hydrocarbons, acute cardiovascular effects, aerosols, air pollutants, air pollution, air quality, airborne pollutants, airway disease, airway inflammation, allergen, ambient aerosol, ambient aerosol particles, ambient air, ambient air quality, ambient particle health effects, animal model, assessment of exposure, asthma, atmospheric aerosols, atmospheric chemistry, biological markers, biological response, cardiopulmonary response, cardiovascular disease, children, children’s vulnerability, combustion, combustion contaminants, combustion emissions, epidemiology, exposure, exposure and effects, exposure assessment, harmful environmental agents, hazardous air pollutants, health effects, health risks, human exposure, human health effects, human health risk, incineration, inhalation, lead, morbidity, mortality, mortality studies, particle exposure, particle transport, particulates, particulate matter, risk assessment,, RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, Geographic Area, Waste, Toxicology, particulate matter, Environmental Chemistry, Health Risk Assessment, air toxics, State, Epidemiology, Northwest, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Biochemistry, Allergens/Asthma, Physical Processes, indoor air, Children's Health, tropospheric ozone, genetic susceptability, Incineration/Combustion, risk assessment, asthma, particulates, health effects, ambient aerosol, ambient air quality, biostatistics, sensitive populations, cardiopulmonary responses, human health effects, morbidity, stratospheric ozone, air pollutants, exposure and effects, health risks, acute cardiovascular effects, ambient air, airway disease, biological response, combustion emissions, exposure, lead, animal model, hazardous air pollutants, fine particulates, children, airway inflammation, air pollution, Human Health Risk Assessment, particle exposure, airborne pollutants, assessment of exposure, children's vulnerablity, human exposure, atmospheric aerosols, PAHs, ambient particle health effects, inhalation, mortality studies, cardiopulmonary response, combustion, epidemeology, harmful environmental agents, hydrocarbons, human susceptibility, PM, California (CA), indoor air quality, biological markers, allergens, incineration, mortality, air quality, indoor environment, combustion contaminants, allergen, exposure assessment, aerosols, particle transport, genetic susceptibility, ambient aerosol particles, atmospheric chemistry, cardiovascular disease

    Relevant Websites:

    http://depts.washington.edu/pmcenter/ Exit

    Progress and Final Reports:

    Original Abstract
  • 1999
  • 2000
  • 2001 Progress Report
  • 2002 Progress Report
  • 2003 Progress Report
  • Final Report
  • Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R827355C001 Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
    R827355C002 Health Effects
    R827355C003 Personal PM Exposure Assessment
    R827355C004 Characterization of Fine Particulate Matter
    R827355C005 Mechanisms of Toxicity of Particulate Matter Using Transgenic Mouse Strains
    R827355C006 Toxicology Project -- Controlled Exposure Facility
    R827355C007 Health Effects Research Core
    R827355C008 Exposure Core
    R827355C009 Statistics and Data Core
    R827355C010 Biomarker Core
    R827355C011 Oxidation Stress Makers