2018 Progress Report: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air): Next Stage

EPA Grant Number: RD838300
Title: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air): Next Stage
Investigators: Kaufman, Joel D. , Allen, Norrina , Barr, R. Graham , Burke, Gregory L. , Folsom, Aaron , Jacobs, David , Kronmal, Richard , Post, Wendy , Sampson, Paul , Szpiro, Adam , Watson, Karol
Institution: University of Washington , Columbia University in the City of New York , Northwestern University , The Johns Hopkins University , University of California - Los Angeles , University of Minnesota , Wake Forest University
EPA Project Officer: Callan, Richard
Project Period: September 1, 2017 through August 31, 2021
Project Period Covered by this Report: September 1, 2017 through August 31,2018
Project Amount: $2,996,426
RFA: Long-term Exposure to Air Pollution and Development of Cardiovascular Disease (2016) RFA Text |  Recipients Lists
Research Category: Air , Health , Airborne Particulate Matter Health Effects , Environmental Health Disparities

Objective:

As stated in the proposal, the aims are as follows:

  1. Evaluate the relationship between individual-level long-term exposures to ambient air pollutants and the incidence of clinical cardiovascular disease in the entire Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) cohort.
  2. Characterize the relationships among individual-level long-term exposures to air pollutants and sub-clinical evidence of cardiovascular dysfunction and its sequelae, including progression of atherosclerosis, as determined by coronary artery calcium measurements, cardiac structure and function by MRI and echocardiography, microvascular remodeling, and cerebrovascular consequences of atrial fibrillation.
  3. Quantify the impact of exposure measurement error (and role of increased model complexity and improved data quality) on health effect estimation and bias.

Progress Summary:

The primary accomplishment for Year 1 was to set up and start follow-up calls for events ascertainment for MESA Air New Recruit participants and MESA Family participants recruited into MESA Air at all six MESA field centers. Additional work conducted during this project period included refinement of exposure covariates (e.g., bus routes), improvements to the NO2 model and planning for the ozone model.

Future Activities:

In Year 2, the primary activity will be continued events ascertainment in all six MESA cities and adjudication. The University of Washington team will continue to make improvements to exposure models and work on events analysis.


Journal Articles on this Report : 6 Displayed | Download in RIS Format

Other project views: All 6 publications 6 publications in selected types All 6 journal articles
Type Citation Project Document Sources
Journal Article Adar SD, Chen YH, D'Souza JC, O'Neill MS, Szpiro AA, Auchincloss AH, Park SK, Daviglus ML, Diez Roux AV, Kaufman JD. Longitudinal analysis of long-term air pollution levels and blood pressure:a cautionary tale from the Multi-Ethnic Study of Atherosclerosis. Environmental Health Perspectives 2018;126(10):107003 (11 pp.). RD838300 (2018)
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  • Journal Article Gronlund CJ, Sheppard L, Adar SD, O'Neill MS, Auchincloss A, Madrigano J, Kaufman J, Diez Roux AV. Vulnerability to the cardiovascular effects of ambient heat in six US cities:Results from the Multi-Ethnic Study of Atherosclerosis (MESA). Epidemiology 2018;29(6):756-764. RD838300 (2018)
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  • Journal Article Keller JP, Larson TV, Austin E, Barr RG, Sheppard L, Vedal S, Kaufman JD, Szpiro AA. Pollutant composition modification of the effect of air pollution on progression of coronary artery calcium:the Multi-Ethnic Study of Atherosclerosis. Environmental Epidemiology 2018;2:e024. RD838300 (2018)
    R834796 (Final)
    R834796C005 (Final)
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  • Journal Article Manichaikul A, Wang XQ, Li L, Erdmann J, Lettre G, Bis JC, Waterworth D, Cushman M, Jenny NS, Post WS, Palmas W, Tsai MY, Wallentin L, White H, Schunkert H, O'Donnell CJ, Herrington DM, Rich SS, O'Donoghue ML, Rodriguez A. Lp-PLA2 , scavenger receptor class B type I gene (SCARB1 ) rs10846744 variant, and cardiovascular disease. PloS One 2018;13(10):e0204352. RD838300 (2018)
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  • Journal Article Miller KA, Spalt EW, Gassett AJ, Curl CL, Larson TV, Avol E, Allen RW, Vedal S, Szpiro AA, Kaufman JD. Estimating ambient-origin PM2.5 exposure for epidemiology: observations, prediction, and validation using personal sampling in the Multi-Ethnic Study of Atherosclerosis. Journal of Exposure Science and Environmental Epidemiology 2019;29(2):227-237. RD838300 (2018)
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  • Journal Article Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Feitosa MF, Kilpelainen TO, Richard MA, Noordam R, Aslibekyan S, Aschard H, Bartz TM, Dorajoo R, Liu Y, Manning AK, Rankinen T, Smith AV, et al. A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure. The American Journal of Human Genetics 2018;102(3):375-400. RD838300 (2018)
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  • Supplemental Keywords:

    Ambient air, human health, particulates, epidemiology, ozone, traffic-related air pollution, exposure modeling, spatio-temporal

    Relevant Websites:

    Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) Exit