The Relationship Of Airborne Pollutants And Allergens To Asthma Morbidity

EPA Grant Number: R826724C004
Subproject: this is subproject number 004 , established and managed by the Center Director under grant R826724
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: CECEHDPR - Johns Hopkins University Hospital
Center Director: Eggleston, Peyton A.
Title: The Relationship Of Airborne Pollutants And Allergens To Asthma Morbidity
Investigators: Eggleston, Peyton A. , Jaakkola, Jouni
Current Investigators: Eggleston, Peyton A. , Diette, Greg
Institution: The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: January 1, 1998 through January 1, 2002
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text |  Recipients Lists
Research Category: Children's Health , Health Effects , Health


This community-based epidemiologic research will compare ambient and indoor exposures to a variety of antigens in the home and ambient environment to children's morbidity from asthma. This study will provide the first interaction of the Center with families in East Baltimore, and will have recruited a group of collaborating families from which to recruit an intervention trial and other projects such as genetic linkage studies. Families will be contacted through the Baltimore City elementary schools-_ A Recruitment Director will obtain approval and create the physical and administrative environment to conduct an 6 weeks asthma self-management education program (the A+ Asthma Club curriculum) into 5-10 schools each year. At the end of the curriculum, parents will again be contacted to recruit them into the baseline evaluation for the epidemiology study. The requirements and benefits of the study will be explained by the recruiters, and those who elect to participate will be given a written informed consent and scheduled for a clinic visit where we will collect demographic, medical and psychosocial questionnaires, apply allergy skin test to the child, perform a venipuncture and pulmonary function tests and collect a urine specimen. A home visit will be conducted to inspect, collect settled dust for allergens, and collect air samples for pollutants. The families will be contacted periodically by telephone to evaluate the child's asthma morbidity and activity. During the epidemiology study clinic visit and home visit, the Intervention Trial will be introduced to the family and child and they will be invited to participate.

Supplemental Keywords:

children, health, asthma, exposure, ozone, genetic risk., RFA, Health, Scientific Discipline, Air, particulate matter, Environmental Chemistry, Genetics, Health Risk Assessment, air toxics, Epidemiology, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Allergens/Asthma, Children's Health, Atmospheric Sciences, genetic susceptability, tropospheric ozone, Biology, asthma, particulates, asthma triggers, health effects, sensitive populations, ozone induced inflammation, human health effects, morbidity, air pollutants, exposure and effects, stratospheric ozone, exposure, ozone, airway disease, biological response, genetic predisposition, air pollution, children, airway inflammation, community based, Human Health Risk Assessment, community-based studies, inhalation, assessment of exposure, childhood respiratory disease, human exposure, epidemeology, community-based, inhaled, environmentally caused disease, environmental effects, human health, intervention, allergen, disease, genetic susceptibility, exposure assessment, air quality, environmental hazard exposures

Progress and Final Reports:

  • 1998
  • 1999
  • 2000
  • Final

  • Main Center Abstract and Reports:

    R826724    CECEHDPR - Johns Hopkins University Hospital

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R826724C001 A Randomized, Controlled Trial of Home Exposure Control in Asthma
    R826724C002 Mechanisms Of Particulate-Induced Allergic Asthma
    R826724C003 Genetic Mechanisms of Susceptibility to Inhaled Pollutants
    R826724C004 The Relationship Of Airborne Pollutants And Allergens To Asthma Morbidity