A Randomized, Controlled Trial of Home Exposure Control in Asthma

EPA Grant Number: R826724C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R826724
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: CECEHDPR - Johns Hopkins University Hospital
Center Director: Eggleston, Peyton A.
Title: A Randomized, Controlled Trial of Home Exposure Control in Asthma
Investigators: Eggleston, Peyton A.
Institution: The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: January 1, 1998 through January 1, 2002
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text |  Recipients Lists
Research Category: Children's Health , Health Effects , Health


This community-based prevention research project will conduct a randomized controlled trial of the effectiveness of current intervention methods to reduce hazardous exposures and their adverse health effects. It will test a global intervention that is composed of several components that have already proven to be effective in middle class homes. The major outcome of this trial will not be changes in health status but will be environmental exposure and it will examine the feasibility of modifying inner city home environments with currently recommended procedures. Data on the child's health status will also be collected, but it is anticipated that future studies with interventions that have already been proven effective will be necessary to provide adequate power to test a health outcome. Families in the Epidemiologic project will be asked to participate in the intervention. If they are willing to participate in the intervention trial, they will be given a second informed consent and assent, and asked to return for a second clinic visit. This visit will serve as the baseline for the intervention trial, and the parent and child will sign the separate consent to participate. We will conduct a second baseline evaluation with a questionnaire, blood sample, spirometry and methacholine inhalation challenge. At the end of the evaluation, they will be randomly assigned to receive treatment or control group and that multiple contacts will be necessary to evaluate the effect of treatment. asthma morbidity once more, the child will inscribe a spirogram, and the family will be randomized to Treatment (n--50) or Control Group (n--50). Treatment Group will receive allergen-proof mattress and pillow encasings for the child's bed, a room air cleaner for the child's room, pest control services if needed, smoking cessation support, and environmental avoidance education. All families will receive two home visits at 6 and 12 months, a telephone interview at 3, 6, 9, and 12 months and a final clinic evaluation.

Supplemental Keywords:

children, health, asthma, exposure, allergic, PM, particulate matter., RFA, Health, Scientific Discipline, Air, particulate matter, Environmental Chemistry, Health Risk Assessment, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Allergens/Asthma, Children's Health, genetic susceptability, indoor air, Biology, asthma, health effects, sensitive populations, home, morbidity, airway disease, ambient air, exposure, respiratory problems, biological response, air pollution, children, household, Human Health Risk Assessment, airborne pollutants, human exposure, assessment of exposure, childhood respiratory disease, PM, epidemeology, antigen, indoor air quality, allergic response, air quality, allergen, human health risk, indoor environment, intervention, asthma morbidity

Progress and Final Reports:

  • 1998
  • 1999
  • 2000 Progress Report
  • Final

  • Main Center Abstract and Reports:

    R826724    CECEHDPR - Johns Hopkins University Hospital

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R826724C001 A Randomized, Controlled Trial of Home Exposure Control in Asthma
    R826724C002 Mechanisms Of Particulate-Induced Allergic Asthma
    R826724C003 Genetic Mechanisms of Susceptibility to Inhaled Pollutants
    R826724C004 The Relationship Of Airborne Pollutants And Allergens To Asthma Morbidity