Center for the Study of Childhood Asthma in the Urban Environment (CCAUE)

EPA Grant Number: R836152
Center: Center for the Study of Childhood Asthma in the Urban Environment
Center Director: Hansel, Nadia
Title: Center for the Study of Childhood Asthma in the Urban Environment (CCAUE)
Investigators: Hansel, Nadia , Diette, Greg
Institution: The Johns Hopkins University
EPA Project Officer: Louie, Nica
Project Period: September 1, 2015 through August 31, 2019
Project Amount: $1,200,000
RFA: Children's Environmental Health and Disease Prevention Research Centers (2014) RFA Text |  Recipients Lists
Research Category: Health , Children's Health

Objective:

The long-term goal of this Center is to understand how exposures to indoor and outdoor airborne pollutants and allergens interact with a variety of contextual factors in the inner city to create high asthma morbidity.

Specific Aim 1: Understand the interactive effects of air pollution and obesity to create high asthma morbidity.

Specific Aim 2: Provide causal evidence to support observational findings in a population of inner city African American children.

Approach:

This application is for the third renewal of the Johns Hopkins Center for the Study of Childhood Asthma in the Urban Environment (CCAUE). Its long term goals have been and will continue to be to understand how exposures to indoor and outdoor airborne pollutants and allergens interact with a variety of contextual factors in the inner city to create high asthma morbidity. Asthma and obesity are public health crises that have risen concurrently over the past three decades, affecting millions of children in the US and disproportionately affecting low-income minority children in urban areas. In this application, we build directly on new findings from our most recent Center studies that obese children with asthma have increased susceptibility to air pollutants. Our aims are to understand these interactive effects and provide causal evidence to support these observational findings in a population of inner city African American children - a population that suffers disproportionate prevalence and morbidity from both asthma and obesity. Our Program, OBesity Enhances Susceptibility to Pollutant Effects in Asthma (OBESE ASTHMA), will study a variety of mechanisms, including increased inflammation and oxidative stress, glucocorticoid resistance, increased tidal volume and increased prevalence of sleep apnea by which exposures to pollutants such as particulate matter with aerodynamic diameter < 2.5 μm (PM2.5) and ultrafine particles (UFP) lead to asthma morbidity. We propose to maintain our highly talented and collaborative team of allergists, pulmonologists, epidemiologists, environmental health scientists, immunologists, toxicologists, and statisticians, as well as a highly supportive and engaged Community Advisory Board. We propose to expand our Center’s capacity by developing new relationships with experts in obesity and sleep medicine to better define the role of obesity and potential mediating factors, such as sleep apnea, on susceptibility to air pollution in children. We capitalize on recent advances in technology to better understand components of particulate matter that contribute to morbidity. Since obesity and asthma have been identified as health crises of epidemic scale, our study findings will have a high potential to impact policy and clinical practice guidelines. We expect to translate our findings into practical targeted interventions to improve pediatric asthma health in the highest risk subpopulation. Because there are existing and emerging methods to both prevent and treat obesity and sleep apnea, there are ripe opportunities to test the impact of these treatments as novel non-pharmacological means to treat asthma in the subset who are overweight or obese. The aims of the Center, led by Center Director and Co-Director, Drs. Hansel and Diette, will be answered in 3 projects (2 human and 1 animal project) supported by Administrative, Environmental, Data, and Community Outreach Cores.


Journal Articles: 9 Displayed | Download in RIS Format

Other center views: All 14 publications 9 publications in selected types All 9 journal articles
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Journal Article Fleury Curado T, Fishbein K, Pho H, Brennick M, Dergacheva O, Sennes LU, Pham LV, Ladenheim EE, Spencer R, Mendelowitz D, Schwartz AR, Polotsky VY. Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency. Scientific Reports 2017;7:44392. R836152 (2017)
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  • Journal Article Javaheri S, Barbe F, Campos-Rodriguez F, Dempsey JA, Khayat R, Javaheri S, Malhotra A, Martinez-Garcia MA, Mehra R, Pack AI, Polotsky VY, Redline S, Somers VK. Sleep apnea: types, mechanisms, and clinical cardiovascular consequences. Journal of the American College of Cardiology 2017;69(7):841-858. R836152 (2017)
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  • Journal Article Jun JC, Devera R, Unnikrishnan D, Shin M-K, Bevans-Fonti S, Yao Q, Rathore A, Younas H, Halberg N, Scherer PE, Polotsky VY. Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis. Journal of Molecular Medicine 2017;95(3):287-297. R836152 (2017)
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  • Journal Article Lu KD, Phipatanakul W, Perzanowski MS, Balcer-Whaley S, Matsui EC. Atopy, but not obesity is associated with asthma severity among children with persistent asthma. Journal of Asthma 2016;53(10):1033-1044. R836152 (2017)
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  • Journal Article Mesarwi OA, Shin MK, Bevans-Fonti S, Schlesinger C, Shaw J, Polotsky VY. Hepatocyte hypoxia inducible factor-1 mediates the development of liver fibrosis in a mouse model of nonalcoholic fatty liver disease. PLoS One 2016;11(12):e0168572. R836152 (2017)
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  • Journal Article Peters KO, Williams AL, Abubaker S, Curtin-Brosnan J, McCormack MC, Peng R, Breysse PN, Matsui EC, Hansel NN, Diette GB, Strickland PT. Predictors of polycyclic aromatic hydrocarbon exposure and internal dose in inner city Baltimore children. Journal of Exposure Science and Environmental Epidemiology 2017;27(3):290-298. R836152 (2017)
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  • Journal Article Pham LV, Polotsky VY. Genome-wide association studies in obstructive sleep apnea. Will we catch a black cat in a dark room? American Journal of Respiratory and Critical Care Medicine 2016;194(7):789-791. R836152 (2017)
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  • Journal Article Shin M-K, Han W, Joo H, Bevans-Fonti S, Shiota M, Stefanovski D, Polotsky VY. Effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia in the frequently sampled intravenous glucose tolerance test. Journal of Applied Physiology 2017;122(4):767-774. R836152 (2017)
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  • Journal Article Sudini K, Diette GB, Breysse PN, McCormack MC, Bull D, Biswal S, Zhai S, Brereton N, Peng RD, Matsui EC. A randomized controlled trial of the effect of broccoli sprouts on antioxidant gene expression and airway inflammation in asthmatics. Journal of Allergy and Clinical Immunology:In Practice 2016;4(5):932-940. R836152 (2017)
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  • Progress and Final Reports:

    2016 Progress Report
    2017 Progress Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R836152C001 Investigating obesity as a susceptibility factor for air pollution in childhood
    R836152C002 Novel exposure metrics for assessing the effects of ultrafine and fine particulate matter on asthma in children
    R836152C003 The Role of Obesity in Biological Responses to Particulate Matter in Mice