2016 Progress Report: Regional Air Pollution Mixtures: The past and future impacts of emissions controls and climate change on air quality and health

EPA Grant Number: R835872
Center: Regional Air Pollution Mixtures
Center Director: Koutrakis, Petros
Title: Regional Air Pollution Mixtures: The past and future impacts of emissions controls and climate change on air quality and health
Investigators: Koutrakis, Petros , Coull, Brent , Dominici, Francesca , Schwartz, Joel , Selin, Noelle Eckley
Institution: Harvard University , Massachusetts Institute of Technology
EPA Project Officer: Keating, Terry
Project Period: December 1, 2015 through November 30, 2020
Project Period Covered by this Report: December 1, 2015 through November 30,2016
Project Amount: $10,000,000
RFA: Air, Climate And Energy (ACE) Centers: Science Supporting Solutions (2014) RFA Text |  Recipients Lists
Research Category: Air , Health , Climate Change , Integrated Assessment of the Consequences of Climate Change , Air Quality and Air Toxics , Social Science , Airborne Particulate Matter Health Effects , Air Toxics , Health Effects

Objective:

This annual report presents an overview and summary of the progress and achievements during the first year of the Harvard University/Massachusetts Institute of Technology Air, Climate and Energy (ACE) Center: Regional Air Pollution Mixtures. The primary objective of the Center is to generate new scientific knowledge on past and future air quality in the US and the associated health impacts, which is of paramount importance to designing sound strategies and solutions. Our Center is investigating the sources, composition, trends, and effects of regional air pollutant mixtures across the US over a relatively long chronological period spanning past and future years (2000-2040), and examining the influence of climate, socioeconomic factors, policy decisions, and control strategies on air pollution, health, and economic outcomes. Our Center’s investigators are a multidisciplinary team with expertise in a wide range of fields, including Exposure Assessment, Air Pollution Modeling, Atmospheric Chemistry, Epidemiology, Climate Change Modeling, Meteorology, Biostatistics, Economics, Urban Planning, Social Behavior, Risk Assessment, Remote Sensing, and Public Policy.

Our ACE Center includes five Research Projects supported by the Air Pollution Core and Administrative Unit. Each Research Project addresses the scientific issues stated in one or more of the EPA ACE Center Research Questions (RQ), and together they address all four RQs using a synergistic and integrative approach. Achievement of our research goals will be made possible by sharing data and analytical methodologies among the research teams. This synergistic approach will enable us to not only more efficiently utilize resources, but also foster collaborations among the Investigators that will cross disciplinary boundaries, enhance productivity, and strengthen the overall Center. The researchers and investigators of this ACE Center are collaborating to: 1) investigate past and projected regional and sub-regional air pollutant mixtures and examine their characteristics and health effects and their relationship to emissions, climate, and modifiable factors; 2) project the potential impact of climate change on regional mixtures; 3) assess the effectiveness of past and future regulatory strategies, and; 4) project and quantify future changes in socioeconomic drivers of air pollution and its health related impact and characterize carbon policy measures with respect to their air co-benefits.

Progress Summary:

During Year 1 of the Center, each of the five Research Projects, the Air Pollution Core, and the Administrative Unit have made progress on their objectives. In project sections of this report, each project is discussed separately. For each project, we summarize the objectives and present the progress and achievements, publications and presentations, changes to key personnel during the first year of the ACE Center.

During Year 1, we have continued our regular working group Research Meetings. These meetings feature presentations on their research by Center investigators, or by others whose research is relevant to Center objectives. These meetings also feature discussion of Center activities, and serve as a forum for issues which may impact Center research. The Steering Committee (SC) has worked together to discuss project updates, data fusion, and recommendations for appointments to the Science Advisory Committee (SAC) for the Center.

Future Activities:

During Year 2, the Center will continue with activities discussed above. Specific Project activities for Year 2 are described in the appended Project Progress Reports included in later sections. Additional planned Center activities during Year 2 include:

  • We will hold our first SAC meeting May 16-17, 2017.
  • The Harvard/MIT ACE Center will host the first ACE Centers annual meeting in Boston during June 1-2, 2017.


Journal Articles: 51 Displayed | Download in RIS Format

Other center views: All 60 publications 51 publications in selected types All 51 journal articles
Type Citation Sub Project Document Sources
Journal Article Abu Awad Y, Koutrakis P, Coull BA, Schwartz J. A spatio-temporal prediction model based on support vector machine regression: ambient black carbon in three New England states. Environmental Research 2017;159:427-434. R835872 (2016)
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  • Journal Article Achilleos S, Kioumourtzoglou M-A, Wu C-D, Schwartz JD, Koutrakis P, Papatheodorou SI. Acute effects of fine particulate matter constituents on mortality: a systematic review and meta-regression analysis. Environment International 2017;109:89-100. R835872 (2016)
    R834798 (Final)
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  • Journal Article Antonelli J, Zigler C, Dominici F. Guided Bayesian imputation to adjust for confounding when combining heterogeneous data sources in comparative effectiveness research. Biostatistics 2017;18(3):553-568. R835872 (2016)
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  • Journal Article Bobb JF, Ho KKL, Yeh RW, Harrington L, Zai A, Liao KP, Dominici F. Time-Course of Cause-Specific Hospital Admissions During Snowstorms: An Analysis of Electronic Medical Records From Major Hospitals in Boston, Massachusetts. American Journal of Epidemiology 2017;185(4):283-294. R835872 (2016)
    R835872C005 (2016)
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  • Journal Article Braun D, Gorfine M, Parmigiani G, Arvold ND, Dominici F, Zigler C.Propensity scores with misclassified treatment assignment: a likelihood-based adjustment.Biostatistics2017;18(4):695-710. R835872 (2016)
    R835872C004 (2016)
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  • Journal Article Cefalu M, Dominici F, Arvold N, Parmigiani G. Model averaged double robust estimation. Biometrics 2017;73(2):410-421. R835872 (2016)
    R834798 (Final)
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  • Journal Article Colicino E, Wilson A, Frisardi MC, Prada D, Power MC, Hoxha M, Dioni L, Spiro III A, Vokonas PS, Weisskopf MG, Schwartz JD, Baccarelli AA. Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men:the VA Normative Aging Study. Environmental Health Perspectives 2017;125(1):76-81. R835872 (2016)
    R832416 (Final)
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  • Journal Article Dai L, Mehta A, Mordukhovich I, Just AC, Shen J, Hou L, Koutrakis P, Sparrow D, Vokonas PS, Baccarelli AA, Schwartz JD. Differential DNA methylation and PM2.5 species in a 450K epigenome-wide association study. Epigenetics 2017;12(2):139-148. R835872 (2016)
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  • Journal Article Di Q, Dai L, Wang Y, Zanobetti A, Choirat C, Schwartz JD, Dominici F. Association of short-term exposure to air pollution with mortality in older adults. JAMA 2017;318(24):2446-2456. R835872 (2016)
    R834798 (Final)
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  • Journal Article Di Q, Rowland S, Koutrakis P, Schwartz J. A hybrid model for spatially and temporally resolved ozone exposures in the continental United States. Journal of the Air & Waste Management Association 2017;67(1):39-52. R835872 (2016)
    R834798 (Final)
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  • Journal Article Di Q, Wang Y, Zanobetti A, Wang Y, Koutrakis P, Choirat C, Dominici F, Schwartz JD. Air pollution and mortality in the Medicare population. New England Journal of Medicine 2017;376(26):2513-2522. R835872 (2016)
    R834798 (Final)
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  • Journal Article Dominici F, Zigler C. Best practices for gauging evidence of causality in air pollution epidemiology. American Journal of Epidemiology 2017;186(12):1303-1309. R835872 (2016)
    R834798 (Final)
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  • Journal Article Dorans KS, Wilker EH, Li W, Rice MB, Ljungman PL, Schwartz J, Coull BA, Kloog I, Koutrakis P, D’Agostino RB, Massaro JM, Hoffmann U, O'Donnell J, Mittleman MA. Residential proximity to major roads, exposure to fine particulate matter, and coronary artery calcium: the Framingham Heart Study. Arteriosclerosis, Thrombosis, and Vascular Biology 2016;36(8):1679-1685. R835872 (2016)
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  • Journal Article Li W, Dorans KS, Wilker EH, Rice MB, Long MT, Schwartz J, Coull BA, Koutrakis P, Gold DR, Fox CS, Mittleman MA. Residential proximity to major roadways, fine particulate matter, and hepatic steatosis: the Framingham Heart Study. American Journal of Epidemiology 2017;186(7):857-865. R835872 (2016)
    R834798 (Final)
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  • Journal Article Li W, Dorans KS, Wilker EH, Rice MB, Ljungman PL, Schwartz JD, Coull BA, Koutrakis P, Gold DR, Keaney Jr JF, Vasan RS, Benjamin EJ, Mittleman MA. Short-term exposure to ambient air pollution and biomarkers of systemic inflammation: the Framingham Heart Study. Arteriosclerosis, Thrombosis, and Vascular Biology 2017;37(9):1793-1800. R835872 (2016)
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  • Journal Article Li W, Dorans KS, Wilker EH, Rice MB, Kloog I, Schwartz JD, Koutrakis P, Coull BA, Gold DR, Meigs JB, Fox CS, Mittleman MA. Ambient air pollution, adipokines, and glucose homeostasis: the Framingham Heart Study. Environment International 2018;111:14-22. R835872 (2016)
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  • Journal Article MacNaughton P, Eitland E, Kloog I, Schwartz J, Allen J. Impact of particular matter exposure and surrounding “greenness” on chronic absenteeism in Massachusetts public schools. International Journal of Environmental Research and Public Health 2017;14(2):E207. R835872 (2016)
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  • Journal Article Makar M, Antonelli J, Di Q, Cutler D, Schwartz J, Dominici F. Estimating the Causal Effect of Low Levels of Fine Particulate Matter on Hospitalization. Epidemiology 2017;28(5):627-634. R835872 (2016)
    R835872C005 (2016)
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  • Journal Article Masri S, Garshick E, Hart J, Bouhamra W, Koutrakis P. Use of visual range measurements to predict fine particulate matter exposures in Southwest Asia and Afghanistan. Journal of the Air & Waste Management Association 2017;67(1):75-85. R835872 (2016)
    R834798 (Final)
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  • Journal Article Masri S, Garshick E, Coull B, Koutrakis P. A novel calibration approach using satellite and visibility observations to estimate fine particulate matter exposures in Southwest Asia and Afghanistan. Journal of the Air & Waste Management Association 2017;67(1):86-95. R835872 (2016)
    R834798 (Final)
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  • Journal Article McGuinn LA, Ward-Caviness C, Neas LM, Schneider A, Di Q, Chudnovsky A, Schwartz J, Koutrakis P, Russell AG, Garcia V, Kraus WE, Hauser ER, Cascio W, Diaz-Sanchez D, Devlin RB. Fine particulate matter and cardiovascular disease: comparison of assessment methods for long-term exposure. Environmental Research 2017;159:16-23. R835872 (2016)
    R834799 (Final)
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  • Journal Article Nwanaji-Enwerem JC, Colicino E, Dai L, Di Q, Just AC, Hou L, Vokonas P, De Vivo I, Lemos B, Lu Q, Weisskopf MG, Baccarelli AA, Schwartz JD. miRNA processing gene polymorphisms, blood DNA methylation age and long-term ambient PM2.5 exposure in elderly men. Epigenomics 2017;9(12):1529-1542. R835872 (2016)
    R832416 (Final)
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  • Journal Article Nwanaji-Enwerem JC, Bind M-A, Dai L, Oulhote Y, Colicino E, Di Q, Just AC, Hou L, Vokonas P, Coull BA, Weisskopf MG, Baccarelli AA, Schwartz JD. Editor’s highlight: Modifying role of endothelial function gene variants on the association of long-term PM2.5 exposure with blood DNA methylation age: the VA Normative Aging Study. Toxicological Sciences 2017;158(1):116-126. R835872 (2016)
    R832416 (Final)
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  • Journal Article Nwanaji-Enwerem JC, Colicino E, Dai L, Cayir A, Sanchez-Guerra M, Laue HE, Nguyen VT, Di Q, Just AC, Hou L, Vokonas P, Coull BA, Weisskopf MG, Baccarelli AA, Schwartz JD. Impacts of the mitochondrial genome on the relationship of long-term ambient fine particle exposure with blood DNA methylation age. Environmental Science & Technology 2017;51(14):8185-8195. R835872 (2016)
    R832416 (Final)
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  • Journal Article Phipatanakul W, Koutrakis P, Coull BA, Kang CM, Wolfson JM, Ferguson ST, Petty CR, Samnaliev M, Cunningham A, Sheehan WJ, Gaffin JM, Baxi SN, Lai PS, Permaul P, Liang L, Thorne PS, Adamkiewicz G, Brennan KJ, Baccarelli AA, Gold DR. The school inner-city asthma intervention study: design, rationale, methods, and lessons learned. Contemporary Clinical Trials 2017;60:14-23. R835872 (2016)
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  • Journal Article Requia WJ, Roig HL, Koutrakis P, Adams MD. Modeling spatial patterns of traffic emissions across 5570 municipal districts in Brazil. Journal of Cleaner Production 2017;148:845-853. R835872 (2016)
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  • Journal Article Requia WJ, Adams MD, Arain A, Koutrakis P, Lee W-C, Ferguson M. Spatio-temporal analysis of particulate matter intake fractions for vehicular emissions: hourly variation by micro-environments in the Greater Toronto and Hamilton Area, Canada. Science of the Total Environment 2017;599-600:1813-1822. R835872 (2016)
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  • Journal Article Requia WJ, Dalumpines R, Adams MD, Arain A, Ferguson M, Koutrakis P. Modeling spatial patterns of link-based PM2.5 emissions and subsequent human exposure in a large Canadian metropolitan area. Atmospheric Environment 2017;158:172-180. R835872 (2016)
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  • Journal Article Requia WJ, Adams MD, Arain A, Koutrakis P, Ferguson M. Carbon dioxide emissions of plug-in hybrid electric vehicles: a life-cycle analysis in eight Canadian cities. Renewable and Sustainable Energy Reviews 2017;78:1390-1396. R835872 (2016)
    R835872C005 (2016)
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  • Journal Article Requia WJ, Higgins CD, Adams MD, Mohamed M, Koutrakis P. The health impacts of weekday traffic: a health risk assessment of PM2.5 emissions during congested periods. Environment International 2018;111:164-176. R835872 (2016)
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  • Journal Article Shen L, Mickley LJ. Effects of El Niño on summertime ozone air quality in the eastern United States. Geophysical Research Letters 2017;44(24):12543-12550. R835872 (2016)
    R835755 (2017)
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  • Journal Article Shen L, Mickley LJ, Leibensperger EM, Li M. Strong dependence of U.S. summertime air quality on the decadal variability of Atlantic sea surface temperatures. Geophysical Research Letters 2017;44(24):12527-12535. R835872 (2016)
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  • Journal Article Shen L, Mickley LJ, Murray LT. Influence of 2000–2050 climate change on particulate matter in the United States:results from a new statistical model. Atmospheric Chemistry and Physics 2017;17(6):4355-4367. R835872 (2016)
    R835755 (2017)
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  • Journal Article Shen L, Mickley LJ. Seasonal prediction of US summertime ozone using statistical analysis of large scale climate patterns. Proceedings of the National Academy of Sciences of the United States of America 2017;114(10):2491-2497. R835872 (2016)
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  • Journal Article Tang CH, Coull BA, Schwartz J, Lyapustin A, Di Q, Koutrakis P. Developing particle emission inventories using remote sensing (PEIRS). Journal of the Air & Waste Management Association 2017;67(1):53-63. R835872 (2016)
    R834798 (Final)
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  • Journal Article Tang CH, Kourakis P, Schwartz J, Coull BA, Di Q. Trends and spatial patterns of fine resolution aerosol optical depth-derived PM2.5 emissions in Northeast United States from 2002 to 2013. Journal of the Air & Waste Management Association 2017;67(1):64-74. R835872 (2016)
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  • Journal Article Tang CH, Garshick E, Grady S, Coull B, Schwartz J, Koutrakis P. Development of a modeling approach to estimate indoor-to-outdoor sulfur ratios and predict indoor PM2.5 and black carbon concentrations for Eastern Massachusetts households. Journal of Exposure Science & Environmental Epidemiology 2018;28(2):125-130. R835872 (2016)
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  • Journal Article Wang Y, Shi L, Lee M, Liu P, Di Q, Zanobetti A, Schwartz JD. Long-term exposure to PM2.5 and mortality among older adults in the Southeastern US. Epidemiology 2017;28(2):207-214. R835872 (2016)
    R836156 (2017)
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  • Journal Article Wang Y, Lee M, Liu P, Shi L, Yu Z, Awad YA, Zanobetti A, Schwartz JD. Doubly robust additive hazards models to estimate effects of a continuous exposure on survival. Epidemiology 2017;28(6):771-779. R835872 (2016)
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  • Journal Article Wang Y, Nordio F, Nairn J, Zanobetti A, Schwartz JD. Accounting for adaptation and intensity in projecting heat wave-related mortality. Environmental Research 2018;161:464-471. R835872 (2016)
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  • Journal Article Zanobetti A, Coull BA, Kloog I, Sparrow D, Vokonas PS, Gold DR, Schwartz J. Fine-scale spatial and temporal variation in temperature and arrhythmia episodes in the VA Normative Aging Study. Journal of the Air & Waste Management Association 2017;67(1):96-104. R835872 (2016)
    R832416 (Final)
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  • Journal Article Zigler CM, Choirat C, Dominici F. Impact of National Ambient Air Quality Standards nonattainment designations on particulate pollution and health. Epidemiology 2018;29(2):165-174. R835872 (2016)
    R836156 (2018)
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  • Journal Article Di Q, Rowland S, Koutrakis P, Schwartz J. (2017) A hybrid model for spatially and temporally resolved ozone exposures in the continental United States. J Air and Waste Management Association, 67.1:39-52. R835872C003 (2016)
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    Journal Article Schwartz J, Bind MA, Koutrakis P. (2017) Estimating causal effects of local air pollution on daily deaths:effect of low levels. Environ Health Perspect 125:23–29; http://dx.doi.org/10.1289/EHP232. R835872C003 (2016)
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    Journal Article Antonelli, J., Schwartz, J., Kloog, I., & Coull, B. A. (2017). Spatial multiresolution analysis of the effect of PM2.5 on birth weights. The Annals of Applied Statistics, 11(2), 792-807. R835872C002 (2016)
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    Journal Article Wang, Y., Shi, L.H., Lee, M., Liu, P.F., Di, Q., Zanobetti, A., and Schwartz, J. (2017). Long-term Exposure to PM2.5 and Mortality Among Older Adults in the Southeastern US. Epidemiology 28, 207-214. R835872C003 (2016)
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    Journal Article Antonelli, J., Zigler, C., and Dominici, F. (2017). Guided Bayesian Imputation to Adjust for Confounding when Combining Heterogeneous Data Sources in Comparative Effectiveness Research. Biostatistics 1–16 doi:10.1093/biostatistics/kxx003, 1-16. R835872C005 (2016)
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    Journal Article Tang C, Coull B, Schwartz J, Lyapustin A, Di Q, Koutrakis P (2016) Trends and Spatial Patterns of Fine Resolution AOD-Derived PM2.5 Emissions in the Northeast United States from 2002 to 2013. Journal of the Air Waste & Management Association. In press. http://dx.doi.org.ezp-prod1.hul.harvard.edu/10.1080/10962247.2016.1218393. R835872C001 (2016)
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    Journal Article Di Q, Kloog I, Koutrakis P, Lyapustin A, Wang Y, Schwartz J (2016) Assessing PM2.5 exposures with high spatiotemporal resolution across the continental United States. Environmental Science & Technology, 50(9):4712-4721. R835872C001 (2016)
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    Journal Article Di Q, Rowland S, Koutrakis P, Schwartz J (2017) A hybrid model for spatially and temporally resolved ozone exposures in the continental United States. Journal of the Air & Waste Management Association, 67(1):39-52. R835872C001 (2016)
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    Journal Article Tang C, Coull B, Schwartz J, Lyapustin A, Di Q, Koutrakis P (2016) Developing Particle Emission Inventories Using Remote Sensing (PEIRS). Journal of the Air Waste & Management Association. In press. http://dx.doi.org.ezp-prod1.hul.harvard.edu/10.1080/10962247.2016.1214630. R835872C001 (2016)
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    Relevant Websites:

    Harvard/MIT ACE Center Exit

    Progress and Final Reports:

    Original Abstract
  • 2017
  • 2018
  • Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R835872C001 Project 1: Regional Air Pollution Mixtures: The Past and Future Impacts of Emission Controls and Climate Change on Air Quality and Health
    R835872C002 Project 2: Air Pollutant Mixtures in Eastern Massachusetts: Spatial Multi-resolution Analysis of Trends, Effects of Modifiable Factors, Climate and Particle-induced Mortality
    R835872C003 Project 3: Causal Estimates of Effects of Regional and National Pollution Mixtures on Health: Providing Tools for Policy Makers
    R835872C004 A Causal Inference Framework to Support Policy Decisions by Evaluating the Effectiveness of Past Air Pollution Control Strategies for the Entire United States
    R835872C005 Project 5: Projecting and Quantifying Future Changes in Socioeconomic Drivers of Air Pollution and its Health-Related Impacts