Southern California Children's Environmental Health Center

EPA Grant Number: R835441
Center: Southern California Children's Environmental Health Center
Center Director: McConnell, Rob Scot
Title: Southern California Children's Environmental Health Center
Investigators: McConnell, Rob Scot
Institution: University of Southern California
EPA Project Officer: Nolt-Helms, Cynthia
Project Period: July 1, 2013 through June 30, 2018 (Extended to June 30, 2019)
Project Amount: $4,146,875
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2012) RFA Text |  Recipients Lists
Research Category: Children's Health , Health

Objective:

The epidemic of childhood obesity threatens the health of a generation of children because it is a major risk factor for type 2 diabetes, non-alcoholic fatty liver disease and cardiovascular diseases (CVD). Recent research suggests that ubiquitous ambient particulate air pollution is a potentially important cause of obesity and its metabolic consequences. New results from the Children's Health Study (CHS) found that growth trajectory of body mass index (BMI) and obesity risk were associated with prenatal and childhood exposure to the near-roadway air pollution (NRAP) mixture. In preliminary clinical studies NRAP was associated with increased visceral adipose tissue and expression of genes in inflammatory pathways in adipose tissue, systemic inflammation and metabolic outcomes, and abnormal pancreatic beta cell function. Together with studies in adults, this emerging science supports the hypothesis that NRAP contributes to development of obesity and metabolic disease. To investigate this broad hypothesis, the Southern California Children's Environmental Health Center is organized around the theme: Air pollution, childhood obesity and metabolic consequences. A multidisciplinary team in an integrated program of population-based, clinical and experimental research will address key research questions: Project 1 (P1) capitalizes on CHS resources and extensive pollutant measurements to investigate the impact of prenatal and childhood exposure on obesity in the cohort and the relationship to fat distribution, glucose homeostasis, lipid profile, systemic inflammation and the metabolic syndrome using cutting edge exposure assessment, imaging and metabolic phenotyping in overweight/obese CHS children. The study will focus on effects of elemental carbon (EC) and transition metals (Fe and Cu) in NRAP, based on preliminary findings and their toxicological properties. P2 investigates the effects of these exposures on adipose tissue inflammation, insulin resistance, and gene expression in macrophages and adipocytes in adipose biopsies from a sample of overweight/obese P1 CHS participants. P3 employs translational mouse models of obesity to investigate critical windows of exposure and temporal sequence of events from gestation to maturity linking NRAP exposure, adipose phenotype and inflammatory profile, and systemic metabolic dysregulation. An innovative hierarchical statistical model will integrate results across projects to examine the mechanistic pathway of NRAP on body fat, adipose inflammation, and metabolic outcomes. A COTC and Administrative Core will support career development and community engagement and translation of findings needed for science-based intervention.


Journal Articles: 59 Displayed | Download in RIS Format

Other center views: All 62 publications 59 publications in selected types All 59 journal articles
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Journal Article Alderete TL, Autran C, Brekke BE, Knight R, Bode L, Goran MI, Fields DA. Associations between human milk oligosaccharides and infant body composition in the first 6 mo of life. American Journal of Clinical Nutrition 2015;102(6):1381-1388. R835441 (2016)
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  • Journal Article Alderete TL, Habre R, Toledo-Corral CM, Berhane K, Chen Z, Lurmann FW, Weigensberg MJ, Goran MI, Gilliland FD. Longitudinal associations between ambient air pollution with insulin sensitivity, β-cell function, and adiposity in Los Angeles Latino children. Diabetes 2017;66(7):1789-1796. R835441 (2018)
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  • Journal Article Alderete TL, Jones RB, Chen Z, Kim JS, Habre R, Lurmann F, Gilliland FD, Goran MI. Exposure to traffic-related air pollution and the composition of the gut microbiota in overweight and obese adolescents. Environmental Research 2018;161:472-478. R835441 (2018)
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  • Journal Article Alderete TL, Song AY, Bastain T, Habre R, Toledo-Corral CM, Salam MT, Lurmann F, Gilliland FD, Breton CV. Prenatal traffic-related air pollution exposures, cord blood adipokines and infant weight. Pediatric Obesity 2018:13(6):348-356. R835441 (2018)
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  • Journal Article Allayee H, Hazen SL. Contribution of gut bacteria to lipid levels: another metabolic role for microbes? Circulation Research 2015;117(9):750-754. R835441 (2016)
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  • Journal Article Berger PK, Fields DA, Demerath EW, Fujiwara H, Goran MI. High-fructose corn-syrup-sweetened beverage intake increases 5-hour breast milk fructose concentrations in lactating women. Nutrients 2018;10(6):669 (9 pp.). R835441 (2018)
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  • Journal Article Bouret S, Levin BE, Ozanne SE. Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity. Physiological Reviews 2015;95(1):47-82. R835441 (2016)
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  • Journal Article Breton CV, Mack WJ, Yao J, Berhane K, Amadeus M, Lurmann F, Gilliland F, McConnell R, Hodis HN, Kunzli N, Avol E. Prenatal air pollution exposure and early cardiovascular phenotypes in young adults. PLoS One 2016;11(3):e0150825 (12 pp.). R835441 (2016)
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  • Journal Article Chen Z, Salam MT, Toledo-Corral C, Watanabe RM, Xiang AH, Buchanan TA, Habre R, Bastain TM, Lurmann F, Wilson JP, Trigo E, Gilliland FD. Ambient air pollutants have adverse effects on insulin and glucose homeostasis in Mexican Americans. Diabetes Care 2016;39(4):547-554. R835441 (2016)
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  • Journal Article Chen Z, Salam MT, Alderete TL, Habre R, Bastain TM, Berhane K, Gilliland FD. Effects of childhood asthma on the development of obesity among school-aged children. American Journal of Respiratory and Critical Care Medicine 2017;195(9):1181-1188. R835441 (2018)
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  • Journal Article Cheng H, Davis DA, Hasheminassab S, Sioutas C, Morgan TE, Finch CE. Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFα in vitro. Journal of Neuroinflammation 2016;13:19 (11 pp.). R835441 (2016)
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  • Journal Article Cho J, Goldenson NI, Pester MS, Khoddam R, Bello MS, Dunton GF, Belcher BR, Leventhal AM. Longitudinal associations between anhedonia and body mass index trajectory groups among adolescents. Journal of Adolescent Health 2018;63(1):81-87. R835441 (2018)
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  • Journal Article Cui X, Gong J, Han H, He L, Teng Y, Tetley T, Sinharay R, Chung KF, Islam T, Gilliland F, Grady S, Garshick E, Li Z, Zhang JJ. Relationship between free and total malondialdehyde, a well-established marker of oxidative stress, in various types of human biospecimens. Journal of Thoracic Disease 2018;10(5):3088-3097. R835441 (2018)
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  • Journal Article Dueker D, Taher M, Wilson J, McConnell R. Evaluating children's location using a personal GPS logging instrument: limitations and lessons learned. Journal of Exposure Science and Environmental Epidemiology 2014;24(3):244-252. R835441 (2015)
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  • Journal Article Dunton GF, O'Connor SG, Belcher BR, Maher JP, Schembre SM. Objectively-measured physical activity and sedentary time are differentially related to dietary fat and carbohydrate intake in children. Frontiers in Public Health 2018;6:198 (6 pp.). R835441 (2018)
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  • Journal Article Fruin S, Urman R, Lurmann F, McConnell R, Gauderman J, Rappaport E, Franklin M, Gilliland FD, Shafer M, Gorski P, Avol E. Spatial variation in particulate matter components over a large urban area. Atmospheric Environment 2014;83:211-219. R835441 (2015)
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  • Journal Article Ghazalpour A, Cespedes I, Bennett BJ, Allayee H. Expanding role of gut microbiota in lipid metabolism. Current Opinion in Lipidology 2016;27(2):141-147. R835441 (2016)
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  • Journal Article Ghosh R, Lurmann F, Perez L, Penfold B, Brandt S, Wilson J, Milet M, Kunzli N, McConnell R. Near-roadway air pollution and coronary heart disease: burden of disease and potential impact of a greenhouse gas reduction strategy in Southern California. Environmental Health Perspectives 2016;124(2):193-200. R835441 (2016)
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  • Journal Article Ghosh R, Gauderman WJ, Minor H, Youn HA, Lurmann F, Cromar KR, Chatzi L, Belcher B, Fielding CR, McConnell R. Air pollution, weight loss and metabolic benefits of bariatric surgery: a potential model for study of metabolic effects of environmental exposures. Pediatric Obesity 2018;13(5):312-320. R835441 (2017)
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  • Journal Article Goran MI, Martin AA, Alderete TL, Fujiwara H, Fields DA. Fructose in breast milk is positively associated with infant body composition at 6 months of age. Nutrients 2017;9(2)146 (11 pp.). R835441 (2018)
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  • Journal Article Habre R, Zhou H, Eckel SP, Enebish T, Fruin S, Bastain T, Rappaport E, Gilliland F. Short-term effects of airport-associated ultrafine particle exposure on lung function and inflammation in adults with asthma. Environment International 2018;118:48-59. R835441 (2018)
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  • Journal Article Hasson RE, Hsu YJ, Davis JN, Goran MI, Spruijt-Metz D. The influence of parental education on dietary intake in Latino youth. Journal of Immigrant and Minority Health 2018;20(1):250-254. R835441 (2018)
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  • Journal Article Hsieh S, Klassen AC, Curriero FC, Caulfield LE, Cheskin LJ, Davis JN, Goran MI, Weigensberg MJ, Spruijt-Metz D. Built environment associations with adiposity parameters among overweight and obese Hispanic youth. Preventive Medicine Reports 2015;2:406-412. R835441 (2016)
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  • Journal Article Hsieh S, Leaderer BP, Feldstein AE, Santoro N, McKay LA, Caprio S, McConnell R. Traffic-related air pollution associations with cytokeratin-18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population. Pediatric Obesity 2018;13(6):342-347. R835441 (2017)
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  • Journal Article Hsu TM, Konanur VR, Taing L, Usui R, Kayser BD, Goran MI, Kanoski SE. Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats. Hippocampus 2015;25(2):227-239. R835441 (2016)
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  • Journal Article Jerrett M, Shankardass K, Berhane K, Gauderman WJ, Künzli N, Avol E, Gilliland F, Lurmann F, Molitor JN, Molitor JT, Thomas DC, Peters J, McConnell R. Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement. Environmental Health Perspectives 2008;116(10):1433-1438. R835441 (2017)
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  • Journal Article Jerrett M, McConnell R, Wolch J, Chang R, Lam C, Dunton G, Gilliland F, Lurmann F, Islam T, Berhane K. Traffic-related air pollution and obesity formation in children: a longitudinal, multilevel analysis. Environmental Health 2014;13:49 (9 pp.). R835441 (2015)
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  • Journal Article Kayser BD, Goran MI, Bouret SG. Perinatal overnutrition exacerbates adipose tissue inflammation caused by high-fat feeding in C57BL/6J mice. PLoS One 2015;10(3):e0121954 (15 pp.). R835441 (2016)
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  • Journal Article Kayser BD, Toledo-Corral CM, Alderete TL, Weigensberg MJ, Goran MI. Temporal relationships between adipocytokines and diabetes risk in Hispanic adolescents with obesity. Obesity 2015;23(7):1479-1485. R835441 (2016)
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  • Journal Article Kim JS, Alderete TL, Chen Z, Lurmann F, Rappaport E, Habre R, Berhane K, Gilliland FD. Longitudinal associations of in utero and early life near-roadway air pollution with trajectories of childhood body mass index. Environmental Health 2018;17(1):64 (10 pp.). R835441 (2018)
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  • Journal Article Kim JY, Goran MI, Toledo-Corral CM, Weigensberg MJ, Shaibi GQ. Comparing glycemic indicators of prediabetes: a prospective study of obese Latino Youth. Pediatric Diabetes 2015;16(8):640-643. R835441 (2016)
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  • Journal Article Li L, Lurmann F, Habre R, Urman R, Rappaport E, Ritz B, Chen JC, Gilliland FD, Wu J. Constrained mixed-effect models with ensemble learning for prediction of nitrogen oxides concentrations at high spatiotemporal resolution. Environmental Science & Technology 2017;51(17):9920-9929. R835441 (2018)
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  • Journal Article Lopez NV, Schembre S, Belcher BR, O'Connor S, Maher JP, Arbel R, Margolin G, Dunton GF. Parenting styles, food-related parenting practices, and children's healthy eating: a mediation analysis to examine relationships between parenting and child diet. Appetite 2018;128:205-213. R835441 (2018)
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  • Journal Article Luo S, O'Connor SG, Belcher BR, Page KA. Effects of physical activity and sedentary behavior on brain response to high-calorie food cues in young adults. Obesity 2018;26(3):540-546. R835441 (2018)
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  • Journal Article Lurmann F, Avol E, Gilliland F. Emissions reduction policies and recent trends in Southern California's ambient air quality. Journal of the Air & Waste Management Association 2015;65(3):324-335. R835441 (2016)
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  • Journal Article McConnell R, Shen E, Gilliland FD, Jerrett M, Wolch J, Chang C-C, Lurmann F, Berhane K. A longitudinal cohort study of body mass index and childhood exposure to secondhand tobacco smoke and air pollution: the Southern California Children's Health Study. Environmental Health Perspectives 2015;123(4):360-366. R835441 (2015)
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  • Journal Article McConnell R, Gilliland FD, Goran M, Allayee H, Hricko A, Mittelman S. Does near-roadway air pollution contribute to childhood obesity? Pediatric Obesity 2016;11(1):1-3. R835441 (2015)
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  • Journal Article Noble EE, Hsu TM, Jones RB, Fodor AA, Goran MI, Kanoski SE. Early-life sugar consumption affects the rat microbiome independently of obesity. The Journal of Nutrition 2017;147(1):20-28. R835441 (2018)
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  • Journal Article O'Connor SG, Ke W, Dzubur E, Schembre S, Dunton GF. Concordance and predictors of concordance of children's dietary intake as reported via ecological momentary assessment and 24 h recall. Public Health Nutrition 2018;21(6):1019-1027. R835441 (2018)
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  • Journal Article O'Reilly GA, Belcher BR, Davis JN, Martinez LT, Huh J, Antunez-Castillo L, Weigensberg M, Goran MI, Spruijt-Metz D. Effects of high-sugar and high-fiber meals on physical activity behaviors in Latino and African American adolescents. Obesity 2015;23(9):1886-1894. R835441 (2016)
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  • Journal Article Pomatto LCD, Cline M, Woodward N, Pakbin P, Sioutas C, Morgan TE, Finch CE, Forman HJ, Davies KJA. Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles ('vehicular smog'). Free Radical Biology and Medicine 2018;121:86-97. R835441 (2018)
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  • Journal Article Ritz B, Qiu J, Lee PC, Lurmann F, Penfold B, Erin Weiss R, McConnell R, Arora C, Hobel C, Wilhelm M. Prenatal air pollution exposure and ultrasound measures of fetal growth in Los Angeles, California. Environmental Research 2014;130:7-13. R835441 (2015)
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  • Journal Article Shankardass K, McConnell R, Jerrett M, Lam C, Wolch J, Milam J, Gilliland F, Berhane K. Parental stress increases body mass index trajectory in pre-adolescents. Pediatric Obesity 2014;9(6):435-442. R835441 (2015)
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  • Journal Article Smallwood T, Allayee H, Bennett BJ. Choline metabolites: gene by diet interactions. Current Opinion in Lipidology 2016;27(1):33-39. R835441 (2017)
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  • Journal Article Su JG, Jerrett M, McConnell R, Berhane K, Dunton G, Shankardass K, Reynolds K, Chang R, Wolch J. Factors influencing whether children walk to school. Health & Place 2013;22:153-161. R835441 (2015)
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  • Journal Article Tellez-Rojo MM, Bellinger DC, Arroyo-Quiroz C, Lamadrid-Figueroa H, Mercado-Garcia A, Schnaas-Arrieta L, Wright RO, Hernandez-Avila M, Hu H. Longitudinal associations between blood lead concentrations lower than 10 μg/dL and neurobehavioral development in environmentally exposed children in Mexico City. Pediatrics 2006;118(2):e323-e330. R835441 (2017)
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  • Journal Article Toledo-Corral CM, Alderete TL, Richey J, Sequeira P, Goran MI, Weigensberg MJ. Fasting, post-OGTT challenge, and nocturnal free fatty acids in prediabetic versus normal glucose tolerant overweight and obese Latino adolescents. Acta Diabetologica 2015;52(2):277-284. R835441 (2016)
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  • Journal Article Toledo-Corral CM, Alderete TL, Habre R, Berhane K, Lurmann FW, Weigensberg MJ, Goran MI, Gilliland FD. Effects of air pollution exposure on glucose metabolism in Los Angeles minority children. Pediatric Obesity 2018;13(1):54-62. R835441 (2018)
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  • Journal Article Urman R, Gauderman J, Fruin S, Lurmann F, Liu F, Hosseini R, Franklin M, Avol E, Penfold B, Gilliland F, Brunekreef B, McConnell R. Determinants of the spatial distributions of elemental carbon and particulate matter in eight Southern Californian communities. Atmospheric Environment 2014;86:84-92. R835441 (2015)
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  • Journal Article Urman R, McConnell R, Islam T, Avol EL, Lurmann FW, Vora H, Linn WS, Rappaport EB, Gilliland FD, Gauderman WJ. Associations of children's lung function with ambient air pollution: joint effects of regional and near-roadway pollutants. Thorax 2014;69(6):540-547. R835441 (2015)
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  • Journal Article Vos MB, Goran MI. Sugar, sugar ... not so sweet for the liver.Gastroenterology 2017;153(3):642-645. R835441 (2018)
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  • Journal Article Wang P, Tuvblad C, Younan D, Franklin M, Lurmann F, Wu J, Baker LA, Chen JC. Socioeconomic disparities and sexual dimorphism in neurotoxic effects of ambient fine particles on youth IQ: a longitudinal analysis. PLoS One 2017;12(12):e0188731 (15 pp.). R835441 (2018)
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  • Journal Article Wheelock K, Zhang JJ, McConnell R, Tang D, Volk HE, Wang Y, Herbstman JB, Wang S, Phillips DH, Camann D, Gong J, Perera F. A novel method for source-specific hemoglobin adducts of nitro-polycyclic aromatic hydrocarbons. Environmental Science: Processes & Impacts 2018;20(5):780-789. R835441 (2018)
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  • Journal Article Wu W, Muller R, Berhane K, Fruin S, Liu F, Jaspers I, Diaz-Sanchez D, Peden DB, McConnell R. Inflammatory response of monocytes to ambient particles varies by highway proximity. American Journal of Respiratory Cell and Molecular Biology 2014;51(6):802-809. R835441 (2015)
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  • Journal Article Younan D, Tuvblad C, Li L, Wu J, Lurmann F, Franklin M, Berhane K, McConnell R, Wu AH, Baker LA, Chen JC. Environmental determinants of aggression in adolescents: role of urban neighborhood greenspace. Journal of the American Academy of Child and Adolescent Psychiatry 2016;55(7):591-601. R835441 (2018)
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  • Journal Article Younan D, Tuvblad C, Franklin M, Lurmann F, Li L, Wu J, Berhane K, Baker LA, Chen JC. Longitudinal analysis of particulate air pollutants and adolescent delinquent behavior in Southern California. Journal of Abnormal Child Psychology 2018;46(6):1283-1293. R835441 (2018)
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  • Journal Article Zigman JM, Bouret SG, Andrews ZB. Obesity impairs the action of the neuroendocrine ghrelin system. Trends in Endocrinology and Metabolism 2016;27(1):54-63. R835441 (2016)
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  • Journal Article Zink J, Belcher BR, Dzubur E, Ke W, O'Connor S, Huh J, Lopez N, Maher JP, Dunton GF. Association between self-reported and objective activity levels by demographic factors: ecological momentary assessment study in children. JMIR mHealth and uHealth 2018;6(6):e150 (12 pp.). R835441 (2018)
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  • Journal Article Volk HE, Lurmann F, Penfold B, Hertz-Picciotto I, McConnell R. Traffic related air pollution, particulate matter, and autism. JAMA Psychiatry 2013;70(1):71-77. R835441 (2017)
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  • Progress and Final Reports:

  • 2014 Progress Report
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  • 2016 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report