Southern California Children's Environmental Health Center

EPA Grant Number: R835441
Center: Southern California Children's Environmental Health Center
Center Director: McConnell, Rob Scot
Title: Southern California Children's Environmental Health Center
Investigators: McConnell, Rob Scot
Institution: University of Southern California
EPA Project Officer: Louie, Nica
Project Period: July 1, 2013 through June 30, 2018
Project Amount: $4,146,875
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2012) RFA Text |  Recipients Lists
Research Category: Children's Health , Health

Objective:

The epidemic of childhood obesity threatens the health of a generation of children because it is a major risk factor for type 2 diabetes, non-alcoholic fatty liver disease and cardiovascular diseases (CVD). Recent research suggests that ubiquitous ambient particulate air pollution is a potentially important cause of obesity and its metabolic consequences. New results from the Children's Health Study (CHS) found that growth trajectory of body mass index (BMI) and obesity risk were associated with prenatal and childhood exposure to the near-roadway air pollution (NRAP) mixture. In preliminary clinical studies NRAP was associated with increased visceral adipose tissue and expression of genes in inflammatory pathways in adipose tissue, systemic inflammation and metabolic outcomes, and abnormal pancreatic beta cell function. Together with studies in adults, this emerging science supports the hypothesis that NRAP contributes to development of obesity and metabolic disease. To investigate this broad hypothesis, the Southern California Children's Environmental Health Center is organized around the theme: Air pollution, childhood obesity and metabolic consequences. A multidisciplinary team in an integrated program of population-based, clinical and experimental research will address key research questions: Project 1 (P1) capitalizes on CHS resources and extensive pollutant measurements to investigate the impact of prenatal and childhood exposure on obesity in the cohort and the relationship to fat distribution, glucose homeostasis, lipid profile, systemic inflammation and the metabolic syndrome using cutting edge exposure assessment, imaging and metabolic phenotyping in overweight/obese CHS children. The study will focus on effects of elemental carbon (EC) and transition metals (Fe and Cu) in NRAP, based on preliminary findings and their toxicological properties. P2 investigates the effects of these exposures on adipose tissue inflammation, insulin resistance, and gene expression in macrophages and adipocytes in adipose biopsies from a sample of overweight/obese P1 CHS participants. P3 employs translational mouse models of obesity to investigate critical windows of exposure and temporal sequence of events from gestation to maturity linking NRAP exposure, adipose phenotype and inflammatory profile, and systemic metabolic dysregulation. An innovative hierarchical statistical model will integrate results across projects to examine the mechanistic pathway of NRAP on body fat, adipose inflammation, and metabolic outcomes. A COTC and Administrative Core will support career development and community engagement and translation of findings needed for science-based intervention.


Journal Articles: 35 Displayed | Download in RIS Format

Other center views: All 35 publications 35 publications in selected types All 35 journal articles
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Journal Article Alderete TL, Autran C, Brekke BE, Knight R, Bode L, Goran MI, Fields DA. Associations between human milk oligosaccharides and infant body composition in the first 6 mo of life. American Journal of Clinical Nutrition 2015;102(6):1381-1388. R835441 (2016)
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  • Journal Article Allayee H, Hazen SL. Contribution of gut bacteria to lipid levels: another metabolic role for microbes? Circulation Research 2015;117(9):750-754. R835441 (2016)
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  • Journal Article Bouret S, Levin BE, Ozanne SE. Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity. Physiological Reviews 2015;95(1):47-82. R835441 (2016)
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  • Journal Article Breton CV, Mack WJ, Yao J, Berhane K, Amadeus M, Lurmann F, Gilliland F, McConnell R, Hodis HN, Kunzli N, Avol E. Prenatal air pollution exposure and early cardiovascular phenotypes in young adults. PLoS One 2016;11(3):e0150825. R835441 (2016)
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  • Journal Article Chen Z, Salam MT, Toledo-Corral C, Watanabe RM, Xiang AH, Buchanan TA, Habre R, Bastain TM, Lurmann F, Wilson JP, Trigo E, Gilliland FD. Ambient air pollutants have adverse effects on insulin and glucose homeostasis in Mexican Americans. Diabetes Care 2016;39(4):547-554. R835441 (2016)
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  • Journal Article Cheng H, Davis DA, Hasheminassab S, Sioutas C, Morgan TE, Finch CE. Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFα in vitro. Journal of Neuroinflammation 2016;13:19. R835441 (2016)
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  • Journal Article Dueker D, Taher M, Wilson J, McConnell R. Evaluating children's location using a personal GPS logging instrument: limitations and lessons learned. Journal of Exposure Science and Environmental Epidemiology 2014;24(3):244-252. R835441 (2015)
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  • Journal Article Fruin S, Urman R, Lurmann F, McConnell R, Gauderman J, Rappaport E, Franklin M, Gilliland FD, Shafer M, Gorski P, Avol E. Spatial variation in particulate matter components over a large urban area. Atmospheric Environment 2014;83:211-219. R835441 (2015)
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  • Journal Article Ghazalpour A, Cespedes I, Bennett BJ, Allayee H. Expanding role of gut microbiota in lipid metabolism. Current Opinion in Lipidology 2016;27(2):141-147. R835441 (2016)
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  • Journal Article Ghosh R, Lurmann F, Perez L, Penfold B, Brandt S, Wilson J, Milet M, Kunzli N, McConnell R. Near-roadway air pollution and coronary heart disease: burden of disease and potential impact of a greenhouse gas reduction strategy in Southern California. Environmental Health Perspectives 2016;124(2):193-200. R835441 (2016)
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  • Journal Article Hsieh S, Klassen AC, Curriero FC, Caulfield LE, Cheskin LJ, Davis JN, Goran MI, Weigensberg MJ, Spruijt-Metz D. Built environment associations with adiposity parameters among overweight and obese Hispanic youth. Preventive Medicine Reports 2015;2:406-412. R835441 (2016)
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  • Journal Article Hsu TM, Konanur VR, Taing L, Usui R, Kayser BD, Goran MI, Kanoski SE. Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats. Hippocampus 2015;25(2):227-239. R835441 (2016)
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  • Journal Article Jerrett M, Shankardass K, Berhane K, Gauderman WJ, Künzli N, Avol E, Gilliland F, Lurmann F, Molitor JN, Molitor JT, Thomas DC, Peters J, McConnell R. Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement. Environmental Health Perspectives 2008;116(10):1433-1438. R835441 (2017)
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  • Journal Article Jerrett M, McConnell R, Wolch J, Chang R, Lam C, Dunton G, Gilliland F, Lurmann F, Islam T, Berhane K. Traffic-related air pollution and obesity formation in children: a longitudinal, multilevel analysis. Environmental Health 2014;13:49. R835441 (2015)
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  • Journal Article Kayser BD, Goran MI, Bouret SG. Perinatal overnutrition exacerbates adipose tissue inflammation caused by high-fat feeding in C57BL/6J mice. PLoS One 2015;10(3):e0121954. R835441 (2016)
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  • Journal Article Kayser BD, Toledo-Corral CM, Alderete TL, Weigensberg MJ, Goran MI. Temporal relationships between adipocytokines and diabetes risk in Hispanic adolescents with obesity. Obesity (Silver Spring) 2015;23(7):1479-1485. R835441 (2016)
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  • Journal Article Kim JY, Goran MI, Toledo-Corral CM, Weigensberg MJ, Shaibi GQ. Comparing glycemic indicators of prediabetes: a prospective study of obese Latino Youth. Pediatric Diabetes 2015;16(8):640-643. R835441 (2016)
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  • Journal Article Lurmann F, Avol E, Gilliland F. Emissions reduction policies and recent trends in Southern California's ambient air quality. Journal of the Air & Waste Management Association 2015;65(3):324-335. R835441 (2016)
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  • Journal Article McConnell R, Shen E, Gilliland FD, Jerrett M, Wolch J, Chang C-C, Lurmann F, Berhane K. A longitudinal cohort study of body mass index and childhood exposure to secondhand tobacco smoke and air pollution: the Southern California Children's Health Study. Environmental Health Perspectives 2015;123(4):360-366. R835441 (2015)
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  • Journal Article McConnell R, Gilliland FD, Goran M, Allayee H, Hricko A, Mittelman S. Does near-roadway air pollution contribute to childhood obesity? Pediatric Obesity 2016;11(1):1-3. R835441 (2015)
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  • Journal Article O'Reilly GA, Belcher BR, Davis JN, Martinez LT, Huh J, Antunez-Castillo L, Weigensberg M, Goran MI, Spruijt-Metz D. Effects of high-sugar and high-fiber meals on physical activity behaviors in Latino and African American adolescents. Obesity (Silver Spring) 2015;23(9):1886-1894. R835441 (2016)
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  • Journal Article Ritz B, Qiu J, Lee PC, Lurmann F, Penfold B, Weiss RE, McConnell R, Arora C, Hobel C, Wilhelm M. Prenatal air pollution exposure and ultrasound measures of fetal growth in Los Angeles, California. Environmental Research 2014;130:7-13. R835441 (2015)
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  • Journal Article Shankardass K, McConnell R, Jerrett M, Lam C, Wolch J, Milam J, Gilliland F, Berhane K. Parental stress increases body mass index trajectory in pre-adolescents. Pediatric Obesity 2014;9(6):435-442. R835441 (2015)
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  • Journal Article Su JG, Jerrett M, McConnell R, Berhane K, Dunton G, Shankardass K, Reynolds K, Chang R, Wolch J. Factors influencing whether children walk to school. Health & Place 2013;22:153-161. R835441 (2015)
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  • Journal Article Tellez-Rojo MM, Bellinger DC, Arroyo-Quiroz C, Lamadrid-Figueroa H, Mercado-Garcia A, Schnaas-Arrieta L, Wright RO, Hernandez-Avila M, Hu H. Longitudinal associations between blood lead concentrations lower than 10 μg/dL and neurobehavioral development in environmentally exposed children in Mexico City. Pediatrics 2006;118(2):e323-e330. R835441 (2017)
    R831725 (2007)
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  • Journal Article Toledo-Corral CM, Alderete TL, Richey J, Sequeira P, Goran MI, Weigensberg MJ. Fasting, post-OGTT challenge, and nocturnal free fatty acids in prediabetic versus normal glucose tolerant overweight and obese Latino adolescents. Acta Diabetologica 2015;52(2):277-284. R835441 (2016)
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  • Journal Article Urman R, Gauderman J, Fruin S, Lurmann F, Liu F, Hosseini R, Franklin M, Avol E, Penfold B, Gilliland F, Brunekreef B, McConnell R. Determinants of the spatial distributions of elemental carbon and particulate matter in eight Southern Californian communities. Atmospheric Environment 2014;86:84-92. R835441 (2015)
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  • Journal Article Urman R, McConnell R, Islam T, Avol EL, Lurmann FW, Vora H, Linn WS, Rappaport EB, Gilliland FD, Gauderman WJ. Associations of children's lung function with ambient air pollution: joint effects of regional and near-roadway pollutants. Thorax 2014;69(6):540-547. R835441 (2015)
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  • Journal Article Wu W, Muller R, Berhane K, Fruin S, Liu F, Jaspers I, Diaz-Sanchez D, Peden DB, McConnell R. Inflammatory response of monocytes to ambient particles varies by highway proximity. American Journal of Respiratory Cell and Molecular Biology 2014;51(6):802-809. R835441 (2015)
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  • Journal Article Zigman JM, Bouret SG, Andrews ZB. Obesity impairs the action of the neuroendocrine ghrelin system. Trends in Endocrinology and Metabolism 2016;27(1):54-63. R835441 (2016)
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  • Journal Article Volk HE, Lurmann F, Penfold B, Hertz-Picciotto I, McConnell R. Traffic related air pollution, particulate matter, and autism. JAMA Psychiatry 2013;70(1):71-77. R835441 (2017)
    R833292 (2012)
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  • Journal Article Ghosh R, Gauderman WJ, Minor H, Youn HA, Lurmann F, Cromar KR, Chatzi L, Belcher B, Fielding CR, McConnell R. Air pollution, weight loss and metabolic benefits of bariatric surgery:a potential model for study of metabolic effects of environmental exposures. Pediatr Obes. 2017. doi:10.1111/ijpo.12210. PubMed PMID:28429404. R835441 (2017)
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    Journal Article Smallwood T, Allayee H, Bennett BJ. Choline metabolites:gene by diet interactions. Current opinion in lipidology. 2016;27(1):33-9. doi:10.1097/MOL.0000000000000259. PubMed PMID:26655287; PMCID:PMC4703434. R835441 (2017)
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    Journal Article neuroinflammation in adolescent rats. Hippocampus. 2015;25(2):227-39. Epub 2014/09/23. doi:10.1002/hipo.22368. PubMed PMID:25242636. R835441 (2017)
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    Journal Article Hsieh S, Leaderer BP, Feldstein AE, Santoro N, McKay LA, Caprio S, McConnell R. Traffic-related air pollution associations with cytokeratin-18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population. Pediatr Obes. 2017. Epub 2017/07/22. doi:10.1111/ijpo.12228. PubMed PMID:28730729. R835441 (2017)
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    Progress and Final Reports:

    2014 Progress Report
    2015 Progress Report
    2016 Progress Report
    2017 Progress Report