Novel Methods to Assess the Effects of Chemicals on Child Development

EPA Grant Number: R835434
Center: Novel Methods to Assess the Effects of Chemicals on Child Development
Center Director: Schantz, Susan L.
Title: Novel Methods to Assess the Effects of Chemicals on Child Development
Investigators: Schantz, Susan L.
Institution: University of Illinois at Urbana-Champaign
EPA Project Officer: Louie, Nica
Project Period: June 1, 2013 through May 31, 2018
Project Amount: $3,962,727
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2012) RFA Text |  Recipients Lists
Research Category: Children's Health , Health

Objective:

This is a proposal to establish a Children's Environmental Health and Disease Prevention Research Center (P01) at the University of Illinois. The Center would expand and extend research initiated under our currently funded Formative Children's Center (P20). The primary goal is to use a multidisciplinary approach to address critical gaps in our knowledge about the impact of exposure to endocrine disrupting chemicals on child development. We will investigate how endocrine disrupters (phthalates; BPA) interact with diets high in saturated fat to impact neurological and reproductive function. The impact of exposures during two critical developmental periods - prenatal and adolescent - will be assessed. At the heart of the research effort will be two human cohorts that together make up Project 1- a prenatal exposure cohort which involves expansion of a prospective pre-birth cohort that is currently underway in Urbana, Illinois and an adolescent exposure cohort to be studied in the context of a long-standing prospective birth cohort study currently underway in New Bedford, Massachusetts. The Center will also include two laboratory rodent studies (Projects 2 and Project 3) that will model the timing of exposures assessed in the two human cohorts. The laboratory studies will explore mechanisms of action and will also help to identify neurological and reproductive outcomes that will be important to assess in longitudinal follow-ups of infants and children in the human cohorts. Central to all three research projects are three key aims: (1) assessment of exposure during two critical periods (prenatal and adolescent), (2) investigation of joint effects of exposure and diet, and (3) investigation of the role oxidative stress and inflammation in mediating outcomes. Projects 2 and 3 will use a phthalate mixture that is based on the pattern of phthalate metabolites found in human urine from Project 1. Additionally, we will actively involve and mentor junior investigators new to children's environmental health research, and we will develop and evaluate innovative strategies to communicate our research findings to the parents, childcare providers and healthcare providers through our Community Outreach and Translation Core (COTC). Center activities will be coordinated through an Administrative Core.


Journal Articles: 15 Displayed | Download in RIS Format

Other center views: All 51 publications 15 publications in selected types All 15 journal articles
Type Citation Sub Project Document Sources
Journal Article Barakat R, Lin P-CP, Rattan S, Brehm ES, Canisso IF, Abosalum ME, Flaws JA, Hess R, Ko C. Prenatal exposure to DEHP induces premature reproductive senescence in male mice. Toxicological Sciences 2017;156(1):96-108. R835434 (2016)
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  • Journal Article Berger A, Ziv-Gal A, Cudiamat J, Wang W, Zhou C, Flaws JA. The effects of in utero bisphenol A exposure on the ovaries in multiple generations of mice. Reproductive Toxicology 2016;60:39-52. R835434 (2015)
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  • Journal Article Gal A, Lin P-C, Barger AM, MacNeill AL, Ko C. Vaginal fold histology reduces the variability introduced by vaginal exfoliative cytology in the classification of mouse estrous cycle stages. Toxicologic Pathology 2014;42(8):1212-1220. R835434 (2013)
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  • Journal Article Li Q, Davila J, Kannan A, Flaws JA, Bagchi MK, Bagchi IC. Chronic exposure to bisphenol A affects uterine function during early pregnancy in mice. Endocrinology 2016;157(5):1764-1774. R835434 (2016)
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  • Journal Article Niermann S, Rattan S, Brehm E, Flaws JA. Prenatal exposure to di-(2-ethylhexyl) phthalate (DEHP) affects reproductive outcomes in female mice. Reproductive Toxicology 2015;53:23-32. R835434 (2014)
    R835434 (2015)
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  • Journal Article Oakley OR, Kim KJ, Lin PC, Barakat R, Cacioppo JA, Li Z, Whitaker A, Chung KC, Mei W, Ko C. Estradiol synthesis in gut-associated lymphoid tissue: leukocyte regulation by a sexually monomorphic system. Endocrinology 2016;157(12):4579-4587. R835434 (2016)
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  • Journal Article Peretz J, Vrooman L, Ricke WA, Hunt PA, Ehrlich S, Hauser R, Padmanabhan V, Taylor HS, Swan SH, VandeVoort CA, Flaws JA. Bisphenol A and reproductive health: update of experimental and human evidence, 2007-2013. Environmental Health Perspectives 2014;122(8):775-786. R835434 (2013)
    R835434 (2014)
    R834593 (Final)
    R834593C001 (Final)
    R835436 (2014)
    R835436 (2015)
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  • Journal Article Wang W, Hafner KS, Flaws JA. In utero bisphenol A exposure disrupts germ cell nest breakdown and reduces fertility with age in the mouse. Toxicology and Applied Pharmacology 2014;276(2):157-164. R835434 (2013)
    R835434 (2014)
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  • Journal Article Wise LM, Sadowski RN, Kim T, Willing J, Juraska JM. Long-term effects of adolescent exposure to Bisphenol A on neuron and glia number in the rat prefrontal cortex: differences between the sexes and cell type. Neurotoxicology 2016;53:186-192. R835434 (2014)
    R835434 (2015)
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  • Journal Article Zhou C, Wang W, Peretz J, Flaws JA. Bisphenol A exposure inhibits germ cell nest breakdown by reducing apoptosis in cultured neonatal mouse ovaries. Reproductive Toxicology 2015;57:87-99. R835434 (2014)
    R835434 (2015)
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  • Journal Article Zhou C, Gao L, Flaws JA. Exposure to an environmentally relevant phthalate mixture causes transgenerational effects on female reproduction in mice. Endocrinology 2017;158(6):1739-1754. R835434 (2016)
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  • Journal Article Zhou C, Flaws JA. Effects of an environmentally relevant phthalate mixture on cultured mouse antral follicles. Toxicological Sciences 2017;156(1):217-229. R835434 (2016)
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  • Journal Article Zhou C, Gao L, Flaws JA. Prenatal exposure to an environmentally relevant phthalate mixture disrupts reproduction in the F1 female mice. Toxicology and Applied Pharmacology 2017;318:49-57. R835434 (2016)
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  • Journal Article Ziv-Gal A, Wang W, Zhou C, Flaws JA. The effects of in utero bisphenol A exposure on reproductive capacity in several generations of mice. Toxicology and Applied Pharmacology 2015;284(3):354-362. R835434 (2014)
    R835434 (2015)
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  • Journal Article Ziv-Gal A, Flaws JA. Evidence for bisphenol A-induced female infertility: a review (2007-2016). Fertility and Sterility 2016;106(4):827-856. R835434 (2016)
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  • Progress and Final Reports:

    2013 Progress Report
    2014 Progress Report
    2015 Progress Report
    2016 Progress Report