2016 Progress Report: Children's Environmental Health & Disease Prevention Research Center at Dartmouth

EPA Grant Number: R835442
Center: Children's Environmental Health and Disease Prevention Center - Dartmouth College 2013
Center Director: Karagas, Margaret Rita
Title: Children's Environmental Health & Disease Prevention Research Center at Dartmouth
Investigators: Karagas, Margaret Rita
Institution: Dartmouth College
EPA Project Officer: Nolt-Helms, Cynthia
Project Period: July 1, 2013 through June 30, 2018 (Extended to June 30, 2019)
Project Period Covered by this Report: July 1, 2015 through June 30,2016
Project Amount: $4,060,713
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2012) RFA Text |  Recipients Lists
Research Category: Children's Health , Health

Objective:

The Center’s core purpose is to identify and address key emerging issues related to health impacts of early life environmental exposures on children. There is a growing body of research connecting exposures early in life to a number of prevalent and life threatening diseases for children. Moreover, it is important to understand these exposures as effects that begin to manifest in childhood may extend beyond, into adult life. Significant gaps remain in our understanding of the effects of early life exposures and of potential treatments or measures to reduce harmful exposures, especially in utero or in early childhood. Thus, the overarching goal of this Center is to conduct research that enables risk assessors, regulators, policy makers, caregivers, and other stakeholders to increase their capacity to implement immediate and long-term strategies to prevent environmentally induced diseases associated with environmental exposures, such as arsenic in children.

Progress Summary:

Major Activities

  • Our synergistic, collaborative Center focused on the integration of all projects and cores. It remains productive and at the forefront of children’s environmental health research.
  • Our established administrative structure supports our multidisciplinary research teams, and ensures clear, organized communications, budget management, fiscal planning, and regulatory compliance. The centralization of research activates is done through the Administrative, Research Integration and Career Development Core, and has led to enhanced productivity within the projects.
  • The innovative new technologies and methodologies being used continue to enhance the promising research program of our Center. These include epigenetic analysis, precision gene expression arrays using NanoString, deep sequencing microbiome analysis, state-of-the-art immune profiling, and trace element measurement of biologic samples. These mechanisms have stimulated high impact biomedical research in children’s environmental health, both within our Center, and on a national and international scale.
  • Our robust mentorship program, pairing early career investigators with recognized scientists, and leaders within our interdisciplinary team, remains a positive and effective element of our Center, and continues to further both the careers of our talented investigators and the Center’s research.
  • The integrative Child Health team, led by prominent pediatric medical geneticist, Dr. John Moeschler, has continued to deepen connections among health care and public health providers, communities, parents, caregivers, and other key stakeholders to effectively reduce risk of environmental threats to children’s health.
  • Our Community Outreach Translation Core (COTC) continues to partner with the Administrative Core, Child Health Specialist, New Hampshire Birth Cohort Study (NHBCS) participants, practice networks and public health partners to translate findings to stakeholders in clinical practices. The COTC continues to pilot a research study to examine the most effective ways to communicate research findings and risk, while observing behavior modification of key stakeholders—parents of children in New England.
  • Our communication protocols include having our COTC Director, Dr. Carolyn Murray—a recognized and respected clinician—review and comment on all press releases and media communications before they are made public. This has greatly streamlined the Center’s messaging to maximize the effectiveness of our research translation.

Significant Results

Our well established and growing New Hampshire Birth Cohort Study (NHBCS) of maternal-infant dyads, continues to be of paramount importance to our research and Center. Building upon detailed exposure history, state-of-the-art biomarker measurements, and a rich collection of archived biospecimens obtained from this cohort, we are accelerating the pace of scientific advancement by leveraging additional Dartmouth resources, such as the Biorepository Core facility. Utilizing said facility as an archiving and retrieval mechanism for our precious biological samples, greatly increases the rate at which we can obtain data, and publish our findings. In this reporting period, our Center continued to refine database creation and management, providing researchers and trainees web access to data descriptions, which is vastly accelerating our scientific productivity, and will continue to be a focus in Year 4 of our Center grant. To advance the expansion of the Center’s research, we were awarded two successful Administrative Supplements, and continue to implement several pilot projects and sub-studies as well as major additions to the cohort study. Researchers within our cohesive Center continue to contribute important scientific findings via national and international conferences and publications, and communicate them to key stakeholders to reduce environmental threats to children and improve their lifelong health.

Key Outcomes/Achievements

Some of our Center’s key achievements over the past year are mentioned below, and highlighted within each core/project report.

  • Project 1 published several papers on novel findings related to fetal and perinatal exposures and the stool microbiota of premature infants; the association of cesarean delivery and formula supplementation with the intestinal microbiome of 6-week old infants, and infant infection and respiratory outcomes in relation to in utero arsenic exposure. To advance the understanding of the role of diet and potential exposure to arsenic, Project 1 in collaboration with Project 2 has worked extensively in this reporting period to analyze dietary data and has several papers elucidating findings related to rice consumption and potential early life exposure to arsenic through rice-containing products.
  • Dr. Margaret Karagas was an invited presenter at the National Academy of Sciences (NAS) Emerging Science for Environmental Health Decisions workshop “Environment and Health: What’s the Human Microbiome Have to Do with It?” in Washington, DC (January 2016).
  • Dr. Wes Viles, a postdoctoral associate presented on “Entropy, statistical dependence, and network structure of the human infant gut microbiome” at the Pacific Symposium on Biocomputing in January 2016 on the Big Island of Hawaii, and again at the Microbiome Data Analysis in New York, New York in February 2016.
  • Dr. Juliette Madan was an invited speaker at the "Altering the Microbiome: Can it Impact Health?" Biopharma Research Council Meeting co-sponsored by NIH/NCI on "Neonatal Microbiome: Exposures and Outcomes" (September 2015).
  • Dr. Anne Hoen, a newly hired early career investigator within the Department of Epidemiology at the Geisel School of Medicine at Dartmouth, has research expertise in microbiome analysis and spatial modeling, and is working with Dr. Karagas on two recently awarded administrative supplements. These supplements are greatly enhancing our novel research on the microbiome and are propelling the project's findings, and the Center research as a whole.
  • Dr. Anne Hoen and graduate student Sara Lundgren were invited to present at the Human Immunity and the Microbiome in Health and Disease Conference in Montreal, Canada (September 28-29, 2015).
  • Dr. Jiang Gui presented a poster and abstract, in collaboration with Dr. Margaret Karagas, of the work, “A Two Step Variable Selection Procedure Using Prioritization of Interactions” followed by LASSO, for the NIEHS Statistical Approaches for Assessing Health Effects of Environmental Chemical Mixtures in Epidemiology Studies Workshop in Research Triangle Park, North Carolina, July 2015.
  • Dr. Tracy Punshon, an early career investigator with Project 2 has been highly productive this reporting period investigating metal concentrations in the placenta in relation to other maternal and infant biomarkers. Dr. Punshon’s work in this area resulted in publications in Environmental Science & Technology and the Journal of Exposure Science and Environmental Epidemiology with several other papers published and underway.
  • Project 2 postdoctoral associate Courtney C. Carignan developed expertise in arsenic exposure assessment and dietary epidemiology through her work with Drs. Cottingham and Gilbert-Diamond. Carignan led three manuscripts emerging from Aim 1 of this Project; the first appeared in Environmental Health Perspectivies in May 2015, the second in the Journal of Exposure Science and Environmental Epidemiology in November 2015, and a third was published this year in the Annals of Global Health.
  • Dr. Susan Korrick of Project 2 is mentoring a post-doctoral fellow, Mahsa Yazdy, who is analyzing parallel data among another birth cohort (the New Bedford Cohort) with biomarkers of prenatal arsenic exposure. Collection of measures of cognitive and behavioral function through adolescence has been completed. Findings from analyses of this complete dataset will help inform analyses of the NHBCS neurobehavioral data.
  • Faculty Development Investigator, and Project 2 co-leader, Dr. Diane Gilbert-Diamond is continuing to study how environmental factors influence early growth and obesity in children. She continues to co-mentor graduate student, Anala Gossai and has published several papers in this reporting period examining the relationship between in utero arsenic exposure and birth outcomes, gene-gene interactions in a statistical epistatis network of 12 candidate genes for obesity, gene-gene interactions and association with body mass index, and the effects of children’s food and beverage promotion on television to parents.
  • Project 3 has continued to focus on the influence of environmental exposure on human epigenetic regulation, which has further fortified the strength between the NHBCS (PI: Karagas) and RICHS (PI: Marsit) birth cohorts.
  • Dr. Benjamin Green, a second year postdoctoral fellow with Project 3 published a manuscript “The role of placental 11-beta hydroxysteroid dehydrogenase type 1 and type 2 methylation on gene expression and infant birth weight,“ in Biology of Reproduction and he was lead author on the arsenic EWAS study that was published in Environmental Health Perspectives on arsenic and placental DNA methylation in the NHBCS.
  • Dr. Marsit, co-leader of Project 3, presented on “Readily Measurable Epigenetic Marks and Significance” at the U.S. EPA offices in Washington DC, for a workgroup considering epigenetic mechanisms in risk assessment. In addition, he presented seminars on Placental Epigenetics in Children’s Environmental Health to the Superfund Research Program at the University of Kentucky, at the Southern California Environmental Health Sciences Center at the University of Southern California, and at the Emory University Rollins School of Public Health.
  • Dr. David Robbins of project 3 continues his work on an NIEHS Children’s Center administrative supplement to investigate sex differences in the Center’s data. He now is in the process of examining how arsenic speciation might contribute to some of the sexually dimorphic responses, and has published on a key development gene over the past year.
  • Dr. Carolyn Murray, our COTC Director worked with the Dartmouth Neukon Center DALI (Digital Arts, Leadership and Innovation) lab to produce an educational tool for parents and the public on arsenic sources and consumption. This work was featured in the August 2015 NIEHS PEHP newsletter.

Future Activities:

During the next reporting period, we will continue to promote the discovery of new scientific findings through a multidisciplinary, integrated approach encompassing the spectrum from exposure, exposure biomarkers, response biomarkers, health outcomes and practice, and policy change of our interdisciplinary Center. Our focus continues to be identifying, and in turn reducing, adverse health consequences of environmental exposures in children. We will continue to strive to communicate new and emerging results to appropriate audiences in order to facilitate change in public health and clinical practice.


Journal Articles: 92 Displayed | Download in RIS Format

Other center views: All 144 publications 92 publications in selected types All 92 journal articles
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Journal Article Appleton AA, Lester BM, Armstrong DA, Lesseur C, Marsit CJ. Examining the joint contribution of placental NR3C1 and HSD11B2 methylation for infant neurobehavior. Psychoneuroendocrinology 2015;52:32-42. R835442 (2015)
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  • Journal Article Armstrong DA, Lesseur C, Conradt E, Lester BM, Marsit CJ. Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research. FASEB Journal 2014;28(5):2088-2097. R835442 (2014)
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  • Journal Article Armstrong DA, Green BB, Blair BA, Guerin DJ, Litzky JF, Chavan NR, Pearson KJ, Marsit CJ. Maternal smoking during pregnancy is associated with mitochondrial DNA methylation. Environmental Epigenetics 2016;2(3):dvw020. R835442 (2017)
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  • Journal Article Banister CE, Koestler DC, Maccani MA, Padbury JF, Houseman EA, Marsit CJ. Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas. Epigenetics 2011;6(7):920-927. R835442 (2014)
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  • Journal Article Beane Freeman LE, Karagas MR, Baris D, Schwenn M, Johnson AT, Colt JS, Jackson B, Hosain GM, Cantor KP, Silverman DT. Is the inverse association between selenium and bladder cancer due to confounding by smoking? American Journal of Epidemiology 2015;181(7):488-495. R835442 (2015)
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  • Journal Article Bommarito PA, Martin E, Smeester L, Palys T, Baker ER, Karagas MR, Fry RC. Fetal-sex dependent genomic responses in the circulating lymphocytes of arsenic-exposed pregnant women in New Hampshire. Reproductive Toxicology 2017;73:184-195. R835442 (2018)
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  • Journal Article Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SK. Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environmental Health Perspectives 2017;125(4):511-526. R835442 (2017)
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  • Journal Article Caito SW, Jackson BP, Punshon T, Scrimale T, Grier A, Gill SR, Love TM, Watson GE, van Wijngaarden E, Rand MD. Editor's Highlight: Variation in methylmercury metabolism and elimination status in humans following fish consumption. Toxicological Sciences 2018;161(2):443-453. R835442 (2018)
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  • Journal Article Cardenas A, Koestler DC, Houseman EA, Jackson BP, Kile ML, Karagas MR, Marsit CJ. Differential DNA methylation in umbilical cord blood of infants exposed to mercury and arsenic in utero. Epigenetics 2015;10(6):508-515. R835442 (2015)
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  • Journal Article Carignan CC, Cottingham KL, Jackson BP, Farzan SF, Gandolfi AJ, Punshon T, Folt CL, Karagas MR. Estimated exposure to arsenic in breastfed and formula-fed infants in a United States cohort. Environmental Health Perspectives 2015;123(5):500-506. R835442 (2015)
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  • Journal Article Chen Y, Karagas MR. Arsenic and cardiovascular disease: new evidence from the United States. Annals of Internal Medicine 2013;159(10):713-714. R835442 (2014)
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  • Journal Article Chernikova DA, Koestler DC, Hoen AG, Housman ML, Hibberd PL, Moore JH, Morrison HG, Sogin ML, Zain-Ul-Abideen M, Madan JC. Fetal exposures and perinatal influences on the stool microbiota of premature infants. Journal of Maternal-Fetal and Neonatal Medicine 2016;29(1):99-105. R835442 (2017)
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  • Journal Article Chernikova DA, Madan JC, Housman ML, Zain-Ul-Abideen M, Lundgren SN, Morrison HG, Sogin ML, Williams SM, Moore JH, Karagas MR, Hoen AG. The premature infant gut microbiome during the first 6 weeks of life differs based on gestational maturity at birth. Pediatric Research 2018;84(1):71-79. R835442 (2018)
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  • Journal Article Cottingham KL, Karimi R, Gruber JF, Zens MS, Sayarath V, Folt CL, Punshon T, Morris JS, Karagas MR. Diet and toenail arsenic concentrations in a New Hampshire population with arsenic-containing water. Nutrition Journal 2013;12:149. R835442 (2014)
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  • Journal Article Davis MA, Gilbert-Diamond D, Karagas MR, Li Z, Moore JH, Williams SM, Frost HR. A dietary-wide association study (DWAS) of environmental metal exposure in US children and adults. PLoS One 2014;9(9):e104768. R835442 (2015)
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  • Journal Article Davis MA, Li Z, Gilbert-Diamond D, Mackenzie TA, Cottingham KL, Jackson BP, Lee JS, Baker ER, Marsit CJ, Karagas MR. Infant toenails as a biomarker of in utero arsenic exposure. Journal of Exposure Science & Environmental Epidemiology 2014;24(5):467-473. R835442 (2015)
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  • Journal Article Davis MA, Higgins J, Li Z, Gilbert-Diamond D, Baker ER, Das A, Karagas MR. Preliminary analysis of in utero low-level arsenic exposure and fetal growth using biometric measurements extracted from fetal ultrasound reports. Environmental Health 2015;14:12 (11 pp.). R835442 (2015)
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  • Journal Article Davis MA, Signes-Pastor AJ, Argos M, Slaughter F, Pendergrast C, Punshon T, Gossai A, Ahsan H, Karagas MR. Assessment of human dietary exposure to arsenic through rice. Science of the Total Environment 2017;586:1237-1244. R835442 (2017)
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  • Journal Article Demidenko E. Exact and approximate statistical inference for nonlinear regression and the estimating equation approach. Scandinavian Journal of Statistics 2017;44(3):636-665. R835442 (2018)
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  • Journal Article Emond JA, Gilbert-Diamond D, Tanski SE, Sargent JD. Energy drink consumption and the risk of alcohol use disorder among a national sample of adolescents and young adults. Journal of Pediatrics 2014;165(6):1194-1200. R835442 (2015)
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  • Journal Article Emond JA, Sargent JD, Gilbert-Diamond D. Patterns of energy drink advertising over US television networks. Journal of Nutrition Education and Behavior 2015;47(2):120-126.e1. R835442 (2015)
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  • Journal Article Emond JA, Karagas MR, Baker ER, Gilbert-Diamond D. Better diet quality during pregnancy is associated with a reduced likelihood of an infant born small for gestational age: an analysis of the Prospective New Hampshire Birth Cohort Study. Journal of Nutrition 2018;148(1):22-30. R835442 (2018)
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  • Journal Article Everson TM, Kappil M, Hao K, Jackson BP, Punshon T, Karagas MR, Chen J, Marsit CJ. Maternal exposure to selenium and cadmium, fetal growth, and placental expression of steroidogenic and apoptotic genes. Environmental Research 2017;158:233-244. R835442 (2017)
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  • Journal Article Everson TM, Punshon T, Jackson BP, Hao K, Lambertini L, Chen J, Karagas MR, Marsit CJ. Cadmium-associated differential methylation throughout the placental genome:epigenome-wide association study of two U.S. birth cohorts. Environmental Health Perspectives 2018;126(1):017010 (13 pp.). R835442 (2018)
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  • Journal Article Farzan SF, Chen Y, Wu F, Jiang J, Liu M, Baker E, Korrick SA, Karagas MR. Blood pressure changes in relation to arsenic exposure in a U.S. pregnancy cohort. Environmental Health Perspectives 2015;123(10):999-1006. R835442 (2015)
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  • Journal Article Farzan SF, Chen Y, Rees JR, Zens MS, Karagas MR. Risk of death from cardiovascular disease associated with low-level arsenic exposure among long-term smokers in a US population-based study. Toxicology and Applied Pharmacology 2015;287(2):93-97. R835442 (2015)
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  • Journal Article Farzan SF, Brickley EB, Li Z, Gilbert-Diamond D, Gossai A, Chen Y, Howe CG, Palys T, Karagas MR. Maternal and infant inflammatory markers in relation to prenatal arsenic exposure in a U.S. pregnancy cohort. Environmental Research 2017;156:426-433. R835442 (2017)
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  • Journal Article Fei DL, Koestler DC, Li Z, Giambelli C, Sanchez-Mejias A, Gosse JA, Marsit CJ, Karagas MR, Robbins DJ. Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study. Environmental Health 2013;12:58 (8 pp.). R835442 (2014)
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  • Journal Article Felix JF, Joubert BR, Baccarelli AA, Sharp GC, Almqvist C, Annesi-Maesano I, Arshad H, Baiz N, Bakermans-Kranenburg MJ, Bakulski KM, Binder EB, Bouchard L, Breton CV, Brunekreef B, Brunst KJ, Burchard EG, Bustamante M, Chatzi L, Cheng Munthe-Kaas M, Corpeleijn E, Czamara D, Dabelea D, Davey Smith G, De Boever P, Duijts L, Dwyer T, Eng C, Eskenazi B, Everson TM, Falahi F, Fallin MD, Farchi S, Fernandez MF, Gao L, Gaunt TR, Ghantous A, Gillman MW, Gonseth S, Grote V, Gruzieva O, Haberg SE. Cohort profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. International Journal of Epidemiology 2018;47(1):22-23u. R835442 (2018)
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  • Journal Article Frediani JK, Naioti EA, Vos MB, Figueroa J, Marsit CJ, Welsh JA. Arsenic exposure and risk of nonalcoholic fatty liver disease (NAFLD) among U.S. adolescents and adults: an association modified by race/ethnicity, NHANES 2005-2014. Environmental Health 2018;17(1):6 (8 pp.). R835442 (2018)
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  • Journal Article Gilbert-Diamond D, Li Z, Adachi-Mejia AM, McClure AC, Sargent JD. Association of a television in the bedroom with increased adiposity gain in a nationally representative sample of children and adolescents. JAMA Pediatrics 2014;168(5):427-434. R835442 (2014)
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  • Journal Article Gossai A, Lesseur C, Farzan S, Marsit C, Karagas MR, Gilbert-Diamond D. Association between maternal urinary arsenic species and infant cord blood leptin levels in a New Hampshire Pregnancy Cohort. Environmental Research 2015;136:180-186. R835442 (2015)
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  • Journal Article Grandjean P, Barouki R, Bellinger DC, Casteleyn L, Chadwick LH, Cordier S, Etzel RA, Gray KA, Ha EH, Junien C, Karagas M, Kawamoto T, Paige Lawrence B, Perera FP, Prins GS, Puga A, Rosenfeld CS, Sherr DH, Sly PD, Suk W, Sun Q, Toppari J, van den Hazel P, Walker CL, Heindel JJ. Endocrinology 2015;156(10):3408-3415. R835442 (2017)
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  • Journal Article Green BB, Armstrong DA, Lesseur C, Paquette AG, Guerin DJ, Kwan LE, Marsit CJ. The role of placental 11-beta hydroxysteroid dehydrogenase type 1 and type 2 methylation on gene expression and infant birth weight. Biology of Reproduction 2015;92(6):149 (8 pp.). R835442 (2015)
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  • Journal Article He X, Karagas R, Murray C. Impact of receipt of private well arsenic test results on maternal use of contaminated drinking water in a U.S. population. Science of the Total Environment 2018;643:1055-1012. R835442 (2018)
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  • Journal Article Hoen AG, Li J, Moulton LA, O'Toole GA, Housman ML, Koestler DC, Guill MF, Moore JH, Hibberd PL, Morrison HG, Sogin ML, Karagas MR, Madan JC. Associations between gut microbial colonization in early life and respiratory outcomes in cystic fibrosis. Journal of Pediatrics 2015;167(1):138-147.e1-3. R835442 (2015)
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  • Journal Article Hoen AG, Madan JC, Li Z, Coker M, Lundgren SN, Morrison HG, Palys T, Jackson BP, Sogin ML, Cottingham KL, Karagas MR. Sex-specific associations of infants' gut microbiome with arsenic exposure in a US population. Scientific Reports 2018;8(1):12627 (10 pp.). R835442 (2018)
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  • Journal Article Houseman EA, Kelsey KT, Wiencke JK, Marsit CJ. Cell-composition effects in the analysis of DNA methylation array data:a mathematical perspective. BMC Bioinformatics 2015;16(1):95 (16 pp.). R835442 (2016)
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  • Journal Article Jackson BP. Fast ion chromatography-ICP-QQQ for arsenic speciation. Journal of Analytical Atomic Spectrometry 2015;30(6):1405-1407. R835442 (2015)
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  • Journal Article Jackson BP, Punshon T. Recent advances in the measurement of arsenic, cadmium, and mercury in rice and other foods. Current Environmental Health Reports 2015;2(1):15-24. R835442 (2015)
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  • Journal Article Jackson BP, Liba A, Nelson J. Advantages of reaction cell ICP-MS on doubly charged interferences for arsenic and selenium analysis in foods. Journal of Analytical Atomic Spectrometry 2015;30(5):1179-1183. R835442 (2015)
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  • Journal Article Karagas MR, Zens MS, Li Z, Stukel TA, Perry AE, Gilbert-Diamond D, Sayarath V, Stephenson RS, Barton D, Nelson HH, Spencer SK. Early-onset basal cell carcinoma and indoor tanning: a population-based study. Pediatrics 2014;134(1):e4-e12. R835442 (2015)
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  • Journal Article Karagas MR, Gossai A, Pierce B, Ahsan H. Drinking water arsenic contamination, skin lesions and malignancies: a systematic review of the global evidence. Current Environmental Health Reports 2015;2(1):52-68. R835442 (2015)
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  • Journal Article Kaushal A, Zhang H, Karmaus WJJ, Everson TM, Marsit CJ, Karagas MR, Tsai SF, Wen HJ, Wang SL. Genome-wide DNA methylation at birth in relation to in utero arsenic exposure and the associated health in later life. Environmental Health 2017;16(1):50. R835442 (2017)
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  • Journal Article Kingsley SL, Deyssenroth MA, Kelsey KT, Awad YA, Kloog I, Schwartz JD, Lambertini L, Chen J, Marsit CJ, Wellenius GA. Maternal residential air pollution and placental imprinted gene expression. Environment International 2017;108:204-211. R835442 (2018)
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  • Journal Article Koestler DC, Avissar-Whiting M, Houseman EA, Karagas MR, Marsit CJ. Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero. Environmental Health Perspectives 2013;121(8):971-977. R835442 (2014)
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  • Journal Article Lansigan RK, Emond JA, Gilbert-Diamond D. Understanding eating in the absence of hunger among young children: a systematic review of existing studies. Appetite 2015;85:36-47. R835442 (2015)
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  • Journal Article Lesseur C, Armstrong DA, Murphy MA, Appleton AA, Koestler DC, Paquette AG, Lester BM, Marsit CJ. Sex-specific associations between placental leptin promoter DNA methylation and infant neurobehavior. Psychoneuroendocrinology 2014;40:1-9. R835442 (2014)
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  • Journal Article Lesseur C, Paquette AG, Marsit CJ. Epigenetic regulation of infant neurobehavioral outcomes. Medical Epigenetics 2014;2(2):71-79. R835442 (2015)
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  • Journal Article Lester BM, Marsit CJ. Epigenetic mechanisms in the placenta related to infant neurodevelopment. Epigenomics 2018;10(3):321-333. R835442 (2018)
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  • Journal Article Li Z, Frost HR, Tosteson TD, Zhao L, Liu L, Lyons K, Chen H, Cole B, Currow D, Bakitas M. A semiparametric joint model for terminal trend of quality of life and survival in palliative care research. Statistics in Medicine 2017;36(29):4692-4704. R835442 (2018)
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  • Journal Article Litzky JF, Boulet SL, Esfandiari N, Zhang Y, Kissin DM, Theiler RN, Marsit CJ. Effect of frozen/thawed embryo transfer on birthweight, macrosomia, and low birthweight rates in US singleton infants. American Journal of Obstetrics Gynecology 2018;218(4):433.e1-433.e10. R835442 (2018)
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  • Journal Article Litzky JF, Boulet SL, Esfandiari N, Zhang Y, Kissin DM, Theiler RN, Marsit CJ. Birthweight in infants conceived through in vitro fertilization following blastocyst or cleavage-stage embryo transfer: a national registry study. Journal of Assisted Reproduction and Genetics 2018;35(6):1027-1037. R835442 (2018)
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  • Journal Article Litzky JF, Deyssenroth MA, Everson TM, Lester BM, Lambertini L, Chen J, Marsit CJ. Prenatal exposure to maternal depression and anxiety on imprinted gene expression in placenta and infant neurodevelopment and growth. Pediatric Research 2018;83(5):1075-1083. R835442 (2018)
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  • Journal Article Lundgren SN, Madan JC, Emond JA, Morrison HG, Christensen BC, Karagas MR, Hoen AG. Maternal diet during pregnancy is related with the infant stool microbiome in a delivery mode-dependent manner. Microbiome 2018;6(1):109(11 pp.). R835442 (2018)
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  • Journal Article Maccani JZ, Koestler DC, Houseman EA, Marsit CJ, Kelsey KT. Placental DNA methylation alterations associated with maternal tobacco smoking at the RUNX3 gene are also associated with gestational age. Epigenomics 2013;5(6):619-630. R835442 (2014)
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  • Journal Article Maccani JZ, Koestler DC, Houseman EA, Armstrong DA, Marsit CJ, Kelsey KT. DNA methylation changes in the placenta are associated with fetal manganese exposure. Reproductive Toxicology 2015;57:43-49. R835442 (2016)
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  • Journal Article Maccani JZJ, Koestler DC, Lester B, Houseman EA, Armstrong DA, Kelsey KT, Marsit CJ. Placental DNA methylation related to both infant toenail mercury and adverse neurobehavioral outcomes. Environmental Health Perspectives 2015;123(7):723-729. R835442 (2015)
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  • Journal Article Marsit CJ, Brummel SS, Kacanek D, Seage III GR, Spector SA, Armstrong DA, Lester BM, Rich K, Pediatric HIV/AIDS Cohort Studies Network. Infant peripheral blood repetitive element hypomethylation associated with antiretroviral therapy in utero. Epigenetics 2015;10(8):708-716. R835442 (2015)
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  • Journal Article Marsit CJ. Influence of environmental exposure on human epigenetic regulation. Journal of Experimental Biology 2015;218(Pt 1):71-79. R835442 (2015)
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  • Journal Article Marsit CJ. Placental epigenetics in children’s environmental health. Seminars in Reproductive Medicine 2016;34(1):36-41. R835442 (2016)
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  • Journal Article Martin E, Smeester L, Bommarito PA, Grace MR, Boggess K, Kuban K, Karagas MR, Marsit CJ, O'Shea TM, Fry RC. Sexual epigenetic dimorphism in the human placenta:implications for susceptibility during the prenatal period. Epigenomics 2017;9(3):267-278. R835442 (2017)
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  • Journal Article Nachman KE, Punshon T, Rardin L, Signes-Pastor AJ, Murray CJ, Jackson BP, Guerinot ML, Burke TA, Chen CY, Ahsan H, Argos M, Cottingham KL, Cubadda F, Ginsberg GL, Goodale BC, Kurzius-Spencer M, Meharg AA, Miller MD, Nigra AE, Pendergrast CB, Raab A, Reimer K, Scheckel KG, Schwerdtle T, Taylor VF, Tokar EJ, Warczak TM, Karagas MR. Opportunities and challenges for dietary arsenic intervention. Environmental Health Perspectives 2018;126(8):84503 (6 pp.). R835442 (2018)
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  • Journal Article Nadeau KC, Li Z, Farzan S, Koestler D, Robbins D, Fei DL, Malipatlolla M, Maecker H, Enelow R, Korrick S, Karagas MR. In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort. Clinical Immunology 2014;155(2):188-197. R835442 (2015)
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  • Journal Article Nygaard UC, Li Z, Palys T, Jackson B, Subbiah M, Malipatlolla M, Sampath V, Maecker H, Karagas MR, Nadeau KC. Cord blood T cell subpopulations and associations with maternal cadmium and arsenic exposures. PLoS One 2017;12(6):e0179606. R835442 (2017)
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  • Journal Article Paquette AG, Lester BM, Koestler DC, Lesseur C, Armstrong DA, Marsit CJ. Placental FKBP5 genetic and epigenetic variation is associated with infant neurobehavioral outcomes in the RICHS cohort. PLoS One 2014;9(8):e104913 (10 pp.). R835442 (2015)
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  • Journal Article Paquette AG, Marsit CJ. The developmental basis of epigenetic regulation of HTR2A and psychiatric outcomes. Journal of Cellular Biochemistry 2014;115(12):2065-2072. R835442 (2015)
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  • Journal Article Patel CJ, Kerr J, Thomas DC, Mukherjee B, Ritz B, Chatterjee N, Jankowska M, Madan J, Karagas MR, McAllister KA, Mechanic LE, Fallin MD, Ladd-Acosta C, Blair IA, Teiltelbaum SL, Amos CI. Opportunities and challenges for environmental exposure assessment in population-based studies. Cancer Epidemiology, Biomarkers & Prevention 2017;26(9):1370-1380. R835442 (2018)
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  • Journal Article Pearce N, Blair A, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli AA, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, 't Mannetje F, McMichael AJ, Mclaughlin JR, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer FE, Monson R, Nordby K-C, Olshan AF, Parent M-E, Perera FP, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Costantini AS, Seixas N, Shy C, Siemiatycki J, Silverman DT, Simonato L,Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart PA, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger D, Wesseling C, Weiderpass E, Zahm SH. IARC Monographs: 40 years of evaluating carcinogenic hazards to humans. Environmental Health Perspectives 2015;123(6):507-514. R835442 (2015)
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  • Journal Article Peng S, Deyssenroth MA, Di Narzo AF, Lambertini L, Marsit CJ, Chen J, Hao K. Expression quantitative trait loci (eQTLs) in human placentas suggest developmental origins of complex diseases. Human Molecular Genetics 2017;26(17):3432-3441. R835442 (2018)
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  • Journal Article Punshon T, Chen S, Finney L, Howard L, Jackson BP, Karagas MR, Ornvold K. High-resolution elemental mapping of human placental chorionic villi using synchrotron X-ray fluorescence spectroscopy. Analytical and Bioanalytical Chemistry 2015;407(22):6839-6850. R835442 (2015)
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  • Journal Article Punshon T, Jackson BP. Essential micronutrient and toxic trace element concentrations in gluten containing and gluten-free foods. Food Chemistry 2018;252:258-264. R835442 (2018)
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  • Journal Article Romano ME, Webster GM, Vuong AM, Zoeller RT, Chen A, Hoofnagle AN, Calafat AM, Karagas MR, Yolton K, Lanphear BP, Braun JM. Gestational urinary bisphenol A and maternal and newborn thyroid hormone concentrations: the HOME Study. Environmental Research 2015;138:453-460. R835442 (2015)
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  • Journal Article Rothenberg SE, Korrick SA, Fayad R. The influence of obesity on blood mercury levels for U.S. non-pregnant adults and children: NHANES 2007-2010. Environmental Research 2015;138:173-180. R835442 (2015)
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  • Journal Article Sharp GC, Salas LA, Monnereau C, Allard C, Yousefi P, Everson TM, Bohlin J, XuZ, Huang RC, Reese SE, Xu CJ, Baiz N, Hoyo C, Agha G, Roy R, Holloway JW, Ghantous A, Merid SK, Bakulski KM, Kupers LK, Zhang H, Richmond RC, Page CM, Duijts L, Lie RT, Melton PE, Vonk JM, Nohr EA, Williams-DeVane C, Huen K, Rifas-Shiman SL, Ruiz-Arenas C, Gonseth S, Rezwan FI, Herceg Z, Ekstrom S, Croen L, Falahi F, Perron P, Karagas MR, Quraishi BM, Suderman M, Magnus MC, Jaddoe VWV, Taylor JA, Anderson D, Zhao S, Smit HA, Josey MJ, Bradman A, Baccarelli AA, Bustamante M, Haberg SE, Pershagen G, Hertz-Picciotto I, Newschaffer C, Corpeleijn E, Bouchard L, Lawlor DA, Maguire RL, Barcellos LF, Davey Smith G, Eskenazi B, Karmaus W, Marsit CJ, Hivert MF, Snieder H, Fallin MD, Melen E, Munthe-Kaas MC, Arshad H, Wiemels JL, Annesi-Maesano I, Vrijheid M, Oken E, Holland N, Murphy SK, Sorensen TIA, Koppelman GH, Newnham JP, Wilcox AJ, Nystad W, London SJ, Felix JF, Relton CL. Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. Human Molecular Genetics 2017;26(20):4067-4085. R835442 (2018)
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  • Journal Article Shi X, Miller S, Mwenda K, Onda A, Rees J, Onega T, Gui J, Karagas M, Demidenko E, Moeschler J. Mapping disease at an approximated individual level using aggregate data: a case study of mapping New Hampshire birth defects. International Journal of Environmental Research and Public Health 2013;10(9):4161-4174. R835442 (2016)
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  • Journal Article Shi X, Ayotte JD, Onda A, Miller S, Rees J, Gilbert-Diamond D, Onega T, Gui J, Karagas M, Moeschler J. Geospatial association between adverse birth outcomes and arsenic in groundwater in New Hampshire, USA. Environmental Geochemistry and Health 2015;37(2):333-351. R835442 (2016)
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  • Journal Article Signes-Pastor AJ, Vioque J, Navarrete-Munoz EM, Carey M, García de la Hera M, Sunyer J, Casas M, Riano-Galan I, Tardon A, Llop S, Amoros R, Amiano P, Bilbao JR, Karagas MR, Meharg AA. Concentrations of urinary arsenic species in relation to rice and seafood consumption among children living in Spain. Environmental Research 2017;159:69-75. R835442 (2018)
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  • Journal Article Signes-Pastor AJ, Cottingham KL, Carey M, Sayarath V, Palys T, Meharg AA, Folt CL, Karagas MR. Infants' dietary arsenic exposure during transition to solid food. Scientific Reports 2018;8(1):7114 (8 pp.). R835442 (2018)
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  • Journal Article Sverrisson EF, Zens MS, Fei DL, Andrews A, Schned A, Robbins D, Kelsey KT, Li H, DiRenzo J, Karagas MR, Seigne JD. Clinicopathological correlates of Gli1 expression in a population-based cohort of patients with newly diagnosed bladder cancer. Urologic Oncology 2014;32(5):539-545. R835442 (2015)
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  • Journal Article Carignan CC, Punshon T, Karagas MR, Cottingham KL. Potential exposure to arsenic from infant rice cereal. Annals of Global Health 2016;82(1):221-224. R835442 (2017)
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  • Journal Article Karagas MR, Punshon T, Sayarath V, Jackson BP, Folt CL, Cottingham KL. Association of rice and rice product consumption with arsenic exposure early in life. JAMA Pediatrics 2016;170(6):609-616. R835442 (2017)
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  • Journal Article Fried D, Rhyu J, Odata KB, Blunt HB, Karagas MR, Gilbert-Diamond D. Maternal and cord blood vitamin D status and childhood infection and allergic disease: a systematic review. Nutrition Reviews 2016;74(6);387-410. R835442 (2017)
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  • Journal Article Everson TM, Armstrong DA, Jackson BP, Green BB, Karagas MR, Marsit CJ. Maternal cadmium, placental PCDHAC1, and fetal development. Reproductive Toxicology 2016;65:263-271. R835442 (2017)
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  • Journal Article Appleton AA, Jackson BP, Karagas M, Marsit CJ. Prenatal exposure to neurotoxic metals is associated with increased placental glucocorticoid receptor DNA methylation. Epigenetics 2017;12(8):607-615. R835442 (2017)
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  • Journal Article Cubadda F, Jackson BP, Cottingham KL, Van Horne YO, Kurzius-Spencer M. Human exposure to dietary inorganic arsenic and other arsenic species:State of knowledge, gaps and uncertainties. Science of the Total Environment 2017;579:1228-1239. R835442 (2017)
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  • Journal Article Deyssenroth MA, Peng S, Hao K, Lambertini L, Marsit CJ, Chen J. Whole-transcriptome analysis delineates the human placenta gene network and its associations with fetal growth. BMC Genomics 2017;18(1):520. R835442 (2017)
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  • Journal Article Rokoff LB, Koutrakis P, Garshick E, Karagas MR, Oken E, Gold DR, Fleisch AF. Wood stove pollution in the developed world: a case to raise awareness among pediatricians. Current Problems in Pediatric and Adolescent Health Care 2017;47(6):123-141. R835442 (2017)
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  • Journal Article Nachman KE, Ginsberg GL, Miller MD, Murray CJ, Nigra AE, Pendergrast CB. Mitigating dietary arsenic exposure: current status in the United States and recommendations for an improved path forward. Science of the Total Environment 2017;581-582:221-236. R835442 (2017)
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  • Journal Article Punshon T, Jackson BP, Meharg AA, Warczack T, Scheckel K, Guerinot ML. Understanding arsenic dynamics in agronomic systems to predict and prevent uptake by crop plants. Science of the Total Environment 2017;581-582:209-220. R835442 (2017)
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  • Journal Article Bulka CM, Davis MA, Karagas MR, Ahsan H, Argos M. The Unintended Consequences of a Gluten-Free Diet. Epidemiology 2017;28(3):e24-e25. R835442 (2017)
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  • Relevant Websites:

    Children's Environmental Health and Disease Prevention Research Center at Dartmouth Exit

    Progress and Final Reports:

    Original Abstract
  • 2014 Progress Report
  • 2015 Progress Report
  • 2017 Progress Report
  • 2018 Progress Report