Children's Environmental Health & Disease Prevention Research Center at Dartmouth

EPA Grant Number: R835442
Center: Children's Environmental Health and Disease Prevention Center - Dartmouth College 2013
Center Director: Karagas, Margaret Rita
Title: Children's Environmental Health & Disease Prevention Research Center at Dartmouth
Investigators: Karagas, Margaret Rita
Institution: Dartmouth College
EPA Project Officer: Louie, Nica
Project Period: July 1, 2013 through June 30, 2018
Project Amount: $4,060,713
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2012) RFA Text |  Recipients Lists
Research Category: Children's Health , Health

Objective:

Dartmouth is to fill critical gaps in our understanding of the role of drinking water and food borne exposure to arsenic (As) and potentially other contaminants in child growth, development and immune response. The Center will support multidisciplinary teams and innovative new technologies that are essential for conducting this research. It will support training and development of talented new investigators, including a Faculty Development Investigator and 3 other early career investigators, and will expedite connections among health care and public health providers, parents, caregivers and other key stakeholders to effectively reduce risk of environmental threats to children's health. To accomplish these goals, the Center comprises an interdisciplinary team of scientists committed to advancing knowledge through three interwoven studies and two integrative cores. Project 1 builds on an ongoing cohort study of pregnant women who use private wells in New Hampshire (NH). Offspring of these women will be evaluated for occurrence of infections, allergies/atopy and vaccine response in the first years of life. Effects of As on the developing microbiome also will be explored. Project 2 will investigate the contribution of diet to early childhood exposure to As. By quantifying all routes of exposure, the impact of As on children's growth and neurodevelopment will be assessed. Project 3 uses advanced techniques to examine epigenetic and gene expression alterations in the placenta in relation to As exposure and health outcomes. The Center leverages Dartmouth's strong institutional support and unique strengths in quantitative biomedical sciences, clinical biomedical informatics, trace element analysis, and genomic medicine. Critical research and translational activities will be integrated through the Administrative, Career Development and Research Integration Core and Community Outreach and Translation Core. Members include 10 health care providers (9 physicians and 1 nurse) who will be brought together by the Child Health Specialist. High-risk features associated with water sources in New Hampshire underscore the need to advance research in this area and to establish a comprehensive Center focused on emerging issues of potential concern to children globally. Establishing a Children's Environmental Health and Disease Prevention Research Center at Dartmouth will expedite research and translation of new discoveries into practice change and public health interventions, support cross disciplinary opportunities and innovative, impactful investigations, and promote careers of a new generation of investigators in children's environmental health research.


Journal Articles: 73 Displayed | Download in RIS Format

Other center views: All 125 publications 73 publications in selected types All 73 journal articles
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Journal Article Appleton AA, Lester BM, Armstrong DA, Lesseur C, Marsit CJ. Examining the joint contribution of placental NR3C1 and HSD11B2 methylation for infant neurobehavior. Psychoneuroendocrinology 2015;52:32-42. R835442 (2015)
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  • Journal Article Armstrong DA, Lesseur C, Conradt E, Lester BM, Marsit CJ. Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research. FASEB Journal 2014;28(5):2088-2097. R835442 (2014)
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  • Journal Article Banister CE, Koestler DC, Maccani MA, Padbury JF, Houseman EA, Marsit CJ. Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas. Epigenetics 2011;6(7):920-927. R835442 (2014)
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  • Journal Article Beane Freeman LE, Karagas MR, Baris D, Schwenn M, Johnson AT, Colt JS, Jackson B, Hosain GM, Cantor KP, Silverman DT. Is the inverse association between selenium and bladder cancer due to confounding by smoking? American Journal of Epidemiology 2015;181(7):488-495. R835442 (2015)
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  • Journal Article Cardenas A, Koestler DC, Houseman EA, Jackson BP, Kile ML, Karagas MR, Marsit CJ. Differential DNA methylation in umbilical cord blood of infants exposed to mercury and arsenic in utero. Epigenetics 2015;10(6):508-515. R835442 (2015)
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  • Journal Article Carignan CC, Cottingham KL, Jackson BP, Farzan SF, Gandolfi AJ, Punshon T, Folt CL, Karagas MR. Estimated exposure to arsenic in breastfed and formula-fed infants in a United States cohort. Environmental Health Perspectives 2015;123(5):500-506. R835442 (2015)
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  • Journal Article Chen Y, Karagas MR. Arsenic and cardiovascular disease: new evidence from the United States. Annals of Internal Medicine 2013;159(10):713-714. R835442 (2014)
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  • Journal Article Cottingham KL, Karimi R, Gruber JF, Zens MS, Sayarath V, Folt CL, Punshon T, Morris JS, Karagas MR. Diet and toenail arsenic concentrations in a New Hampshire population with arsenic-containing water. Nutrition Journal 2013;12:149. R835442 (2014)
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  • Journal Article Davis MA, Gilbert-Diamond D, Karagas MR, Li Z, Moore JH, Williams SM, Frost HR. A dietary-wide association study (DWAS) of environmental metal exposure in US children and adults. PLoS One 2014;9(9):e104768. R835442 (2015)
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  • Journal Article Davis MA, Li Z, Gilbert-Diamond D, Mackenzie TA, Cottingham KL, Jackson BP, Lee JS, Baker ER, Marsit CJ, Karagas MR. Infant toenails as a biomarker of in utero arsenic exposure. Journal of Exposure Science & Environmental Epidemiology 2014;24(5):467-473. R835442 (2015)
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  • Journal Article Davis MA, Higgins J, Li Z, Gilbert-Diamond D, Baker ER, Das A, Karagas MR. Preliminary analysis of in utero low-level arsenic exposure and fetal growth using biometric measurements extracted from fetal ultrasound reports. Environmental Health 2015;14:12 (11 pp.). R835442 (2015)
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  • Journal Article Emond JA, Gilbert-Diamond D, Tanski SE, Sargent JD. Energy drink consumption and the risk of alcohol use disorder among a national sample of adolescents and young adults. Journal of Pediatrics 2014;165(6):1194-1200. R835442 (2015)
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  • Journal Article Emond JA, Sargent JD, Gilbert-Diamond D. Patterns of energy drink advertising over US television networks. Journal of Nutrition Education and Behavior 2015;47(2):120-126.e1. R835442 (2015)
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  • Journal Article Farzan SF, Chen Y, Wu F, Jiang J, Liu M, Baker E, Korrick SA, Karagas MR. Blood pressure changes in relation to arsenic exposure in a U.S. pregnancy cohort. Environmental Health Perspectives 2015;123(10):999-1006. R835442 (2015)
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  • Journal Article Farzan SF, Chen Y, Rees JR, Zens MS, Karagas MR. Risk of death from cardiovascular disease associated with low-level arsenic exposure among long-term smokers in a US population-based study. Toxicology and Applied Pharmacology 2015;287(2):93-97. R835442 (2015)
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  • Journal Article Fei DL, Koestler DC, Li Z, Giambelli C, Sanchez-Mejias A, Gosse JA, Marsit CJ, Karagas MR, Robbins DJ. Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study. Environmental Health 2013;12:58 (8 pp.). R835442 (2014)
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  • Journal Article Gilbert-Diamond D, Li Z, Adachi-Mejia AM, McClure AC, Sargent JD. Association of a television in the bedroom with increased adiposity gain in a nationally representative sample of children and adolescents. JAMA Pediatrics 2014;168(5):427-434. R835442 (2014)
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  • Journal Article Gossai A, Lesseur C, Farzan S, Marsit C, Karagas MR, Gilbert-Diamond D. Association between maternal urinary arsenic species and infant cord blood leptin levels in a New Hampshire Pregnancy Cohort. Environmental Research 2015;136:180-186. R835442 (2015)
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  • Journal Article Green BB, Armstrong DA, Lesseur C, Paquette AG, Guerin DJ, Kwan LE, Marsit CJ. The role of placental 11-beta hydroxysteroid dehydrogenase type 1 and type 2 methylation on gene expression and infant birth weight. Biology of Reproduction 2015;92(6):149 (8 pp.). R835442 (2015)
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  • Journal Article Hoen AG, Li J, Moulton LA, O'Toole GA, Housman ML, Koestler DC, Guill MF, Moore JH, Hibberd PL, Morrison HG, Sogin ML, Karagas MR, Madan JC. Associations between gut microbial colonization in early life and respiratory outcomes in cystic fibrosis. Journal of Pediatrics 2015;167(1):138-147.e1-3. R835442 (2015)
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  • Journal Article Houseman EA, Kelsey KT, Wiencke JK, Marsit CJ. Cell-composition effects in the analysis of DNA methylation array data:a mathematical perspective. BMC Bioinformatics 2015;16(1):95 (16 pp.). R835442 (2016)
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  • Journal Article Jackson BP. Fast ion chromatography-ICP-QQQ for arsenic speciation. Journal of Analytical Atomic Spectrometry 2015;30(6):1405-1407. R835442 (2015)
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  • Journal Article Jackson BP, Punshon T. Recent advances in the measurement of arsenic, cadmium, and mercury in rice and other foods. Current Environmental Health Reports 2015;2(1):15-24. R835442 (2015)
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  • Journal Article Jackson BP, Liba A, Nelson J. Advantages of reaction cell ICP-MS on doubly charged interferences for arsenic and selenium analysis in foods. Journal of Analytical Atomic Spectrometry 2015;30(5):1179-1183. R835442 (2015)
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  • Journal Article Karagas MR, Zens MS, Li Z, Stukel TA, Perry AE, Gilbert-Diamond D, Sayarath V, Stephenson RS, Barton D, Nelson HH, Spencer SK. Early-onset basal cell carcinoma and indoor tanning: a population-based study. Pediatrics 2014;134(1):e4-e12. R835442 (2015)
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  • Journal Article Karagas MR, Gossai A, Pierce B, Ahsan H. Drinking water arsenic contamination, skin lesions and malignancies: a systematic review of the global evidence. Current Environmental Health Reports 2015;2(1):52-68. R835442 (2015)
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  • Journal Article Koestler DC, Avissar-Whiting M, Houseman EA, Karagas MR, Marsit CJ. Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero. Environmental Health Perspectives 2013;121(8):971-977. R835442 (2014)
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  • Journal Article Lansigan RK, Emond JA, Gilbert-Diamond D. Understanding eating in the absence of hunger among young children: a systematic review of existing studies. Appetite 2015;85:36-47. R835442 (2015)
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  • Journal Article Lesseur C, Armstrong DA, Murphy MA, Appleton AA, Koestler DC, Paquette AG, Lester BM, Marsit CJ. Sex-specific associations between placental leptin promoter DNA methylation and infant neurobehavior. Psychoneuroendocrinology 2014;40:1-9. R835442 (2014)
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  • Journal Article Lesseur C, Paquette AG, Marsit CJ. Epigenetic regulation of infant neurobehavioral outcomes. Medical Epigenetics 2014;2(2):71-79. R835442 (2015)
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  • Journal Article Maccani JZ, Koestler DC, Houseman EA, Marsit CJ, Kelsey KT. Placental DNA methylation alterations associated with maternal tobacco smoking at the RUNX3 gene are also associated with gestational age. Epigenomics 2013;5(6):619-630. R835442 (2014)
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  • Journal Article Maccani JZ, Koestler DC, Houseman EA, Armstrong DA, Marsit CJ, Kelsey KT. DNA methylation changes in the placenta are associated with fetal manganese exposure. Reproductive Toxicology 2015;57:43-49. R835442 (2016)
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  • Journal Article Maccani JZJ, Koestler DC, Lester B, Houseman EA, Armstrong DA, Kelsey KT, Marsit CJ. Placental DNA methylation related to both infant toenail mercury and adverse neurobehavioral outcomes. Environmental Health Perspectives 2015;123(7):723-729. R835442 (2015)
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  • Journal Article Marsit CJ, Brummel SS, Kacanek D, Seage III GR, Spector SA, Armstrong DA, Lester BM, Rich K, Pediatric HIV/AIDS Cohort Studies Network. Infant peripheral blood repetitive element hypomethylation associated with antiretroviral therapy in utero. Epigenetics 2015;10(8):708-716. R835442 (2015)
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  • Journal Article Marsit CJ. Influence of environmental exposure on human epigenetic regulation. Journal of Experimental Biology 2015;218(Pt 1):71-79. R835442 (2015)
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  • Journal Article Marsit CJ. Placental epigenetics in children’s environmental health. Seminars in Reproductive Medicine 2016;34(1):36-41. R835442 (2016)
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  • Journal Article Nadeau KC, Li Z, Farzan S, Koestler D, Robbins D, Fei DL, Malipatlolla M, Maecker H, Enelow R, Korrick S, Karagas MR. In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort. Clinical Immunology 2014;155(2):188-197. R835442 (2015)
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  • Journal Article Paquette AG, Lester BM, Koestler DC, Lesseur C, Armstrong DA, Marsit CJ. Placental FKBP5 genetic and epigenetic variation is associated with infant neurobehavioral outcomes in the RICHS cohort. PLoS One 2014;9(8):e104913 (10 pp.). R835442 (2015)
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  • Journal Article Paquette AG, Marsit CJ. The developmental basis of epigenetic regulation of HTR2A and psychiatric outcomes. Journal of Cellular Biochemistry 2014;115(12):2065-2072. R835442 (2015)
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  • Journal Article Pearce N, Blair A, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli AA, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, Cardis E, Cherrie JW, Christiani DC, Cocco P, Coggon D, Comba P, Demers PA, Dement JM, Douwes J, Eisen EA, Engel LS, Fenske RA, Fleming LE, Fletcher T, Fontham E, Forastiere F, Frentzel-Beyme R, Fritschi L, Gerin M, Goldberg M, Grandjean P, Grimsrud TK, Gustavsson P, Haines A, Hartge P, Hansen J, Hauptmann M, Heederik D, Hemminki K, Hemon D, Hertz-Picciotto I, Hoppin JA, Huff J, Jarvholm B, Kang D, Karagas MR, Kjaerheim K, Kjuus H, Kogevinas M, Kriebel D, Kristensen P, Kromhout H, Laden F, Lebailly P, LeMasters G, Lubin JH, Lynch CF, Lynge E, 't Mannetje F, McMichael AJ, Mclaughlin JR, Marrett L, Martuzzi M, Merchant JA, Merler E, Merletti F, Miller A, Mirer FE, Monson R, Nordby K-C, Olshan AF, Parent M-E, Perera FP, Perry MJ, Pesatori AC, Pirastu R, Porta M, Pukkala E, Rice C, Richardson DB, Ritter L, Ritz B, Ronckers CM, Rushton L, Rusiecki JA, Rusyn I, Samet JM, Sandler DP, de Sanjose S, Schernhammer E, Costantini AS, Seixas N, Shy C, Siemiatycki J, Silverman DT, Simonato L,Smith AH, Smith MT, Spinelli JJ, Spitz MR, Stallones L, Stayner LT, Steenland K, Stenzel M, Stewart BW, Stewart PA, Symanski E, Terracini B, Tolbert PE, Vainio H, Vena J, Vermeulen R, Victora CG, Ward EM, Weinberg CR, Weisenburger D, Wesseling C, Weiderpass E, Zahm SH. IARC Monographs: 40 years of evaluating carcinogenic hazards to humans. Environmental Health Perspectives 2015;123(6):507-514. R835442 (2015)
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  • Journal Article Punshon T, Chen S, Finney L, Howard L, Jackson BP, Karagas MR, Ornvold K. High-resolution elemental mapping of human placental chorionic villi using synchrotron X-ray fluorescence spectroscopy. Analytical and Bioanalytical Chemistry 2015;407(22):6839-6850. R835442 (2015)
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  • Journal Article Romano ME, Webster GM, Vuong AM, Zoeller RT, Chen A, Hoofnagle AN, Calafat AM, Karagas MR, Yolton K, Lanphear BP, Braun JM. Gestational urinary bisphenol A and maternal and newborn thyroid hormone concentrations: the HOME Study. Environmental Research 2015;138:453-460. R835442 (2015)
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  • Journal Article Rothenberg SE, Korrick SA, Fayad R. The influence of obesity on blood mercury levels for U.S. non-pregnant adults and children: NHANES 2007-2010. Environmental Research 2015;138:173-180. R835442 (2015)
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  • Journal Article Shi X, Miller S, Mwenda K, Onda A, Rees J, Onega T, Gui J, Karagas M, Demidenko E, Moeschler J. Mapping disease at an approximated individual level using aggregate data: a case study of mapping New Hampshire birth defects. International Journal of Environmental Research and Public Health 2013;10(9):4161-4174. R835442 (2016)
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  • Journal Article Shi X, Ayotte JD, Onda A, Miller S, Rees J, Gilbert-Diamond D, Onega T, Gui J, Karagas M, Moeschler J. Geospatial association between adverse birth outcomes and arsenic in groundwater in New Hampshire, USA. Environmental Geochemistry and Health 2015;37(2):333-351. R835442 (2016)
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  • Journal Article Sverrisson EF, Zens MS, Fei DL, Andrews A, Schned A, Robbins D, Kelsey KT, Li H, DiRenzo J, Karagas MR, Seigne JD. Clinicopathological correlates of Gli1 expression in a population-based cohort of patients with newly diagnosed bladder cancer. Urologic Oncology 2014;32(5):539-545. R835442 (2015)
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  • Journal Article Armstrong DA, Green BB, Blair BA, Guerin DJ, Litzky JF, Chavan NR, Pearson KJ, Marsit CJ. Maternal Smoking During Pregnancy is Associated with Mitochondrial DNA Methylation. Environmental Epigenetics 2016, 2(3):dvw020. (PMID In Process) (https://academic.oup.com/eep/article/2415103). R835442 (2017)
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    Journal Article Thompson JA, Marsit CJ. A methylation-to-expression feature model for generating accurate prognostic risk scores and identifying diease targets in clear cell kidney cancer. Pac Symp Biocomput. 2016;22:509-520. PMID:27897002 PMCID:PMC5177986 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC5177986). R835442 (2017)
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    Journal Article Davis MA, Signes-Pastor AJ, Argos M, Slaughter F, Pendergrast C, Punshon T, Gossai A, Ahsan H, Karagas MR. Assessment of human dietary exposure to arsenic through rice. Sci Total Environ. 2017 May 15;586:1237-1244. PMID:28233618 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=28233618). R835442 (2017)
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    Journal Article Karagas MR, Punshon T, Sayarath V, Jackson BP, Folt CL, Cottingham KL. Association of rice and rice product consumption with arsenic exposure early in life. JAMA Pediatrics. 2016 Jun 1; 170(6):609-16. PMID:27111102 PMCID:PMC5215769 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC5215769). R835442 (2017)
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    Journal Article Singh S, Karagas MR, Mueller NT. Charting the Maternal and Infant Microbiome:What Is the Role of Diabetes and Obesity in Pregnancy? Curr Diab Rep. 2017 Feb;17(2):11. PMID:28176229 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=28176229). R835442 (2017)
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    Journal Article Nygaard UC, Li Z, Palys T, Jackson B, Subbiah M, Malipatlolla M, Sampath V, Maecker H, Karagas MR, Nadeau KC. Cord blood T cell subpopulations and associations with maternal cadmium and arsenic exposures. PLoS One. 2017 Jun 29;12(6):e0179606. doi:10.1371/journal.pone.0179606. eCollection 2017. PMID:28662050 PMCID:PMC5491028 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC5491028). R835442 (2017)
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    Journal Article Taylor VF, Li Z, Sayarath V, Palys TJ, Morse KR, Scholz-Bright RA, Karagas MR. Distinct arsenic metabolites following seaweed consumption in humans. Sci Rep. 2017 Jun 20;7(1):3920. doi:10.1038/s41598-017-03883-7. PMID:28634348 PMCID:PMC5478658 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC5478658). R835442 (2017)
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    Journal Article Chernikova DA, Koestler DC, Hoen AG, Housman ML, Hibberd PL, Moore JH, Morrison HG, Sogin ML, Zain-Ul-Abideen M, Madan JC. Fetal exposures and perinatal influences on the stool microbiota of premature infants. J Matern Fetal Neonatal Med. 2016;29(1):99-105. doi:10.3109/14767058.2014.987748. PMID:25394613 PMCID:PMC4476945 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC4476945). R835442 (2017)
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    Journal Article Kaushal A, Zhang H, Karmaus WJJ, Everson TM, Marsit CJ, Karagas MR, Tsai SF, Wen HJ, Wang SL. Genome-wide DNA methylation at birth in relation to in utero arsenic exposure and the associated health in later life. Environ Health. 2017 May 30;16(1):50. doi:10.1186/s12940-017-0262-0. PMID:28558807 PMCID:PMC5450181 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC5450181). R835442 (2017)
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    Journal Article Taylor V, Goodale B, Raab A, Schwerdtle T, Reimer K, Conklin S, Karagas MR, Francesconi KA. Human Exposure to Organic Arsenic Species from Seafood. Sci Total Environ. 2017 Feb 15;580:266-282. doi:10.1016/j.scitotenv.2016.12.113. Epub 2016 Dec 24. PMID:28024743 PMCID:PMC5326596 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC5326596). R835442 (2017)
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    Journal Article Cubadda F, Jackson BP, Cottingham KL, Van Horne YO, Kurzius-Spencer M. Human exposure to dietary inorganic arsenic and other arsenic species:State of knowledge, gaps and uncertainties. Sci Total Environ. 2017 Feb 1;579:1228-1239. doi:10.1016/j.scitotenv.2016.11.108. Epub 2016 Nov 30. PMID:27914647 PMCID:PMC5207036 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC5207036). R835442 (2017)
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    Journal Article Grandjean P, Barouki R, Bellinger DC, Casteleyn L, Chadwick LH, Cordier S, Etzel RA, Gray KA, Ha EH, Junien C, Karagas M, Kawamoto T, Paige Lawrence B, Perera FP, Prins GS, Puga A, Rosenfeld CS, Sherr DH, Sly PD, Suk W, Sun Q, Toppari J, van den Hazel P, Walker CL, Heindel JJ. Life-Long Implications of Developmental Exposure to Environmental Stressors:New Perspectives. Endocrinology. 2015 Oct;156(10):3408-15. doi:10.1210/EN.2015-1350. PMCID:PMC4588822 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC4588822). R835442 (2017)
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    Journal Article Fried D, Rhyu J, Odata KB, Blunt HB, Karagas MR, Gilbert-Diamond D. Maternal and cord blood vitamin D status and childhood infection and allergic disease:a systematic review. Nutrition Reviews. 2016 Jun;74(6);387-410. pii:nuv108. PMID:27083486. PMCID:PMC4892299. (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC4892299). R835442 (2017)
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    Journal Article Farzan SF, Brickley EB, Li Z, Gilbert-Diamond D, Gossai A, Chen Y, Howe CG, Palys T, Karagas MR. Maternal and infant inflammatory markers in relation to prenatal arsenic exposure in a U.S. pregnancy cohort. Environ Res. 2017 Jul;156:426-433. doi:10.1016/j.envres.2017.03.056. Epub 2017 Apr 12. PMID:28410520 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=28410520). R835442 (2017)
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    Journal Article Everson TM, Armstrong DA, Jackson BP, Green BB, Karagas MR, Marsit CJ. Maternal cadmium, placental PCDHAC1, and fetal development. Reprod Toxicol 2016 Oct;65:263-271. PMID:27544570. PMCID:PMC5226342 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC5226342). R835442 (2017)
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    Journal Article Everson TM, Kappil M, Hao K, Jackson BP, Punshon T, Karagas MR, Chen J, Marsit CJ. Maternal exposure to selenium and cadmium, fetal growth, and placental expression of steroidogenic and apoptotic genes. Environ Res. 2017 Jun 26;158:233-244. doi:10.1016/j.envres.2017.06.016. [Epub ahead of print] PMID:28662449 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=28662449). R835442 (2017)
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    Journal Article Nachman KE, Ginsberg GL, Miller MD, Murray CJ, Nigra AE, Pendergrast CB. Mitigating dietary arsenic exposure:Current status in the United States and recommendations for an improved path forward. Sci Total Environ. 2017 Mar 1;581-582:221-236. doi:10.1016/j.scitotenv.2016.12.112. PMID:28065543 PMCID:PMC5303536 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC5303536). R835442 (2017)
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    Journal Article Carignan CC, Punshon T, Karagas MR, Cottingham KL. Potential exposure to arsenic from infant rice cereal. 2016 Jan-Feb;82(1):221-4. Annals of Global Health. PMID:27325082 PMCID:PMC5179225 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC5179225). R835442 (2017)
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    Journal Article Appleton AA, Jackson BP, Karagas M, Marsit CJ. Prenatal exposure to neurotoxic metals is associated with increased placental glucocorticoid receptor DNA methylation. Epigenetics. 2017 May 26:0. doi:10.1080/15592294.2017.1320637. [Epub ahead of print] PMID:28548590 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=28548590). R835442 (2017)
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    Journal Article Houseman EA, Kile M, Christiani D, Tan I, Kelsey KT, Marsit CJ. Reference-free deconvolution of DNA methylation data and mediation by cell composition effects. BMC Bioinformatics 2016, 17:259. PMID:27358049 PMCID:PMC4928286 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC4928286). R835442 (2017)
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    Journal Article Martin E, Smeester L, Bommarito PA, Grace MR, Boggess K, Kuban K, Karagas MR, Marsit CJ, O'Shea TM, Fry RC. Sexual epigenetic dimorphism in the human placenta:implications for susceptibility during the prenatal period. Epigenomics. 2017 Mar;9(3):267-278. PMID:28234023 PMCID:PMC5331919 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC5331919). R835442 (2017)
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    Journal Article Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SK. Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies:The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environ Health Perspect. 2017 Apr;125(4):511-526. doi:10.1289/EHP595. PMID:28362264 PMCID:PMC5382002 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC5382002). R835442 (2017)
    RD834515 (Final)
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    Journal Article Bulka CM, Davis MA, Karagas MR, Ahsan H, Argos M. The Unintended Consequences of a Gluten-Free Diet. Epidemiology. 2017 May;28(3):e24-e25. PMID:28166100 PMCID:PMC5429976 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC5429976). R835442 (2017)
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    Journal Article Winterbottom EF, Koestler DC, Fei DL, Wika E, Capobianco AJ, Marsit CJ, Karagas MR, Robbins DJ. The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression. Environ Health 2017 Jun 14;16(1):59. PMID:28615018 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=28615018). R835442 (2017)
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    Journal Article Punshon T, Jackson BP, Meharg AA, Warczack T, Scheckel K, Guerinot ML. Understanding arsenic dynamics in agronomic systems to predict and prevent uptake by crop plants. Sci Total Environ. 2017 Mar 1;581-582:209-220. doi:10.1016/j.scitotenv.2016.12.111. PMID:28043702 PMCID:PMC5303541 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC5303541). R835442 (2017)
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    Journal Article Deyssenroth MA, Peng S, Hao K, Lambertini L, Marsit CJ, Chen J. Whole-transcriptome analysis delineates the human placenta gene network and its associations with fetal growth. BMC Genomics 2017 Jul 10;18(1):520. PMID:28693416 PMCID:PMC5502484 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=PMC5502484). R835442 (2017)
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    Journal Article Rokoff LB, Koutrakis P, Garshick E, Karagas MR, Oken E, Gold DR, Fleisch AF. Wood Stove Pollution in the Developed World:A Case to Raise Awareness Among Pediatricians. Curr Probl Pediatr Adolesc Health Care. 2017 Jun;47(6):123-141. doi:10.1016/j.cppeds.2017.04.001. Epub 2017 Jun 2. PMID:28583817 (https://www-ncbi-nlm-nih-gov.dartmouth.idm.oclc.org/pubmed/?term=28583817). R835442 (2017)
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    Progress and Final Reports:

    2014 Progress Report
    2015 Progress Report
    2016 Progress Report
    2017 Progress Report