The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center

EPA Grant Number: R835433
Center: The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center
Center Director: Woodruff, Tracey J.
Title: The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center
Investigators: Woodruff, Tracey J.
Institution: University of California - San Francisco
EPA Project Officer: Louie, Nica
Project Period: June 1, 2013 through May 31, 2018
Project Amount: $3,312,848
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2012) RFA Text |  Recipients Lists
Research Category: Children's Health , Health

Objective:

The UCSF Pregnancy Exposures to Environmental Chemicals Children's Center will advance scientific and public understanding of how environmental chemicals affect the seminal early stages of human in utero development, which could manifest as adverse effects on children's health. We are testing the hypothesis that the mechanisms include damage to the placenta—which governs in utero programming, birth weight and consequently, childhood health—and that these effects are exacerbated by social stress. The approach integrates our unique capacity to systematically measure environmental chemicals during mid-pregnancy with our well-developed in vitro and in vivo systems for understanding the consequences of these exposures. Thus, we propose a generalizable, multi-disciplinary experimental strategy that could be used to study the impact of a wide array of environmental chemicals on prenatal human development. We have chosen to focus on polybrominated diphenyl ethers (PBDEs) and perfluorinated chemicals (PFCs). These compounds, which are found in virtually all pregnant US women, are implicated in endocrine disruption, placental pathologies and adverse birth outcomes. Project 1 will use basic science approaches and a novel in vitro model of human placentation to study the effects of these chemicals on trophoblasts—the basic building blocks of this organ—at transcriptomic, epigenomic and functional levels. Project 2 joins exposure science with placental biology. The Investigators will use targeted and non-targeted biomonitoring approaches to generate new data on human maternal and fetal exposures to PBDEs, PFCs and chemicals that are being measured for the first time during the second trimester. Then the relationship between these exposures and morphological and molecular markers of placental development will be evaluated to determine possible associations. Project 3 will evaluate the cumulative effects of prenatal PBDE and PFC exposures and chronic psychosocial stress on fetal growth in a diverse population of pregnant women. The investigators will employ innovative approaches for measuring psychosocial stress, including geocoded neighborhood measures of the social environment and interviews to assess participants' perceived stress and social standing. Biological assays—telomere length and hormone levels—will be used to measure maternal and fetal stress responses. The experimental design of this Center is highly interactive. We will determine if the novel PBDE and PFC targets that are discovered in Project 1 are misexpressed in the placental samples collected by Project 2. Project 3 will assess chemical effects on fetal growth with priority placed on the PFC and PBDE congeners identified as having strong adverse placental effects in Projects 1 and 2. Finally, Investigators on all the Projects will work with the Clinical Outreach and Translation Core to disseminate study results to key audiences in the clinical and policy arenas. The goal is to reduce the lag time between scientific discovery and prevention of harmful exposures during pregnancy, thus promoting child health.


Journal Articles: 23 Displayed | Download in RIS Format

Other center views: All 45 publications 27 publications in selected types All 23 journal articles
Type Citation Sub Project Document Sources
Journal Article Di Renzo GC, Conry JA, Blake J, DeFrancesco MS, DeNicola N, Martin Jr. JN, McCue KA, Richmond D, Shah A, Sutton P, Woodruff TJ, van der Poel SZ, Giudice LC. International Federation of Gynecology and Obstetrics opinion on reproductive health impacts of exposure to toxic environmental chemicals. International Journal of Gynaecology and Obstetrics 2015;131(3):219-225. R835433 (2015)
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  • Journal Article Gerona RR, Pan J, Zota AR, Schwartz JM, Friesen M, Taylor JA, Hunt PA, Woodruff TJ. Direct measurement of bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: a cross-sectional study. Environmental Health 2016;15:50. R835433 (2015)
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  • Journal Article Johnson PI, Sutton P, Atchley DS, Koustas E, Lam J, Sen S, Robinson KA, Axelrad DA, Woodruff TJ. The Navigation Guide—evidence-based medicine meets environmental health: systematic review of human evidence for PFOA effects on fetal growth. Environmental Health Perspectives 2014;122(10):1028-1039. R835433 (2014)
    R834678 (Final)
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  • Journal Article Johnson PI, Koustas E, Vesterinen HM, Sutton P, Atchley DS, Kim AN, Campbell M, Donald JM, Sen S, Bero L, Zeise L, Woodruff TJ. Application of the Navigation Guide systematic review methodology to the evidence for developmental and reproductive toxicity of triclosan. Environment International 2016;92-93:716-728. R835433 (2015)
    R835433 (2016)
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  • Journal Article Koustas E, Lam J, Sutton P, Johnson PI, Atchley DS, Sen S, Robinson KA, Axelrad DA, Woodruff TJ. The Navigation Guide—evidence-based medicine meets environmental health: systematic review of nonhuman evidence for PFOA effects on fetal growth. Environmental Health Perspectives 2014;122(10):1015-1027. R835433 (2014)
    R834678 (Final)
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  • Journal Article Lam J, Koustas E, Sutton P, Johnson PI, Atchley DS, Sen S, Robinson KA, Axelrad DA, Woodruff TJ. The Navigation Guide—evidence-based medicine meets environmental health: integration of animal and human evidence for PFOA effects on fetal growth. Environmental Health Perspectives 2014;122(10):1040-1051. R835433 (2014)
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  • Journal Article Morgan RL, Thayer KA, Bero L, Bruce N, Falck-Ytter Y, Ghersi D, Guyatt G, Hooijmans C, Langendam M, Mandrioli D, Mustafa RA, Rehfuess EA, Rooney AA, Shea B, Silbergeld EK, Sutton P, Wolfe MS, Woodruff TJ, Verbeek JH, Holloway AC, Santesso N, Schunemann HJ. GRADE: assessing the quality of evidence in environmental and occupational health. Environment International 2016;92-93:611-616. R835433 (2015)
    R835433 (2016)
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  • Journal Article Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi X, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Naph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M. Integrative analysis of 111 reference human epigenomes. Nature 2015;518(7539):317-330. R835433 (2014)
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  • Journal Article Solomon GM, Morello-Frosch R, Zeise L, Faust JB. Cumulative environmental impacts: science and policy to protect communities. Annual Review of Public Health 2016;37:83-96. R835433 (2015)
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  • Journal Article Stotland NE, Sutton P, Trowbridge J, Atchley DS, Conry J, Trasande L, Gerbert B, Charlesworth A, Woodruff TJ. Counseling patients on preventing prenatal environmental exposures--a mixed-methods study of obstetricians. PLoS ONE 2014;9(6):e98771 (7 pp.). R835433 (2014)
    R834678 (Final)
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  • Journal Article Sutton PM, Giudice LC, Woodruff TJ. Moving from awareness to action on preventing patient exposure to toxic environmental chemicals. American Journal of Obstetrics and Gynecology 2016;214(5):555-558. R835433 (2015)
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  • Journal Article Sutton, P, Woodruff, TJ, Conry, J, Giudice, LC. Exposure to toxic chemicals:reproductive health professionals speak about the first 1,000 days. San Francisco Medicine 2014;87(9):12-13. R835433 (2014)
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  • Journal Article Vandenberg LN, Ågerstrand M, Beronius A, Beausoleil C, Bergman A, Bero LA, Bornehag CG, Boyer CS, Cooper GS, Cotgreave I, Gee D, Grandjean P, Guyton KZ, Hass U, Heindel JJ, Jobling S, Kidd KA, Kortenkamp A, Macleod MR, Martin OV, Norinder U, Scheringer M, Thayer KA, Toppari J, Whaley P, Woodruff TJ, Ruden C. A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals. Environmental Health 2016;15(1):74. R835433 (2015)
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  • Journal Article Vesterinen HM, Johnson PI, Koustas E, Lam J, Sutton P, Woodruff TJ. In support of EHP's proposal to adopt the ARRIVE guidelines. Environmental Health Perspectives 2013;121(11‐12):A325. R835433 (2013)
    R835433 (2014)
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  • Journal Article Wang A, Padula A, Sirota M, Woodruff TJ. Environmental influences on reproductive health: the importance of chemical exposures. Fertility and Sterility 2016;106(4):905-929. R835433 (2016)
    R835643 (2016)
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  • Journal Article Woodruff TJ, Sutton P. The Navigation Guide systematic review methodology: a rigorous and transparent method for translating environmental health science into better health outcomes. Environmental Health Perspectives 2014;122(10):1007-1014. R835433 (2014)
    R834678 (Final)
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  • Journal Article Morello-Frosch R, Cushing LJ, Jesdale BM, Schwartz JM, Guo W, Guo T, Wang M, Harwani S, Petropoulou SE, Duong W, Park J, Petreas MX, Gajek R, Alvaran J, She J, Dobraca D, Das R, Woodruff TJ. Environmental chemicals in an urban population of pregnant women and their newborns from San Francisco. Environmental Science & Technology 2016, October 4 [epub ahead of print]. R835433 (2015)
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  • Journal Article Lam, J., Sutton P, McPartland J, et al. Developmental PBDE Exposure and IQ/ADHD in Childhood:A Systematic Review and Meta-analysis. Environ Health Perspect. 2017 Aug; 125(8). doi:10.1289/EHP1632. R835433 (2016)
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    Journal Article Lam J, Sutton P, Kalkbrenner A, Windham G, Halladay A, Koustas E, Lawler C, Davidson L, Daniels N, Newschaffer C, Woodruff T. A Systematic Review and Meta-Analysis of Multiple Airborne Pollutants and Autism Spectrum Disorder. PLoS One. 2016 Sep 21;11(9):e0161851. doi:10.1371/journal.pone.0161851. PubMed PMID:27653281; PubMed Central PMCID:PMC5031428. R835433 (2016)
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    Journal Article Morello-Frosch R, Cushing LJ, Jesdale BM, Schwartz JM, Guo W, Guo T, Wang M, Harwani S, Syrago-Petropoulou SSE, Duong W, Park J-S, Petreas M, Gajek R, Alvaran J, She J, Dobraca D, Das R, Woodruff TJ (2016) Environmental Chemicals in an Urban Population of Pregnant Women and their Newborns from San Francisco. Environ Sci and Technol DOI:10.1021/acs.est.6b03492. R835433 (2016)
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    Journal Article Environmental Factors in Reproduction. In:Yen and Jaffe’s Reproductive Endocrinology 8th Edition textbook (Sutton P, Zlatnik M, Woodruff TJ and Giudice LC) (in press). R835433 (2016)
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    Journal Article Johnson PI, Sutton P, Koustas E, Vesterinen HM, Woodruff TJ. Response to correspondence by Heather Lynch, Julie Goodman and Nancy Beck Re:"Application of the Navigation Guide systematic review methodology to the evidence for developmental and reproductive toxicity of triclosan". Environ Int. 2017 Feb 21. pii:S0160-4120(17)30231-3. doi:10.1016/j.envint.2017.02.007. [Epub ahead of print] PubMed PMID:28236502. R835433 (2016)
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    Journal Article Robinson JF, Kapidzic M, Gormley M, Ona K, Dent T, Seifikar H, Hamilton EG, Fisher SJ. Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts. Endocrinology. 2017 Jun 1;158(6):1581-1594. doi:10.1210/en.2016-1635. PubMed PMID:28323933. R835433 (2016)
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    Progress and Final Reports:

    2013 Progress Report
    2014 Progress Report
    2015 Progress Report
    2016 Progress Report