UC Berkeley/Stanford Children's Environmental Health Center

EPA Grant Number: RD835435
Center: UC Berkeley/Stanford Children’s Environment Health Center 2013
Center Director: Tager, Ira
Title: UC Berkeley/Stanford Children's Environmental Health Center
Investigators: Hammond, S. Katharine , Balmes, John R. , Shaw, Gary M.
Institution: University of California - Berkeley
EPA Project Officer: Louie, Nica
Project Period: July 1, 2013 through June 30, 2018
Project Amount: $4,765,843
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2012) RFA Text |  Recipients Lists
Research Category: Children's Health , Health

Objective:

The Children's Health and Air Pollution Study in the San Joaquin Va­­lley (CHAPS-SJV) is a direct descendent of the University of California, UC Berkeley/Stanford Children's Environmental Health Center (CEHC Pre-Center) with the same name. Our proposed Center expands to include research colleagues from California State University Fresno and UCSF-Fresno. The proposed CHAPS-SJV CEHC is innovative in terms of the scientific focus, exposure assessment and methods of data analysis. We have four research projects: 1) Exposures to Air Pollutants, Modifying Genes, and Risk of Birth Defects and Preterm Birth; 2) Mechanisms of Polycyclic Aromatic Hydrocarbon-linked immunopathogenesis in Atopy; 3) Obesity/Glucose Dysregulation; and, 4) Transit Exposures in utero.  

Our objectives are to link exposures to air pollutants, particularly polycyclic aromatic hydrocarbons (PAHs), to adverse birth outcomes, regulatory T-cell function and allergic disorders, body weight and fat composition and hemoglobin A1c percentage. Our overarching hypothesis is that inhalational exposure to air pollutants induces oxidative stress which in turn leads to systemic inflammation. Downstream adverse health outcomes can occur throughout childhood and are dependent on both genetic factors and neighborhood contextual factors. In these projects, we will study mechanistic pathways including the potential modifying effects of genes critical in the metabolism of xenobiotics and epigenetic regulation of T-cell function. Extending our work from the P20 [Grant RD834596], we also will evaluate the role of neighborhood and socioeconomic factors as modifiers of the air pollution-adverse health outcome associations. Critical to our proposed work is recruitment of children at multiple age strata, high-quality exposure assessment, and statistical analysis at the cutting edge of an innovative body of causal inference methods. The proposed projects will provide new data on a) the associations between exposures to air pollutants, particularly PAHs, and important health outcomes throughout childhood, from gestation to late adolescence; b) mechanistic pathways by which air pollutants cause adverse outcomes; and c) the modifying role of both genetic and neighborhood contextual factors. The themes of our proposed projects build on our P20 work and the resulting data will allow improved risk assessment in a region characterized by both high air pollution and health disparities related to socioeconomic and minority ethnic status.

Rationale:

The impact of our work stems directly from its innovation. New insights into mechanisms that underlie health effects associated with exposure to ambient pollutants throughout childhood (birth defects and premature birth, allergic diseases, obesity, and diabetes) and the role of neighborhood contextual factors will result from the proposed projects. This information will enable policymakers to formulate regulatory strategies to improve air quality that are targeted to improve children’s health, both in the region of study, the San Joaquin Valley, and the nation as a whole.


Journal Articles: 13 Displayed | Download in RIS Format

Other center views: All 66 publications 13 publications in selected types All 13 journal articles
Type Citation Sub Project Document Sources
Journal Article Cossi M, Zuta S, Padula AM, Gould JB, Stevenson DK, Shaw GM. Role of infant sex in the association between air pollution and preterm birth. Annals of Epidemiology 2015;25(11):874-876. RD835435 (2015)
RD835435 (2016)
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  • Abstract: Annals of Epidemiology-Abstract
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  • Journal Article Hew KM, Walker AI, Kohli A, Garcia M, Syed A, McDonald-Hyman C, Noth EM, Mann JK, Pratt B, Balmes J, Hammond SK, Eisen EA, Nadeau KC. Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells. Clinical & Experimental Allergy 2015;45(1):238-248. RD835435 (2014)
    RD835435 (2015)
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    R834596 (2012)
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    R834596C003 (Final)
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  • Journal Article Lessard LN, Alcala E, Capitman JA. Pollution, poverty, and potentially preventable childhood morbidity in central California. The Journal of Pediatrics 2016;168:198-204. RD835435 (2014)
    RD835435 (2016)
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  • Journal Article Noth EM, Lurmann F, Northcross A, Perrino C, Vaughn D, Hammond K. Spatial and temporal distribution of polycyclic aromatic hydrocarbons and elemental carbon in Bakersfield, California. Air Quality, Atmosphere & Health 2016;9(8):899–908. RD835435 (2016)
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  • Journal Article Padula AM, Mortimer KM, Tager IB, Hammond SK, Lurmann FW, Yang W, Stevenson DK, Shaw GM. Traffic-related air pollution and risk of preterm birth in the San Joaquin Valley of California. Annals of Epidemiology 2014;24(12):888-895e4. RD835435 (2015)
    RD835435 (2016)
    R834596 (2012)
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    R834596C001 (2012)
    R834596C001 (Final)
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  • Journal Article Padula AM, Noth EM, Hammond SK, Lurmann FW, Yang W, Tager IB, Shaw GM. Exposure to airborne polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth. Environmental Research 2014;135:221-226. RD835435 (2014)
    RD835435 (2015)
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  • Journal Article Padula AM, Balmes JR, Eisen EA, Mann J, Noth EM, Lurmann FW, Pratt B, Tager IB, Nadeau K, Hammond SK. Ambient polycyclic aromatic hydrocarbons and pulmonary function in children. Journal of Exposure Science & Environmental Epidemiology 2015;25(3):295-302. RD835435 (2014)
    RD835435 (2015)
    RD835435 (2016)
    R834596 (2012)
    R834596 (Final)
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  • Abstract: Nature Publishing-Abstract
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  • Journal Article Padula AM, Yang W, Carmichael SL, Tager IB, Lurmann FW, Hammond SK, Shaw GM. Air pollution, neighbourhood socioeconomic factors, and neural tube defects in the San Joaquin Valley of California. Paediatric and Perinatal Epidemiology 2015;29(6):536-545. RD835435 (2015)
    RD835435 (2016)
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  • Journal Article Prunicki, M and Nadeau, K. (2016) The Air We Breathe:How Extreme Weather Conditions Harm Us in Extreme Weather, Health, and Communities:Interdisciplinary Engagement, Springer Publishers. RD835435 (2017)
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    Journal Article Prunicki, M., et al., Exposure to NO2, CO, and PM2.5 Is Linked to Regional DNA Methylation Differences in Asthma (submitted). RD835435 (2017)
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    Journal Article Padula AM, Yang W, Carmichael SL, Lurmann F, Balmes J, Hammond K, Shaw GM. Air pollution, neighborhood acculturation factors and neural tube defects among Hispanic women in California. Birth Def Res A 2017;109:403-422. RD835435 (2017)
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    Journal Article Padula AM, Yang W, Schultz K, Lee C, Lurmann F, Hammond SK, Shaw GM. Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida. (submitted). RD835435 (2017)
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    Journal Article Zografos, K; Alcala, E; & Capitman, J. Integrating Research Experiences into Public Health Curricula:Effects on Undergraduate Students’ Overall Educational Experience. To be submitted to:Pedagogy in Health Promotion. RD835435 (2017)
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    Supplemental Keywords:

    Air pollution, polycyclic aromatic hydrocarbons, birth defects, premature birth, allergies, asthma, immune function, obesity, diabetes, metabolic syndrome, neighborhood environment, socioeconomic status, health disparities

    Relevant Websites:

    Children’s Health and Air Pollution Study-San Joaquin Valley (CHAPS-SJV) Exit

    Progress and Final Reports:

    2014 Progress Report
    2015 Progress Report
    2016 Progress Report
    2017 Progress Report