Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome

EPA Grant Number: R835436
Center: Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome
Center Director: Peterson, Karen E.
Title: Lifecourse Exposures & Diet: Epigenetics, Maturation & Metabolic Syndrome
Investigators: Peterson, Karen E. , Padmanabhan, Vasantha
Institution: University of Michigan
EPA Project Officer: Louie, Nica
Project Period: June 1, 2013 through May 31, 2018
Project Amount: $3,651,990
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2012) RFA Text |  Recipients Lists
Research Category: Children's Health , Health

Objective:

Endocrine-disrupting chemicals (EDCs) can have adverse impacts on children's physical growth and tempo of maturation and have been related to development of adult chronic conditions, e.g., obesity, type 2 diabetes mellitus and cardiovascular disease. Metabolic syndrome, a constellation of these outcomes, affects up to 25% of US adults and 30% of obese adolescents. Research on developmental origins has focused primarily on early life exposures, with less attention on the role exposures to EDC mixtures during the pubertal transition may play in exacerbating metabolic consequences leading to metabolic syndrome. Research on the effects of maternal prenatal diet on developmental origins of chronic disease has not been well integrated with environmental health research, despite growing evidence that nutrition is a modulator of susceptibility to environmental pollutants through effects on absorption, distribution, and/or toxicity. Hypothesized mechanisms for dietary modulation include down-regulation of signaling pathways involved in the inflammatory response, protection against oxidative stress, and restoration of metabolic homeostasis. Because nutrients may serve as agonists or antagonists of toxic effects of environmental chemicals depending on factors such as dose, more studies are necessary to accurately determine the role it plays in altering the effects of environmental toxicants and the future development of disease. This application aims to understand the mechanisms by which exposure to EDC mixtures (BPA, phthalates, lead, cadmium) interact with diet in utero and peripuberty to impact markers of metabolic homeostasis, oxidative stress and risk of metabolic syndrome.. Capitalizing on two existing human cohorts [Early Life Exposures in Mexico to ENvironmental Toxicants (ELEMENT) and the Michigan Mother-Infant Pairs (MMIP)] and the viable yellow agouti mouse model, the focus of this center is to dissect out the impact of EDC mixtures and its interaction with diet on metabolic health. Research findings will shed light on epigenetic and transcriptional changes leading to changes in growth, maturation and metabolic outcomes, and provide an invaluable base for designing future interventions to reduce the impact of pervasive EDCs on children's health.


Journal Articles: 49 Displayed | Download in RIS Format

Other center views: All 72 publications 53 publications in selected types All 49 journal articles
Type Citation Sub Project Document Sources
Journal Article Baek J, Sancehz BN, Berrocal VJ, Sanchez-Vaznaugh EV. Distributed lag models: examining associations between the built environment and health. Epidemiology 2016;27(1):116-124. R835436 (2016)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract:
    Exit
  • Other: University of Michigan-Abstract
    Exit
  • Journal Article Baek J, Sanchez-Vaznaugh EV, Sanchez BN. Hierarchial distributed-lag models: exploring varying geographic scale and magnitude in associations between built environment and health. American Journal of Epidemiology 2016;183(6):583-592. R835436 (2016)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: OUP-Full Text-HTML
    Exit
  • Abstract: OUP-Abstract
    Exit
  • Other: OUP-Full Text-PDF
    Exit
  • Journal Article Cantonwine DE, Hauser R, Meeker JD. Bisphenol A and human reproductive health. Expert Review of Obstetrics & Gynecology 2013;8(4):329-335. R835436 (2014)
    R835436 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Taylor & Francis-Abstract
    Exit
  • Journal Article Cantoral A, Tellez-Rojo MM, Levy TS, Hernandez-Avila M, Schnaas L, Hu H, Peterson KE, Ettinger AS. Differential association of lead on length by zinc status in two-year old Mexican children. Environmental Health 2015;14:95. R835436 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: BioMed Central-Full Text PDF
    Exit
  • Abstract: BioMed Central-Abstract & Full Text HTML
    Exit
  • Journal Article Cantoral A, Tellez-Rojo MM, Ettinger AS, Hu H, Hernandez-Avila M, Peterson K. Early introduction and cumulative consumption of sugar-sweetened beverages during the pre-school period and risk of obesity at 8-14 years of age. Pediatric Obesity 2016;11(1):68-74. R835436 (2014)
    R835436 (2015)
    R835436 (2016)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Wiley Online-Full Text-HTML
    Exit
  • Abstract: Wiley Online-Abstract
    Exit
  • Other: Wiley Online-Full Text-PDF
    Exit
  • Journal Article Chavarro JE, Watkins DJ, Afeiche MC, Zhang Z, Sanchez BN, Cantonwine D, Mercado-Garcia A, Blank-Goldenberg C, Meeker JD, Tellez-Rojo MM, Peterson KE. Validity of self-assessed sexual maturation against physician assessments and hormone levels. The Journal of Pediatrics 2017;186:172-178.e3. R835436 (2016)
  • Abstract from PubMed
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: JPEDS-Abstract
    Exit
  • Journal Article Chen Y-H, Ferguson KK, Meeker JD, McElrath TF, Mukherjee B. Statistical methods for modeling repeated measures of maternal environmental exposure biomarkers during pregnancy in association with preterm birth. Environmental Health 2015;14(1):9 (13 pp.). R835436 (2014)
    R835436 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: BioMed Central-Full Text PDF
    Exit
  • Abstract: BioMed Central-Abstract & Full Text HTML
    Exit
  • Journal Article Faulk C, Liu K, Barks A, Goodrich JM, Dolinoy DC. Longitudinal epigenetic drift in mice perinatally exposed to lead. Epigenetics 2014;9(7):934-941. R835436 (2014)
    R835436 (2015)
    R834800 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Taylor & Francis-Full Text HTML
    Exit
  • Abstract: Taylor & Francis-Abstract
    Exit
  • Other: Taylor & Francis-Full Text PDF
    Exit
  • Journal Article Ferguson KK, Peterson KE, Lee JM, Mercado-Garcia A, Blank-Goldenberg C, Tellez-Rojo MM, Meeker JD. Prenatal and peripubertal phthalates and bisphenol A in relation to sex hormones and puberty in boys. Reproductive Toxicology 2014;47:70-76. R835436 (2014)
    R835436 (2015)
    R834800 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Ferguson KK, McElrath TF, Chen Y-H, Loch-Caruso R, Mukherjee B, Meeker JD. Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth. American Journal of Obstetrics & Gynecology 2015;212(2):208.e1-208.e8 (15 pp.). R835436 (2014)
    R835436 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ResearchGate-Full Text PDF
    Exit
  • Abstract: AJOG-Abstract
    Exit
  • Journal Article Ferguson KK, McElrath TF, Cantonwine DE, Mukherjee B, Meeker JD. Phthalate metabolites and bisphenol-A in association with circulating angiogenic biomarkers across pregnancy. Placenta 2015;36(6):699-703. R835436 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: ScienceDirect-Abstract
    Exit
  • Journal Article Ferguson KK, Meeker JD, Cantonwine DE, Chen Y-H, Mukherjee B, McElrath TF. Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth. Environment International 2016;94:531-537. R835436 (2016)
    R836155 (2017)
    R836155C003 (2017)
  • Abstract from PubMed
  • Full-text: ScienceDirect-Full Text-HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text-PDF
    Exit
  • Journal Article Fortenberry GZ, Meeker JD, Sánchez BN, Barr DB, Panuwet P, Bellinger D, Schnaas L, Solano-González M, Ettinger AS, Hernandez-Avila M, Hu H, Tellez-Rojo MM. Urinary 3,5,6-trichloro-2-pyridinol (TCPY) in pregnant women from Mexico City: distribution, temporal variability, and relationship with child attention and hyperactivity. International Journal of Hygiene and Environmental Health 2014; 217(2-3):405-412. R835436 (2014)
    R835436 (2015)
    R834800 (2013)
    R834800 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Other: ScienceDirect-PDF
    Exit
  • Journal Article Goodrich JM, Sanchez BN, Dolinoy DC, Zhang Z, Hernandez-Avila M, Hu H, Peterson KE, Tellez-Rojo MM. Quality control and statistical modeling for environmental epigenetics: a study on in utero lead exposure and DNA methylation at birth. Epigenetics 2015;10(1):19-30. R835436 (2014)
    R835436 (2015)
    R834800 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Taylor & Francis-Full Text HTML
    Exit
  • Abstract: Taylor & Francis-Abstract
    Exit
  • Other: Taylor & Francis-Full Text PDF
    Exit
  • Journal Article Goodrich JM, Dolinoy DC, Sanchez BN, Zhang Z, Meeker JD, Mercado-Garcia A, Solano-Gonzalez M, Hu H, Tellez-Rojo MM, Peterson KE. Adolescent epigenetic profiles and environmental exposures from early life through peri-adolescence. Environmental Epigenetics 2016;2(3):dvw018. R835436 (2016)
  • Full-text: OUP-Full Text-HTML
    Exit
  • Abstract: OUP-Abstract
    Exit
  • Other: OUP-Full Text-PDF
    Exit
  • Journal Article Goodrich JM, Chou HN, Gruninger SE, Fraznblau A, Baus N. Exposures of dental professionals to elemental mercury and methylmercury. Journal of Exposure Science and Environmental Epidemiology 2016;26(1):78-85. R835436 (2016)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: JESEE-Abstract
    Exit
  • Other: ResearchGate-Abstract
    Exit
  • Journal Article Huang S, Hu H, Sanchez BN, Peterson KE, Ettinger AS, Lamadrid-Figueroa H, Schnaas L, Mercado-Garcia A, Wright RO, Basu N, Cantonwine DE, Hernandez-Avila M, Tellez-Rojo MM. Childhood blood lead levels and symptoms of Attention Deficit Hyperactivity Disorder (ADHD): a cross-sectional study of Mexican children. Environmental Health Perspectives 2016;124(6):868-874. R835436 (2016)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: EHP-Full Text-HTML
  • Abstract: EHP-Abstract
  • Other: EHP-Full Text-PDF
  • Journal Article Kasper N, Peterson KE, Zhang Z, Ferguson KK, Sanchez BN, Cantoral A, Meeker JD, Tellez-Rojo MM, Pawlowski CM, Ettinger AS. Association of bisphenol A exposure with breastfeeding and perceived insufficient milk supply in Mexican women. Maternal and Child Health Journal 2016;20(8):1713-1719. R835436 (2015)
    R835436 (2016)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: SpringerLink-Abstract
    Exit
  • Other: ResearchGate-Abstract
    Exit
  • Journal Article Kochmanski J, Montrose L, Goodrich JM, Dolinoy DC. Environmental deflection: the impact of toxicant exposures on the aging epigenome. Toxicological Sciences 2017;156(2):325-335. R835436 (2016)
  • Abstract from PubMed
  • Full-text: OUP-Full Text-HTML
    Exit
  • Abstract: OUP-Abstract
    Exit
  • Other: OUP-Full Text-PDF
    Exit
  • Journal Article Kochmanski J, Marchlewicz EH, Savidge M, Montrose L, Faulk C, Dolinoy DC. Longitudinal effects of perinatal bisphenol A and variable diet exposures on epigenetic drift in mice. Reproductive Toxicology 2017;68:154-163. R835436 (2016)
  • Abstract from PubMed
  • Full-text: ScienceDirect-Full Text-HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text-PDF
    Exit
  • Journal Article Lewis RC, Meeker JD. Biomarkers of exposure to molybdenum and other metals in relation to testosterone among men from the United States National Health and Nutrition Examination Survey 2011-2012. Fertility and Sterility 2015;103(1):172-178. R835436 (2014)
    R835436 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: Fertility and Sterility-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Lewis RC, Johns LE, Meeker JD. Serum biomarkers of exposure to perfluoroalkyl substances in relation to serum testosterone and measures of thyroid function among adults and adolescents from NHANES 2011-2012. International Journal of Environmental Research and Public Health 2015;12(6):6098-6114. R835436 (2014)
    R835436 (2015)
    R836155C003 (2017)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: MDPI-Full Text HTML
    Exit
  • Abstract: MDPI-Abstract
    Exit
  • Other: MDPI-Full Text PDF
    Exit
  • Journal Article Lewis RC, Johns LE, Meeker JD. Exploratory analysis of the potential relationship between urinary molybdenum and bone mineral density among adult men and women from NHANES 2007-2010. Chemosphere 2016;164:677-682. R835436 (2016)
  • Abstract from PubMed
  • Full-text: ScienceDirect-Full Text-HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text-PDF
    Exit
  • Journal Article Liu Y, Peterson KE. Maternal exposure to synthetic chemicals and obesity in the offspring: recent findings. Current Environmental Health Reports 2015;2(4):339-347. R835436 (2015)
  • Abstract from PubMed
  • Full-text: SpringerLink-Full Text PDF
    Exit
  • Abstract: SpringerLink-Abstract & Full Text HTML
    Exit
  • Journal Article Marchlewicz EH, Dolinoy DC, Tang L, Milewski S, Jones TR, Goodrich JM, Soni T, Domino SE, Song PXK, Burant C, Padmanabhan V. Lipid metabolism is associated with developmental epigenetic programming. Scientific Reports 2016;6:34857. R835436 (2016)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Scientific Reports-Full Text-HTML
    Exit
  • Abstract: Scientific Reports-Abstract
    Exit
  • Other: Scientific Reports-Full Text-PDF
    Exit
  • Journal Article Meeker JD, Ferguson KK. Urinary phthalate metabolites are associated with decreased serum testosterone in men, women, and children from NHANES 2011-2012. The Journal of Clinical Endocrinology and Metabolism 2014;99(11):4346-4352. R835436 (2014)
    R835436 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Full-text: JCEM-Full Text HTML
    Exit
  • Abstract: JCEM-Abstract
    Exit
  • Other: JCEM-Full Text PDF
    Exit
  • Journal Article Moynihan M, Peterson KE, Cantoral A, Song PXK, Jones A, Solano-Gonzalez M, Meeker JD, Basu N, Tellez-Rojo MM. Dietary predictors of urinary cadmium among pregnant women and children. Science of the Total Environment 2017;575:1255-1262. R835436 (2016)
  • Abstract from PubMed
  • Full-text: ScienceDirect-Full Text-HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text-PDF
    Exit
  • Journal Article Neier K, Marchlewicz EH, Dolinoy DC, Padmanabhan V. Assessing human health risk to endocrine disrupting chemicals: a focus on prenatal exposures and oxidative stress. Endocrine Disruptors (Austin);2015;3(1):e1069916 (8 pp.). R835436 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Taylor & Francis-Full Text PDF
    Exit
  • Abstract: Taylor & Francis-Abstract & Full Text HTML
    Exit
  • Journal Article Omoike OE, Lewis RC, Meeker JD. Association between urinary biomarkers of exposure to organophosphate insecticides and serum reproductive hormones in men from NHANES 1999-2002. Reproductive Toxicology 2015;53:99-104. R835436 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Peretz J, Vrooman L, Ricke WA, Hunt PA, Ehrlich S, Hauser R, Padmanabhan V, Taylor HS, Swan SH, VandeVoort CA, Flaws JA. Bisphenol A and reproductive health: update of experimental and human evidence, 2007-2013. Environmental Health Perspectives 2014;122(8):775-786. R835436 (2014)
    R835436 (2015)
    R834593 (Final)
    R834593C001 (Final)
    R835434 (2013)
    R835434 (2014)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: EHP-Full Text PDF
  • Abstract: EHP-Abstract & Full Text HTML
  • Journal Article Perng W, Watkins DJ, Cantoral A, Mercado-Garcia A, Meeker JD, Tellez-Rojo MM, Peterson KE. Exposure to phthalates is associated with lipid profile in peripubertal Mexican youth. Environmental Research 2017;154:311-317. R835436 (2016)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ScienceDirect-Full Text-HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text-PDF
    Exit
  • Journal Article Sanchez-Vaznaugh EV, Sanchez BN, Crawford PB, Egerter S. Association between competitive food and beverage policies in elementary schools and childhood overweight/obesity trends:differences by neighborhood socioeconomic resources. JAMA Pediatrics 2015;169(5):e150781 (17 pp.). R835436 (2014)
    R835436 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: JAMA Pediatrics-Full Text HTML
    Exit
  • Abstract: JAMA Pediatrics-Abstract
    Exit
  • Journal Article Silver MK, Lozoff B, Meeker JD. Blood cadmium is elevated in iron deficient U.S. children: a cross-sectional study. Environmental Health 2013;12(1):117 (9 pp.). R835436 (2014)
    R835436 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: BioMed Central-Full Text HTML
    Exit
  • Abstract: BioMed Central-Abstract
    Exit
  • Other: BioMed Central-Full Text PDF
    Exit
  • Journal Article Somers EC, Monrad SU, Warren JS, Solano M, Schnaas L, Hernandez-Avila M, Tellez-Rojo MM, Hu H. Antinuclear antibody prevalence in a general pediatric cohort from Mexico City: discordance between immunofluorescence and multiplex assays. Clinical Epidemiology 2017;9:1-8. R835436 (2016)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Dovepress-Full Text-HTML
    Exit
  • Abstract: Dovepress-Abstract
    Exit
  • Other: Dovepress-Full Text-PDF
    Exit
  • Journal Article Sun Z, Tao Y, Li S, Ferguson KK, Meeker JD, Park SK, Batterman SA, Mukherjee B. Statistical strategies for constructing health risk models with multiple pollutants and their interactions: possible choices and comparisons. Environmental Health 2013;12(1):85 (19 pp.). R835436 (2014)
    R835436 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: BioMed Central-Full Text HTML
    Exit
  • Abstract: BioMed Central-Abstract
    Exit
  • Other: BioMed Central-Full Text PDF
    Exit
  • Journal Article Tao Y, Sanchez BN, Mukherjee B. Latent variable models for gene-environment interactions in longitudinal studies with multiple correlated exposures. Statistics in Medicine 2015;34(7):1227-1241. R835436 (2014)
    R835436 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Wiley-Abstract
    Exit
  • Other: ResearchGate-Abstract
    Exit
  • Journal Article Trentacosta CJ, Davis-Kean P, Mitchell C, Hyde L, Dolinoy DC. Environmental contaminants and child development. Child Developmental Perspectives 2016;10(4):228-233. R835436 (2016)
  • Abstract: Wiley-Abstract
    Exit
  • Other: ResearchGate-Abstract
    Exit
  • Journal Article Vandenberg LN, Gerona RR, Kannan K, Taylor JA, van Breemen RB, Dickenson CA, Liao C, Yuan Y, Newbold RR, Padmanabhan V, vom Saal FS, Woodruff TJ. A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environmental Health 2014;13(1):25 (20 pp.). R835436 (2014)
    R835436 (2015)
    R834678 (Final)
    R834678C001 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: BioMed Central-Full Text HTML
    Exit
  • Abstract: BioMed Central-Abstract
    Exit
  • Other: BioMed Central-Full Text PDF
    Exit
  • Journal Article Veiga-Lopez A, Pennathur S, Kannan K, Patisaul HB, Dolinoy DC, Zeng L, Padmanabhan V. Impact of gestational bisphenol A on oxidative stress and free fatty acids: human association and interspecies animal testing studies. Endocrinology 2015;156(3):911-922. R835436 (2014)
    R835436 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Full-text: Endocrinology-Full Text HTML
    Exit
  • Abstract: Endocrinology-Abstract
    Exit
  • Other: Endocrinology-Full Text PDF
    Exit
  • Journal Article Veiga-Lopez A, Kannan K, Liao C, Ye W, Domino S, Padmanabhan V. Gender-specific effects on gestational length and birth weight by early pregnancy BPA exposure. Journal of Clinical Endocrinology and Metabolism 2015;100(11):E1394-E1403. R835436 (2015)
  • Abstract from PubMed
  • Abstract: Endocrine Society-Abstract
    Exit
  • Journal Article Watkins DJ, Tellez-Rojo MM, Ferguson KK, Lee JM, Solano-Gonzalez M, Blank-Goldenberg C, Peterson KE, Meeker JD. In utero and peripubertal exposure to phthalates and BPA in relation to female sexual maturation. Environmental Research 2014;134:233-241. R835436 (2014)
    R835436 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Watkins DJ, Peterson KE, Ferguson KK, Mercado-Garcia A, Tamayo y Ortiz M, Cantoral A, Meeker JD, Tellez-Rojo MM. Relating phthalate and BPA exposure to metabolism in peripubescence: the role of exposure timing, sex, and puberty. Journal of Clinical Endocrinology & Metabolism 2016;101(1):79-88. R835436 (2015)
    R835436 (2016)
  • Full-text from PubMed
  • Abstract from PubMed
  • Full-text: OUP-Full Text-HTML
    Exit
  • Abstract: OUP-Abstract
    Exit
  • Other: OUP-Full Text-PDF
    Exit
  • Journal Article Watkins DJ, Fortenberry GZ, Sanchez BN, Barr DB, Panuwet P, Schnaas L, Osorio-Valencia E, Solano-Gonzalez M, Ettinger AS, Hernandez-Avila M, Hu H, Tellez-Rojo MM, Meeker JD. Urinary 3-phenoxybenzoic acid (3-PBA) levels among pregnant women in Mexico City: distribution and relationships with child neurodevelopment. Environmental Research 2016;147:307-313. R835436 (2015)
    R835436 (2016)
    R836155 (2017)
    R836155C003 (2017)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ScienceDirect-Full Text-HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text-PDF
    Exit
  • Journal Article Watkins DJ, Milewski S, Domino SE, Meeker JD, Padmanabhan V. Maternal phthalate exposure during early pregnancy and at delivery in relation to gestational age and size at birth: a preliminary analysis. Reproductive Toxicology 2016;65:59-65. R835436 (2016)
  • Abstract from PubMed
  • Full-text: ScienceDirect-Full Text-HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text-PDF
    Exit
  • Journal Article Watkins DJ, Sanchez BN, Tellez-Rojo MM, Lee JM, Mercado-Garcia A, Blank-Goldenberg C, Peterson KE, Meeker JD. Impact of phthalate and BPA exposure during the in utero windows of susceptibility on reproductive hormones and sexual maturation in peripubertal males. Environmental Health 2017 Jun;16(1):69. R835436 (2016)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: BioMed Central-Full Text-HTML
    Exit
  • Abstract: BioMed Central-Abstract
    Exit
  • Other: BioMed Central-Full Text-PDF
    Exit
  • Journal Article Wu J, Wen XW, Faulk C, Boehnke K, Zhang H, Dolinoy DC, Xi C. Perinatal lead exposure alters gut microbiota composition and results in sex-specific body weight increases in adult mice. Toxicological Sciences 2016;151(2):324-333. R835436 (2016)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: OUP-Full Text-HTML
    Exit
  • Abstract: OUP-Abstract
    Exit
  • Other: OUP-Full Text-PDF
    Exit
  • Journal Article Yang TC, Peterson KE, Meeker JD, Sanchez BN, Zhang Z, Cantoral A, Solano M, Tellez-Rojo MM. Bisphenol A and phthalates in utero and in childhood:association with child BMI z-score and adiposity. Environmental Research 2017;156:326-333. R835436 (2016)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ScienceDirect-Full Text-HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text-PDF
    Exit
  • Journal Article Zhang Z, O’Neill MS, Sanchez BN. Using a latent variable model with non-constant factor loadings to examing PM2.5 constituents related to secondary inorganic aerosols. Statistical Modeling 2016;16(2):91-113. R835436 (2016)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Sage Publications-Abstract
    Exit
  • Other: University of Michigan-Abstract
    Exit
  • Journal Article Zhou Y, Wang P, Wang X, Zhu J, Song PX. Sparse multivariate factor analysis regression models and its applications to integrative genomics analysis. Genetic Epidemiology 2017;41(1):70-80. R835436 (2016)
  • Abstract from PubMed
  • Full-text: Wiley-Full Text-HTML
    Exit
  • Abstract: Wiley-Abstract
    Exit
  • Other: Wiley-Full Text-PDF
    Exit
  • Progress and Final Reports:

    2013 Progress Report
    2014 Progress Report
    2015 Progress Report
    2016 Progress Report