Grantee Research Project Results
Publications submitted after final report Details for Grant Number R835166
Carolina Center for Computational Toxicology: Assays, models and tools for NextGen safety assessments
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year (Date Added to Report) | Document Sources |
|---|---|---|---|---|---|---|
| Journal Article | In vitro screening for population variability in toxicity of pesticide-containing mixtures. | None | Abdo N, Wetmore BA, Chappell GA, Shea D, Wright FA, Rusyn I | Abdo N, Wetmore BA, Chappell GA, Shea D, Wright FA, Rusyn I. In vitro screening for population variability in toxicity of pesticide-containing mixtures. Environment International 2015;85:147-155. |
R835166 (2015) (04/23/25) |
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| Journal Article | Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. | None | Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, Rusyn I, Wright FA | Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, Rusyn I, Wright FA. Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environmental Health Perspectives 2015;123(5):458-466. |
R835166 (2015) (04/23/25) |
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| Journal Article | Chemical safety assessment using read-across: assessing the use of novel testing methods to strengthen the evidence base for decision making. | None | Berggren E, Amcoff P, Benigni R, Blackburn K, Carney E, Cronin M, Deluyker H, Gautier F, Judson RS, Kass GE, Keller D, Knight D, Lilienblum W, Mahony C, Rusyn I, Schultz T, Schwarz M, Schuurmann G, White A, Burton J, Lostia AM, Munn S, Worth A | Berggren E, Amcoff P, Benigni R, Blackburn K, Carney E, Cronin M, Deluyker H, Gautier F, Judson RS, Kass GE, Keller D, Knight D, Lilienblum W, Mahony C, Rusyn I, Schultz T, Schwarz M, Schuurmann G, White A, Burton J, Lostia AM, Munn S, Worth A. Chemical safety assessment using read-across: assessing the use of novel testing methods to strengthen the evidence base for decision making. Environmental Health Perspectives 2015;123(12):1232-1240. |
R835166 (2015) (04/23/25) |
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| Journal Article | Prediction of human population responses to toxic compounds by a collaborative competition. | None | Eduati F, Mangravite LM, Wang T, Tang H, Bare JC, Huang R, Norman T, Kellen M, Menden MP, Yang J, Zhan X, Zhong R, Xiao G, Xia M, Abdo N, Kosyk O, NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration, Friend S, Dearry A, Simeonov A, Tice RR, Rusyn I, Wright FA, Stolovitzky G, Xie Y, Saez-Rodriguez J | Eduati F, Mangravite LM, Wang T, Tang H, Bare JC, Huang R, Norman T, Kellen M, Menden MP, Yang J, Zhan X, Zhong R, Xiao G, Xia M, Abdo N, Kosyk O, NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration, Friend S, Dearry A, Simeonov A, Tice RR, Rusyn I, Wright FA, Stolovitzky G, Xie Y, Saez-Rodriguez J. Prediction of human population responses to toxic compounds by a collaborative competition. Nature Biotechnology 2015;33(9):933-940. |
R835166 (2015) (04/23/25) |
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| Journal Article | Multi-Dimensional in Vitro Bioactivity Profiling for Grouping of Glycol Ethers. | REGULATORY TOXICOLOGY AND PHARMACOLOGY | Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N,Rusyn I | Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N, Rusyn I. Multi-Dimensional in Vitro Bioactivity Profiling for Grouping of Glycol Ethers. Regulatory Toxicology and Pharmacology 2019;101:91-102. |
R835166 (Final) (04/30/19) R835802 (2018) (07/16/19) R835802C001 (2018) (07/22/19) |
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| Journal Article | Advancing probabilistic risk assessment by integrating human biomonitoring, new approach methods, and Bayesian modeling: A case study with the mycotoxin deoxynivalenol | None | Lu E, Grimm F, Rusyn I, De Saeger S, De Bouvre M, Chiu W | Lu E, Grimm F, Rusyn I, De Saeger S, De Bouvre M, Chiu W. Advancing probabilistic risk assessment by integrating human biomonitoring, new approach methods, and Bayesian modeling:A case study with the mycotoxin deoxynivalenol. ENVIRONMENT INTERNATIONAL 2023;182(108326). |
R835166 (Final) (01/26/24) R835802 (Final) (01/26/24) |
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| Journal Article | Evaluating scientific confidence in the concordance of in vitro and in vivo protective points of departure | REGULATORY TOXICOLOGY AND PHARMACOLOGY | Lu E, Ford L, Chen Z, Burnett S, Rusyn I, Chiu W | Lu E, Ford L, Chen Z, Burnett S, Rusyn I, Chiu W. Evaluating scientific confidence in the concordance of in vitro and in vivo protective points of departure. REGULATORY TOXICOLOGY AND PHARMACOLOGY 2024;148(105596) |
R835166 (Final) (06/17/24) |
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| Journal Article | CERAPP: Collaborative Estrogen Receptor Activity Prediction Project. | ENVIRONMENTAL HEALTH PERSPECTIVES | Mansouri K, Abdelaziz A, Rybacka A, Roncaglioni A, Tropsha A, Varnek A, Zakharov A, Worth A, Richard AM, Grulke CM, Trisciuzzi D, Fourches D, Horvath D, Benfenati E, Muratov E, Wedebye EB, Grisoni F, Mangiatordi GF, Incisivo GM, Hong H, Ng HW, Tetko IV, Balabin I, Kancherla J, Shen J, Burton J, Nicklaus M, Cassotti M, Nikolov NG, Nicolotti O, Andersson PL, Zang Q, Politi R, Beger RD, Todeschini R, Huang R, Farag S, Rosenberg SA, Slavov S, Hu X, Judson RS | Mansouri K, Abdelaziz A, Rybacka A, Roncaglioni A, Tropsha A, Varnek A, Zakharov A, Worth A, Richard AM, Grulke CM, Trisciuzzi D, Fourches D, Horvath D, Benfenati E, Muratov E, Wedebye EB, Grisoni F, Mangiatordi GF, Incisivo GM, Hong H, Ng HW, Tetko IV, Balabin I, Kancherla J, Shen J, Burton J, Nicklaus M, Cassotti M, Nikolov NG, Nicolotti O, Andersson PL, Zang Q, Politi R, Beger RD, Todeschini R, Huang R, Farag S, Rosenberg SA, Slavov S, Hu X, Judson RS. CERAPP: Collaborative Estrogen Receptor Activity Prediction Project. Environmental Health Perspectives 2016;124(7):1023-1033. |
R835166 (2015) (04/23/25) |
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| Journal Article | Toxicokinetic triage for environmental chemicals. | TOXICOLOGICAL SCIENCES | Wambaugh JF, Wetmore BA, Pearce R, Strope C, Goldsmith R, Sluka JP, Sedykh A, Tropsha A, Bosgra S, Shah I, Judson R, Thomas RS, Setzer RW | Wambaugh JF, Wetmore BA, Pearce R, Strope C, Goldsmith R, Sluka JP, Sedykh A, Tropsha A, Bosgra S, Shah I, Judson R, Thomas RS, Setzer RW. Toxicokinetic triage for environmental chemicals. Toxicological Sciences 2015;147(1):55-67. |
R835166 (2015) (04/23/25) |
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| Presentation | The 1000 genomes toxicity screening project:utilizing the power of human genome variation for population scale in vitro testing. | None | Abdo N, Xia M, Kosyk O, Huang R, Sakamuru S, Brown C | Abdo N, Xia M, Kosyk O, Huang R, Sakamuru S, Brown C. The 1000 genomes toxicity screening project:utilizing the power of human genome variation for population scale in vitro testing. Presented at the Society of Toxicology 52nd Annual Meeting & ToxExpo™, San Antonio, TX, March 10-14, 2013. |
R835166 (Final) (04/30/19) |
not available |
| Presentation | Toxicological categorization of petroleum substances through high-content screening of induced pluripotent stem cell (iPSC) derived cardiomyocytes and hepatocytes. | None | Grimm FA, Iwata Y, Sirenko O, Crittenden C, Roy T, Boogaard P, Ketelslegers H, Rohde A, Rusyn I | Grimm FA, Iwata Y, Sirenko O, Crittenden C, Roy T, Boogaard P, Ketelslegers H, Rohde A, Rusyn I. Toxicological categorization of petroleum substances through high-content screening of induced pluripotent stem cell (iPSC) derived cardiomyocytes and hepatocytes. Presented at the Society of Toxicology (SOT) 54th Annual Meeting and ToxExpo, San Diego, CA, March 22-26, 2015. |
R835166 (2015) (04/23/25) |
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| Presentation | Toxicological categorization of P-and E-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. | None | Iwata Y, Grimm F, Wilson M, Bittner M, Sirenko O, Rowlands JC, Ball N, Rusyn I | Iwata Y, Grimm F, Wilson M, Bittner M, Sirenko O, Rowlands JC, Ball N, Rusyn I. Toxicological categorization of P-and E-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835166 (2015) (04/23/25) R835802 (2018) (07/16/19) |
not available |
| Presentation | Categorization of UVCBs using chemical-biological read across. | None | Rusyn I | Rusyn I. Categorization of UVCBs using chemical-biological read across. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835166 (Final) (04/30/19) R835802 (2018) (07/16/19) |
not available |
| Presentation | Toxicological categorization of p-and e-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. | None | Rusyn I | Rusyn I. Toxicological categorization of p-and e-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835166 (Final) (04/30/19) R835802 (2018) (07/16/19) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.