Grantee Research Project Results

Development of Innovative Approaches to Assess the Toxicity of Chemical Mixtures Request for Applications (RFA)

EPA awarded $7,770,044 in research grant funding to 11 institutions to develop and evaluate innovative methods and approaches to inform our understanding of the human health risks that may result from exposure to chemical mixtures in the environment.

Request for Applications closing date: December 8, 2021

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#	Grant Number	Abstract	Principal Investigator	Institution	Grant Amount	PROJECT PERIOD	Project Start Date	Project End Date	Extended End Date	State

<< STAR GRANTS AND STAR CENTERS >>
#	Grant Number	Abstract	Principal Investigator	Institution	Grant Amount	PROJECT PERIOD	Project Start Date	Project End Date	Extended End Date	State
1	R840450 Grant Check to remove this grant from results.	A tiered hybrid experimental-computational strategy for rapid risk assessment of complex environmental mixtures using novel analytical and toxicological methods	Rusyn, Ivan Chiu, Weihsueh A Wright, Fred A. Zhou, Yihui	Texas A & M University, North Carolina State University	$750,000	September 01, 2022 - May 02, 2025	September 01, 2022	May 02, 2025		TX
2	R840451 Grant Check to remove this grant from results.	Assessment of neurotoxicity of mixtures of PFAS and other neuroactive organic pollutants through integrated in silico, in vitro cellular and in vivo models	Aga, Diana S. Atilla-Gokcumen, Ekin Rajan, Krishna Sirotkin, Howard	The State University of New York at Buffalo, The State University of New York at Stony Brook	$750,000	October 01, 2022 - September 30, 2025 (Extended to March 31, 2026)	October 01, 2022	September 30, 2025	March 31, 2026	NY
3	R840452 Grant Check to remove this grant from results.	High-Throughput Lung Damage and Inflammation Assessment of Polyaromatic Hydrocarbon Mixtures	Takayama, Shuichi Ng, Nga Lee	Georgia Institute of Technology	$749,999	September 01, 2022 - May 09, 2025	September 01, 2022	May 09, 2025		GA
4	R840453 Grant Check to remove this grant from results.	Development of a quantitative adverse outcome pathway (qAOP) network to assess neurodevelopmental toxicity of per- and polyfluoroalkyl substances (PFAs) mixture in C. elegans	Tang, Lili Huang, Qingguo Shen, Ye Wang, Jia-Sheng	University of Georgia	$750,000	September 01, 2022 - August 31, 2025 (Extended to August 31, 2026)	September 01, 2022	August 31, 2025	August 31, 2026	GA
5	R840454 Grant Check to remove this grant from results.	Innovative approach to assess the effect of metal mixtures from infant meconium associated with adverse infant outcomes by identifying methylation loci in mothers and infants	Pavilonis, Brian Cai, Bo Cai, Guoshuai Kavouras, Ilias Maroko, Andrew McDermott, Suzanne Shin, Jin	Research Foundation of CUNY, Medgar Evers College, University of South Carolina at Columbia	$746,154	October 01, 2022 - May 12, 2025	October 01, 2022	May 12, 2025		NY
6	R840455 Grant Check to remove this grant from results.	Whole animal New Approach Methodologies for predicting developmental effects of air pollutant mixtures	Poynton, Helen C Connon, Richard E Díaz-Vázquez, Liz M Estrada-Martinez, Lorena Segarra, Amelie Young, Thomas M	University of Massachusetts - Boston, University of California Davis, University of Puerto Rico - Rio Piedras Campus	$750,000	October 01, 2022 - September 30, 2025 (Extended to September 30, 2026)	October 01, 2022	September 30, 2025	September 30, 2026	MA
7	R840456 Grant Check to remove this grant from results.	Protein Binding Affinity as the Driver for Studying PFAS Mixture Toxicity	Sepulveda, Maria Gantz, JD Hoskins, Tyler Hoverman, Jason Kar, Supratik Lee, Linda S. Leszczynski, Jerry	Purdue University, Hendrix College, Jackson State University, Kean University	$725,481	September 01, 2022 - August 31, 2025	September 01, 2022	August 31, 2025		IN
8	R840457 Grant Check to remove this grant from results.	Oral toxicity assessment of PAH mixtures using an in vitro 3D cell culture bioreactor mimicking the in vivo intestinal tract environment	Rodrigues, Debora Liu, Xinli	University of Houston	$749,926	September 01, 2022 - May 01, 2025	September 01, 2022	May 01, 2025		TX
9	R840458 Grant Check to remove this grant from results.	Wildfire Smoke Mixtures Toxicity Testing	Rager, Julia Jaspers, Ilona Kim, Yong Ho Rebuli, Meghan E Reif, David	University of North Carolina at Chapel Hill, North Carolina State University	$599,999	October 01, 2022 - May 09, 2025	October 01, 2022	May 09, 2025		NC
10	R840459 Grant Check to remove this grant from results.	Assessment of Underlying Molecular Mechanisms Promoting Adipogenic Outcomes in Complex Mixtures	Kassotis, Christopher Dennis Ghosh, Samiran Korzeniewski, Steven	Wayne State University	$598,487	September 01, 2022 - May 12, 2025	September 01, 2022	May 12, 2025		MI
11	R840460 Grant Check to remove this grant from results.	Developing an Integrated Framework for Evaluating Toxicity of Real-Life Chemical Mixtures	Pearce, John L Bain, Lisa Baldwin, William Hunt, Kelly	Medical University of South Carolina, Clemson University	$599,998	October 01, 2022 - May 09, 2025	October 01, 2022	May 09, 2025		SC

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

Grantee Research Project Results

Development of Innovative Approaches to Assess the Toxicity of Chemical Mixtures Request for Applications (RFA)

Request for Applications closing date: December 8, 2021

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