Grantee Research Project Results
Selected Publications Details for Grant Number R831709C002
Genetic Susceptibility to Pesticides
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Centers for Children's Environmental Health and Disease Prevention Research (2003)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Book | Gene-Environment Interactions: Fundamentals of Ecogenetics. | None | Costa LG, Eaton DL, eds. | Costa LG, Eaton DL, eds. Gene-Environment Interactions: Fundamentals of Ecogenetics. Hoboken, NJ: John Wiley & Sons, Inc., March 2006, 557 pp. |
R831709 (2006) R831709 (2007) R831709 (Final) R831709C002 (2006) |
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| Book Chapter | Paraoxonase polymorphisms and susceptibility to organophosphate pesticides. | None | Battuello K, Furlong C, Fenske R, Austin MA, Burke W | Battuello K, Furlong C, Fenske R, Austin MA, Burke W. Paraoxonase polymorphisms and susceptibility to organophosphate pesticides. In:Khoury MJ, Little J, Burke W, eds. Human Genome Epidemiology:A Scientific Foundation for Using Genetic Information To Improve Health and Prevent Disease. Oxford, UK:Oxford University Press, 2004, Chapter 18, pp. 305-321. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
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| Book Chapter | Paraoxonase (PON1) gene polymorphisms. | None | Costa LG, Furlong CE | Costa LG, Furlong CE. Paraoxonase (PON1) gene polymorphisms. In: Fuchs J, Podda M, eds. Encyclopedia of Medical Genomics and Proteomics. New York, NY: Taylor & Francis, 2004, pp. 965-969. |
R831709 (2007) R831709 (Final) R831709C002 (2004) |
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| Book Chapter | Paraoxonase (PON1) polymorphisms and toxicity of organophosphates. | None | Costa LG, Cole TB, Vitalone A, Furlong CE | Costa LG, Cole TB, Vitalone A, Furlong CE. Paraoxonase (PON1) polymorphisms and toxicity of organophosphates. In: Gupta RC, ed. Toxicology of Organophosphates & Carbamate Compounds. San Diego, CA: Academic Press, 2005, Chapter 18, pp. 247-255. |
R831709 (2005) R831709 (2006) R831709 (Final) R831709C002 (2005) R831709C002 (2006) |
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| Book Chapter | Paraoxonase, butyrylcholinesterase, and epoxide hydrolase. | None | Costa LG, Cole TB, Geiss GK, Furlong CE | Costa LG, Cole TB, Geiss GK, Furlong CE. Paraoxonase, butyrylcholinesterase, and epoxide hydrolase. In: Costa LG, Eaton DL, eds. Gene-Environment Interactions: Fundamentals of Ecogenetics. Hoboken, NJ: John Wiley & Sons, Inc., 2006, Chapter 9, pp. 159-177. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) R831709C002 (2006) |
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| Book Chapter | Receptors and ion channels. | None | Costa LG | Costa LG. Receptors and ion channels. In: Costa LG, Eaton DL, eds. Gene-Environment Interactions:Fundamentals of Ecogenetics. Hoboken, NJ: John Wiley & Sons, Inc., 2006, Chapter 11, pp. 197-210. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2006) |
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| Book Chapter | Toxic effects of pesticides. | None | Costa LG | Costa LG. Toxic effects of pesticides. In: Klaassen CD, ed. Casarett & Doull’s Toxicology: The Basic Science of Poisons, 7th Edition. New York, NY: McGraw-Hill, 2007, Chapter 22, pp. 883-932. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2007) |
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| Book Chapter | Understanding the significance of genetic variability in the human PON1 gene. | None | Furlong CE, Li W-F, Cole TB, Jampsa R, Richter RJ, Jarvik GP, Shih DM, Tward A, Lusis AJ, Costa LG | Furlong CE, Li W-F, Cole TB, Jampsa R, Richter RJ, Jarvik GP, Shih DM, Tward A, Lusis AJ, Costa LG. Understanding the significance of genetic variability in the human PON1 gene. In: Valdes JJ, Sekowski JW, eds. Toxicogenomics and Proteomics, NATO Science Series: Life and Behavioural Sciences, Volume 356. Amsterdam, Netherlands: IOS Press, 2004. |
R831709 (2007) R831709 (Final) R831709C002 (2004) |
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| Book Chapter | Neurodegenerative diseases. | None | Kelada SN, Checkoway H, Costa LG | Kelada SN, Checkoway H, Costa LG. Neurodegenerative diseases. In: Costa LG, Eaton DL, eds. Gene-Environment Interactions: Fundamentals of Ecogenetics. Hoboken, NJ: John Wiley & Sons, Inc., 2006, Chapter 15, pp. 253-269. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709C002 (2006) |
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| Book Chapter | Determination of paraoxonase 1 status and genotypes at specific polymorphic sites. | None | Richter RJ, Jampsa RL, Jarvik GP, Costa LG, Furlong CE | Richter RJ, Jampsa RL, Jarvik GP, Costa LG, Furlong CE. Determination of paraoxonase 1 status and genotypes at specific polymorphic sites. In: Maines M, Costa LG, Hodgson E, Reed DJ, eds. Current Protocols in Toxicology. New York, NY: John Wiley & Sons, Inc., 2004, pp. Unit 4.12. |
R831709C002 (2004) |
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| Journal Article | Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. | PHARMACOGENETICS AND GENOMICS | Cole TB, Walter BJ, Shih DM, Tward AD, Lusis AJ, Timchalk C, Richter RJ, Costa LG, Furlong CE | Cole TB, Walter BJ, Shih DM, Tward AD, Lusis AJ, Timchalk C, Richter RJ, Costa LG, Furlong CE. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. Pharmacogenetics and Genomics 2005;15(8):589-598. |
R831709 (2005) R831709 (Final) R831709C002 (2005) |
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| Journal Article | Paraoxonase (PON1) as a biomarker of susceptibility for organophosphate toxicity. | BIOMARKERS | Costa LG, Richter RJ, Li W-F, Cole T, Guizzetti M, Furlong CE | Costa LG, Richter RJ, Li W-F, Cole T, Guizzetti M, Furlong CE. Paraoxonase (PON1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 2003;8(1):1-12. |
R826886 (2000) R826886C002 (2002) R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
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| Journal Article | Functional genomics of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism. | ANNUAL REVIEW OF MEDICINE | Costa LG, Cole TB, Jarvik GP, Furlong CE | Costa LG, Cole TB, Jarvik GP, Furlong CE. Functional genomics of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism. Annual Review of Medicine 2003;54:371-392. |
R826886 (2000) R826886C002 (2002) R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
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| Journal Article | Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates. | JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY | Costa LG, Cole TB, Furlong CE | Costa LG, Cole TB, Furlong CE. Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates. Clinical Toxicology 2003;41(1):37-45. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
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| Journal Article | Modulation of paraoxonase (PON1) activity. | BIOCHEMICAL PHARMACOLOGY | Costa LG, Vitalone A, Cole TB, Furlong CE | Costa LG, Vitalone A, Cole TB, Furlong CE. Modulation of paraoxonase (PON1) activity. Biochemical Pharmacology 2005;69(4):541-550. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
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| Journal Article | Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity. | CLINICA CHIMICA ACTA | Costa LG, Cole TB, Vitalone A, Furlong CE | Costa LG, Cole TB, Vitalone A, Furlong CE. Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity. Clinica Chimica Acta 2005;352(1-2):37-47. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
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| Journal Article | Gene-environment interactions: paraoxonase (PON1) and sensitivity to organophosphate toxicity. | LABMEDICINE | Costa LG, Cole TB, Furlong CE | Costa LG, Cole TB, Furlong CE. Gene-environment interactions:paraoxonase (PON1) and sensitivity to organophosphate toxicity. LabMedicine 2006;37(2):109-113. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2007) R831709C002 (2007) |
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| Journal Article | Neurotoxicity of pesticides: a brief review. | FRONTIERS IN BIOSCIENCE | Costa LG, Giordano G, Guizzetti M, Vitalone A | Costa LG, Giordano G, Guizzetti M, Vitalone A. Neurotoxicity of pesticides: a brief review. Frontiers in Bioscience 2008;13(4):1240-1249. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2007) R831709C002 (2007) |
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| Journal Article | Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. | ENVIRONMENTAL HEALTH PERSPECTIVES | Eskenazi B, Harley K, Bradman A, Weltzien E, Jewell NP, Barr DB, Furlong CE, Holland NT | Eskenazi B, Harley K, Bradman A, Weltzien E, Jewell NP, Barr DB, Furlong CE, Holland NT. Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environmental Health Perspectives 2004;112(10):1116-1124. |
R831709 (2007) R831709 (Final) R831709C002 (2004) R831710 (2004) R831710 (2005) R831710 (Final) R831710C001 (2004) |
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| Journal Article | Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants. | NEUROTOXICOLOGY | Furlong CE, Cole TB, Jarvik GP, Pettan-Brewer C, Geiss GK, Richter RJ, Shih DM, Tward AD, Lusis AJ, Costa LG | Furlong CE, Cole TB, Jarvik GP, Pettan-Brewer C, Geiss GK, Richter RJ, Shih DM, Tward AD, Lusis AJ, Costa LG. Role of paraoxonase (PON1) status in pesticide sensitivity:genetic and temporal determinants. Neurotoxicology 2005;26(4):651-659. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
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| Journal Article | Paraoxonase 1 (PON1) status and risk of insecticide exposure. | JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | Furlong CE, Cole TB, Walter BJ, Shih DM, Tward A, Lusis AJ, Timchalk C, Richter RJ, Costa LG | Furlong CE, Cole TB, Walter BJ, Shih DM, Tward A, Lusis AJ, Timchalk C, Richter RJ, Costa LG. Paraoxonase 1 (PON1) status and risk of insecticide exposure. Journal of Biochemical and Molecular Toxicology 2005;19(3):182-183. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2005) |
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| Journal Article | PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity. | PHARMACOGENETICS AND GENOMICS | Furlong CE, Holland N, Richter RJ, Bradman A, Ho A, Eskenazi B | Furlong CE, Holland N, Richter RJ, Bradman A, Ho A, Eskenazi B. PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity. Pharmacogenetics and Genomics 2006;16(3):183-190. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C002 (2006) R831710 (2004) R831710 (2005) R831710 (Final) R831710C001 (2007) R831710C003 (2006) R831710C003 (2007) |
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| Journal Article | Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG | Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicology and Applied Pharmacology 2007;219(2-3):181-189. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C001 (2006) R831709C001 (2007) R831709C002 (2007) |
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| Journal Article | Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. | TOXICOLOGY | Guizzetti M, Pathak S, Giordano G, Costa LG | Guizzetti M, Pathak S, Giordano G, Costa LG. Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. Toxicology 2005;215(3):182-190. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C001 (2005) R831709C001 (2006) R831709C002 (2006) |
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| Journal Article | Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newborns. | ENVIRONMENTAL HEALTH PERSPECTIVES | Holland N, Furlong C, Bastaki M, Richter R, Bradman A, Huen K, Beckman K, Eskenazi B | Holland N, Furlong C, Bastaki M, Richter R, Bradman A, Huen K, Beckman K, Eskenazi B. Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newborns. Environmental Health Perspectives 2006;114(7):985-991. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C002 (2006) R831710 (2004) R831710 (2005) R831710 (Final) R831710C001 (2007) R831710C003 (2006) R832734 (2006) R832734 (2007) R832734 (Final) |
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| Journal Article | Novel paraoxonase (PON1) nonsense and missense mutations predicted by functional genomic assay of PON1 status. | PHARMACOGENETICS | Jarvik GP, Jampsa R, Richter RJ, Carlson CS, Rieder MJ, Nickerson DA, Furlong CE | Jarvik GP, Jampsa R, Richter RJ, Carlson CS, Rieder MJ, Nickerson DA, Furlong CE. Novel paraoxonase (PON1) nonsense and missense mutations predicted by functional genomic assay of PON1 status. Pharmacogenetics 2003;13(5):291-295. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
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| Journal Article | Paraoxonase 1 promoter and coding region polymorphisms in Parkinson's disease. | JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | Kelada SN, Costa-Mallen P, Checkoway H, Viernes HA, Farin FM, Smith-Weller T, Franklin GM, Costa LG, Longstreth Jr WT, Furlong CE, Javrik GP, Swanson PD | Kelada SN, Costa-Mallen P, Checkoway H, Viernes HA, Farin FM, Smith-Weller T, Franklin GM, Costa LG, Longstreth Jr WT, Furlong CE, Javrik GP, Swanson PD. Paraoxonase 1 promoter and coding region polymorphisms in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry 2003;74(4):546-547. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
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| Journal Article | Genetic polymorphisms and mechanisms of neurotoxicity: overview. | NEUROTOXICOLOGY | Tiffany-Castiglioni E, Venkratraj V, Qian Y | Tiffany-Castiglioni E, Venkratraj V, Qian Y. Genetic polymorphisms and mechanisms of neurotoxicity:overview. Neurotoxicology 2005;26(4):641-649. |
R831709 (2007) R831709C002 (2004) |
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| Journal Article | Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. | NEUROTOXICOLOGY | Young JG, Eskenazi B, Gladstone EA, Bradman A, Pedersen L, Johnson C, Barr DB, Furlong CE, Holland NT | Young JG, Eskenazi B, Gladstone EA, Bradman A, Pedersen L, Johnson C, Barr DB, Furlong CE, Holland NT. Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. NeuroToxicology 2005;26(2):199-209. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C002 (2004) R831709C002 (2006) R831710 (2004) R831710 (2005) R831710 (Final) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.