Grantee Research Project Results
Selected Publications Details for Grant Number R826886
Center for Child Environmental Health Risks Research
RFA:
Centers for Children's Environmental Health and Disease Prevention Research (1998)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Book Chapter | PON1 polymorphisms. | None | Brophy VH, Jarvik GP, Furlong CE | Brophy VH, Jarvik GP, Furlong CE. PON1 polymorphisms. In: Costa LG, Furlong CE, eds. Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects. Boston, MA: Springer, 2002, Chapter 3, pp. 53-77. |
R826886 (2000) R826886C002 (2001) R826886C002 (2002) R831709 (2007) |
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| Book Chapter | PON1 and organophosphate toxicity. | None | Costa LG, Li W-F, Richter RJ, Shih DM, Lucis AJ, Furlong CE | Costa LG, Li W-F, Richter RJ, Shih DM, Lucis AJ, Furlong CE. PON1 and organophosphate toxicity. In: Costa LG, Furlong CE, eds. Paraoxonase(PON1) in Health and Disease: Basic and Clinical Aspects. Boston, MA: Springer, 2002, Chapter 8, pp. 165-183. |
R826886 (2000) R831709 (2005) R831709 (Final) |
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| Book Chapter | Perspectives in PON1 research. | None | Costa LG, Furlong CE | Costa LG, Furlong CE. Perspectives in PON1 research. In: Costa LG, Furlong CE, eds. Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects. Boston, MA: Springer, 2002, Chapter 10, pp. 197-210. |
R826886 (2000) R826886C002 (2002) |
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| Journal Article | Quantitative mechanistically based dose-response modeling with endocrine-active compounds. | ENVIRONMENTAL HEALTH PERSPECTIVES | Andersen ME, Conolly RB, Faustman EM, Kavlock RJ, Portier CJ, Sheehan DM, Wier PJ, Ziese L | Andersen ME, Conolly RB, Faustman EM, Kavlock RJ, Portier CJ, Sheehan DM, Wier PJ, Ziese L. Quantitative mechanistically based dose-response modeling with endocrine-active compounds. Environmental Health Perspectives 1999;107(Suppl 4):631-638. |
R826886 (2000) |
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| Journal Article | Risk estimation and value-of-information analysis for three proposed genetic screening programs for chronic beryllium disease prevention. | RISK ANALYSIS | Bartell SM, Ponce RA, Takaro TK, Zerbe RO, Omenn GS, Faustman EM | Bartell SM, Ponce RA, Takaro TK, Zerbe RO, Omenn GS, Faustman EM. Risk estimation and value-of-information analysis for three proposed genetic screening programs for chronic beryllium disease prevention. Risk Analysis 2000;20(1):87-99. |
R826886 (2000) |
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| Journal Article | Harmonization of cancer and non-cancer risk assessment: proceedings of a consensus-building workshop. | TOXICOLOGICAL SCIENCES | Bogdanffy MS, Daston G, Faustman EM, Kimmel CA, Kimmel GL, Seed J, Vu V | Bogdanffy MS, Daston G, Faustman EM, Kimmel CA, Kimmel GL, Seed J, Vu V. Harmonization of cancer and non-cancer risk assessment: proceedings of a consensus-building workshop. Toxicological Sciences 2001;61(1):18-31. |
R826886 (2000) |
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| Journal Article | Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype. | PHARMACOGENETICS | Brophy VH, Jarvik GP, Richter RJ, Rozek LS, Schellenberg GD, Furlong CE | Brophy VH, Jarvik GP, Richter RJ, Rozek LS, Schellenberg GD, Furlong CE. Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype. Pharmacogenetics 2000;10(5):453-460. |
R826886 (2000) |
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| Journal Article | Polymorphisms in the human paraoxonase (PON1) promoter. | PHARMACOGENETICS | Brophy VH, Hastings MD, Clendenning JB, Richter RJ, Jarvik GP, Furlong CE | Brophy VH, Hastings MD, Clendenning JB, Richter RJ, Jarvik GP, Furlong CE. Polymorphisms in the human paraoxonase (PON1) promoter. Pharmacogenetics 2001;11(1):77-84. |
R826886 (2000) R826886C002 (2001) |
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| Journal Article | Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression. | AMERICAN JOURNAL OF HUMAN GENETICS | Brophy VH, Jampsa RL, Clendenning JB, McKinstry LA, Jarvik GP, Furlong CE | Brophy VH, Jampsa RL, Clendenning JB, McKinstry LA, Jarvik GP, Furlong CE. Effects of 5' regulatory-region polymorphisms on paraoxonase-gene (PON1) expression. American Journal of Human Genetics 2001;68(6):1428-1436. |
R826886 (2000) R826886C002 (2001) R831709 (2007) |
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| Journal Article | Methods for studying nonhuman primates in neurobehavioral toxicology and teratology. | NEUROTOXICOLOGY AND TERATOLOGY | Burbacher TM, Grant KS | Burbacher TM, Grant KS. Methods for studying nonhuman primates in neurobehavioral toxicology and teratology. Neurotoxicology and Teratology 2000;22(4):475-486. |
R826886 (2000) |
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| Journal Article | Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons. | JOURNAL OF NEUROSCIENCE | Cavanaugh JE, Ham J, Hetman M, Poser S, Yan C, Xia Z | Cavanaugh JE, Ham J, Hetman M, Poser S, Yan C, Xia Z. Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons. Journal of Neuroscience 2001;21(2):434-443. |
R826886 (2000) |
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| Journal Article | DNA elements of the type 1 adenylyl cyclase gene locus enhance reporter gene expression in neurons and pinealocytes. | EUROPEAN JOURNAL OF NEUROSCIENCE | Chan GC, Lernmark U, Xia Z, Storm DR | Chan GC, Lernmark U, Xia Z, Storm DR. DNA elements of the type 1 adenylyl cyclase gene locus enhance reporter gene expression in neurons and pinealocytes. European Journal of Neuroscience 2001;13(11):2054-2066. |
R826886 (2000) |
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| Journal Article | The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. | CHEMICO-BIOLOGICAL INTERACTIONS | Costa LG, Li WF, Richter RJ, Shih DM, Lusis A, Furlong CE | Costa LG, Li WF, Richter RJ, Shih DM, Lusis A, Furlong CE. The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. Chemico–Biological Interactions 1999;119-120:429-438. |
R826886 (2000) R826886C002 (2000) |
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| Journal Article | The emerging field of ecogenetics. | NEUROTOXICOLOGY | Costa LG | Costa LG. The emerging field of ecogenetics. Neurotoxicology 2000;21(1-2):85-89. |
R826886 (2000) R826886C002 (2000) |
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| Journal Article | Intracellular signal transduction pathways as targets for neurotoxicants. | TOXICOLOGY | Costa LG, Guizzetti M, Lu H, Bordi F, Vitalone A, Tita B, Palmery M, Valeri P, Silvestrini B | Costa LG, Guizzetti M, Lu H, Bordi F, Vitalone A, Tita B, Palmery M, Valeri P, Silvestrini B. Intracellular signal transduction pathways as targets for neurotoxicants. Toxicology 2001;160(1-3):19-26. |
R826886 (2000) |
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| Journal Article | Pesticide exposure: differential risk for neurotoxic outcomes due to enzyme polymorphisms. | CLINICS IN OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | Costa LG | Costa LG. Pesticide exposure: differential risk for neurotoxic outcomes due to enzyme polymorphisms. Clinics in Occupational and Environmental Medicine 2001;1(3):511-523. |
R826886 (2000) |
not available |
| Journal Article | Developmental neurotoxicity: do similar phenotypes indicate a common mode of action? A comparison of fetal alcohol syndrome, toluene embryopathy and maternal phenylketonuria. | TOXICOLOGY LETTERS | Costa LG, Guizzetti M, Burry , Oberdoerster J | Costa LG, Guizzetti M, Burry , Oberdoerster J. Developmental neurotoxicity: do similar phenotypes indicate a common mode of action? A comparison of fetal alcohol syndrome, toluene embryopathy and maternal phenylketonuria. Toxicology Letters 2002;127(1-3):197-205. |
R826886 (2000) |
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| Journal Article | Paraoxonase (PON1) as a biomarker of susceptibility for organophosphate toxicity. | BIOMARKERS | Costa LG, Richter RJ, Li W-F, Cole T, Guizzetti M, Furlong CE | Costa LG, Richter RJ, Li W-F, Cole T, Guizzetti M, Furlong CE. Paraoxonase (PON1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 2003;8(1):1-12. |
R826886 (2000) R826886C002 (2002) R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
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| Journal Article | Functional genomics of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism. | ANNUAL REVIEW OF MEDICINE | Costa LG, Cole TB, Jarvik GP, Furlong CE | Costa LG, Cole TB, Jarvik GP, Furlong CE. Functional genomics of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism. Annual Review of Medicine 2003;54:371-392. |
R826886 (2000) R826886C002 (2002) R831709 (2005) R831709 (2007) R831709 (Final) R831709C002 (2004) |
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| Journal Article | Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children. | ENVIRONMENTAL HEALTH PERSPECTIVES | Curl CL, Fenske RA, Kissel JC, Shirai JH, Moate TF, Griffith W, Coronado G, Thompson B | Curl CL, Fenske RA, Kissel JC, Shirai JH, Moate TF, Griffith W, Coronado G, Thompson B. Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children. Environmental Health Perspectives 2002;110(12):A787-A792. |
R826886 (2000) R826886C003 (2001) R826886C003 (2002) R826886C004 (2001) R826886C004 (2002) |
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| Journal Article | Time-location analysis for exposure assessment studies of children using a novel global positioning system instrument. | ENVIRONMENTAL HEALTH PERSPECTIVES | Elgethun K, Fenske RA, Yost MG, Palcisko GJ | Elgethun K, Fenske RA, Yost MG, Palcisko GJ. Time-location analysis for exposure assessment studies of children using a novel global positioning system instrument. Environmental Health Perspectives 2003;111(1):115-122. |
R826886 (2000) R826886C004 (2002) R831709 (2005) R831709 (2007) R831709 (Final) |
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| Journal Article | Prenatal Organophosphor Pesticide Exposure and Child Neurodevelopment at 24 Months: An Analysis of Four Birth Cohorts | None | Engel S, Bradman A, Wolf M, Rauh V | Engel S, Bradman A, Wolf M, Rauh V. Prenatal Organophosphor Pesticide Exposure and Child Neurodevelopment at 24 Months:An Analysis of Four Birth Cohorts. ENVIRONMENTAL HEALTH PERSPECTIVES 2016;124(6):822-830. |
R826709 (2002) R826886 (2000) R827027 (2002) R827039 (2002) R828609 (Final) R832141 (Final) |
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| Journal Article | Biologically based dose-response models for developmental toxicants: lessons from methylmercury. | INHALATION TOXICOLOGY | Faustman EM, Lewandowski TA, Ponce RA, Bartell SM | Faustman EM, Lewandowski TA, Ponce RA, Bartell SM. Biologically based dose-response models for developmental toxicants: lessons from methylmercury. Inhalation Toxicology 1999;11(6-7):559-572. |
R826886 (2000) |
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| Journal Article | Mechanisms underlying children's susceptibility to environmental toxicants. | ENVIRONMENTAL HEALTH PERSPECTIVES | Faustman EM, Silbernagel SM, Fenske RA, Burbacher TM, Ponce RA | Faustman EM, Silbernagel SM, Fenske RA, Burbacher TM, Ponce RA. Mechanisms underlying children's susceptibility to environmental toxicants. Environmental Health Perspectives 2000;108(Suppl 1):13-21. |
R825173 (1999) R825173 (2000) R826886 (2000) |
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| Journal Article | Investigations of methylmercury-induced alterations in neurogenesis. | ENVIRONMENTAL HEALTH PERSPECTIVES | Faustman EM, Ponce RA, Ou YC, Mendoza MA, Lewandowski T, Kavanagh T | Faustman EM, Ponce RA, Ou YC, Mendoza MA, Lewandowski T, Kavanagh T. Investigations of methylmercury-induced alterations in neurogenesis. Environmental Health Perspectives 2002;110(Suppl 5):859-864. |
R826886 (2000) |
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| Journal Article | Strategies for assessing children’s organophosphorus pesticide exposures in agricultural communities. | JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY | Fenske RA, Lu C, Simcox NJ, Loewenherz C, Touchstone J, Moate TF, Allen EH, Kissel JC | Fenske RA, Lu C, Simcox NJ, Loewenherz C, Touchstone J, Moate TF, Allen EH, Kissel JC. Strategies for assessing children’s organophosphorus pesticide exposures in agricultural communities. Journal of Exposure Analysis and Environmental Epidemiology 2000;10(6 Pt 2):662-671. |
R825171 (2000) R826886 (2000) R826886C004 (2001) |
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| Journal Article | Biologically based pesticide dose estimates for children in an agricultural community. | ENVIRONMENTAL HEALTH PERSPECTIVES | Fenske RA, Kissel JC, Lu C, Kalman DA, Simcox NJ, Allen EH, Keifer MC | Fenske RA, Kissel JC, Lu C, Kalman DA, Simcox NJ, Allen EH, Keifer MC. Biologically based pesticide dose estimates for children in an agricultural community. Environmental Health Perspectives 2000;108(6):515-520. |
R826886 (2000) R826886C004 (2001) |
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| Journal Article | Assessment of organophosphorous pesticide exposures in the diets of preschool children in Washington State. | JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY | Fenske RA, Kedan G, Lu C, Fisker-Andersen JA, Curl CL | Fenske RA, Kedan G, Lu C, Fisker-Andersen JA, Curl CL. Assessment of organophosphorous pesticide exposures in the diets of preschool children in Washington State. Journal of Exposure Analysis and Environmental Epidemiology 2002;12(1):21-28. |
R826886 (2000) |
not available |
| Journal Article | Children's exposure to chlorpyrifos and parathion in an agricultural community in central Washington State. | ENVIRONMENTAL HEALTH PERSPECTIVES | Fenske RA, Lu C, Barr D, Needham L | Fenske RA, Lu C, Barr D, Needham L. Children's exposure to chlorpyrifos and parathion in an agricultural community in central Washington State. Environmental Health Perspectives 2002;110(5):549-553. |
R826886 (2000) |
not available |
| Journal Article | Taxol induces apoptosis in cortical neurons by a mechanism independent of Bcl-2 phosphorylation. | JOURNAL OF NEUROSCIENCE | Figueroa-Masot XA, Hetman M, Higgins MJ, Kokot N, Xia Z | Figueroa-Masot XA, Hetman M, Higgins MJ, Kokot N, Xia Z. Taxol induces apoptosis in cortical neurons by a mechanism independent of Bcl-2 phosphorylation. Journal of Neuroscience 2001;21(13):4657-4667. |
R826886 (2000) |
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| Journal Article | The PON1 gene and detoxication. | NEUROTOXICOLOGY | Furlong CE, Li WF, Brophy VH, Jarvik GP, Richter RJ, Shih DM, Lusis AJ, Costa LG | Furlong CE, Li WF, Brophy VH, Jarvik GP, Richter RJ, Shih DM, Lusis AJ, Costa LG. The PON1 gene and detoxication. NeuroToxicology 2000;21(4):581-587. |
R826886 (2000) R826886C002 (2001) |
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| Journal Article | PON1 status and neurologic symptom complexes in Gulf War veterans. | GENOME RESEARCH | Furlong CE | Furlong CE. PON1 status and neurologic symptom complexes in Gulf War veterans. Genome Research 2000;10(2):153-155. |
R826886 (2000) |
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| Journal Article | Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1). | NEUROTOXICOLOGY | Furlong CE, Li WF, Richter RJ, Shih DM, Lusis AJ, Alleva E, Costa LG | Furlong CE, Li WF, Richter RJ, Shih DM, Lusis AJ, Alleva E, Costa LG. Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1). NeuroToxicology 2000;21(1-2):91-100. |
R826886 (2000) R826886C002 (2000) R826886C002 (2001) |
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| Journal Article | Pharmacogenomic considerations of the paraoxonase polymorphisms. | PHARMACOGENETICS | Furlong CE, Cole TB, Jarvik GP, Costa LG | Furlong CE, Cole TB, Jarvik GP, Costa LG. Pharmacogenomic considerations of the paraoxonase polymorphisms. Pharmacogenomics 2002;3(3):341-348. |
R826886 (2000) R826886C002 (2002) |
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| Journal Article | Genetic factors in susceptibility: serum PON1 variation between individuals and species. | HUMAN AND ECOLOGICAL RISK ASSESSMENT | Furlong CE, Li W-F, Shih DM, Lusis AJ, Richter RJ, Costa LG | Furlong CE, Li W-F, Shih DM, Lusis AJ, Richter RJ, Costa LG. Genetic factors in susceptibility: serum PON1 variation between individuals and species. Human and Ecological Risk Assessment 2002;8(1):31-43. |
R826886 (2000) R826886C002 (2002) |
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| Journal Article | Adult responses to a survey of soil contact-related behaviors. | JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY | Garlock TJ, Shirai JH, Kissel JC | Garlock TJ, Shirai JH, Kissel JC. Adult responses to a survey of soil contact-related behaviors. Journal of Exposure Analysis and Environmental Epidemiology 1999;9(2):134-142. |
R826886 (2000) |
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| Journal Article | p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. | JOURNAL OF CELL BIOLOGY | Ghatan S, Larner S, Kinoshita Y, Hetman M, Patel L, Xia Z, Youle RJ, Morrison RS | Ghatan S, Larner S, Kinoshita Y, Hetman M, Patel L, Xia Z, Youle RJ, Morrison RS. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. Journal of Cell Biology 2000;150(2):335-347. |
R826886 (2000) |
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| Journal Article | A computational model for neocortical neuronogenesis predicts ethanol-induced neocortical neuron number deficits. | DEVELOPMENTAL NEUROSCIENCE | Gohlke JM, Griffith WC, Bartell SM, Lewandowski TA, Faustman EM | Gohlke JM, Griffith WC, Bartell SM, Lewandowski TA, Faustman EM. A computational model for neocortical neuronogenesis predicts ethanol-induced neocortical neuron number deficits. Developmental Neuroscience 2002;24(6):467-477. |
R826886 (2000) |
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| Journal Article | Stakeholder participation: Experience from the CRESP program. | ENVIRONMENTAL EPIDEMIOLOGY AND TOXICOLOGY | Goldstein BD, Erdal S, Burger J, Faustman EM, Friedlander BR, Greenberg M, Leschine TM, Powers CW, Waishwell L, Williams B | Goldstein BD, Erdal S, Burger J, Faustman EM, Friedlander BR, Greenberg M, Leschine TM, Powers CW, Waishwell L, Williams B. Stakeholder participation: Experience from the CRESP program. Environmental Epidemiology and Toxicology 2000;2:103-111. |
R826886 (2000) |
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| Journal Article | Prenatal exposure to organophosphorous pesticides and fetal growth: pooled results from four longitudinal birth cohort studies. | None | Harley KG, Engel SM, Vedar MG, Eskenazi B, Whyatt RM, Lanphear BP, Bradman A, Rauh VA, Yolton K, Hornung RW, Wetmur JG, Chen J, Holland NT, Barr DB, Perera FP, Wolff MS | Harley KG, Engel SM, Vedar MG, Eskenazi B, Whyatt RM, Lanphear BP, Bradman A, Rauh VA, Yolton K, Hornung RW, Wetmur JG, Chen J, Holland NT, Barr DB, Perera FP, Wolff MS. Prenatal exposure to organophosphorous pesticides and fetal growth: pooled results from four longitudinal birth cohort studies. Environmental Health Perspectives 2016;124(7):1084-1092. |
R826709 (2002) R826886 (2000) R827027 (2002) R827039 (2002) R828609 (Final) R831710 (Final) R832141 (Final) R834513C001 (2015) |
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| Journal Article | Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular-signal-regulated kinase and phosphatidylinositol-3 kinase. | JOURNAL OF BIOLOGICAL CHEMISTRY | Hetman M, Kanning KC, Smith-Cavanaugh JE, Xia Z | Hetman M, Kanning KC, Smith-Cavanaugh JE, Xia Z. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular-signal-regulated kinase and phosphatidylinositol-3 kinase. Journal of Biological Chemistry 1999;(274):22569-22580. |
R826886 (2000) |
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| Journal Article | Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal. | JOURNAL OF NEUROSCIENCE | Hetman M, Cavanaugh JE, Kimelman D, Xia Z | Hetman M, Cavanaugh JE, Kimelman D, Xia Z. Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal. Journal of Neuroscience 2000;20(7):2567-2574. |
R826886 (2000) |
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| Journal Article | Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype. | ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY | Jarvik GP, Rozek LS, Brophy VH, Hatsukami TS, Richter RJ, Schellenberg GD, Furlong CE | Jarvik GP, Rozek LS, Brophy VH, Hatsukami TS, Richter RJ, Schellenberg GD, Furlong CE. Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype. Arteriosclerosis, Thrombosis, and Vascular Biology 2000;20(11):2441-2447. |
R826886 (2000) |
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| Journal Article | Alternative strategies for PCB risk reduction from contaminated seafood: options for children as susceptible populations. | BULLETIN OF ENVIRONMENTAL CONTAMINANTS AND TOXICOLOGY | Judd NL, Griffith WC, Ylitalo GM, Faustman EM | Judd NL, Griffith WC, Ylitalo GM, Faustman EM. Alternative strategies for PCB risk reduction from contaminated seafood: options for children as susceptible populations. Bulletin of Environmental Contaminants and Toxicology 2002;69(6):847-854. |
R826886 (2000) |
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| Journal Article | Temporal association of children's pesticide exposure and agricultural spraying: Report of a longitudinal biological monitoring study | ENVIRONMENTAL HEALTH PERSPECTIVES | Koch D, Lu CS, Fisker-Andersen J, Jolley L, Fenske RA | Koch D, Lu CS, Fisker-Andersen J, Jolley L, Fenske RA. Temporal association of children's pesticide exposure and agricultural spraying: Report of a longitudinal biological monitoring study. Environmental Health Perspectives 2002;110(8):829-833. |
R825171 (2000) R826886 (2000) |
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| Journal Article | CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. | NEURON | Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, Greenberg M | Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, Greenberg M. CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Neuron 2002;34(2):221-233. |
R826886 (2000) |
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| Journal Article | Methylmercury distribution in the pregnant rat and embryo during early midbrain organogenesis. | TERATOLOGY | Lewandowski TA, Pierce CH, Pingree SD, Hong S, Faustman EM | Lewandowski TA, Pierce CH, Pingree SD, Hong S, Faustman EM. Methylmercury distribution in the pregnant rat and embryo during early midbrain organogenesis. Teratology 2002;66(5):235-241. |
R825358 (Final) R826886 (2000) |
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| Journal Article | Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds. | PHARMACOGENETICS | Li WF, Costa LG, Richter RJ, Hagen T, Shih DM, Tward A, Lusis AJ, Furlong CE | Li WF, Costa LG, Richter RJ, Hagen T, Shih DM, Tward A, Lusis AJ, Furlong CE. Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds. Pharmacogenetics 2000;10(9):767-779. |
R826886 (2000) R826886C002 (2000) R826886C002 (2001) |
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| Journal Article | Teratogen-induced activation of caspase-9 and the mitochondrial apoptotic pathway in early postimplantation mouse embryos. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Little SA, Mirkes PE | Little SA, Mirkes PE. Teratogen-induced activation of caspase-9 and the mitochondrial apoptotic pathway in early postimplantation mouse embryos. Toxicology and Applied Pharmacology 2002;181(2):142-151. |
R826886 (2000) |
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| Journal Article | Biological monitoring survey of organophosphorus pesticide exposure among preschool children in the Seattle metropolitan area | ENVIRONMENTAL HEALTH PERSPECTIVES | Lu CS, Knutson DE, Fisker-Andersen J, Fenske RA | Lu CS, Knutson DE, Fisker-Andersen J, Fenske RA. Biological monitoring survey of organophosphorus pesticide exposure among preschool children in the Seattle metropolitan area. Environmental Health Perspectives 2001;109(3):299-303. |
R825171 (2000) R826886 (2000) |
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| Journal Article | Dermal transfer of chlorpyrifos residues from residential surfaces: comparison of hand press, hand drag, wipe, and polyurethane foam roller measurements after broadcast and aerosol pesticide applications. | ENVIRONMENTAL HEALTH PERSPECTIVES | Lu C, Fenske RA | Lu C, Fenske RA. Dermal transfer of chlorpyrifos residues from residential surfaces: comparison of hand press, hand drag, wipe, and polyurethane foam roller measurements after broadcast and aerosol pesticide applications. Environmental Health Perspectives 1999;107(6):463-467. |
R826886 (2000) R826886C004 (2001) |
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| Journal Article | Pesticide exposure of children in an agricultural community: evidence of household proximity to farmland and take home exposure pathways. | ENVIRONMENTAL RESEARCH | Lu C, Fenske RA, Simcox NJ, Kalman D | Lu C, Fenske RA, Simcox NJ, Kalman D. Pesticide exposure of children in an agricultural community: evidence of household proximity to farmland and take home exposure pathways. Environmental Research 2000;84(3):290-302. |
R826886 (2000) R826886C004 (2001) |
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| Journal Article | p21WAF1/CIP1 inhibits cell cycle progression but not G2/M-phase transition following methylmercury exposure. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Mendoza MAC, Ponce RA, Ou YC, Faustman EM | Mendoza MAC, Ponce RA, Ou YC, Faustman EM. p21WAF1/CIP1 inhibits cell cycle progression but not G2/M-phase transition following methylmercury exposure. Toxicology and Applied Pharmacology 2002;178(2):117-125. |
R825358 (Final) R826886 (2000) |
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| Journal Article | Teratogen-induced cell death in postimplantation mouse embryos: differential tissue sensitivity and hallmarks of apoptosis. | CELL DEATH AND DIFFERENTIATION | Mirkes PE, Little SA | Mirkes PE, Little SA. Teratogen-induced cell death in postimplantation mouse embryos: differential tissue sensitivity and hallmarks of apoptosis. Cell Death and Differentiation 1998;5(7):592-600. |
R826886 (2000) |
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| Journal Article | Heat shock protein 70 (Hsp70) protects postimplantation murine embryos from the embryolethal effects of hyperthermia. | DEVELOPMENTAL DYNAMICS | Mirkes PE, Cornel LM, Wilson KL, Dilmann WH | Mirkes PE, Cornel LM, Wilson KL, Dilmann WH. Heat shock protein 70 (Hsp70) protects postimplantation murine embryos from the embryolethal effects of hyperthermia. Developmental Dynamics 1999;214(2):159-170. |
R826886 (2000) |
not available |
| Journal Article | Cytochrome c release from mitochondria of early postimplantation murine embryos exposed to 4-hydroperoxycyclophosphamide, heat shock, and staurosporine. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Mirkes PE, Little SA | Mirkes PE, Little SA. Cytochrome c release from mitochondria of early postimplantation murine embryos exposed to 4-hydroperoxycyclophosphamide, heat shock, and staurosporine. Toxicology and Applied Pharmacology 2000;162(3):197-206. |
R826886 (2000) R826886C001 (2001) |
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| Journal Article | Teratogen-induced activation of ERK, JNK, and p38 MAP kinases in early postimplantation murine embryos. | TERATOLOGY | Mirkes PE, Wilson KL, Cornel LM | Mirkes PE, Wilson KL, Cornel LM. Teratogen-induced activation of ERK, JNK, and p38 MAP kinases in early postimplantation murine embryos. Teratology 2000;62(1):14-25. |
R826886 (2000) R826886C001 (2001) |
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| Journal Article | 2001 Warkany lecture: to die or not to die, the role of apoptosis in normal and abnormal mammalian development. | TERATOLOGY | Mirkes PE | Mirkes PE. 2001 Warkany lecture: to die or not to die, the role of apoptosis in normal and abnormal mammalian development. Teratology 2002;65(5):228-239. |
R826886 (2000) |
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| Journal Article | Improved cleanup and determination of dialkyl phosphates in the urine of children exposed to organophosphorus insecticides. | JOURNAL OF ANALYTICAL TOXICOLOGY | Moate TF, Lu C, Fenske RA, Hahne RMA, Kalman DA | Moate TF, Lu C, Fenske RA, Hahne RMA, Kalman DA. Improved cleanup and determination of dialkyl phosphates in the urine of children exposed to organophosphorus insecticides. Journal of Analytical Toxicology 1999;23(4):230-236. |
R825171 (1999) R825171 (2000) R826886 (2000) R826886C004 (2001) |
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| Journal Article | Size exclusion chromatographic cleanup for GC/MS determination of organophosphorus pesticide residues in household and vehicle dust. | JOURNAL OF AOAC INTERNATIONAL | Moate TF, Furia M, Curl C, Muniz JF, Yu J, Fenske RA | Moate TF, Furia M, Curl C, Muniz JF, Yu J, Fenske RA. Size exclusion chromatographic cleanup for GC/MS determination of organophosphorus pesticide residues in household and vehicle dust. Journal of the AOAC International 2002;85(1):36-43. |
R826886 (2000) R826886C004 (2001) R826886C004 (2002) |
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| Journal Article | Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. | JOURNAL OF NEUROSCIENCE | Namgung U, Xia Z | Namgung U, Xia Z. Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. Journal of Neuroscience 2000;20(17):6442-6451. |
R826886 (2000) |
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| Journal Article | Arsenic induces apoptosis in rat cerebellar neurons via activation of JNK3 and p38 MAP kinases. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Namgung U, Xia Z | Namgung U, Xia Z. Arsenic induces apoptosis in rat cerebellar neurons via activation of JNK3 and p38 MAP kinases. Toxicology and Applied Pharmacology 2001;174(2):130-138. |
R826886 (2000) R826886C001 (2002) |
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| Journal Article | Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Ou YC, Thompson SA, Ponce RA, Schroeder J, Kavanagh TJ, Faustman EM | Ou YC, Thompson SA, Ponce RA, Schroeder J, Kavanagh TJ, Faustman EM. Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo. Toxicology and Applied Pharmacology 1999;157(3):203-212. |
R825358 (Final) R826886 (2000) |
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| Journal Article | The role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells. | NEUROTOXICOLOGY | Ou YC, White CC, Krejsa CM, Ponce RA, Kavanagh TJ, Faustman EM | Ou YC, White CC, Krejsa CM, Ponce RA, Kavanagh TJ, Faustman EM. The role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells. NeuroToxicology 1999;20(5):793-804. |
R825358 (Final) R826886 (2000) |
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| Journal Article | Developmental toxicity: web resources for evaluating risk in humans. | TOXICOLOGY | Polifka JE, Faustman EM | Polifka JE, Faustman EM. Developmental toxicity: web resources for evaluating risk in humans. Toxicology 2002;173(1-2):35-65. |
R826886 (2000) |
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| Journal Article | Use of quality-adjusted life year weights with dose-response models for public health decisions: A case study of the risks and benefits of fish consumption. | RISK ANALYSIS | Ponce RA, Bartell SM, Wong EY, LaFlamme D, Carrington C, Lee RC, Patrick DL, Faustman EM, Bloger M | Ponce RA, Bartell SM, Wong EY, LaFlamme D, Carrington C, Lee RC, Patrick DL, Faustman EM, Bloger M. Use of quality-adjusted life year weights with dose-response models for public health decisions: A case study of the risks and benefits of fish consumption. Risk Analysis 2000;20(4):529-542. |
R826886 (2000) |
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| Journal Article | Quality adjusted life years (QALYs) and dose-response models in environmental health policy analysis--methodological considerations. | SCIENCE OF THE TOTAL ENVIRONMENT | Ponce RA, Wong EY, Faustman EM | Ponce RA, Wong EY, Faustman EM. Quality adjusted life years (QALYs) and dose-response models in environmental health policy analysis--methodological considerations. Science of the Total Environment 2001;274(1-3):79-91. |
R826886 (2000) |
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| Journal Article | SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation. | EMBO JOURNAL | Poser S, Impey S, Trinh K, Xia Z, Storm DR | Poser S, Impey S, Trinh K, Xia Z, Storm DR. SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation. EMBO Journal 2000;19(18):4955-4966. |
R826886 (2000) |
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| Journal Article | Determination of paraoxonase (PON1) status requires more than genotyping. | PHARMACOGENETICS | Richter RJ, Furlong CE | Richter RJ, Furlong CE. Determination of paraoxonase (PON1) status requires more than genotyping. Pharmacogenetics 1999;9(6):745-753. |
R826886 (2000) |
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| Journal Article | Effects of uncertainties on exposure estimates to methylmercury: A Monte Carlo analysis of biomarkers of exposure vs. dietary recall estimation. | RISK ANALYSIS | Sanga RN, Bartell SM, Ponce RA, Boischio AAP, Joiris CR, Pierce CH, Faustman EM | Sanga RN, Bartell SM, Ponce RA, Boischio AAP, Joiris CR, Pierce CH, Faustman EM. Effects of uncertainties on exposure estimates to methylmercury: A Monte Carlo analysis of biomarkers of exposure vs. predictive dietary estimation. Risk Analysis 2001;21(5):859-868. |
R826886 (2000) |
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| Journal Article | Identifying constituents to participate in a project to control pesticide exposure in children of farmworkers. | ENVIRONMENTAL HEALTH PERSPECTIVES | Thompson B, Coronado G, Puschel K, Allen E | Thompson B, Coronado G, Puschel K, Allen E. Identifying constituents to participate in a project to control pesticide exposure in children of farmworkers. Environmental Health Perspectives 2001;109(Suppl 3):443-448. |
R826886 (2000) R826886C003 (2001) R826886C003 (2002) R826886C004 (2001) R826886C004 (2002) |
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| Journal Article | Pesticide take-home pathway among children of agricultural workers: study design, methods, and baseline findings. | JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | Thompson B, Coronado GD, Grossman JE, Puschel K, Solomon CC, Islas I, Curl CL, Shirai JH, Kissel JC, Fenske RA | Thompson B, Coronado GD, Grossman JE, Puschel K, Solomon CC, Islas I, Curl CL, Shirai JH, Kissel JC, Fenske RA. Pesticide take-home pathway among children of agricultural workers: study design, methods, and baseline findings. Journal of Occupational and Environmental Medicine 2003;45(1):42-53. |
R826886 (2000) R826886C003 (2002) R831709 (2005) R831709 (2007) R831709 (Final) R831709C003 (2004) |
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| Journal Article | Co-localization of active caspase-3 and DNA fragmentation (TUNEL) in normal and hyperthermia-induced abnormal mouse development. | TERATOLOGY | Umpierre CC, Little SA, Mirkes PE | Umpierre CC, Little SA, Mirkes PE. Co-localization of active caspase-3 and DNA fragmentation (TUNEL) in normal and hyperthermia-induced abnormal mouse development. Teratology 2001;63(3):134-143. |
R826886 (2000) R826886C001 (2001) R826886C001 (2002) |
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| Journal Article | Individual prior information in a physiological model of 2H8-toluene kinetics: an empirical Bayes estimation strategy. | RISK ANALYSIS | Vicini P, Pierce CH, Dills RL, Morgan MS, Kalman DA | Vicini P, Pierce CH, Dills RL, Morgan MS, Kalman DA. Individual prior information in a physiological model of 2H8-toluene kinetics: an empirical Bayes estimation strategy. Risk Analysis 1999;19(6):1127-1134. |
R826886 (2000) |
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| Journal Article | Adult proxy responses to a survey of children's dermal soil contact activities. | JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY | Wong EY, Shirai JH, Garlock TJ, Kissel JC | Wong EY, Shirai JH, Garlock TJ, Kissel JC. Adult proxy responses to a survey of children's dermal soil contact activities. Journal of Exposure Analysis and Environmental Epidemiology 2000;10(6 Pt 1):509-517. |
R826886 (2000) |
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| Journal Article | Survey of selected activities relevant to exposures to soils. | BULLETIN OF ENVIORNMENTAL CONTAMINANTS AND TOXICOLOGY | Wong EY, Shirai JH, Garlock TJ, Kissel JC | Wong EY, Shirai JH, Garlock TJ, Kissel JC. Survey of selected activities relevant to exposures to soils. Bulletin of Enviornmental Contaminants and Toxicology 2000;65(4):443-450. |
R826886 (2000) |
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| Journal Article | TL1, a novel tumor necrosis factor-like cytokine, induces apoptosis in endothelial cells. Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) and caspase-3-like protease. | JOURNAL OF BIOLOGICAL CHEMISTRY | Yue TL, Ni J, Romanic AM, Gu JL, Keller P, Wang C, Kumar S, Yu GL, Hart TK, Wang X, Xia Z, DeWolf Jr WE, Feuerstein GZ | Yue TL, Ni J, Romanic AM, Gu JL, Keller P, Wang C, Kumar S, Yu GL, Hart TK, Wang X, Xia Z, DeWolf Jr WE, Feuerstein GZ. TL1, a novel tumor necrosis factor-like cytokine, induces apoptosis in endothelial cells. Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) and caspase-3-like protease. Journal of Biological Chemistry 1999;274(3):1479-1486. |
R826886 (2000) |
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| Journal Article | p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons. | JOURNAL OF BIOLOGICAL CHEMISTRY | Zhu Y, Mao XO, Sun Y, Xia Z, Greenberg DA | Zhu Y, Mao XO, Sun Y, Xia Z, Greenberg DA. p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons. Journal of Biological Chemistry 2002;277(25):22909-22914. |
R826886 (2000) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.