TY - CHAP A1 - Kwekel, J C A1 - Burgoon, L D A1 - Zacharewski, T T1 - Comparative toxicogenomics in mechanistic and predictive toxicology. Y1 - 2008// N1 - R831847 SP - 299 EP - 320 ER - TY - JOUR A1 - Kidambi, S A1 - Udpa, N A1 - Schroeder, S A A1 - Findlan, R A1 - Lee, I A1 - Chan, C T1 - Cell adhesion on polyelectrolyte multilayer coated polydimethylsiloxane surfaces with varying topographies. Y1 - 2007// N1 - R831847 JF - TISSUE ENGINEERING J1 - TISSUE ENG VL - 13 IS - 8 SP - 2105 EP - 2117 ER - TY - JOUR A1 - Kidambi, S A1 - Sheng, L A1 - Yarmush, M L A1 - Toner, M A1 - Lee, I A1 - Chan, C T1 - Patterned co-culture of primary hepatocytes and fibroblasts using polyelectrolyte multilayer templates. Y1 - 2007// N1 - R831847 JF - MACROMOLECULAR BIOSCIENCE VL - 7 IS - 3 SP - 344 EP - 353 ER - TY - JOUR A1 - Kiyosawa, N A1 - Kwekel, J C A1 - Burgoon, L D A1 - Williams, K J A1 - Tashiro, C A1 - Chittim, B A1 - Zacharewski, T R T1 - o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature, ovariectomized rat liver. Y1 - 2008/02/ N1 - R831847 JF - TOXICOLOGICAL SCIENCES J1 - TOXICOL SCI J2 - Toxicol.Sci. J3 - Toxicological Sciences SP - 350 EP - 363 ER - TY - JOUR A1 - Kwekel, J C A1 - Burgoon, L D A1 - Burt, J W A1 - Harkema, J R A1 - Zacharewski, T R T1 - A cross-species analysis of the rodent uterotrophic program: elucidation of conserved responses and targets of estrogen signaling. Y1 - 2005/11/17 N1 - R831847 JF - PHYSIOLOGICAL GENOMICS J1 - PHYSIOL GENOMICS VL - 23 IS - 3 SP - 327 EP - 342 ER - TY - JOUR A1 - Kwekel, J A1 - Forgacs, A A1 - Williams, K A1 - Zacharewski, T T1 - o-p'-DDT-mediated uterotrophy and gene expression in immature C57BL/6 mice and Sprague-Dawley rats Y1 - 2013/12/15 N1 - R831847 JF - TOXICOLOGY AND APPLIED PHARMACOLOGY J1 - TOXICOL APPL PHARM J2 - Toxicol.Appl.Pharmacol. J3 - Toxicol Appl Pharmacol J4 - Toxicology and Applied Pharmacology VL - 273 IS - 3 SP - 532 EP - 541 ER - TY - JOUR A1 - Li, Z A1 - Shaw, S M A1 - Yedwabnick, M J A1 - Chan, C T1 - Using a state-space model with hidden variables to infer transcription factor activities. Y1 - 2006/03/15 N1 - R831847 JF - BIOINFORMATICS J1 - BIOINFORMATICS J2 - LECT NOTES COMPUT SC J3 - METHOD BIOCHEM ANAL VL - 22 IS - 6 SP - 747 EP - 754 ER - TY - JOUR A1 - Li, Z A1 - Srivastava, S A1 - Mittal, S A1 - Yang, X A1 - Sheng, L A1 - Chan, C T1 - A three stage integrative pathway search (TIPS©) framework to identify toxicity relevant genes and pathways. Y1 - 2007/06/14 N1 - R831847 JF - BMC BIOINFORMATICS VL - 8 SP - 202 ER - TY - JOUR A1 - Li, Z A1 - Srivastava, S A1 - Yang, X A1 - Mittal, S A1 - Norton, P A1 - Resau, J A1 - Haab, B A1 - Chan, C T1 - A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells. Y1 - 2007/05/11 N1 - R831847 JF - BMC SYSTEMS BIOLOGY VL - 1 SP - 21 ER - TY - JOUR A1 - Li, Z A1 - Srivastava, S A1 - Findlan, R A1 - Chan, C T1 - Using dynamic gene module map analysis to identify targets that modulate free fatty acid induced cytotoxicity. Y1 - 2008/01/ N1 - R831847 JF - BIOTECHNOLOGY PROGRESS J1 - BIOTECHNOL PROGR VL - 24 IS - 1 SP - 29 EP - 37 ER - TY - JOUR A1 - Patil, S A1 - Melrose, J A1 - Chan, C T1 - Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons. Y1 - 2007/10/1 N1 - R831847 JF - EUROPEAN JOURNAL OF NEUROSCIENCE J1 - EUR J NEUROSCI VL - 26 IS - 8 SP - 2131 EP - 2141 ER - TY - JOUR A1 - Srivastava, S A1 - Chan, C T1 - Hydrogen peroxide and hydroxyl radicals mediate palmitate-induced cytotoxicity to hepatoma cells: relation to mitochondrial permeability transition. Y1 - 2007/01/ N1 - R831847 JF - FREE RADICAL RESEARCH J1 - FREE RADICAL RES VL - 41 IS - 1 SP - 38 EP - 49 ER - TY - JOUR A1 - Srivastava, S A1 - Li, Z A1 - Yang, X A1 - Yedwabnick, M A1 - Shaw, S A1 - Chan, C T1 - Identification of genes that regulate multiple cellular processes/responses in the context of lipotoxicity to hepatoma cells. Y1 - 2007/10/9 N1 - R831847 JF - BMC GENOMICS VL - 8 SP - 364 ER - TY - JOUR A1 - Srivastava, S A1 - Chan, C T1 - Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line. Y1 - 2008/02/1 N1 - R831847 JF - BIOTECHNOLOGY AND BIOENGINEERING J1 - BIOTECHNOL BIOENG VL - 99 IS - 2 SP - 399 EP - 410 ER - TY - JOUR A1 - Yang, X A1 - Chan, C T1 - Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2. Y1 - 2009/04/ N1 - R831847 JF - CELL RESEARCH J1 - CELL RES VL - 19 IS - 4 SP - 469 EP - 486 ER - TY - CONF A1 - Burgoon, L D A1 - Hung, S A1 - Kwekel, J C A1 - Boverhof, D R A1 - Dere, E A1 - Fong, C J A1 - Lang, W A1 - Zacharewski, T R T1 - Novel analytical methods for toxicogenomics. Y1 - 2006/12/4-6 N1 - R831847 ER - TY - CONF A1 - Chan, C T1 - Integrating multi-source biological data. Y1 - 2004/11/ N1 - R831847 ER - TY - CONF A1 - Chan, C T1 - A systems biology approach to reconstructing networks. Y1 - 2005/04/ N1 - R831847 ER - TY - CONF A1 - Chan, C T1 - Reconstructing biological networks from gene expression and phenotypic data. Y1 - 2005/11/ N1 - R831847 ER - TY - CONF A1 - Chan, C T1 - Reconstructing cellular networks from multi-level data. Y1 - 2005/10/ N1 - R831847 ER - TY - CONF A1 - Chan, C T1 - TIPS© for reconstructing signaling networks from high-throughput data. Y1 - 2005/10/ N1 - R831847 ER - TY - CONF A1 - Chan, C T1 - Integration of micro-array and metabolic data. Y1 - 2006/08/15-17 N1 - R831847 ER - TY - CONF A1 - Chan, C T1 - Reconstructing cellular networks from high throughput data. Y1 - 2006/12/ N1 - R831847 ER - TY - CONF A1 - Chan, C T1 - Using graphical models to infer pathways and networks from gene expression data. Y1 - 2006/03/ N1 - R831847 ER - TY - CONF A1 - Chan, C T1 - Using graphical models to infer transcription activities to networks. Y1 - 2006/03/ N1 - R831847 ER - TY - CONF A1 - Chan, C T1 - Methods that integrate domain knowledge with gene expression data to identify physiologically relevant discriminating genes. Y1 - 2007/04/30 N1 - R831847 ER - TY - CONF A1 - Chan, C T1 - Chemical engineering as preparation for systems biology. Y1 - 2007/11/4-9 N1 - R831847 ER - TY - CONF A1 - Chan, C T1 - Does domain knowledge contribute to the robustness of the network reconstructed from expression data? Y1 - 2007/09/26-29 N1 - R831847 ER - TY - CONF A1 - Forgacs, A A1 - Kwekel, J A1 - Burgoon, L A1 - Zacharewski, T R T1 - Comparative analysis of temporal gene expression, morphometry and utertrophy in o,p-DDT and ethynyl estradiol treated rats. Y1 - 2007/03/25-29 N1 - R831847 ER - TY - CONF A1 - Jin, R A1 - Si, L A1 - Srivastava, S A1 - Li, Z A1 - Chan, C T1 - A knowledge driven regression model for gene expression and microarray analysis. Y1 - 2006/08/30-3 N1 - R831847 ER - TY - CONF A1 - Kidambi, S A1 - Lee, I A1 - Chan, C T1 - Polyelectrolyte multilayer as bioactive surfaces for cell co-culture. Y1 - 2005/08/28-1 N1 - R831847 ER - TY - CONF A1 - Kidambi, S A1 - Lee, I A1 - Chan, C T1 - Patterns of aptamers on polyelectrolyte multilayers. Y1 - 2005// N1 - R831847 ER - TY - CONF A1 - Kidambi, S A1 - Chan, C A1 - Lee, I T1 - pH and salt responsive PEG SAMs on polyelectrolyte multilayer. Y1 - 2005// N1 - R831847 ER - TY - CONF A1 - Kidambi, S A1 - Lee, I A1 - Chan, C T1 - Salt tunable m-dPEG acid patterns on polyelectrolyte multilayers-templates for directed deposition of macromolecules. Y1 - 2006/03/26-30 N1 - R831847 ER - TY - CONF A1 - Kidambi, S A1 - Lee, I A1 - Chan, C T1 - Engineering aptamer and siRNA based drug delivery systems using polyelectrolyte multilayer films. Y1 - 2006/10/30-4 N1 - R831847 ER - TY - CONF A1 - Kwekel, J C A1 - Dalgleish, H A A1 - Burgoon, L D A1 - Harkema, J R A1 - Zacharewski, T R T1 - Analysis of gene expression during uterine induction and regression in immature, ovariectomized rats following treatment with ethynyl estradiol. Toxicogenomics. Y1 - 2005/06/5-10 N1 - R831847 ER - TY - CONF A1 - Kwekel, J C A1 - Dalgleish, H A A1 - Burgoon, L D A1 - Harkema, J R A1 - Zacharewski, T R T1 - Analysis of gene expression during uterine induction and regression in immature, ovariectomized rats following treatment with ethynyl estradiol. Y1 - 2005/03/6-10 N1 - R831847 ER - TY - CONF A1 - Kwekel, J C A1 - Fong, C J A1 - Forgacs, A L A1 - Burgoon, L D A1 - Zacharewski, T R T1 - Comparative analysis of temporal gene expression, morphometry and uterotrophy in ethynylestradiol and tamoxifen treated rats. Y1 - 2006/03/5-9 N1 - R831847 ER - TY - CONF A1 - Kwekel, J A1 - Fong, C A1 - Burgoon, L A1 - Zacharewski, T R T1 - Species-specific, compound-conserved gene expression of estrogen receptor ligands during uterotrophy. Y1 - 2007/06/1-6 N1 - R831847 ER - TY - CONF A1 - Kwekel, J A1 - Fong, C A1 - Burgoon, L B A1 - Zacharewski, T R T1 - Cross-species comparison of Tamoxifen and estrogen induced uterotrophy in rodents. Y1 - 2007/03/25-29 N1 - R831847 ER - TY - CONF A1 - Kwekel, J A1 - Fong, C A1 - Burgoon, L A1 - Zacharewski, T R T1 - Species-specific, compound-conserved gene expression of estrogen receptor ligands during uterotrophy. Y1 - 2007/05/21-23 N1 - R831847 ER - TY - CONF A1 - Li, Z A1 - Chan, C T1 - Systems approach based upon feature selection, Bayesian network and independent component analysis to integrate gene expression and metabolic profiles. Y1 - 2004// N1 - R831847 ER - TY - CONF A1 - Li, Z A1 - Srivastava, S A1 - Yang, X A1 - Chan, C T1 - Reconstructing gene regulatory and signaling pathways from high throughput data. Y1 - 2005/07/10-14 N1 - R831847 ER - TY - CONF A1 - Li, Z A1 - Srivastava, S A1 - Yang, X A1 - Chan, C T1 - Integrating gene expression and metabolic profiles to infer pathways and networks that confer palmitate induced cytotoxicity in HepG2 cells. Y1 - 2005/06/22-26 N1 - R831847 ER - TY - CONF A1 - Li, Z A1 - Srivastava, S A1 - Chan, C T1 - Integrating gene expression and metabolic profiles to identify genes that confer cytotoxicity in HepG2 cells. Y1 - 2005/03/13-17 N1 - R831847 ER - TY - CONF A1 - Li, Z A1 - Srivastava, S A1 - Yang, X A1 - Chan, C T1 - A systems approach to reconstructing pathways by integrating gene expression and metabolic profiles. Y1 - 2005// N1 - R831847 ER - TY - CONF A1 - Li, Z A1 - Srivastava, S A1 - Yang, A1 - X, A1 - Chan, C T1 - A systems approach to reconstructing pathways to connect genes with metabolites. Y1 - 2005// N1 - R831847 ER - TY - CONF A1 - Li, Z A1 - Shaw, S M A1 - Yedwabnick, M J A1 - Chan, C T1 - Inferring transcription factor activities with a probabilistic framework of Hidden Markov Model. Y1 - 2005// N1 - R831847 ER - TY - CONF A1 - Li, Z A1 - Srivastava, S A1 - Chan, C T1 - Network reconstruction to identify molecular targets of toxicity. Y1 - 2006/10/11-14 N1 - R831847 ER - TY - CONF A1 - Li, Z A1 - Srivastava, S A1 - Chan, C T1 - A hierarchical approach to identify phenotype relevant pathways. Y1 - 2006/10/30-4 N1 - R831847 ER - TY - CONF A1 - Li, Z A1 - Srivastava, S A1 - Chan, C T1 - Dynamic model integrating gene expression and metabolite profiles to identify lipotoxic pathways. Y1 - 2006/09/10-14 N1 - R831847 ER - TY - CONF A1 - Li, Z A1 - Srivastava, S A1 - Findlan, R A1 - Chan, C T1 - Identifying toxicity pathways through analysis of global transcriptional dynamics. Y1 - 2007/08/19-23 N1 - R831847 ER - TY - CONF A1 - Li, Z A1 - Srivastava, S A1 - Finland, R A1 - Chan, C T1 - Using dynamic analysis of module mapping to identify targets that modulate free fatty acid and tumor necrosis factor (TNF)-α induced cytotoxicity. Y1 - 2007/01/14-18 N1 - R831847 ER - TY - CONF A1 - Li, Z A1 - Srivastava, S A1 - Findlan, R A1 - Chan, C T1 - A study of the transcriptional dynamics of free fatty acids in liver cells. Y1 - 2007/07/15-19 N1 - R831847 ER - TY - CONF A1 - Li, Z A1 - Zhou, Y A1 - Srivastava, S A1 - Jin, R A1 - Chan, C T1 - Knowledge driven matrix factorization to reconstruct modular gene regulatory network. Y1 - 2007/11/4-9 N1 - R831847 ER - TY - CONF A1 - Li, Z A1 - Srivastava, S A1 - Zhang, L A1 - Jin, R A1 - Chan, C T1 - Identifying pathophysiology relevant pathways by integrating gene expression, metabolic profile with a priori knowledge. Y1 - 2007/09/26-29 N1 - R831847 ER - TY - CONF A1 - Mehrotra, S A1 - Lee, I A1 - Chan, C T1 - Three-dimensional (3-D) cellular assembly using self-standing composite polyelectrolyte multilayers. Y1 - 2007/11/4-9 N1 - R831847 ER - TY - CONF A1 - Patil, S A1 - Chan, C T1 - Involvement of saturated fatty acids in the pathogenesis of Alzheimer’s disease. Y1 - 2005// N1 - R831847 ER - TY - CONF A1 - Patil, S A1 - Chan, C T1 - Involvement of saturated fatty acids in the pathogenesis of Alzheimer’s disease. Y1 - 2006/04/1-5 N1 - R831847 ER - TY - CONF A1 - Patil, S A1 - Chan, C T1 - Involvement of saturated fatty acids in the pathogenesis of Alzheimer's disease. Y1 - 2006/07/15-20 N1 - R831847 ER - TY - CONF A1 - Patil, S A1 - Chan, C T1 - Astroglia-mediated involvement of saturated fatty acids in the pathogenesis of Alzheimer's disease. Y1 - 2006/09/29-1 N1 - R831847 ER - TY - CONF A1 - Patil, S A1 - Chan, C T1 - Role of astroglial fatty acid metabolism in the pathogenesis of Alzheimer's disease: a metabolic flux analysis (MFA) study. Y1 - 2007/08/19-23 N1 - R831847 ER - TY - CONF A1 - Srivastava, S A1 - Chan, C T1 - Application of metabolic flux analysis to identify the pathways of free fatty acid toxicity to liver cells. Y1 - 2005/07/10-14 N1 - R831847 ER - TY - CONF A1 - Srivastava, S A1 - Chan, C T1 - Integration of genetic and metabolic information to identify the mechanism of fatty acid toxicity. Y1 - 2005// N1 - R831847 ER - TY - CONF A1 - Srivastava, S A1 - Chan, C T1 - Knowledge-based integration of metabolic and genetic information to identify targets of fatty acid toxicity. Y1 - 2005// N1 - R831847 ER - TY - CONF A1 - Srivastava, S A1 - Zhang, L A1 - Jin, R A1 - Chan, C T1 - Unsupervised classification and identification of physiologically relevant features by integrating ontology information and expression data using Bayesian regression mixture models. Y1 - 2007/08/19-23 N1 - R831847 ER - TY - CONF A1 - Srivastava, S A1 - Jin, R A1 - Chan, C T1 - A novel feature selection method which incorporates ontology information to identify functionally relevant genes regulating processes of interest. Y1 - 2007/07/15-19 N1 - R831847 ER - TY - CONF A1 - Srivastava, S A1 - Chan, C T1 - Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line. Y1 - 2007/11/4-9 N1 - R831847 ER - TY - CONF A1 - Srivatsan, K A1 - Lee, I A1 - Chan, C T1 - Aptamer incorporated polyelectroyte multilayer films targeting influenza virus hemagglutinin. Y1 - 2007/08/19-23 N1 - R831847 ER - TY - CONF A1 - Srivatsan, K A1 - Mehrotra, S A1 - Gredell, J A1 - Walton, S P A1 - Lee, I A1 - Chan, C T1 - Polyelectrolyte multilayer films as platforms for efficient siRNA delivery. Y1 - 2007/08/19-23 N1 - R831847 ER - TY - CONF A1 - Wu, Y A1 - Leekumjorn, S A1 - Sum, A K A1 - Chan, C T1 - Experimental and computational investigation of trehalose protection from Palmitate induced toxicity of HepG2 cells. Y1 - 2007/11/4-9 N1 - R831847 ER - TY - CONF A1 - Yang, X A1 - Li, Z A1 - Srivastava, S A1 - Chan, C T1 - Regulation of apoptosis by free fatty acids and TNF-α: role of double-stranded RNA-dependent protein kinase (PKR). Y1 - 2005// N1 - R831847 ER - TY - CONF A1 - Yang, X A1 - Chan, C T1 - Connecting PKR and Bcl-2: a candidate mechanism for palmitate-induced apoptosis of human liver cells. Y1 - 2006/10/30-4 N1 - R831847 ER - TY - CONF A1 - Yang, X A1 - Chan, C T1 - Suppression of PKR activity mediates the apoptosis induced by palmitic acid and TNF-α in HepG2 cells. Y1 - 2007/08/19-23 N1 - R831847 ER - TY - CONF A1 - Yang, X A1 - Chan, C T1 - Regulation of cellular apoptosis by palmitic acid: involvement of signal transduction pathways from PKR to Bcl-2. Y1 - 2007/01/14-18 N1 - R831847 ER - TY - CONF A1 - Yang, X A1 - Chan, C T1 - PKR is involved in regulating both insulin signaling and hepatocellular apoptosis pathways. Y1 - 2007/11/4-9 N1 - R831847 ER - TY - CONF A1 - Yang, X A1 - Chan, C T1 - PKR is involved in regulating both insulin signaling and hepatocellular apoptosis pathways. Y1 - 2007/09/26-29 N1 - R831847 ER - TY - CONF A1 - Zacharewski, T R T1 - Computational and empirical investigation of estrogen and dioxin elicited effects: a comparative analysis. Cross-species Toxicology in the Age of Genomics Symposium. Y1 - 2005/03/6-10 N1 - R831847 ER - TY - CONF A1 - Zacharewski, T R T1 - Incorporation of toxicogenomics into quantitative risk assessment. Y1 - 2005/11/15 N1 - R831847 ER - TY - CONF A1 - Zacharewski, T R T1 - Identification of early biomarkers of toxicity for the development of high throughput screening assays using comparative toxicogenomics. Y1 - 2006/08/15-16 N1 - R831847 ER - TY - CONF A1 - Zacharewski, T R T1 - Comparative analysis of the rodent uterotropic response: identification of conserved responses and mechanisms of action. Advancing Toxicology by Improving Linkage of Traditional Toxicity and Pathology Endpoints with Toxicogenomics. Y1 - 2006/03/5-9 N1 - R831847 ER - TY - CONF A1 - Zacharewski, T R T1 - Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD. Y1 - 2006/11/3 N1 - R831847 ER - TY - CONF A1 - Zacharewski, T R T1 - Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD. Y1 - 2006/11/9 N1 - R831847 ER - TY - CONF A1 - Zacharewski, T R T1 - Toxicogenomic assessment of endocrine disruptors. Y1 - 2006/09/8-9 N1 - R831847 ER - TY - CONF A1 - Zacharewski, T R T1 - Toxicogenomics: what have we learned about mechanisms of toxicity? Y1 - 2007/07/17 N1 - R831847 ER - TY - CONF A1 - Zhang, L A1 - Howes, T A1 - Wright, N T A1 - Chan, C T1 - Studying the regulation of mesenchymal stem cell proliferation versus differentiation by cAMP signaling. Y1 - 2006/10/30-4 N1 - R831847 ER - TY - CONF A1 - Zhang, L A1 - Chan, C T1 - cAMP induced neural differentiation of mesenchymal stem cells: real differentiation or pseudo-differentiation? Y1 - 2007/08/19-23 N1 - R831847 ER - TY - CONF A1 - Zhang, L A1 - Howes, T A1 - Wright, N T A1 - Chan, C T1 - Studying the regulation of mesenchymal stem cell proliferation versus differentiation by cAMP signaling. Y1 - 2007/01/14-18 N1 - R831847 ER - TY - CONF A1 - Zhang, L A1 - Chan, C T1 - cAMP signaling caused apoptosis in Palmitate conditioned HepG2 cells. Y1 - 2007/11/4-9 N1 - R831847 ER - TY - CONF A1 - Zhang, L A1 - Chan, C T1 - cAMP induced both differentiation and apoptosis of mesenchymal stem cells. Y1 - 2007/09/26-29 N1 - R831847 ER -