TY - Abstract A1 - Chen, G Q A1 - Zhou, L A1 - Chen, Z A1 - Jing, Y K A1 - Styblo, M A1 - Waxman, S T1 - Arsenic trioxide-induced apoptosis of acute promyelocytic leukemia (APL) cells is associated with reduced akt phosphorylation and modified by arsenic methylation. Y1 - 2001// N1 - R826136 JF - BLOOD J1 - BLOOD VL - 98 SP - 1296 ER - TY - Abstract A1 - Del, R A1 - Styblo, M A1 - Cullen, W R A1 - Thomas, D J T1 - Determination of urinary trivalent arsenicals (MMAsIII and DMAsIII) in individuals chronically exposed to arsenic. Y1 - 2001/03/ N1 - R826136 JF - THE TOXICOLOGIST VL - 60 IS - 1 SP - 1496 ER - TY - Abstract A1 - Easterling, M R A1 - Styblo, M A1 - Evans, M V A1 - Kenyon, E M T1 - A pharmacokinetic model for arsenic metabolism in primary rat hepatocytes. Y1 - 2001/03/ N1 - R826136 JF - THE TOXICOLOGIST VL - 60 IS - 1 SP - 712 ER - TY - Abstract A1 - Lin, S A1 - Del, R A1 - Styblo, M A1 - Wang, C A1 - Cullen, W R A1 - Thomas, D J T1 - Arsenic inhibits thioredoxin reductase activity in cultured rat hepatocytes. Y1 - 2001/03/ N1 - R826136 JF - THE TOXICOLOGIST VL - 60 IS - 1 SP - 359 ER - TY - Abstract A1 - Mass, M J A1 - Tennant, A A1 - Roop, B A1 - Kundu, B A1 - Brock, K A1 - Kligerman, A A1 - Demarini, D A1 - Wang, C A1 - Cullen, W R A1 - Thomas, D J A1 - Styblo, M T1 - Methylated arsenic(III) species react directly with DNA and are potential proximate or ultimate genotoxic forms of arsenic. Y1 - 2001/03/ N1 - R826136 JF - THE TOXICOLOGIST VL - 60 IS - 1 SP - 358 ER - TY - Abstract A1 - Styblo, M A1 - Hamilton, G A A1 - LeCluyse, E L A1 - Thomas, D J T1 - Arsenic-selenium interactions in human and rat hepatocytes. Y1 - 2000/03/ N1 - R826136 JF - THE TOXICOLOGIST VL - 54 IS - 1 SP - 1958 ER - TY - Abstract A1 - Styblo, M A1 - Del, R A1 - LeCluyse, E L A1 - Thomas, D J T1 - Metabolism and toxicity of arsenicals in primary rat hepatocytes. Y1 - 2000/03/ N1 - R826136 JF - THE TOXICOLOGIST VL - 54 IS - 1 SP - 416 ER - TY - Abstract A1 - Styblo, M A1 - Hamilton, G A A1 - LeCluyse, E L A1 - Thomas, D J T1 - Apparent sexual differences in metabolism of inorganic arsenic in primary human hepatocytes. Y1 - 2001/03/ N1 - R826136 JF - THE TOXICOLOGIST VL - 60 IS - 1 SP - 1493 ER - TY - JOUR A1 - Del, R A1 - Styblo, M A1 - Cullen, W R A1 - Thomas, D J T1 - Determination of trivalent methylated arsenicals in biological matrices. Y1 - 2001/08/1 N1 - R826136 JF - TOXICOLOGY AND APPLIED PHARMACOLOGY J1 - TOXICOL APPL PHARM J2 - Toxicol.Appl.Pharmacol. J3 - Toxicol Appl Pharmacol J4 - Toxicology and Applied Pharmacology VL - 174 IS - 3 SP - 282 EP - 293 ER - TY - JOUR A1 - Easterling, M R A1 - Styblo, M A1 - Evans, M V A1 - Kenyon, E M T1 - Pharmacokinetic modeling of arsenite uptake and metabolism in hepatocytes–mechanistic insights and implications for further experiments. Y1 - 2002/06/ N1 - R826136 VL - 29 IS - 3 SP - 207 EP - 234 ER - TY - JOUR A1 - Lin, S A1 - Del, R A1 - Styblo, M A1 - Wang, C A1 - Cullen, W R A1 - Thomas, D J T1 - Arsenicals inhibit thioredoxin reductase in cultured rat hepatocytes. Y1 - 2001/03/ N1 - R826136 JF - CHEMICAL RESEARCH IN TOXICOLOGY J1 - CHEM RES TOXICOL VL - 14 IS - 3 SP - 305 EP - 311 ER - TY - JOUR A1 - Lin, S A1 - Shi, Q A1 - Nix, F B A1 - Styblo, M A1 - Beck, M A A1 - Herbin-Davis, K M A1 - Hall, L L A1 - Simeonsson, J B A1 - Thomas, D J T1 - A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol. Y1 - 2002/03/29 N1 - R826136 JF - JOURNAL OF BIOLOGICAL CHEMISTRY J1 - J BIOL CHEM J2 - J.Biol.Chem. VL - 277 IS - 13 SP - 10795 EP - 10803 ER - TY - JOUR A1 - Mass, M J A1 - Tennant, A A1 - Roop, B C A1 - Cullen, W R A1 - Styblo, M A1 - Thomas, D J A1 - Kligerman, A D T1 - Methylated trivalent arsenic species are genotoxic. Y1 - 2001/04/ N1 - R826136 JF - CHEMICAL RESEARCH IN TOXICOLOGY J1 - CHEM RES TOXICOL VL - 14 IS - 4 SP - 355 EP - 361 ER - TY - JOUR A1 - Styblo, M A1 - Del, R A1 - LeCluyse, E L A1 - Hamilton, G A A1 - Wang, C A1 - Cullen, W R A1 - Thomas, D J T1 - Metabolism of arsenic in primary cultures of human and rat hepatocytes. Y1 - 1999/07/ N1 - R826136 JF - CHEMICAL RESEARCH IN TOXICOLOGY J1 - CHEM RES TOXICOL VL - 12 IS - 7 SP - 560 EP - 565 PB - American Chemical Society ER - TY - JOUR A1 - Styblo, M A1 - Del, R A1 - Vega, L A1 - Germolic, D R A1 - LeCluyse, E L A1 - Hamilton, G A A1 - Reed, W A1 - Wang, C A1 - Cullen, W R A1 - Thomas, D J T1 - Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Y1 - 2000/08/ N1 - R826136 JF - TOXICOLOGY AND APPLIED PHARMACOLOGY J1 - TOXICOL APPL PHARM J2 - Toxicol.Appl.Pharmacol. J3 - Toxicol Appl Pharmacol J4 - Toxicology and Applied Pharmacology VL - 74 IS - 6 SP - 289 EP - 299 ER - TY - JOUR A1 - Styblo, M A1 - Thomas, D J T1 - Selenium modifies the metabolism and toxicity of arsenic in primary rat hepatocytes. Y1 - 2001/04/1 N1 - R826136 JF - TOXICOLOGY AND APPLIED PHARMACOLOGY J1 - TOXICOL APPL PHARM J2 - Toxicol.Appl.Pharmacol. J3 - Toxicol Appl Pharmacol J4 - Toxicology and Applied Pharmacology VL - 172 IS - 1 SP - 52 EP - 61 ER - TY - JOUR A1 - Styblo, M A1 - Drobna, Z A1 - Jaspers, I A1 - Lin, S A1 - Thomas, D J T1 - The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update. Y1 - 2002/10/ N1 - R826136 JF - ENVIRONMENTAL HEALTH PERSPECTIVES J1 - ENVIRON HEALTH PERSP J2 - Environ.Health Perspect. J3 - Environ Health Perspect J4 - Environmental Health Perspectives VL - 110 IS - Suppl 5 SP - 767 EP - 771 ER - TY - JOUR A1 - Thomas, D J A1 - Styblo, M A1 - Shan, L T1 - The cellular metabolism and systemic toxicity of arsenic. Y1 - 2001/10/15 N1 - R826136 JF - TOXICOLOGY AND APPLIED PHARMACOLOGY J1 - TOXICOL APPL PHARM J2 - Toxicol.Appl.Pharmacol. J3 - Toxicol Appl Pharmacol J4 - Toxicology and Applied Pharmacology VL - 176 IS - 2 SP - 127 EP - 144 ER - TY - JOUR A1 - Thomas, D J A1 - Waters, S B A1 - Styblo, M T1 - Elucidating the pathway for arsenic methylation. Y1 - 2004/08/1 N1 - R826136 VL - 198 IS - 3 SP - 319 EP - 326 ER - TY - JOUR A1 - Vega, L A1 - Styblo, M A1 - Patterson, R A1 - Cullen, W A1 - Wang, C A1 - Germolec, D T1 - Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytes. Y1 - 2001/05/1 N1 - R826136 JF - TOXICOLOGY AND APPLIED PHARMACOLOGY J1 - TOXICOL APPL PHARM J2 - Toxicol.Appl.Pharmacol. J3 - Toxicol Appl Pharmacol J4 - Toxicology and Applied Pharmacology VL - 172 IS - 3 SP - 225 EP - 232 ER - TY - CONF A1 - Styblo, M A1 - Del%20Razo, L M A1 - Thomas, D J T1 - Metabolism and toxicity of arsenicals in primary rat hepatocytes. N1 - R826136 ER - TY - CONF A1 - Chen, G Q A1 - Zhou, L A1 - Chen, Z A1 - Jing, Y K A1 - Styblo, M A1 - Waxman, S T1 - Arsenic trioxide-induced apoptosis of Acute Promyelocytic Leukemic (APL) cells is associated with reduced akt phosphorylation and modified by arsenic methylation. Y1 - 2001/12/7-11 N1 - R826136 ER - TY - CONF A1 - Del, R A1 - Styblo, M A1 - Thomas, D J T1 - Determination of trivalent methylated arsenic species in water, cultured rat hepatocytes and human urine. Y1 - 2000/06/ N1 - R826136 ER - TY - CONF A1 - Del, R A1 - Styblo, M A1 - Cullen, W R A1 - Thomas, D J T1 - Determination of urinary trivalent arsenicals (MMAsIII and DMAsIII) in individuals chronically exposed to arsenic. Y1 - 2001/03/ N1 - R826136 ER - TY - CONF A1 - Easterling, M R A1 - Styblo, M A1 - Evans, M V A1 - Kenyon, E M T1 - A pharmacokinetic model for arsenic metabolism in primary rat hepatocytes. Y1 - 2000/06/ N1 - R826136 ER - TY - CONF A1 - Easterling, M R A1 - Styblo, M A1 - Evans, M V A1 - Kenyon, E M T1 - A pharmacokinetic model for arsenic metabolism in primary rat hepatocytes. Y1 - 2001/03/ N1 - R826136 ER - TY - CONF A1 - Lin, S A1 - Styblo, M A1 - Del, R A1 - Thomas, D J T1 - Inhibition of thioredoxin reductase activity in rat hepatocytes by arsenicals. Y1 - 2000/06/ N1 - R826136 ER - TY - CONF A1 - Lin, S A1 - Styblo, M A1 - Del, R A1 - Thomas, D J T1 - Metabolism of arsenic and inhibition of thioredoxin reductase in rat hepatocytes. Y1 - 2000/05/7-10 N1 - R826136 ER - TY - CONF A1 - Lin, S A1 - Del, R A1 - Styblo, M A1 - Wang, C A1 - Cullen, W R A1 - Thomas, D J T1 - Arsenic inhibits thioredoxin reductase activity in cultured rat hepatocytes. Y1 - 2001/03/ N1 - R826136 ER - TY - CONF A1 - Marc, M J A1 - Tennant, A A1 - Roop, B A1 - Kundu, B A1 - Brock, K A1 - Kligerman, A A1 - Demarini, D A1 - Wang, C A1 - Cullen, W R A1 - Thomas, D J A1 - Styblo, M T1 - Methylated arsenic(III) species react directly with DNA and are potential proximate or ultimate genotoxic forms of arsenic. Y1 - 2001/03/ N1 - R826136 ER - TY - CONF A1 - Mass, M J A1 - Roop, B A1 - Tennant, A A1 - Brock, K A1 - Kundu, B A1 - Pimentel, M A1 - Demarini, D A1 - Kligerman, A A1 - Nesnow, S A1 - Wang, C A1 - Thomas, D J A1 - Styblo, M A1 - Cullen, W R T1 - Arsenic(III) methylated species react with DNA directly and could be proximate/ultimate genotoxic forms of arsenic. Y1 - 2000/04/1-5 N1 - R826136 ER - TY - CONF A1 - Styblo, M T1 - Metabolism and toxicity of arsenicals in cultured cells. Y1 - 1998/07/12-15 N1 - R826136 ER - TY - CONF A1 - Styblo, M A1 - Del, R A1 - Thomas, D J T1 - Metabolism and toxicity of arsenicals in primary rat hepatocytes. Y1 - 1999/03/ N1 - R826136 ER - TY - CONF A1 - Styblo, M T1 - Novel markers of arsenic exposure and toxicity in human cells. Y1 - 2000/07/12-13 N1 - R826136 ER - TY - CONF A1 - Styblo, M T1 - Toxic consequences of the metabolism of arsenic. Y1 - 2000/06/18-22 N1 - R826136 ER - TY - CONF A1 - Styblo, M T1 - Toxicity of methylarsenic species in human cells. Y1 - 2000/06/25-1 N1 - R826136 ER - TY - CONF A1 - Styblo, M A1 - Hamilton, G A A1 - LeCluyse, E L A1 - Thomas, D J T1 - Arsenic-selenium interactions in human and rat hepatocytes. Y1 - 2000/03/ N1 - R826136 ER - TY - CONF A1 - Styblo, M A1 - Del, R A1 - LeCluyse, E L A1 - Thomas, D J T1 - Metabolism and toxicity of arsenicals in primary rat hepatocytes. Y1 - 2000/03/ N1 - R826136 ER - TY - CONF A1 - Styblo, M T1 - Metabolism of inorganic and methylated arsenicals in primary human hepatocytes. Y1 - 2000/05/7-10 N1 - R826136 ER - TY - CONF A1 - Styblo, M A1 - Hamilton, G A A1 - LeCluyse, E L A1 - Thomas, D J T1 - Apparent sexual differences in metabolism of inorganic arsenic in primary human hepatocytes. Y1 - 2001/03/ N1 - R826136 ER - TY - CONF A1 - Styblo, M T1 - Does biomethylation contribute to the toxicity and genotoxicity of arsenic? Y1 - 2001/09/1-8 N1 - R826136 ER - TY - CONF A1 - Styblo, M A1 - Vega, L A1 - Germolec, D R A1 - Luster, M I A1 - Del, R A1 - Wang, C A1 - Cullen, W R A1 - Thomas, D J T1 - Metabolism and toxicity of arsenicals in cultured cells. Y1 - 1998/07/12-15 N1 - R826136 SP - 311 EP - 323 ER - TY - CONF A1 - Styblo, M A1 - Lin, S A1 - Del, R A1 - Thomas, D J T1 - Trivalent methylated arsenicals: toxic products of the metabolism of inorganic arsenic. Y1 - 2000/07/18-22 N1 - R826136 SP - 325 EP - 337 ER -