Grantee Research Project Results
Publications Details for Grant Number R831709C001
Molecular Mechanisms of Pesticide-Induced Developmental Toxicity
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Centers for Children's Environmental Health and Disease Prevention Research (2003)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Abstract | Toxicant affects on ubiquitin-proteosome systems: lessons from cross-compound and cross-system assessments. | THE TOXICOLOGIST | Faustman EM, Yu X, Sidhu J, Robinson J | Faustman EM, Yu X, Sidhu J, Robinson J. Toxicant affects on ubiquitin-proteosome systems: lessons from cross-compound and cross-system assessments. The Toxicologist 2005;84(S1):1655. |
R831709 (Final) R831709C001 (2005) |
not available |
| Abstract | Lessons learned from longitudinal studies to identify high exposure groups using OP pesticide urinary biomarkers. | TOXICOLOGY LETTERS | Faustman EM, Griffith WC, Vigoren E | Faustman EM, Griffith WC, Vigoren E. Lessons learned from longitudinal studies to identify high exposure groups using OP pesticide urinary biomarkers. Toxicology Letters 2006;164(Suppl 1):S161. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2007) |
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| Abstract | Reactive oxygen species mediate the neurotoxicity induced by organophosphorus insecticides in mouse cerebellar granule cells. | TOXICOLOGIST | Giordano G, Afsharinejad Z, Kavanagh T, Costa L | Giordano G, Afsharinejad Z, Kavanagh T, Costa L. Reactive oxygen species mediate the neurotoxicity induced by organophosphorus insecticides in mouse cerebellar granule cells. The Toxicologist 2006;90(1):301. |
R831709 (2005) R831709 (2006) R831709C001 (2006) R831709C001 (2007) |
not available |
| Abstract | Computational models for the acquisition of neocortical neurons in the developing humans, monkey, and mouse: cross species comparison of toxicodynamics. | THE TOXICOLOGIST | Gohlke JM, Griffith WC, Faustman EM | Gohlke JM, Griffith WC, Faustman EM. Computational models for the acquisition of neocortical neurons in the developing humans, monkey, and mouse: cross species comparison of toxicodynamics. The Toxicologist 2005;84(S1):69. |
R831709C001 (2005) |
not available |
| Abstract | A role for p53 in mouse midbrain neural precursor cell (NPC) cell cycle arrest and premature neuronal differentiation following methylmercury exposure. | TOXICOLOGIST | Gribble E, Yu X, Hong S, Faustman E | Gribble EJ, Yu X, Hong S, Faustman EM. A role for p53 in mouse midbrain neural precursor cell (NPC) cell cycle arrest and premature neuronal differentiation following methylmercury exposure. The Toxicologist 2006;90:366. |
R831709 (2005) R831709 (2006) R831709C001 (2006) |
not available |
| Abstract | Examination of metal-induced cell cycle alterations and apoptosis in C57BL/6 and SWV mouse embryonic fibroblasts. | THE TOXICOLOGIST | Robinson J, Yu X, Sidhu J, Hong S, Kim E, Faustman EM | Robinson J, Yu X, Sidhu J, Hong S, Kim E, Faustman EM. Examination of metal-induced cell cycle alterations and apoptosis in C57BL/6 and SWV mouse embryonic fibroblasts. The Toxicologist 2005;84(S1):2257. |
R831709C001 (2005) |
not available |
| Abstract | Differential impact of cadmium on gene expression during neuralation in the C57BL/6 and SWV. | BIRTH DEFECTS RESEARCH PART A< | Robinson J, Yu X, Hong S, Kim E, Sullivan R, Griffith W, Faustman E | Robinson J, Yu X, Hong S, Kim E, Sullivan R, Griffith W, Faustman E. Differential impact of cadmium on gene expression during neuralation in the C57BL/6 and SWV. Birth Defects Research Part A 2006;76(5):392. |
R831709 (2005) R831709 (2006) R831709C001 (2006) |
not available |
| Abstract | Examination of arsenic-induced alterations in cell cycle progression and global gene expression in p53 transgenic mouse embryonic fibroblasts. | TOXICOLOGIST | Robinson J, Yu X, Gribble E, Hong S, Kim E, Sidhu J, Faustman E | Robinson JF, Yu X, Gribble EJ, Hong S, Kim E, Sidhu JS, Faustman EM. Examination of arsenic-induced alterations in cell cycle progression and global gene expression in p53 transgenic mouse embryonic fibroblasts. The Toxicologist 2006;90:91-92. |
R831709 (2005) R831709 (2006) R831709C001 (2006) |
not available |
| Abstract | Integrative analysis of genome-wide gene expression and pathway mapping in mouse embryonic fibroblast (MEF) exposed to cadmium, arsenic, and methylmercury: induction of oxidative stress, disruption of ubiquitin-proteasome system and cell cycle regulation. | THE TOXICOLOGIST | Yu X, Sidhu J, Robinson J, Hong S, Faustman EM | Yu X, Sidhu J, Robinson J, Hong S, Faustman EM. Integrative analysis of genome-wide gene expression and pathway mapping in mouse embryonic fibroblast (MEF) exposed to cadmium, arsenic, and methylmercury: induction of oxidative stress, disruption of ubiquitin-proteasome system and cell cycle regulation. The Toxicologist 2005;84(S1):1155. |
R831709C001 (2005) |
not available |
| Abstract | Functional interpretation of dose and time-dependent microarray data: quantitative integration of GO ontology analysis for toxicology and risk assessment. | TOXICOLOGIST | Yu X, Griffith W, Hanspers K, Robinson J, Faustman EM | Yu X, Griffith W, Hanspers K, Robinson J, Faustman EM. Functional interpretation of dose-and time-dependent microarray data: quantitative integration of GO ontology analysis for toxicology and risk assessment. The Toxicologist 2006;90(1):182-183. |
R831709 (2005) R831709 (2006) R831709C001 (2006) R831709C001 (2007) |
not available |
| Abstract | A systems based approach to identify potential signalling pathways during gonad development from microarray data. | BIRTH DEFECTS RESEARCH PART A | Yu X, Griffith W, Hanspers K, Ong H, Faustman E | Yu X, Griffith WC, Hanspers K, Ong H, Faustman EM. A system based approach to identify potential signalling pathways during gonad development from microarray data. Birth Defects Research Part A 2006;76(5):339. |
R831709 (2005) R831709 (2006) R831709C001 (2006) |
not available |
| Book Chapter | Experimental approaches to evaluate mechanisms of developmental toxicity. | None | Faustman EM, Gohlke JM, Ponce RA, Lewandowski TA, Seeley MR, Whittaker SG, Griffith WC | Faustman EM, Gohlke JM, Ponce RA, Lewandowski TA, Seeley MR, Whittaker SG, Griffith WC. Experimental approaches to evaluate mechanisms of developmental toxicity. In: Hood RD, ed. Developmental and Reproductive Toxicology: A Practical Approach, 2nd edition. Boca Raton, FL: CRC Press, Inc., 2005, Chapter 2, pp. 15-60. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2004) |
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| Journal Article | Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases. | TOXICOLOGICAL SCIENCES | Caughlan A, Newhouse K, Namgung U, Xia Z | Caughlan A, Newhouse K, Namgung U, Xia Z. Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases. Toxicological Sciences 2004;78(1):125-134. |
R831709 (2007) R831709C001 (2004) |
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| Journal Article | Current issues in organophosphate toxicology. | CLINICA CHIMICA ACTA | Costa LG | Costa LG. Current issues in organophosphate toxicology. Clinica Chimica Acta 2006;366(1-2):1-13. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C001 (2006) |
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| Journal Article | Gene-environment interactions: paraoxonase (PON1) and sensitivity to organophosphate toxicity. | LABMEDICINE | Costa LG, Cole TB, Furlong CE | Costa LG, Cole TB, Furlong CE. Gene-environment interactions:paraoxonase (PON1) and sensitivity to organophosphate toxicity. LabMedicine 2006;37(2):109-113. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2007) R831709C002 (2007) |
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| Journal Article | Neurotoxicity of pesticides: a brief review. | FRONTIERS IN BIOSCIENCE | Costa LG, Giordano G, Guizzetti M, Vitalone A | Costa LG, Giordano G, Guizzetti M, Vitalone A. Neurotoxicity of pesticides: a brief review. Frontiers in Bioscience 2008;13(4):1240-1249. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2007) R831709C002 (2007) |
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| Journal Article | A framework for assessing risks to children from exposure to environmental agents. | ENVIRONMENTAL HEALTH PERSPECTIVES | Daston G, Faustman E, Ginsberg G, Fenner-Crisp P, Olin S, Sonawane B, Bruckner J, Breslin W, McLaughlin TJ | Daston G, Faustman E, Ginsberg G, Fenner-Crisp P, Olin S, Sonawane B, Bruckner J, Breslin W, McLaughlin TJ. A framework for assessing risks to children from exposure to environmental agents. Environmental Health Perspectives 2004;112(2):238-256. |
R831709 (2007) R831709C001 (2004) |
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| Journal Article | Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. | ENVIRONMENTAL HEALTH PERSPECTIVES | Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K | Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. |
R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) R829390 (2005) R829390 (Final) R829390C002 (2005) R831709 (2005) R831709 (Final) R831709C001 (2004) R831710 (2005) R831710 (Final) R831710C001 (2006) R831710C002 (2006) R831711 (2005) R831711 (2006) R831711 (2007) R831711 (Final) R831711C001 (2006) R831711C002 (2004) R831711C002 (2006) R831711C003 (2006) R832141 (2005) R832141 (2007) R832141 (Final) |
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| Journal Article | Modeling developmental processes in animals: applications in neurodevelopmental toxicology. | None | Faustman EM, Gohlke J, Judd NL, Lewandowski TA, Bartell SM, Griffith WC | Faustman EM, Gohlke J, Judd NL, Lewandowski TA, Bartell SM, Griffith WC. Modeling developmental processes in animals:applications in neurodevelopmental toxicology. Environmental Toxicology and Pharmacology 2005;19(3):615-624. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C001 (2004) R831709C001 (2005) R831709C001 (2006) |
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| Journal Article | Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG | Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicology and Applied Pharmacology 2007;219(2-3):181-189. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C001 (2006) R831709C001 (2007) R831709C002 (2007) |
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| Journal Article | The role of cell death during neocortical neurogenesis and synaptogenesis: implications from a computational model for the rat and mouse. | DEVELOPMENTAL BRAIN RESEARCH | Gohlke JM, Griffith WC, Faustman EM | Gohlke JM, Griffith WC, Faustman EM. The role of cell death during neocortical neurogenesis and synaptogenesis:implications from a computational model for the rat and mouse. Developmental Brain Research 2004;151(1-2):43-54. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2004) |
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| Journal Article | A systems-based computational model for dose-response comparisons of two mode of action hypotheses for ethanol-induced neurodevelopmental toxicity. | TOXICOLOGY SCIENCE | Gohlke JM, Griffith WC, Faustman EM | Gohlke JM, Griffith WC, Faustman EM. A systems-based computational model for dose-response comparisons of two mode of action hypotheses for ethanol-induced neurodevelopmental toxicity. Toxicological Sciences 2005;86(2):470-484. |
R831709 (2004) R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2005) |
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| Journal Article | The magnitude of methylmercury-induced cytotoxicity and cell cycle arrest is p53-dependent. | BIRTH DEFECTS RESEARCH PART A: CLINICAL AND MOLECULAR TERATOLOGY | Gribble EJ, Hong SW, Faustman EM | Gribble EJ, Hong SW, Faustman EM. The magnitude of methylmercury-induced cytotoxicity and cell cycle arrest is p53-dependent. Birth Defects Research Part A:Clinical and Molecular Teratology 2005;73(1):29-38. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2004) |
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| Journal Article | Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. | TOXICOLOGY | Guizzetti M, Pathak S, Giordano G, Costa LG | Guizzetti M, Pathak S, Giordano G, Costa LG. Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. Toxicology 2005;215(3):182-190. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C001 (2005) R831709C001 (2006) R831709C002 (2006) |
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| Journal Article | Changes in cell cycle parameters and cell number in the rat midbrain during organogenesis. | DEVELOPMENTAL BRAIN RESEARCH | Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM | Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM. Changes in cell cycle parameters and cell number in the rat midbrain during organogenesis. Developmental Brain Research 2003;141(1-2):117-128. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2004) |
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| Journal Article | Effect of methylmercury on midbrain cell proliferation during organogenesis: potential cross-species differences and implications for risk assessment. | TOXICOLOGICAL SCIENCES | Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM | Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM. Effect of methylmercury on midbrain cell proliferation during organogenesis:potential cross-species differences and implications for risk assessment. Toxicological Sciences 2003;75(1):124-133. |
R831709 (2005) R831709 (2007) R831709 (Final) R831709C001 (2004) |
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| Journal Article | Cell cycle inhibition by sodium arsenite in primary embryonic rat midbrain neuroepithelial cells. | TOXICOLOGICAL SCIENCES | Sidhu JS, Ponce RA, Vredevoogd MA, Yu X, Gribble E, Hong S-W, Schneider E, Faustman EM | Sidhu JS, Ponce RA, Vredevoogd MA, Yu X, Gribble E, Hong S-W, Schneider E, Faustman EM. Cell cycle inhibition by sodium arsenite in primary embryonic rat midbrain neuroepithelial cells. Toxicological Sciences 2006;89(2):475-484. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C001 (2005) R831709C001 (2006) |
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| Journal Article | A system-based approach to interpret dose- and time-dependent microarray data: quantitative integration of gene ontology analysis for risk assessment. | TOXICOLOGICAL SCIENCES | Yu X, Griffith WC, Hanspers K, Dillman III JF, Ong H, Vredevoogd MA, Faustman EM | Yu X, Griffith WC, Hanspers K, Dillman III JF, Ong H, Vredevoogd MA, Faustman EM. A system-based approach to interpret dose-and time-dependent microarray data:quantitative integration of gene ontology analysis for risk assessment. Toxicological Sciences 2006;92(2):560-577. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709 (Final) R831709C001 (2006) R832733 (2007) |
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| Presentation | Integration of toxicogenomic and knowledge-based pathway mapping for elucidating shared molecular mechanisms of metal toxicity. | None | Faustman EM, Yu X, Sidhu JS, Hong S, et al | Faustman EM, Yu X, Sidhu JS, Hong S, et al. Integration of toxicogenomic and knowledge-based pathway mapping for elucidating shared molecular mechanisms of metal toxicity. Poster presented at the 10th International Congress of Toxicology, Tampere, Finland, July 11-15, 2004. |
R831709 (Final) R831709C001 (2005) |
not available |
| Presentation | Toxicant affects on ubiquitin-proteosome systems: lessons from cross-compound and cross-system assessments. | None | Faustman EM, Yu X, Sidhu J, Robinson J | Faustman EM, Yu X, Sidhu J, Robinson J. Toxicant affects on ubiquitin-proteosome systems: lessons from cross-compound and cross-system assessments. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 6-10, 2005. |
R831709 (Final) R831709C001 (2005) |
not available |
| Presentation | Computational model for dose-response comparisons of two mechanistic hypotheses for ethanol-induced neurodevelopmental toxicity. | None | Gohlke JM, Griffith WC, Faustman EM | Gohlke JM, Griffith WC, Faustman EM. Computational model for dose-response comparisons of two mechanistic hypotheses for ethanol-induced neurodevelopmental toxicity. Presented at the Society for Risk Analysis 2004 Annual Meeting, Palm Springs, CA, December 5-8, 2004. |
R831709 (Final) R831709C001 (2005) |
not available |
| Presentation | Computational models for the acquisition of neocortical neurons in the developing humans, monkey, and mouse: cross species comparison of toxicodynamics. | None | Gohlke JM, Griffith WC, Faustman EM | Gohlke JM, Griffith WC, Faustman EM. Computational models for the acquisition of neocortical neurons in the developing humans, monkey, and mouse: cross species comparison of toxicodynamics. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 6-10, 2005. |
R831709 (Final) R831709C001 (2005) |
not available |
| Presentation | Examination of metal-induced cell cycle alterations and apoptosis in C57BL/6 and SWV mouse embryonic fibroblasts. | None | Robinson J, Yu X, Sidhu J, Hong S, Kim E, Faustman EM | Robinson J, Yu X, Sidhu J, Hong S, Kim E, Faustman EM. Examination of metal-induced cell cycle alterations and apoptosis in C57BL/6 and SWV mouse embryonic fibroblasts. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 6-10, 2005. |
R831709 (Final) R831709C001 (2005) |
not available |
| Presentation | Integrative analysis of genome-wide gene expression and pathway mapping in mouse embryonic fibroblast (MEF) exposed to cadmium, arsenic, and methylmercury: induction of oxidative stress, disruption of ubiquitin-proteasome system and cell cycle regulation. | None | Yu X, Sidhu J, Robinson J, Hong S, Faustman EM | Yu X, Sidhu J, Robinson J, Hong S, Faustman EM. Integrative analysis of genome-wide gene expression and pathway mapping in mouse embryonic fibroblast (MEF) exposed to cadmium, arsenic, and methylmercury: induction of oxidative stress, disruption of ubiquitin-proteasome system and cell cycle regulation. Presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 6-10, 2005. |
R831709C001 (2005) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.