Grantee Research Project Results
Publications Details for Grant Number R830954
Effect of Diesel Exhaust Particulate Exposures on Endothelial Function in Humans: The Role of Oxidative Stress
RFA:
Airborne Particulate Matter Health Effects: Cardiovascular Mechanisms (2002)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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| Abstract | Oxidative stress and antioxidant responses to diesel exhaust in metabolic syndrome subjects: a randomized, blinded, cross-over experiment. | None | Allen J, Trenga C, Peretz A, Sullivan J, Carlsten C, Aulet M, Stewart J, Kaufman JD | Allen J, Trenga C, Peretz A, Sullivan J, Carlsten C, Aulet M, Stewart J, Kaufman JD. Oxidative stress and antioxidant responses to diesel exhaust in metabolic syndrome subjects: a randomized, blinded, cross-over experiment. Free Radical Biology and Medicine 2006;41(Suppl 1):S93 (Abstract 234). |
R830954 (Final) |
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| Abstract | Results from a pilot study of diesel exhaust exposure health effects in humans. | PROCEEDINGS OF THE AMERICAN THORACIC SOCIETY | Trenga CA, Sullivan JH, Hubbard R, Jarvis SS, Curtis HM, Sands FN, Gould T, Stewart J, Shepherd K, Larson TV, Kaufman JD | Trenga CA, Sullivan JH, Hubbard R, Jarvis SS, Curtis HM, Sands FN, Gould T, Stewart J, Shepherd K, Larson TV, Kaufman JD. Results from a pilot study of diesel exhaust exposure health effects in humans. Proceedings of the American Thoracic Society 2005;2:A266. |
R827355 (Final) R827355C006 (Final) R830954 (2005) |
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| Journal Article | Effect of diesel exhaust inhalation on antioxidant and oxidative stress responses in adults with metabolic syndrome. | INHALATION TOXICOLOGY | Allen J, Trenga CA, Peretz A, Sullivan JH, Carlsten CC, Kaufman JD | Allen J, Trenga CA, Peretz A, Sullivan JH, Carlsten CC, Kaufman JD. Effect of diesel exhaust inhalation on antioxidant and oxidative stress responses in adults with metabolic syndrome. Inhalation Toxicology 2009;21(13):1061-1067. |
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| Journal Article | Coagulation markers in healthy human subjects exposed to diesel exhaust. | None | Carlsten C, Kaufman JD, Peretz A, Trenga CA, Sheppard L, Sullivan JH | Carlsten C, Kaufman JD, Peretz A, Trenga CA, Sheppard L, Sullivan JH. Coagulation markers in healthy human subjects exposed to diesel exhaust. Thrombosis Research 2007;120(6):849-855. |
R830954 (2007) R830954 (Final) |
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| Journal Article | Thrombotic markers in metabolic syndrome subjects exposed to diesel exhaust. | None | Carlsten C, Kaufman JD, Trenga CA, Allen J, Peretz A, Sullivan JH | Carlsten C, Kaufman JD, Trenga CA, Allen J, Peretz A, Sullivan JH. Thrombotic markers in metabolic syndrome subjects exposed to diesel exhaust. Inhalation Toxicology 2008;20(10):917-921. |
R830954 (Final) |
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| Journal Article | Blood pressure response to controlled diesel exhaust exposure in human subjects. | HYPERTENSION | Cosselman KE, Krishnan RM, Oron AP, Jansen K, Peretz A, Sullivan JH, Larson TV, Kaufman JD | Cosselman KE, Krishnan RM, Oron AP, Jansen K, Peretz A, Sullivan JH, Larson TV, Kaufman JD. Blood pressure response to controlled diesel exhaust exposure in human subjects. Hypertension 2012;59(5):943-948. |
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| Journal Article | A controlled inhalation diesel exhaust exposure facility with dynamic feedback control of PM concentration. | INHALATION TOXICOLOGY | Gould T, Larson T, Stewart J, Kaufman JD, Slater D, McEwen N | Gould T, Larson T, Stewart J, Kaufman JD, Slater D, McEwen N. A controlled inhalation diesel exhaust exposure facility with dynamic feedback control of PM concentration. Inhalation Toxicology 2008;20(1):49-52. |
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| Journal Article | A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans. | PARTICLE AND FIBRE TOXICOLOGY | Krishnan RM, Sullivan JH, Carlsten C, Wilkerson HW, Beyer RP, Bammler T, Farin F, Peretz A, Kaufman JD | Krishnan RM, Sullivan JH, Carlsten C, Wilkerson HW, Beyer RP, Bammler T, Farin F, Peretz A, Kaufman JD. A randomized cross-over study of inhalation of diesel exhaust, hematological indices, and endothelial markers in humans. Particle and Fibre Toxicology 2013;10:7 (10 pp.). |
R830954 (Final) |
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| Journal Article | Flow mediated dilation of the brachial artery: an investigation of methods requiring further standardization. | None | Peretz A, Leotta DF, Sullivan JH, Trenga CA, Sands FN, Aulet MR, Paun M, Gill EA, Kaufman JD | Peretz A, Leotta DF, Sullivan JH, Trenga CA, Sands FN, Aulet MR, Paun M, Gill EA, Kaufman JD. Flow mediated dilation of the brachial artery: an investigation of methods requiring further standardization. BMC Cardiovascular Disorders 2007;7:11 (8 pp.). |
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| Journal Article | Diesel exhaust inhalation and assessment of peripheral blood mononuclear cell gene transcription effects: an exploratory study of healthy human volunteers. | None | Peretz A, Peck EC, Bammler TK, Beyer RP, Sullivan JH, Trenga CA, Srinouanprachnah S, Farin FM, Kaufman JD | Peretz A, Peck EC, Bammler TK, Beyer RP, Sullivan JH, Trenga CA, Srinouanprachnah S, Farin FM, Kaufman JD. Diesel exhaust inhalation and assessment of peripheral blood mononuclear cell gene transcription effects: an exploratory study of healthy human volunteers. Inhalation Toxicology 2007;19(14):1107-1119. |
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| Journal Article | Diesel exhaust inhalation elicits acute vasoconstriction in vivo. | ENVIRONMENTAL HEALTH PERSPECTIVES | Peretz A, Sullivan JH, Leotta DF, Trenga CA, Sands FN, Allen J, Carlsten C, Wilkinson CW, Gill EA, Kaufman JD | Peretz A, Sullivan JH, Leotta DF, Trenga CA, Sands FN, Allen J, Carlsten C, Wilkinson CW, Gill EA, Kaufman JD. Diesel exhaust inhalation elicits acute vasoconstriction in vivo. Environmental Health Perspectives 2008;116(7):937-942. |
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| Journal Article | Effects of diesel exhaust inhalation on heart rate variability in human volunteers. | None | Peretz A, Kaufman JD, Trenga CA, Allen J, Carlsten C, Aulet MR, Adar SD, Sullivan JH | Peretz A, Kaufman JD, Trenga CA, Allen J, Carlsten C, Aulet MR, Adar SD, Sullivan JH. Effects of diesel exhaust inhalation on heart rate variability in human volunteers. Environmental Research 2008;107(2):178-184. |
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| Presentation | Effect of diesel exhaust on antioxidant and oxidative stress responses in metabolic syndrome patients. | None | Allen J, Trenga CA, Peretz A, Sullivan JH, Carlsten CR, Kaufman JD | Allen J, Trenga CA, Peretz A, Sullivan JH, Carlsten CR, Kaufman JD. Effect of diesel exhaust on antioxidant and oxidative stress responses in metabolic syndrome patients. Presented at the American Thoracic Society International Conference, San Francisco, CA, May 18-23, 2007. |
R830954 (Final) |
not available |
| Presentation | Blood coagulation markers in healthy subjects exposed to diesel exhaust. | None | Carlsten C, Kaufman JD, Trenga CA, Curtiss H, Peretz A, Aulet M, Stewart JA, Larson TV, Sullivan JH | Carlsten C, Kaufman JD, Trenga CA, Curtiss H, Peretz A, Aulet M, Stewart JA, Larson TV, Sullivan JH. Blood coagulation markers in healthy subjects exposed to diesel exhaust. Presented at the American Thoracic Society International Conference, San Diego, CA, May 19-24, 2006. |
R830954 (Final) |
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| Presentation | Coagulation markers in metabolic syndrome subjects exposed to diesel exhaust. | None | Carlsten C, Kaufman JD, Trenga CA, Peretz A, Sullivan JH | Carlsten C, Kaufman JD, Trenga CA, Peretz A, Sullivan JH. Coagulation markers in metabolic syndrome subjects exposed to diesel exhaust. Presented at the American Thoracic Society International Conference, San Francisco, CA, May 18-23, 2007. |
R830954 (2007) R830954 (Final) |
not available |
| Presentation | Effect of diesel exhaust on antioxidant and oxidative stress responses in metabolic syndrome subjects. | None | Effect of Diesel Exhaust on Antioxidant and Oxidative Stress Responses in Metabolic Syndrome Subjects | Effect of diesel exhaust on antioxidant and oxidative stress responses in metabolic syndrome subjects. Presented at the American Thoracic Society International Conference, San Francisco, CA, May 2007. |
R830954 (2007) |
not available |
| Presentation | Results from a pilot study of diesel exhaust exposure health effects in humans. | None | Kaufman J | Kaufman J. Results from a pilot study of diesel exhaust exposure health effects in humans. Poster presented at the American Thoracic Society International Conference, San Diego, CA, May 20-25, 2005. |
R830954 (2005) R830954 (Final) |
not available |
| Presentation | A pilot study of the effect of diesel exhaust on exhaled NO measures in healthy adults. | None | Kaufman J | Kaufman J. A pilot study of the effect of diesel exhaust on exhaled NO measures in healthy adults. Poster presented at the American Thoracic Society International Conference, San Diego, CA, May 20-25, 2005. |
R830954 (2005) |
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| Presentation | Microarray studies of peripheral blood mononuclear cells from healthy human volunteers exposed to diesel exhaust. | None | Kaufman J | Kaufman J. Microarray studies of peripheral blood mononuclear cells from healthy human volunteers exposed to diesel exhaust. Poster presented at the Third Diet and Optimum Health Conference, Portland, OR, May 18-21, 2005. |
R830954 (2005) |
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| Presentation | Diesel exposure facility and cardiovascular pilot study design. | None | Larson T | Larson T. Diesel exposure facility and cardiovascular pilot study design. Presented at the Health Effects Institute Annual Conference, Boston, MA, May 2004. |
R830954 (2004) |
not available |
| Presentation | Microarray studies of peripheral blood mononuclear cells from healthy human volunteers exposed to diesel exhaust. | None | Peck EC, Trenga CA, Beyer RP, Bammler TP, Srinouanprachanh S, Sullivan JH, Farin FH, Kaufman JD | Peck EC, Trenga CA, Beyer RP, Bammler TP, Srinouanprachanh S, Sullivan JH, Farin FH, Kaufman JD. Microarray studies of peripheral blood mononuclear cells from healthy human volunteers exposed to diesel exhaust. Presented at the Linus Pauling Institute’s Diet and Optimum Health Conference, Portland, OR, May 18-21, 2005. |
R830954 (Final) |
not available |
| Presentation | Gene expression in peripheral blood mononuclear cells from healthy human volunteers exposed to diesel exhaust. | None | Peck EC, Trenga CA, Beyer RP, Bammler TK, Srinouanprachanh S, Sullivan JH, Farin FM, Kaufman JD | Peck EC, Trenga CA, Beyer RP, Bammler TK, Srinouanprachanh S, Sullivan JH, Farin FM, Kaufman JD. Gene expression in peripheral blood mononuclear cells from healthy human volunteers exposed to diesel exhaust. Presented at the American Thoracic Society International Conference, San Diego, CA, May 19-24, 2006. |
R830954 (2006) R830954 (Final) |
not available |
| Presentation | A pilot study of the effect of diesel exhaust on exhaled NO measures in healthy adults. | PROCEEDINGS OF THE AMERICAN THORACIC SOCIETY | Peretz A, Sullivan JH, Trenga CA, Shepherd K, Mieras J, Kaufman JD | Peretz A, Sullivan JH, Trenga CA, Shepherd K, Mieras J, Kaufman JD. A pilot study of the effect of diesel exhaust on exhaled NO measures in healthy adults. Presented at the American Thoracic Society International Conference, San Diego, CA, May 20-25, 2005. |
R827355 (Final) R827355C006 (Final) R830954 (2005) R830954 (Final) |
not available |
| Presentation | Brachial artery response in humans exposed to diesel exhaust. | None | Peretz A, Sands FN, Sullivan JH, Trenga CA, Leotta DF, Gill EA, Stewart JA, Kaufman JD | Peretz A, Sands FN, Sullivan JH, Trenga CA, Leotta DF, Gill EA, Stewart JA, Kaufman JD. Brachial artery response in humans exposed to diesel exhaust. Presented at the American Thoracic Society International Conference, San Diego, CA, May 19-24, 2006. |
R830954 (Final) |
not available |
| Presentation | Endothelial-mediated acute vasoconstriction in response to diesel exhaust. | None | Peretz A, Sullivan JH, Leotta DF, Trenga CA, Sands FN, Allen J, Carlsten C, Aulet MR, Gill EA, Kaufman JD | Peretz A, Sullivan JH, Leotta DF, Trenga CA, Sands FN, Allen J, Carlsten C, Aulet MR, Gill EA, Kaufman JD. Endothelial-mediated acute vasoconstriction in response to diesel exhaust. Presented at the American Thoracic Society International Conference, San Francisco, CA, May 18-23, 2007. |
R830954 (2007) R830954 (Final) |
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| Presentation | S. | None | Presented at the U | Presented at the U.S. EPA's Research Meeting on Mechanisms and Health Risks of Exposure to Ambient Particulate Matter, April 2006. |
R830954 (2006) |
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| Presentation | . | None | Presented at the UBC/UW Occupational Environmental Health Conference, January 2006 | Presented at the UBC/UW Occupational and Environmental Health Conference, January 2006. |
R830954 (2006) |
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| Presentation | Effect of controlled diesel exhaust exposures on levels of inflammatory cytokines and markers of endothelial activation in healthy adults. | None | Sullivan JH, Trenga CA, Peretz A, Carlsten C, Farin FM, Curtiss HM, Stewart JA, Aulet MR, Larson RV, Wilkerson JH, Kaufman JD | Sullivan JH, Trenga CA, Peretz A, Carlsten C, Farin FM, Curtiss HM, Stewart JA, Aulet MR, Larson RV, Wilkerson JH, Kaufman JD. Effect of controlled diesel exhaust exposures on levels of inflammatory cytokines and markers of endothelial activation in healthy adults. Presented at the American Thoracic Society International Conference, San Diego, CA, May 19-24, 2006. |
R830954 (Final) |
not available |
| Presentation | Effect of controlled diesel exhaust exposures on levels of inflammatory cytokines in adults with metabolic syndrome. | None | Sullivan JH, Peretz A, Carlsten C, Farin FM, Allen J, Wilkerson JH, Aulet MR, Stewart JA, Larson TV, Kaufman JD | Sullivan JH, Peretz A, Carlsten C, Farin FM, Allen J, Wilkerson JH, Aulet MR, Stewart JA, Larson TV, Kaufman JD. Effect of controlled diesel exhaust exposures on levels of inflammatory cytokines in adults with metabolic syndrome. Presented at the American Thoracic Society International Conference, San Francisco, CA, May 18-23, 2007. |
R830954 (2007) R830954 (Final) |
not available |
| Presentation | Diesel exhaust controlled exposure facility and human studies. | None | Trenga C | Trenga C. Diesel exhaust controlled exposure facility and human studies. Presented at the University of Washington/U.S. Environmental Protection Agency Research Center for Particulate Air Pollution and Health 2005 Air Pollution Research Symposium, Seattle, WA, January 24, 2005. |
R830954 (2005) |
not available |
| Proceedings | Blood coagulation markers in healthy subjects exposed to diesel exhaust. | None | Kaufman J | Kaufman J. Blood coagulation markers in healthy subjects exposed to diesel exhaust. In: Proceedings of the American Thoracic Society, San Diego, CA, 2006, A385. |
R830954 (2006) |
not available |
| Proceedings | Brachial artery response in humans exposed to diesel exhaust. | None | Kaufman J | Kaufman J. Brachial artery response in humans exposed to diesel exhaust. In: Proceedings of the American Thoracic Society, San Diego, CA, 2006, A551. |
R830954 (2006) |
not available |
| Proceedings | Effect of controlled diesel exhaust exposures on levels of inflammatory cytokines and markers of endothelial activation in healthy adults. | None | Kaufman J | Kaufman J. Effect of controlled diesel exhaust exposures on levels of inflammatory cytokines and markers of endothelial activation in healthy adults. In: Proceedings of the American Thoracic Society, San Diego, CA, 2006, A552. |
R830954 (2006) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.