Grantee Research Project Results
Publications Details for Grant Number R830683
Biomarkers of Human Exposure to Pesticides Utilizing a New PBPK/PD Model and Kinetic Data on Pesticide Metabolism in Humans
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Abstract | Kinetic data on organophosphate pesticide metabolism in humans to allow PBPK/PD models to assess risk. | None | Foxenberg R, Knaak J, McGarrigle B, Kransler K | Foxenberg R, Knaak J, McGarrigle B, Kransler K, et al. Kinetic data on organophosphate pesticide metabolism in humans to allow PBPK/PD models to assess risk. Experimental Biology 2005 Meeting Abstracts. The FASEB Journal 2005;19 (Abstract #321.1). |
R830683 (2005) |
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Abstract | Kinetic data on pesticide metabolism in humans to allow PBPK/PD models for parathion and chlorpyrifos to predict susceptibility. | THE TOXICOLOGIST | Olson J, Knaak J, McGarrigle B, Kransler K | Olson J, Knaak J, McGarrigle B, Kransler K, et al. Kinetic data on pesticide metabolism in humans to allow PBPK/PD models for parathion and chlorpyrifos to predict susceptibility. The Toxicologist 2005;84(Suppl 1) (abstract). |
R830683 (2005) |
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Journal Article | Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos | TOXICOLOGY | Ellison C, Smith J, Lein P, Olson J | Ellison C, Smith J, Lein P, Olson J. Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos. TOXICOLOGY 2011;287(1-3):137-144. |
R830683 (2005) |
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Journal Article | Human hepatic cytochrome P450-specific metabolism of the organophosphorus pesticides methyl parathion and diazinon | DRUG METABOLISM AND DISPOSITION | Ellison C, Tian Y, Knaak J, Kostyniak P, Olson J | Ellison C, Tian Y, Knaak J, Kostyniak P, Olson J. Human hepatic cytochrome P450-specific metabolism of the organophosphorus pesticides methyl parathion and diazinon. DRUG METABOLISM AND DISPOSITION 2012;40(1):1-5. |
R830683 (2005) |
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Journal Article | Human hepatic cytochrome P450-specific metabolism of parathion and chlorpyrifos. | DRUG METABOLISM AND DISPOSITION | Foxenberg RJ, McGarrigle BP, Knaak JB, Kostyniak PJ, Olson JR | Foxenberg RJ, McGarrigle BP, Knaak JB, Kostyniak PJ, Olson JR. Human hepatic cytochrome P450-specific metabolism of parathion and chlorpyrifos. Drug Metabolism and Disposition 2007;35(2):189-193. |
R830683 (2005) |
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Journal Article | Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion. | TOXICOLOGY | Foxenberg RJ, Ellison CA, Knaak JB, Ma CX, Olson JR | Foxenberg RJ, Ellison CA, Knaak JB, Ma CX, Olson JR. Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion. Toxicology 2011;285(1-2):57-66. |
R830683 (2005) |
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Presentation | Utilizing human cytochrome P450 specific content and activity to better model parathion and chlorpyrifos metabolism in infants, children, and adults. | None | Foxenberg RJ, Knaak JB, McGarrigle BP, Kostyniak PJ | Foxenberg RJ, Knaak JB, McGarrigle BP, Kostyniak PJ, et al. Utilizing human cytochrome P450 specific content and activity to better model parathion and chlorpyrifos metabolism in infants, children, and adults. Presented at the Society of Toxicology (SOT) Annual Meeting, San Diego, CA, March 5-9, 2006. |
R830683 (2005) |
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Presentation | Biomarkers of human exposure to pesticides utilizing a new PBPK/PD model and kinetic data on pesticide metabolism. | None | Olson JR, Knaak JB | Olson JR, Knaak JB. Biomarkers of human exposure to pesticides utilizing a new PBPK/PD model and kinetic data on pesticide metabolism. Presented at the U.S. Environmental Protection Agency 2004 Science to Achieve Results Progress Review Workshop—Human Health Symposium, Philadelphia, PA, October 28-29, 2004. |
R830683 (2005) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.