Grantee Research Project Results
Publications Details for Grant Number R830800
Reducing Uncertainty in Children’s Risk Assessment: Development of a Quantitative Approach for Assessing Internal Dosimetry Through Physiologically-Based Pharmacokinetic Modeling
RFA:
Children's Vulnerability to Toxic Substances in the Environment (2002)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Abstract | Characterization of deltamethrin metabolism in adult male Sprague-Dawley rats. | TOXICOLOGIST | Anand SS, Haines WT, Bruckner JV, Fisher JW, et al | Anand SS, Haines WT, Bruckner JV, Fisher JW, et al. Characterization of deltamethrin metabolism in adult male Sprague-Dawley rats (Abstract ID# 2095). Toxicologist 2005; 84(S-1):429. |
R830800 (2004) |
not available |
| Abstract | Toxicokinetics of deltamethrin in different vehicles . | TOXICOLOGIST | Kim HJ, Kim K, Muralidhara S, Bruckner JV | Kim HJ, Kim K, Muralidhara S, Bruckner JV. Toxicokinetics of deltamethrin in different vehicles (Abstract ID# 1245). Toxicologist 2005; 84(S-1):255. |
R830800 (2004) |
not available |
| Abstract | Toxicokinetic study for deltamethrin and its metabolite, 3-phenoxybenzoic acid, in immature and adult rats. | TOXICOLOGIST | Kim K, Bruckner JV, Kim H | Kim K, Bruckner JV, Kim H. Toxicokinetic study for deltamethrin and its metabolite, 3-phenoxybenzoic acid, in immature and adult rats (Abstract ID# 1247). Toxicologist 2005; 84(S-1):255-256. |
R830800 (2004) |
not available |
| Journal Article | Characterization of deltamethrin metabolism by rat plasma and liver microsomes. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Anand SS, Bruckner JV, Haines WT, Muralidhara S, Fisher JW, Padilla S | Anand SS, Bruckner JV, Haines WT, Muralidhara S, Fisher JW, Padilla S. Characterization of deltamethrin metabolism by rat plasma and liver microsomes. Toxicology and Applied Pharmacology 2006;212(2):156-166. |
R830800 (2005) R830800 (2006) R830800 (Final) |
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| Journal Article | Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity. | DRUG METABOLISM AND DISPOSITION | Anand SS, Kim K-B, Padilla S, Muralidhara S, Kim HJ, Fisher JW, Bruckner JV | Anand SS, Kim K-B, Padilla S, Muralidhara S, Kim HJ, Fisher JW, Bruckner JV. Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity. Drug Metabolism and Disposition 2006;34(3):389-397. |
R830800 (2005) R830800 (2006) R830800 (Final) |
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| Journal Article | Determination of deltamethrin and its metabolite 3-phenoxybenzoic acid in male rat plasma by high-performance liquid chromatography. | JOURNAL OF CHROMATOGRAPHY B | Ding Y, White CA, Muralidhara S, Bruckner JV, Bartlett MG | Ding Y, White CA, Muralidhara S, Bruckner JV, Bartlett MG. Determination of deltamethrin and its metabolite 3-phenoxybenzoic acid in male rat plasma by high-performance liquid chromatography. Journal of Chromatography B 2004;810(2):221-227. |
R830800 (2003) R830800 (2004) R830800 (2005) R830800 (2006) R830800 (Final) R830900 (2004) |
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| Journal Article | Determination of deltamethrin and its metabolites, 3-phenoxybenzoic acid and 3-phenoxybenzyl alcohol, in maternal plasma, amniotic fluid, and placental and fetal tissues by HPLC. | JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | Ding Y, White CA, Bruckner JV, Bartlett MG | Ding Y, White CA, Bruckner JV, Bartlett MG. Determination of deltamethrin and its metabolites, 3-phenoxybenzoic acid and 3-phenoxybenzyl alcohol, in maternal plasma, amniotic fluid, and placental and fetal tissues by HPLC. Journal of Liquid Chromatography & Related Technologies 2004;27(12):1875-1892. |
R830800 (2003) R830800 (2004) R830800 (2005) R830800 (2006) R830800 (Final) R830900 (2004) |
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| Journal Article | Rapid determination of the synthetic pyrethroid insecticide, deltamethrin, in rat plasma and tissues by HPLC. | JOURNAL OF CHROMATOGRAPHY B | Kim KB, Bartlett MG, Anand SS, Bruckner JV, Kim HJ | Kim KB, Bartlett MG, Anand SS, Bruckner JV, Kim HJ. Rapid determination of the synthetic pyrethroid insecticide, deltamethrin, in rat plasma and tissues by HPLC. Journal of Chromatography B 2006;834(1-2):141-148. |
R830800 (2005) R830800 (2006) R830800 (Final) |
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| Journal Article | Formulation-dependent toxicokinetics explains differences in the GI absorption, bioavailability and acute neurotoxicity of deltamethrin in rats. | TOXICOLOGY | Kim K-B, Anand SS, Muralidhara S, Kim HJ, Bruckner JV | Kim K-B, Anand SS, Muralidhara S, Kim HJ, Bruckner JV. Formulation-dependent toxicokinetics explains differences in the GI absorption, bioavailability and acute neurotoxicity of deltamethrin in rats. Toxicology 2007;234(3):194-202. |
R830800 (2006) R830800 (Final) |
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| Journal Article | Toxicokinetics and tissue distribution study of deltamethrin in adult Sprague-Dawley rats. | TOXICOLOGICAL SCIENCES | Kim K-B, Anand SS, Kim HJ, White CA, Bruckner JV | Kim K-B, Anand SS, Kim HJ, White CA, Bruckner JV. Toxicokinetics and tissue distribution study of deltamethrin in adult Sprague-Dawley rats. Toxicological Sciences 2008;101(2):197-205. |
R830800 (Final) |
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| Journal Article | Age, dose, and time-dependency of plasma and tissue distribution of deltamethrin in immature rats. | TOXICOLOGICAL SCIENCES | Kim K-B, Anand SS, Kim HJ, White CA, Fisher JW, Tornero-Velez R, Bruckner JV | Kim K-B, Anand SS, Kim HJ, White CA, Fisher JW, Tornero-Velez R, Bruckner JV. Age, dose, and time-dependency of plasma and tissue distribution of deltamethrin in immature rats. Toxicological Sciences 2010;115(2):354-368. |
R830800 (Final) |
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| Journal Article | Development of a physiologically based pharmacokinetic model for deltamethrin in the adult male Sprague-Dawley rat. | None | Mirfazaelian A, Kim K-B, Anand SS, Kim HJ, Tornero-Velez R, Bruckner JV, Fisher JW | Mirfazaelian A, Kim K-B, Anand SS, Kim HJ, Tornero-Velez R, Bruckner JV, Fisher JW. Development of a physiologically based pharmacokinetic model for deltamethrin in the adult male Sprague-Dawley rat. Toxicological Sciences 2006;93(2):432-442. |
R830800 (2005) R830800 (2006) R830800 (Final) R840032 (2023) |
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| Journal Article | Organ growth functions in maturing male Sprague-Dawley rats based on a collective database. | Journal of Toxicology and Environmental Health Part A | Mirfazaelian A, Fisher JW | Mirfazaelian A, Fisher JW. Organ growth functions in maturing male Sprague-Dawley rats based on a collective database. Journal of Toxicology and Environmental Health Part A 2007;70(12):1052-1063. |
R830800 (2005) R830800 (Final) |
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| Journal Article | Organ growth functions in maturing male Sprague-Dawley rats. | JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A | Mirfazaelian A, Kim K-B, Lee S, Kim HJ, Bruckner JV, Fisher JW | Mirfazaelian A, Kim K-B, Lee S, Kim HJ, Bruckner JV, Fisher JW. Organ growth functions in maturing male Sprague-Dawley rats. Journal of Toxicology and Environmental Health-Part A 2007;70(5):429-438. |
R830800 (2006) R830800 (Final) |
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| Journal Article | Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Tornero-Velez R, Mirfazaelian A, Kim K-B, Anand SS, Kim HJ, Haines WT, Bruckner JV, Fisher JW | Tornero-Velez R, Mirfazaelian A, Kim K-B, Anand SS, Kim HJ, Haines WT, Bruckner JV, Fisher JW. Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model. Toxicology and Applied Pharmacology 2010;244(2):208-217. |
R830800 (Final) |
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| Presentation | Age-and gender-dependent in vitro hepatic metabolism and acute neurotoxicity of pyrethroid insecticide, deltamethrin (DLM) in rats. | None | Anand SS, Kim K, Bruckner JV | Anand SS, Kim K, Bruckner JV. Age-and gender-dependent in vitro hepatic metabolism and acute neurotoxicity of pyrethroid insecticide, deltamethrin (DLM) in rats. Presented at the FASEB Experimental Biology 2006 Meeting, San Francisco, CA, April 1-5, 2006. |
R830800 (2005) R830800 (2006) R830800 (Final) |
not available |
| Presentation | Characterization of deltamethrin (DLT) metabolism in adult male Sprague-Dawley rats. | None | Anand SS, Hanes WT, Bruckner JV, Fisher JW, Muralidhara S, Hunter DL, Padilla S | Anand SS, Hanes WT, Bruckner JV, Fisher JW, Muralidhara S, Hunter DL, Padilla S. Characterization of deltamethrin (DLT) metabolism in adult male Sprague-Dawley rats. Presented at the 44th Annual Meeting and ToxExpo of the Society of Toxicology, New Orleans, LA, March 6-10, 2005. |
R830800 (2005) R830800 (2006) R830800 (Final) |
not available |
| Presentation | Age-dependent PBPK model for the pyrethroid, deltamethrin (DLT) in rats. | None | Bruckner JV, Fisher JW | Bruckner JV, Fisher JW. Age-dependent PBPK model for the pyrethroid, deltamethrin (DLT) in rats. Presented at the 46th Annual Meeting and Tox Expo of the Society of Toxicology, Charlotte, NC, March 25-29, 2007. |
R830800 (Final) |
not available |
| Presentation | Extra-hepatic metabolism of deltamethrin. | None | Bruckner JV, Anand SS, Kim K-B | Bruckner JV, Anand SS, Kim K-B. Extra-hepatic metabolism of deltamethrin. Presented at the 46th Annual Meeting and ToxExpo of the Society of Toxicology, Charlotte, NC, March 25-29, 2007. |
R830800 (Final) |
not available |
| Presentation | Determination of deltamethrin from rat plasma by LC-MS. | None | Ding Y, Bruckner JV, Bartlett MG | Ding Y, Bruckner JV, Bartlett MG. Determination of deltamethrin from rat plasma by LC-MS. Presented at the 51st National Meeting of the American Society for Mass Spectrometry, Montreal, Quebec, Canada, May 2003. |
R830800 (2003) |
not available |
| Presentation | Determination of deltamethrin from rat plasma by LC-MS-MS. | None | Ding Y, Bruckner JV, Bartlett MG | Ding Y, Bruckner JV, Bartlett MG. Determination of deltamethrin from rat plasma by LC-MS-MS. Presented to the American Society of Mass Spectrometry, Montreal, Canada, June 2004. |
R830800 (2006) |
not available |
| Presentation | Determination of deltamethrin from rat plasma by LC-MS-MS. | None | Ding Y, Bruckner JV, Bartlett MG | Ding Y, Bruckner JV, Bartlett MG. Determination of deltamethrin from rat plasma by LC-MS-MS. Presented at the 51st American Society for Mass Spectrometry Conference, Montreal, Quebec, Canada, June 8-12, 2003. |
R830800 (2005) |
not available |
| Presentation | Toxicokinetics of deltamethrin in different vehicles in rats. | None | Kim HJ, Kim K, Muralidhara S, Bruckner JV | Kim HJ, Kim K, Muralidhara S, Bruckner JV. Toxicokinetics of deltamethrin in different vehicles in rats. Presented at the 44th Annual Meeting and ToxExpo of the Society of Toxicology, New Orleans, LA, March 6-10, 2005. |
R830800 (2005) R830800 (2006) R830800 (Final) |
not available |
| Presentation | Toxicokinetic and tissue distribution study of deltamethrin in adult Sprague-Dawley rats. | None | Kim K, Anand SS, Kim H, White CA, Fisher JW, Bruckner JV | Kim K, Anand SS, Kim H, White CA, Fisher JW, Bruckner JV. Toxicokinetic and tissue distribution study of deltamethrin in adult Sprague-Dawley rats. Presented at the 46th Annual Meeting and ToxExpo of the Society of Toxicology, Charlotte, NC, March 25-29, 2007. |
R830800 (Final) |
not available |
| Presentation | Age-and dose-dependent tissue-distribution of deltamethrin (DLM) in male Sprague-Dawley (S-D) rats. | None | Kim K-B, Bruckner JV, Anand SS, Kim HJ | Kim K-B, Bruckner JV, Anand SS, Kim HJ. Age-and dose-dependent tissue-distribution of deltamethrin (DLM) in male Sprague-Dawley (S-D) rats. Presented at the 45th Annual Meeting and ToxExpo of the Society of Toxicology, San Diego, CA, March 5-9, 2006. |
R830800 (2005) R830800 (2006) R830800 (Final) |
not available |
| Presentation | Toxicokinetic study for deltamethrin and its metabolite, 3-phenoxybenzoic acid, in immature and mature rats. | None | Kim K, Bruckner JV, Kim H | Kim K, Bruckner JV, Kim H. Toxicokinetic study for deltamethrin and its metabolite, 3-phenoxybenzoic acid, in immature and mature rats. Presented at the 44th Annual Meeting and ToxExpo of the Society of Toxicology, New Orleans, LA, March 6-10, 2005. |
R830800 (2005) R830800 (2006) R830800 (Final) |
not available |
| Presentation | A comprehensive study of the toxicokinetics (TK) of deltamethrin (DLM) in adult rats. | None | Kim K-B, Anand SS, Muralidhara S, Bruckner JV | Kim K-B, Anand SS, Muralidhara S, Bruckner JV. A comprehensive study of the toxicokinetics (TK) of deltamethrin (DLM) in adult rats. Presented at the Eleventh International Congress of Toxicology, Montreal, Quebec, Canada, July 14-21, 2007. |
R830800 (Final) |
not available |
| Presentation | Development of a physiologically based pharmacokinetic model for deltamethrin in adult and developing Sprague-Dawley rats. | None | Mirfazaelian A, Kim K-B, Anand SS, Kim HJ, Tornero-Velez R, Bruckner JV, Fisher JW | Mirfazaelian A, Kim K-B, Anand SS, Kim HJ, Tornero-Velez R, Bruckner JV, Fisher JW. Development of a physiologically based pharmacokinetic model for deltamethrin in adult and developing Sprague-Dawley rats. Presented at the 45th Annual Meeting and ToxExpo of the Society of Toxicology, San Diego, CA, March 5-9, 2006. |
R830800 (2005) R830800 (2006) R830800 (Final) |
not available |
| Presentation | The toxicokinetics (TK) of deltamethrin (DLM) during maturation of the rat. | None | Tornero-Velez R, Fisher JW, Kim K-B, Anand S, White CA, Bruckner JA | Tornero-Velez R, Fisher JW, Kim K-B, Anand S, White CA, Bruckner JA. The toxicokinetics (TK) of deltamethrin (DLM) during maturation of the rat. Presented at the 49th Annual Meeting and ToxExpo of the Society of Toxicology, Salt Lake City, UT, March 7-11, 2010. |
R830800 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.