Grantee Research Project Results

Levin M, Mori C, De Guise S. Phagocytosis is mediated by in vitro exposure to organochlorine mixtures in marine mammals and mice. In: Abstracts of the Northeast Chapter of the Society of Toxicology, Groton, CT, November 8, 2002, p. 20.

Levin M, Mori C, Morsey BM, De Guise S. Effects of in vitro exposure to organochlorine mixtures on marine mammal and mouse immune functions. In: Abstracts of the 9th Congress of the International Society of Developmental and Comparative Immunology, St. Andrews, Scotland, June 29-July 4, 2003, p. 114.

Levin M, Morsey B, Mori C, De Guise S. Modulation of innate immune functions upon in vitro exposure to organochlorine mixtures in marine mammals, humans and mice. In: Abstracts of the Annual Meeting of the North Atlantic Chapter Regional Society of Environmental Toxicology and Chemistry, Portsmouth, RI, June 9-11, 2004, p. 9.

Levin M, Morsey B, De Guise S. Modulation of phagocytosis and the respiratory burst by organochlorines in marine mammals, humans, and mice. In: Abstracts of the 10th International Congress of the International Society for Developmental and Comparative Immunology, Charleston, SC, July 1-6, 2006, p. 151.

Mori C, Morsey B, Levin M, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorines in marine mammals and mice. In: Abstracts of the 15th Biennial Conference of the Biology of Marine Mammals, Greensboro, NC, December 14-19, 2003, p. 114.

Mori C, Levin M, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorines on T cell proliferation in marine mammal and mice. In: Abstracts of the Northeast Chapter of the Society of Toxicology, Groton, CT, November 8, 2002, p. 21.

Mori C, Morsey B, Levin M, Nambiar PR, TrailSmith M, De Guise S. Mixture of organochlorines modulate B and T lymphocyte proliferation in marine mammals and mice and leukocyte subsets in humans and mice. In: Abstracts of the 16th Biennial Conference of the Biology of Marine Mammals, San Diego, CA, December 12-16, 2005, p. 198.

De Guise S. Cellular immunology of cetaceans. In: Pfeiffer CJ, ed. Cell and Molecular Biology of Marine Mammals. Malabar, FL: Krieger Publishing Company, 2002, pp. 235-244.

Levin M. Immunomodulatory effects of in vitro exposure to organochlorine mixtures in marine mammals, humans and mice. Ph.D. Dissertation. Department of Pathobiology, University of Connecticut, CT, 2004.

Mori C. Immunomodulatory effects of organochlorine mixtures. Ph.D. Dissertation. Department of Pathobiology, University of Connecticut, CT, 2005.

Levin M, Morsey B, De Guise S. Calcium modulation as a possible mechanism for PCB-induced modulation of phagocytosis in marine mammals. Toxicology (submitted, 2005).

Levin M, Morsey B, Mori C, Nambiar PR, De Guise S. PCBs and TCDD, alone and in mixtures, modulate marine mammal but not B6C3F1 mouse leukocyte phagocytosis. Journal of Toxicology and Environmental Health-Part A 2005;68(8):635-656.

Levin M, Morsey B, De Guise S. Modulation of the respiratory burst by organochlorine mixtures in marine mammals, humans and mice. Journal of Toxicology and Environmental Health-Part A 2007;70(1):73-83.

• Abstract from PubMed

Levin M, Morsey B, Mori C, Nambiar PR, De Guise S. Modulation of respiratory burst by in vitro exposure to organochlorines in marine mammals and mice (in preparation, 2005).

Mori C, Morsey B, Ma X, Levin M, De Guise S. Effects of individual and mixtures of organochlorines on the mitogen-induced lymphocyte proliferation and phenotype of lymphocytes of humans and mice (in preparation, 2005).

Mori C, Levin M, Morsey B, Nambiar PR, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorines on B cell proliferation in marine mammals and mice (in preparation, 2005).

De Guise S, Levin M, Mori C, Morsey B, Nambiar P. Immunotoxicity of PCBs in marine mammals, mouse and humans upon in vitro exposure. Presented at the 13th International Symposium of the Pollutant Responses in Marine Organisms, Alessandria, Italy, June 19-22, 2005.

De Guise S. Comparative in vitro immunotoxicity of organochlorine mixtures. Presented at the Human Health Symposium – A Science To Achieve Results Progress Review Workshop, Washington, DC, April 9-10, 2003.

Levin M, Morsey B, Mori C, De Guise S. Non-coplanar PCB-induced modulation of phagocytosis in marine mammals, humans, and mice: new mechanisms. Presented at the Annual Meeting of the North Atlantic Chapter Regional Society of Environmental Toxicology and Chemistry, Burlington, VT, June 8-10, 2005.

Levin MJ, Mori C, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorine mixtures in marine mammals and mice. Presented at the 23rd Annual Meeting of the Society for Environmental Toxicology and Chemistry, Salt Lake City, UT, November 16-20, 2002.

Levin MJ, Morsey BM, Mori C, De Guise S. Mechanisms of phagocytosis modulation upon in vitro exposure to organochlorines in marine mammals. Presented at the 24th Annual Meeting of the Society for Environmental Toxicology and Chemistry, Austin, TX, November 9-13, 2003.

Levin MJ, Morsey B, Mori C, De Guise S. Mechanisms for modulation of phagocytosis by organochlorines in bottlenose dolphins and beluga whales. Presented at the 35th Annual International Association for Aquatic Animal Medicine Conference, Galveston, TX, April 4-9, 2004.

Levin M, De Guise S. In vitro exposure to organochlorine mixtures modulates lymphocyte proliferation and phagocytosis in selected marine mammals and mice. Presented at the 14th Biennial Conference of the Biology of Marine Mammals, Vancouver, British Columbia, Canada, November 28-December 3, 2001.

Levin M, De Guise S. Effects of in vitro exposure of organochlorine mixtures on phagocytosis and lymphocyte proliferation in selected marine mammals and mice. Presented at the 32nd Annual International Association for Aquatic Animal Medicine Conference Tampa, FL, April 28-May 2, 2001.

Levin M, De Guise S, Ross PS. Contaminants and immune function in newborn harbor seals (Phoca vitulina). Presented at the 33rd Annual International Association for Aquatic Animal Medicine Conference, Albufeira, Portugal, May 4-8, 2002.

Levin M, De Guise S. Immunology and stranded marine mammals. Presented at the Northeast Regional Stranding Network Annual Meeting and Conference, Mystic, CT, May 10-12, 2002.

Levin M, Mori C, De Guise S. Phagocytosis is mediated by in vitro exposure to organochlorine mixtures in marine mammals and mice. Presented at the Northeast Chapter of the Society of Toxicology 2002 Annual Meeting, Groton, CT, November 8, 2002.

Levin M, Mori C, Morsey BM, De Guise S. Effects of in vitro exposure to organochlorine mixtures on marine mammal and mouse immune functions. Presented at the 9th Congress of the International Society of Developmental and Comparative Immunology, St. Andrews, Scotland, June 29-July 4, 2003.

Levin M, Mori C, Morsey BM, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorine mixtures in marine mammals and mice. Presented at the 34th Annual International Association for Aquatic Animal Medicine Conference, Waikoloa, HI, May 9-14, 2003.

Levin M, Morsey B, Mori C, De Guise S. 2004. Modulation of innate immune functions upon in vitro exposure to organochlorine mixtures in marine mammals, humans and mice. Presented at the North Atlantic Chapter Regional Society of Environmental Toxicology and Chemistry 10th Annual Meeting, Portsmouth, RI, June 9-11, 2004.

Levin M, Morsey B, Mori C, De Guise S. Non-coplanar PCBs specifically modulate phagocytosis in dolphins, belugas, and humans but not in mice. Presented at the Northeast Chapter of the Society of Toxicology, Portland, ME, October 8, 2004.

Mori C, Levin M, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorines on T cell proliferation in marine mammal and mice. Presented at the Northeast Chapter of the Society of Toxicology 2002 Annual Meeting, Groton, CT, November 8, 2002.

Mori C, Morsey B, Levin M, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorines in marine mammals and mice. Presented at the 15th Biennial Conference of the Biology of Marine Mammals, Greensboro, NC, December 14-19, 2003.

Mori C, Levin M, Morsey B, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorines in marine mammals and mice. Presented at the 24th Annual Meeting of the Society for Environmental Toxicology and Chemistry, Austin, TX, November 9-13, 2003.

Mori C, Levin M, Morsey B, De Guise S. Modulation of mitogen-induced lymphocyte proliferation upon in vitro exposure to organochlorines in marine mammals and mice. Presented at the North Atlantic Chapter Regional Society of Environmental Toxicology and Chemistry 10th Annual Meeting, Portsmouth, RI, June 9-11, 2004.

Mori C, Morsey B, Levin M, De Guise S. Mixtures of organochlorines modulate B and T lymphocyte proliferation in marine mammals and mice. Presented at the 25th Annual Meeting of the Society for Environmental Toxicology and Chemistry, Portland, OR, November 13-19, 2004.

Mori C, Morsey B, Levin M, Nambiar P, De Guise S. Mixtures of organochlorines modulate B and T Lymphocyte proliferation and leukocyte subsets in marine mammals, humans and mice. To be presented at the Society of Toxicology Workshop, Charting the Future: Building the Scientific Foundation for Mixtures Joint Toxicity and Risk Assessment, Atlanta, GA, February 16-17, 2005.

De Guise S. Comparative in vitro immunotoxicity of organochlorine mixtures. In: Proceedings of the Human Health Symposium – A Science To Achieve Results Progress Review Workshop, Washington, DC: U.S. Environmental Protection Agency, December 2003, EPA/600/R-03/038, p. 27.

Levin MJ, Mori C, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorine mixtures in marine mammals and mice. In: Proceedings of the 23rd Annual Meeting of the Society for Environmental Toxicology and Chemistry, Salt Lake City, UT, November 16-20, 2002, p. 139.

Levin MJ, Morsey BM, Mori C, De Guise S. Mechanisms of phagocytosis modulation upon in vitro exposure to organochlorines in marine mammals. In: Proceedings of the 24th Annual Meeting of the Society for Environmental Toxicology and Chemistry, Austin, TX, November 8-13, 2003, p. 20.

Levin MJ, Morsey B, Mori C, De Guise S. Mechanisms for modulation of phagocytosis by organochlorines in bottlenose dolphins and beluga whales. In: Proceedings of the 35th Annual International Association for Aquatic Animal Medicine Conference, Galveston, TX, April 4-9, 2004, p. 141.

Levin M, De Guise S. Effects of in vitro exposure of organochlorine mixtures on phagocytosis and lymphocyte proliferation in selected marine mammals and mice. In: Proceedings of the 32nd Annual International Association for Aquatic Animal Medicine Conference, Tampa, FL, April 28-May 2, 2001, p. 126.

Levin M, De Guise S, Ross PS. Contaminants and immune function in newborn harbor seals (Phoca vitulina). In: Proceedings of the 33rd Annual International Association for Aquatic Animal Medicine Conference, Albufeira, Portugal, May 4-8, 2002, p. 25.

Levin M, Mori C, Morsey BM, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorine mixtures in marine mammals and mice. In: Proceedings of the 34th Annual International Association for Aquatic Animal Medicine Conference, Waikoloa HI, May 9-14, 2003, p. 69.

Levin M, Morsey B, Mori C, Nambiar P, De Guise S. Mechanisms involved in the non-coplanar PCB –induced modulation of phagocytosis in marine mammals, humans and mice. In: Proceedings of the 36th Annual International Association for Aquatic Animal Medicine Conference, Seward, AK, May 14-18, 2005, p. 285.

Levin M, Morsey B, Mori C, Nambiar PN, De Guise S. Mechanisms involved in the non-coplanar PCB-induced modulation of phagocytosis in marine mammals, humans, and mice. In: Proceedings of the 26th Annual meeting of the Society for Environmental Toxicology and Chemistry, Baltimore, MD, November 13-17, 2005.

Mori C, Levin M, Morsey B, De Guise S. Immunomodulatory effects of in vitro exposure to organochlorines in marine mammals and mice. In: Proceedings of the 24th Annual Meeting of the Society for Environmental Toxicology and Chemistry, Austin, TX, November 8-13, 2003, p. 21.

Mori C, Morsey B, Levin M, De Guise S. Mixtures of organochlorines modulate B and T lymphocyte proliferation in marine mammals and mice. In: Proceedings of the 25th Annual meeting of the Society for Environmental Toxicology and Chemistry, Portland, OR, November 14-18, 2004, p. 28.