Grantee Research Project Results
Publications Details for Grant Number R826129
Metabolic Androgenization of Invertebrates by Endocrine-Disrupting Chemicals
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Reference Type | Citation | Progress Report Year | Document Sources |
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Book Chapter | Andren AW, Bober TW. Silver in the Environment: Transport, Fate, and Effects. SETAC, . 2002: |
R826129 (Final) |
not available |
Book Chapter | Bell R, Bielmayer G, Galvez F, Hogstrand C, LeBlanc G, Lee, B-G, Luoma S, Purcell T, Santore R, Santschi P, Shaw J. In: SETAC Press: Transport, Fate and Effects of Silver in the Environment. |
R826129 (2000) |
not available |
Book Chapter | DeFur P, Crane M, Ingersoll C, Tattersfield L. Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment. SETAC, . 1999: |
R826129 (Final) |
not available |
Book Chapter | DeFur PL, Crane M, Tattersfield LJ, Ingersoll CG, Stahl RG, Matthiessen P, DeFur PL, Crane M, Ingersoll CG, Tattersfield LJ. Executive Summary on EDIETA Workshop. SETAC Press, Pensacola, FL. 1999;1-6 |
R826129 (Final) |
not available |
Book Chapter | deFur PL, Crane M, Tattersfield LJ, Ingersoll CG, Stahl RG Jr, Matthiessen P, et al. Workshop on Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment (EDIETA): Executive Summary. Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment. DeFur P, Crane M, Ingersoll C, Tattersfield L, eds. SETAC, Pensacola, FL, 1999:1-6. |
R826129 (1999) |
not available |
Book Chapter | Henshel DS, Harrass MC, Black MC. Environmental Toxicology and Risk Assessment: Standardization of Biomarkers for Endocrine Disruption and Environmental Assessment. 8th Volume. 1999. |
R826129 (Final) |
not available |
Book Chapter | LeBlanc GA, Dauterman WC. Conjugation and elimination of toxicants. In: Hodgson E, Smart RC, eds. Introduction to Biochemical Toxicology, 3rd Edition. New York, NY: John Wiley & Sons, Inc., 2001, Chapter 6, pp. 115-136. |
R826129 (2000) R826129 (Final) R829358 (Final) |
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Book Chapter | LeBlanc GA. Immunochemical techniques in toxicology. In: Hodgson E, Smart RC, eds. Biochemical Toxicology. East Norwalk, CT: Appleton & Lange. In press. Ch. 3, pp. 33-50. |
R826129 (2000) R826129 (Final) |
not available |
Book Chapter | LeBlanc GA. Screening approaches for the evaluation of endocrine disruption in invertebrates. In: Environmental Toxicology and Risk Assessment: Standardization of Biomarkers for Endocrine Disruption and Environmental Assessment. Henshel DS, Black MC, Harrass MC, eds. STP 1364. American Society of Testing and Materials, West Conshohocken, PA, 1999;8:3-23. |
R826129 (1999) R826129 (Final) |
not available |
Book Chapter | LeBlanc GA. Steroid hormone-regulated processes in invertebrates and their susceptibility to environmental endocrine disruption. In: Guillette Jr L, Crain DA, eds. Environmental Endocrine Disrupters: An Evolutionary Perspective. London: Taylor and Francis Publishers, 2000, pp. 126-154. |
R826129 (2000) R826129 (Final) |
not available |
Book Chapter | Luoma SN, Hogstrand C, Bell RA, Bielmyer GK, Galvez F, LeBlanc GA, Byeong-Gweon L, Purcell TW, Santore RC, Santschi PH, Shaw JR, Andren AW, Bober TW. Biological processes. SETAC Press, Pensacola, FL. 2002;65-96 |
R826129 (Final) |
not available |
Journal Article | Angus RA, McNatt HB, Howell WM, Peoples SD. Gonopodium development in normal male and 11-ketotestosterone-treated female mosquitofish (Gambusia affinis): a quantitative study using computer image analysis. General and Comparative Endocrinology 2001;123(2):222-234. |
R826129 (Final) R826130 (1999) |
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Journal Article | Gooding MP, Gallardo CS, LeBlanc GA. Imposex in three marine gastropod species in Chile and potential impact on muriculture. Marine Pollution Bulletin 1999;38(12):1227-1231 |
R826129 (1999) |
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Journal Article | Gooding MP, LeBlanc GA. Biotransformation and disposition of testosterone in the eastern mud snail Ilyanassa obsoleta. General and Comparative Endocrinology 2001;122(2):172-180. |
R826129 (2000) R826129 (Final) |
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Journal Article | Gooding MP, Wilson VS, Folmar LC, Marcovich DT, LeBlanc GA. The biocide tributyltin reduces the accumulation of testosterone as fatty acid esters in the mud snail (Ilyanassa obsoleta). Environmental Health Perspectives 2003;111(4):426-430. |
R826129 (Final) |
not available |
Journal Article | Gooding MP, LeBlanc GA. Seasonal variation in the regulation of testosterone levels in the eastern mud snail (Ilyanassa obsoleta). Invertebrate Biology 2004;123(3):237-243 |
R826129 (Final) |
not available |
Journal Article | Gunderson MP, LeBlanc GA, Guillette LJ. Alterations in sexually dimorphic biotransformation of testosterone in juvenile American alligators (Alligator mississippiensis) from contaminated lakes. Environmental Health Perspectives 2001;109(12):1257-1264. |
R826129 (2000) R826129 (2001) R826129 (Final) |
not available |
Journal Article | Kast-Hutcheson K, Rider CV, LeBlanc GA. The fungicide propiconazole interferes with embryonic development of the crustacean Daphnia magna. Environmental Toxicology and Chemistry 2001;20(3):502-509 |
R826129 (2000) R826129 (Final) |
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Journal Article | Korte JJ, Kahl MD, Jensen KM, Pasha MS, Parks LG, Leblanc GA, Ankley GT. Fathead minnow vitellogenin: Complementary DNA sequence and messenger RNA and protein expression after 17 beta-estradiol treatment. Environmental Toxicology and Chemistry 2000;19(4):972-981. |
R826129 (2000) R826129 (Final) |
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Journal Article | LeBlanc GA, McLachlan JB. Changes in the metabolic elimination profile of testosterone following exposure of the crustacean Daphnia magna to tributyltin. Ecotoxicology and Environmental Safety 2000;45(3):296-303. |
R826129 (2000) R826129 (Final) |
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Journal Article | LeBlanc GA, Mu XY, Rider CV. Embryotoxicity of the alkylphenol degradation product 4-nonylphenol to the crustacean Daphnia magna. Environmental Health Perspectives 2000;108(12):1133-1138. |
R826129 (2000) R826129 (Final) |
not available |
Journal Article | LeBlanc GA. Crustacean endocrine toxicology: a review. Ecotoxicology 2007;16(1):61-81. |
R826129 (Final) R831300 (Final) R832739 (2007) R832739 (Final) |
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Journal Article | LeBlanc GA, McLachlan JB. Molt-independent growth inhibition of Daphnia magna by an anti-androgen. Environmental Toxicology and Chemistry 1999;18:1450?1455. |
R826129 (1999) R826129 (Final) |
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Journal Article | Mu XY, LeBlanc GA. Environmental antiecdysteroids alter embryo development in the crustacean Daphnia magna. ournal of Experimental Zoology 2002;292(3):287-292. |
R826120 (Final) R826129 (2001) R826129 (Final) R829358 (2003) |
not available |
Journal Article | Mu XY, LeBlanc GA. Synergistic interaction of endocrine-disrupting chemicals: model development using an ecdysone receptor antagonist and a hormone synthesis inhibitor. Environmental Toxicology and Chemistry 2004;23(4):1085-1091. |
R826129 (Final) R829358 (2003) R829358 (2004) R829358 (Final) |
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Journal Article | Mu XY, LeBlanc GA. Cross communication between signaling pathways: juvenoid hormones modulate ecdysteroid activity in a crustacean. Journal of Experimental Zoology Part A–Comparative Experimental Biology 2004;301A(10):793-801. |
R826129 (Final) R829358 (2004) R829358 (Final) R831300 (2004) |
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Journal Article | Mu XY, LeBlanc GA. Developmental toxicity of testosterone in the crustacean Daphnia magna involves anti-ecdysteroidal activity. General and Comparative Endocrinology 2002;129(2):127-133. |
R826129 (Final) R829358 (2003) |
not available |
Journal Article | Olmstead AW, LeBlanc GA. Effects of endocrine-active chemicals on the development of sex characteristics of Daphnia magna. Environmental Toxicology and Chemistry 2000;19(8):2107-2113. |
R826129 (2000) R826129 (Final) |
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Journal Article | Olmstead AW, LeBlanc GA. Low exposure concentration effects of methoprene on endocrine-regulated processes in the crustacean Daphnia magna. Toxicological Sciences 2001;62(2):268-273. |
R826129 (2001) R826129 (Final) |
not available |
Journal Article | Olmstead AW, LeBlanc GA. Temporal and quantitative changes in sexual reproductive cycling of the cladoceran Daphnia magna by a juvenile hormone analog. Journal of Experimental Zoology 2001;290(2):148-155. |
R826129 (2000) R826129 (Final) |
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Journal Article | Olmstead AW, LeBlanc GA. Juvenoid hormone methyl farnesoate is a sex determinant in the crustacean Daphnia magna. Journal of Experimental Zoology 2002;293(7):736-739. |
R826129 (Final) R829358 (2003) |
not available |
Journal Article | Olmstead AW, LeBlanc GA. Insecticidal juvenile hormone analogs stimulate the production of male offspring in the crustacean Daphnia magna. Environmental Health Perspectives 2003;111(7):919-924. |
R826129 (Final) R829358 (2003) |
not available |
Journal Article | Putz O, Schwartz CB, Kim S, LeBlanc GA, Cooper RL, Prins GS. Neonatal low- and high-dose exposure to estradiol benzoate in the male rat: I. Effects on the prostate gland. Biology of Reproduction 2001;65(5):1496-1505. |
R826129 (2001) R826129 (Final) R826299 (1999) |
not available |
Journal Article | Putz O, Schwartz CB, LeBlanc GA, Cooper GL, Prins GS. Neonatal low- and high-dose exposure to estradiol benzoate in the male rat: II. Effects on male puberty and the reproductive tract. Biology of Reproduction 2001;65(5):1506-1517. |
R826129 (2001) |
not available |
Journal Article | Wilson VS, LeBlanc GA. Petroleum pollution. In: Hodgson E, ed. Reviews in Toxicology. Volume 3. Environmental Toxicology. Amsterdam: IOS Press, 2000, pp. 77-112. |
R826129 (2000) R826129 (Final) |
not available |
Journal Article | Wilson VS, LeBlanc GA. The contribution of hepatic inactivation of testosterone to the lowering of serum testosterone levels by ketoconazole. Toxicological Sciences 2000;54(1):128-137. |
R826129 (2000) R826129 (Final) |
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Journal Article | Wolf CJ, LeBlanc GA, Ostby JS, Gray LE. Characterization of the period of sensitivity of fetal male sexual development to vinclozolin. Toxicological Sciences 2000;55(1):152-161. |
R826129 (2000) R826129 (Final) |
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Journal Article | Wolf CJ, Hotchkiss A, Ostby JS, LeBlanc GA, Gray LE. Effects of prenatal testosterone propionate on the sexual development of male and female rats: A dose-response study. Toxicological Sciences 2002;65(1):71-86. |
R826129 (2001) R826129 (Final) R829358 (2003) |
not available |
Paper | Olmstead AW, LeBlanc GA. Effects of endocrine active chemicals on the development of sex characteristics of Daphnia magna. Environ Toxicol Chem. |
R826129 (1999) |
not available |
Presentation | Gooding MP, LeBlanc GA. Biotransformation and disposition of testosterone in the American mud snail (Ilyanassa obsoleta). Poster presented at E.hormone 2000, New Orleans, LA, 2000. |
R826129 (2000) R826129 (2001) |
not available |
Presentation | Gooding M.P. and LeBlanc G.A. The biocide tributyltin alters testosterone esterification in the mud snail (Ilyanassa obsoleta). Presented at the E. Hormone 2001 Meeting, New Orleans, LA, 2001. |
R826129 (2001) |
not available |
Presentation | Kast-Hutcheson K, LeBlanc GA. Developmental toxicity of the agricultural fungicide propiconazole to Daphnia magna. Poster presented at the Society for Environmental Toxicology and Chemistry 20th Annual Meeting, Philadelphia, PA, 1999. |
R826129 (1999) |
not available |
Presentation | LeBlanc GA, Mu X, Rider CV. Antiecdysteroidal activity of the fungicide fenarimol results in developmental abnormalities in a crustacean. Presented at PRIMO, Plymouth, UK, 2001. |
R826129 (2001) |
not available |
Presentation | LeBlanc GA. Approaches for the rapid assessment of endocrine-disrupting toxicity in invertebrates. Presented at the American Society for Testing and Materials Meeting, Atlanta, GA, 1998. |
R826129 (1999) |
not available |
Presentation | LeBlanc GA. Chemical-induced sexual ambiguity: some causes and consequences. Presented at Wesleyan College, Rocky Mount, NC, 2001. |
R826129 (2001) |
not available |
Presentation | LeBlanc GA. Chemical-induced sexual ambiguity: some causes and consequences. Presented at North Carolina Central University, Durham, NC, 2001. |
R826129 (2001) |
not available |
Presentation | LeBlanc GA, Rider C, Kast-Hutcheson K, Olmstead AW. Developmental toxicity of testosterone and chemicals that inhibit steroid clearance in daphnids: the elusive mechanism. Presented at the Society for Environmental Toxicology and Chemistry 20th Annual Meeting, Philadelphia, PA, 1999. |
R826129 (1999) |
not available |
Presentation | LeBlanc GA. Endocrine disruption and developmental toxicity in invertebrates. Presented at the Nicholas School of the Environment, Duke University, Durham, NC, 1999. |
R826129 (1999) |
not available |
Presentation | LeBlanc GA. Endocrine strategies: did invertebrates get it right? Presented at the Gordon Conference on Environmental Endocrine Disruptors, Plymouth, NH, 2000. |
R826129 (2000) |
not available |
Presentation | LeBlanc GA, Gooding MP. Identification of a novel mechanism by which tributyltin elevates testosterone levels in the mud snail (Ilyanassa obsoleta). Presented at PRIMO, Plymouth, UK, 2001. |
R826129 (2001) |
not available |
Presentation | LeBlanc GA. Invertebrate endocrine responses to environmental signaling: a tale of two hormones. Presented at E.hormone 2000, New Orleans, LA, 2000. |
R826129 (2000) |
not available |
Presentation | LeBlanc GA. Invertebrate endocrinology: state of the science. Society for Environmental Toxicology and Chemistry. Presented at the NA/Europe Invertebrate Endocrine Disruptor Workshop, Amsterdam, Netherlands, 1998. |
R826129 (1999) |
not available |
Presentation | LeBlanc GA. Metabolic androgenization and developmental toxicity in invertebrates. Presented at the Gordon Conference, Plymouth, NH, 1999. |
R826129 (1999) |
not available |
Presentation | Mu X, LeBlanc GA. Environmental antiecdysteroids alter embryo development in the crustacean Daphnia magna. Presented at the E. Hormone 2001 Meeting, New Orleans, LA, 2001. |
R826129 (2001) |
not available |
Presentation | Mu X, LeBlanc GA. Environmental antiecdysteroids alter embryo development in the crustacean Daphnia magna. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) Meeting, Baltimore, MD, 2001. |
R826129 (2001) |
not available |
Presentation | Olmstead AW, LeBlanc GA. Effects of endocrine active chemicals on the development of sex characteristics of Daphnia magna. Poster presented at the Society for Environmental Toxicology and Chemistry 19th Annual Meeting, Charlotte, NC, 1998. |
R826129 (1999) |
not available |
Presentation | Olmstead AW, LeBlanc GA. Multiple mechanisms of methoprene reproductive toxicity to Daphnia magna. Poster presented at the Society for Environmental Toxicology and Chemistry 20th annual meeting, Philadelphia, PA, 1999. |
R826129 (1999) |
not available |
Presentation | Olmstead AW, LeBlanc GA. Susceptibility of sexual reprodution to chemical insult in Daphnia magna. Presented at the Society of Environmental Toxicology and Chemistry (SETAC) Meeting, Baltimore, MD, 2001. |
R826129 (2001) |
not available |
Presentation | Olmstead AW, LeBlanc GA. Temporal and quantitative changes in sexual reproductive cycling of the cladoceran Daphnia magna by a juvenile hormone analogue. Poster presented at E.hormone 2000, New Orleans, LA, 2000. |
R826129 (2000) R826129 (2001) |
not available |
Proceedings | LeBlanc GA, Cambell PM, den Besten P, Brown RP, Chang E, Coats J, et al. The endocrinology of invertebrates. In: Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment. deFur PL, Crane M, Ingersoll C, Tattersfield L, eds. SETAC Press, Pensacola, FL, 1999;23-106. |
R826129 (1999) |
not available |
Report | LeBlanc GA. Screening approaches for the evaluation of endocrine disruption in invertebrates. In: Henshel DS, Black MC, Harrass MC, eds. Environmental Toxicology and Risk Assessment: Standardization of Biomarkers for Endocrine Disruption and Environmental Assessment. STP 1364. American Society of Testing and Materials, West Conshohocken, PA, 1999;8:3-23. |
R826129 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.