Grantee Research Project Results
Publications Details for Grant Number R835736C003
Validating a fetal membrane on a chip model for characterizing reproductive toxicant exposure risks
RFA:
Organotypic Culture Models for Predictive Toxicology Center (2013)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Journal Article | Developmental toxicant exposure is associated with transgenerational adenomyosis in a murine model. | None | Bruner-Tran KL, Duleba AJ, Taylor HS, Osteen KG | Bruner-Tran KL, Duleba AJ, Taylor HS, Osteen KG. Developmental toxicant exposure is associated with transgenerational adenomyosis in a murine model. Biology of Reproduction 2016;95(4):73 (10 pp.). |
R835736 (2015) R835736 (2016) R835736C003 (2018) |
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| Journal Article | Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: translating lessons from murine models. | None | Bruner-Tran KL, Gnecco J, Ding T, Glore DR, Pensabene V, Osteen KG | Bruner-Tran KL, Gnecco J, Ding T, Glore DR, Pensabene V, Osteen KG. Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: translating lessons from murine models. Reproductive Toxicology 2017;68:59-71. |
R826300 (Final) R835736 (2015) R835736 (2016) R835736 (2017) R835736C003 (2016) R835736C003 (2017) R835736C003 (2018) |
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| Journal Article | Rodent Models of Experimental Endometriosis: Identifying Mechanisms of Disease and Therapeutic Targets. | CURRENT WOMEN'S HEALTH REVIEWS | Bruner-Tran KL, Mokshagundam S, Herington JL, Osteen KG | Bruner-Tran KL, Mokshagundam S, Herington JL, Osteen KG. Rodent Models of Experimental Endometriosis: Identifying Mechanisms of Disease and Therapeutic Targets. Current Women's Health Reviews 2018;14(2):173–188 |
R835736C003 (2018) |
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| Journal Article | Sex-dependent influence of developmental toxicant exposure on group B Streptococcus -mediated preterm birth in a murine model. | None | Ding T, Lambert LA, Aronoff DM, Osteen KG, Bruner-Tran KL | Ding T, Lambert LA, Aronoff DM, Osteen KG, Bruner-Tran KL. Sex-dependent influence of developmental toxicant exposure on group B Streptococcus -mediated preterm birth in a murine model. Reproductive Sciences 2018;25(5):662-673. |
R835736 (2017) R835736C003 (2017) R835736C003 (2018) |
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| Journal Article | Instrumenting a fetal membrane on a chip as emerging technology for preterm birth research. | None | Gnecco JS, Anders AP, Cliffel D, Pensabene V, Rogers LM, Osteen K, Aronoff DM | Gnecco JS, Anders AP, Cliffel D, Pensabene V, Rogers LM, Osteen K, Aronoff DM. Instrumenting a fetal membrane on a chip as emerging technology for preterm birth research. Current Pharmaceutical Design 2017;23(40):6115-6124. |
R835736 (2016) R835736 (2017) R835736C003 (2016) R835736C003 (2017) R835736C003 (2018) |
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| Journal Article | Compartmentalized culture of perivascular stroma and endothelial cells in a microfluidic model of the human endometrium. | None | Gnecco JS, Pensabene V, Li DJ, Ding T, Hui EE, Bruner-Tran KL, Osteen KG | Gnecco JS, Pensabene V, Li DJ, Ding T, Hui EE, Bruner-Tran KL, Osteen KG. Compartmentalized culture of perivascular stroma and endothelial cells in a microfluidic model of the human endometrium. Annals of Biomedical Engineering 2017;45(7):1758-1769. |
R835736 (2017) R835736C003 (2016) |
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| Journal Article | Compartmentalized culture of perivascular stroma and endothelial cells in a microfluidic model of the human endometrium. | None | Gnecco JS, Pensabene V, Li DJ, Ding T, Hui EE, Bruner-Tran KL, Osteen KG | Gnecco JS, Pensabene V, Li DJ, Ding T, Hui EE, Bruner-Tran KL, Osteen KG. Compartmentalized culture of perivascular stroma and endothelial cells in a microfluidic model of the human endometrium. Annals of Biomedical Engineering 2017;45(7):1758-1769. |
R835736 (2015) R835736 (2016) R835736C003 (2017) R835736C003 (2018) |
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| Journal Article | Hemodynamic forces enhance decidualization via endothelial-derived prostaglandin E2 and prostacyclin in a microfluidic model of the human endometrium | HUMAN REPRODUCTION | Gnecco JS, Ding T, Smith C, Lu J, Bruner-Tran KL, Osteen KG | Gnecco JS, Ding T, Smith C, Lu J, Bruner-Tran KL, Osteen KG. Hemodynamic forces enhance decidualization via endothelial-derived prostaglandin E2 and prostacyclin in a microfluidic model of the human endometrium. Human Reproduction 2019;43(4):702-714 |
R835736C003 (2018) R839501 (2022) |
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| Journal Article | Organs-on-chips as bridges for predictive toxicology. | None | Hutson MS, Alexander PG, Allwardt V, Aronoff DM, Bruner-Tran KL, Cliffel DE, Davidson JM, Gough A, Markov DA, McCawley LJ, McKenzie JR, McLean JA, Osteen KG, Pensabene V, Samson PC, Senutovitch NK, Sherrod SD, Shotwell MS, Taylor DL, Tetz LM, Tuan RS, Vernetti LA, Wikswo JP | Hutson MS, Alexander PG, Allwardt V, Aronoff DM, Bruner-Tran KL, Cliffel DE, Davidson JM, Gough A, Markov DA, McCawley LJ, McKenzie JR, McLean JA, Osteen KG, Pensabene V, Samson PC, Senutovitch NK, Sherrod SD, Shotwell MS, Taylor DL, Tetz LM, Tuan RS, Vernetti LA, Wikswo JP. Organs-on-chips as bridges for predictive toxicology. Applied In Vitro Toxicology 2016;2(2):97-102. |
R835736 (2015) R835736 (2016) R835736 (2017) R835736C001 (2018) R835736C003 (2016) R835736C003 (2017) R835736C003 (2018) |
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| Journal Article | Decidual stromal cell-derived PGE(2) regulates macrophage responses to microbial threat | AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | Rogers JM, Anders AP, Doster RS, Gill EA, Gnecco JS, Holley JM, Randis TM, Ratner AJ, Gaddy JA, Osteen K, Arnoff DM | Rogers JM, Anders AP, Doster RS, Gill EA, Gnecco JS, Holley JM, Randis TM, Ratner AJ, Gaddy JA, Osteen K, Arnoff DM. Decidual stromal cell-derived PGE(2) regulates macrophage responses to microbial threat. American Journal of Reproductive Immunology 2018;80(4). |
R835736C003 (2018) |
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| Journal Article | Reproductive Sciences 25(5):662-673 Bruner-Tran KL et al, 2018. | None | Ding T et al, 2018 | Ding T et al, 2018. Reproductive Sciences 25(5):662-673 Bruner-Tran KL et al, 2018. Current Women’s Health Rev Jun;14(2):173-188 Rogers et al, 2018. American Journal of Reproductive Immunology Oct;80(4):e13032. |
R835736C003 (2018) |
not available |
| Presentation | Exposure to an environmental endocrine disrupting chemical promotes transgenerational reproductive dysfunction. | None | Bruner-Tran KL, Gnecco JS, Osteen KG | Bruner-Tran KL, Gnecco JS, Osteen KG. Exposure to an environmental endocrine disrupting chemical promotes transgenerational reproductive dysfunction. Presented at PPTOX V, 5th Conference on Prenatal Programming and Toxicity, Kitakyushu, Fukuoka, Japan, November 13-16, 2016. |
R835736 (2016) R835736 (2017) R835736C003 (2017) |
not available |
| Presentation | Paternal developmental exposure to TCDD alters the adult sperm and placental epigenome and negatively effects pregnancy outcomes in control partners. | None | Ding T, Archibong A, Osteen KG, Bruner-Tran KL | Ding T, Archibong A, Osteen KG, Bruner-Tran KL. Paternal developmental exposure to TCDD alters the adult sperm and placental epigenome and negatively effects pregnancy outcomes in control partners. Presented at PPTOX V, 5th Conference on Prenatal Programming and Toxicity, Kitakyushu, Fukuoka, Japan, November 13-16, 2016. |
R835736 (2016) R835736 (2017) R835736C003 (2017) R835736C003 (2018) |
not available |
| Presentation | TCDD exposure alters monocyte and macrophage behavior: a combined murine and microfluidic human cell approach to understanding the immune/endocrine microenvironment of endometriosis. | None | Gnecco JS, Ding TB, Pensabene V, Arosh J, Bruner-Tran KL, Osteen KG | Gnecco JS, Ding TB, Pensabene V, Arosh J, Bruner-Tran KL, Osteen KG. TCDD exposure alters monocyte and macrophage behavior: a combined murine and microfluidic human cell approach to understanding the immune/endocrine microenvironment of endometriosis. Poster presented at the Annual Meeting of the Society for the Study of Reproduction, San Juan, Puerto Rico, June 18-22, 2015. |
R835736 (2016) R835736 (2017) R835736C003 (2015) R835736C003 (2017) R835736C003 (2018) |
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| Presentation | Implementation of PEG hydrogels for microfluidic models of the human female reproductive tract. | None | Gnecco JS, Cook C, Hill A, Pensabene V, Ding T, Aronoff D, Griffith L, Osteen KG | Gnecco JS, Cook C, Hill A, Pensabene V, Ding T, Aronoff D, Griffith L, Osteen KG. Implementation of PEG hydrogels for microfluidic models of the human female reproductive tract. Presented at the Infection and Immunology Symposium, Vanderbilt University Medical Center, Nashville, TN, April 8, 2016. |
R835736 (2016) R835736 (2017) R835736C003 (2017) R835736C003 (2018) |
not available |
| Presentation | A novel microfluidic model of the human endometrial perivascular stroma crosstalk. | None | Gnecco JS, Ding T, Pensabene V, Aronoff D, Bruner-Tran KL, Osteen KG | Gnecco JS, Ding T, Pensabene V, Aronoff D, Bruner-Tran KL, Osteen KG. A novel microfluidic model of the human endometrial perivascular stroma crosstalk. Poster presented at the Society for Reproductive Investigation (SRI) 63rd Annual Scientific Meeting, Montreal, Quebec, Canada, March 16-19, 2016. |
R835736 (2016) R835736 (2017) R835736C003 (2017) R835736C003 (2018) |
not available |
| Presentation | Exposure of human fetal membranes to dioxin ex vivo is associated with a hyperinflammatory response: potential relevance to preterm birth. | None | Gnecco JS, Ding T, Aronoff D, Bruner-Tran KL, Osteen KG | Gnecco JS, Ding T, Aronoff D, Bruner-Tran KL, Osteen KG. Exposure of human fetal membranes to dioxin ex vivo is associated with a hyperinflammatory response: potential relevance to preterm birth. Poster presented at PPTOX V, 5th Conference on Prenatal Programming and Toxicity, Kitakyushu, Fukuoka, Japan, November 13-16, 2016. |
R835736 (2016) R835736 (2017) R835736C003 (2017) R835736C003 (2018) |
not available |
| Presentation | Shear stress-induced prostaglandins enhance progesterone action in the perivascular stroma of the human endometrium. | None | Gnecco JS, Ding T, Smith C, Bruner-Tran KL, Osteen KG | Gnecco JS, Ding T, Smith C, Bruner-Tran KL, Osteen KG. Shear stress-induced prostaglandins enhance progesterone action in the perivascular stroma of the human endometrium. Poster presented at the Vanderbilt Translational Research Forum, Nashville, TN, October 13, 2017. |
R835736 (2017) R835736C003 (2018) |
not available |
| Presentation | Is it in your genes or the environment? Envisioning a modifiable “endometriosis phenotype." | None | Osteen KG, Bruner-Tran KL | Osteen, KG and Bruner-Tran KL. Is it in your genes or the environment? Envisioning a modifiable "endometriosis phenotype." Presented at the American Society for Reproductive Medicine Annual Meeting, International Endometriosis Association Sponsored Forum, Baltimore, MD, October 17-21, 2015. |
R835736 (2015) R835736 (2016) R835736 (2017) R835736C003 (2015) R835736C003 (2017) R835736C003 (2018) |
not available |
| Presentation | Envisioning a modifiable systemic endometriosis phenotype: the future of endometriosis. | None | Osteen KG, Gnecco JS, Bruner-Tran KL | Osteen KG, Gnecco JS, Bruner-Tran KL. Envisioning a modifiable systemic endometriosis phenotype: the future of endometriosis. Presented at the Massachusetts Institute of Technology, Cambridge, MA, July 2016. |
R835736 (2016) R835736 (2017) R835736C003 (2017) R835736C003 (2018) |
not available |
| Presentation | Building an organ-on-a-chip model of the human menstrual cycle. | None | Osteen KG | Osteen KG. Building an organ-on-a-chip model of the human menstrual cycle. Presented at Rutgers University, NJ, April 2017. |
R835736 (2017) R835736C003 (2018) |
not available |
| Presentation | Inflammatory triggers of the systemic endometriosis/pre-term birth phenotype. | None | Osteen K | Osteen K. Inflammatory triggers of the systemic endometriosis/pre-term birth phenotype. Presented at the University of California, San Diego, CA, February 2017. |
R835736 (2017) R835736C003 (2018) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.