Grantee Research Project Results
Publications Details for Grant Number R835802C001
High-throughput Hazard,Dose-responseandPopulationVariabilityAssessmentofCardiotoxicity in aHumanInducedPluripotentStem Cell(iPSC)-derivedinvitro Culture Model
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Organotypic Culture Models for Predictive Toxicology Center (2013)
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Journal Article | Thorough QT/QTc in a dish: An in vitro human model that accurately predicts clinical concentration-QTc relationships. | CLINICAL PHARMACOLOGY AND THERAPEUTICS | Blanchette AD, Grimm FA, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS,Anson B, Rusyn I, Chiu WA | Blanchette AD, Grimm FA, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS, Anson B, Rusyn I, Chiu WA. Thorough QT/QTc in a dish:An in vitro human model that accurately predicts clinical concentration-QTc relationships. Clinical Pharmacology and Therapeutics 2019;105:1175-1186. |
R835802 (2018) R835802C001 (2018) |
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Journal Article | Beyond the RfD: Broad application of a probabilistic approach to improve chemical dose-response assessments for noncancer effects. | None | Chiu WA, Axelrad DA, Dalaijamts C, Dockins C, Shao K, Shapiro AJ, PaoliG | Chiu WA, Axelrad DA, Dalaijamts C, Dockins C, Shao K, Shapiro AJ, Paoli G. Beyond the RfD:Broad application of a probabilistic approach to improve chemical dose-response assessments for noncancer effects. Environmental Health Perspective 2018;126(6):067009. |
R835802 (2018) R835802C001 (2018) |
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Journal Article | The next generation of risk assessment multi-year study--highlights of findings, applications to risk assessment, and future directions. | None | Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWos | Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS. The next generation of risk assessment multi-year study--highlights of findings, applications to risk assessment, and future directions. Environmental Health Perspectives 2016;124(11):1671-1682. |
R835166 (Final) R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
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Journal Article | Advancements in life cycle human exposure and toxicity characterization. | ENVIRONMETNAL HEALTH PERSPECTIVE | Fantke P, Aylward L, Bare J, Chiu WA, Dodson R, Dwyer R, ErnstoffA,Howard B, Jantunen M, Jolliet O, Judson R, Kirchhübel N, Li D, MillerA,Paoli G, Price P, Rhomberg L, Shen B, Shin HM, Teeguarden J, ValleroD,Wambaugh J, Wetmore BA, Zaleski R, McKone TE | Fantke P, Aylward L, Bare J, Chiu WA, Dodson R, Dwyer R, Ernstoff A, Howard B, Jantunen M, Jolliet O, Judson R, Kirchhübel N, Li D, Miller A, Paoli G, Price P, Rhomberg L, Shen B, Shin HM, Teeguarden J, Vallero D, Wambaugh J, Wetmore BA, Zaleski R, McKone TE. Advancements in life cycle human exposure and toxicity characterization. Environmetnal Health Perspective 2018;126:125001. |
R835802 (2018) R835802C001 (2018) |
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Journal Article | High-content assay multiplexing for toxicity screening in induced pluripotent stem cell-derived cardiomyocytes and hepatocytes. | None | Grimm FA, Iwata Y, Sirenko O, Bittner M, Rusyn I | Grimm FA, Iwata Y, Sirenko O, Bittner M, Rusyn I. High-content assay multiplexing for toxicity screening in induced pluripotent stem cell-derived cardiomyocytes and hepatocytes. Assay and Drug Development Technologies 2015;13(9):529-546. |
R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
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Journal Article | A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives. | GREEN CHEMISTRY | Grimm FA, Iwata Y, Sirenko O, Chappell GA, Wright FA, Reif DM, Braisted J, Gerhold DL, Yeakley JM, Shepard P, Seligmann B, Roy T, Boogaard PJ, Ketelslegers HB, Rohde AM, Rusyn I | Grimm FA, Iwata Y, Sirenko O, Chappell GA, Wright FA, Reif DM, Braisted J, Gerhold DL, Yeakley JM, Shepard P, Seligmann B, Roy T, Boogaard PJ, Ketelslegers HB, Rohde AM, Rusyn I. A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives. Green Chemistry 2016;18(16):4407-4419. |
R835166 (Final) R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
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Journal Article | A human population-based organotypic in vitro model for cardiotoxicity screening. | None | Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh NH, Dalaijamts C,Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I | Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh NH, Dalaijamts C, Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I. A human population-based organotypic in vitro model for cardiotoxicity screening. ALTEX 2018;35:441-452. |
R835802 (2018) R835802C001 (2018) R835802C003 (2018) |
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Journal Article | Multi-Dimensional in Vitro Bioactivity Profiling for Grouping of Glycol Ethers. | REGULATORY TOXICOLOGY AND PHARMACOLOGY | Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N,Rusyn I | Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N, Rusyn I. Multi-Dimensional in Vitro Bioactivity Profiling for Grouping of Glycol Ethers. Regulatory Toxicology and Pharmacology 2019;101:91-102. |
R835166 (Final) R835802 (2018) R835802C001 (2018) |
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Journal Article | gQTL: a web application for QTL analysis using the collaborative cross mouse genetic reference population. | None | Konganti K, Ehrlich A, Rusyn I, Threadgill DW | Konganti K, Ehrlich A, Rusyn I, Threadgill DW. gQTL:a web application for QTL analysis using the collaborative cross mouse genetic reference population. G3:Genes, Genomes, Genetics 2018;8(8):2559-2562 |
R835802 (2017) R835802 (2018) R835802C001 (2018) R835802C002 (2018) |
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Journal Article | ToxPi Graphical User Interface 2.0: dynamic exploration, visualization, and sharing of integrated data models. | BMC BIOINFORMATICS | Marvel SW, To K, Grimm FA, Wright FA, Rusyn , Reif DM | Marvel SW, To K, Grimm FA, Wright FA, Rusyn I, Reif DM. ToxPi Graphical User Interface 2.0: dynamic exploration, visualization, and sharing of integrated data models. BMC Bioinformatics 2018;19(1):80 (7 pp.). |
R835802 (2017) R835802 (2018) R835802C001 (2018) R835802C003 (2018) |
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Journal Article | Applying a global sensitivity analysis workflow to improve the computational efficiencies in physiologically-based pharmacokinetic modeling. | FRONTIERS IN PHARMACOLOGY | Hsieh NH, Reisfeld, B, Bois FY, Chiu WA | Hsieh NH, Reisfeld, B, Bois FY, Chiu WA. Applying a global sensitivity analysis workflow to improve the computational efficiencies in physiologically-based pharmacokinetic modeling. Frontiers in Pharmacology 2018 9:588. |
R835802 (2018) R835802C001 (2018) |
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Presentation | Accurate clinical concentration-response predictions for cardiac arrhythmias using a population-based in vitro/in silico model. | None | Chiu W | Chiu W. Accurate clinical concentration-response predictions for cardiac arrhythmias using a population-based in vitro/in silico model. Laboratory Animal Sciences Virtual Event. Online Conference by Labroots, Inc. February 2019. |
R835802 (2018) R835802C001 (2018) |
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Presentation | Categorization of UVCBs using chemical-biological read across. | None | Grimm FA, Iwata Y, Sirenko O, Russell WK, Luo Y, Crittenden C, Wright FA, Reif DM, Yeakley J, Seligmann B, Shepard P, Roy T, Boogaard PJ, Ketelslegers H, Rohde AM, Rusyn I | Grimm FA, Iwata Y, Sirenko O, Russell WK, Luo Y, Crittenden C, Wright FA, Reif DM, Yeakley J, Seligmann B, Shepard P, Roy T, Boogaard PJ, Ketelslegers H, Rohde AM, Rusyn I. Categorization of UVCBs using chemical-biological read across. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835166 (2016) R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
not available |
Presentation | High-content assay multiplexing for toxicity screening in induced pluripotent stem cell-derived cardiomyocytes and hepatocytes. | None | Grimm F, Iwata Y, Sirenko O, Bittner M, Rusyn I | Grimm F, Iwata Y, Sirenko O, Bittner M, Rusyn I. High-content assay multiplexing for toxicity screening in induced pluripotent stem cell-derived cardiomyocytes and hepatocytes. Poster presented at the Society for Biomolecular Imaging and Informatics Annual Meeting, Boston, MA, September 15-17, 2015. |
R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
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Presentation | Toxicological categorization of P-and E-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. | None | Iwata Y, Grimm F, Wilson M, Bittner M, Sirenko O, Rowlands JC, Ball N, Rusyn I | Iwata Y, Grimm F, Wilson M, Bittner M, Sirenko O, Rowlands JC, Ball N, Rusyn I. Toxicological categorization of P-and E-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835166 (2016) R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
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Presentation | Mouse vs. | None | Rusyn I | Rusyn I. Mouse vs. Machine: Are animal studies being supplanted by computers? Society of Toxicology Annual Meeting, Baltimore, MD, March 2019. |
R835802 (2018) R835802C001 (2018) |
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Presentation | Data integration and visualization for transparent communication of the category read across: glycol ethers case study. | None | Wilson MR, Rowlands JC, Ball N, Wignall JA, Fourches D, Rusyn I | Wilson MR, Rowlands JC, Ball N, Wignall JA, Fourches D, Rusyn I. Data integration and visualization for transparent communication of the category read across: glycol ethers case study. Poster presented at the International Council of Chemical Associations’ Long-Range Research Initiative (ICCA-LRI) Workshop, New Orleans, LA, June 16-17, 2015. |
R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
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Presentation | A multi-tissue organotypic human in vitro model for rapid hazard identification of environmental chemicals and mixtures. | None | Chen Z, Yanagisawa L, Chiu WA, Rusyn I | Chen Z, Yanagisawa L, Chiu WA, Rusyn I. A multi-tissue organotypic human in vitro model for rapid hazard identification of environmental chemicals and mixtures. Presented at The Harvey Research Symposium, Corpus Christie, TX, 2018. |
R835802 (2018) R835802C001 (2018) |
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Presentation | An in vitro human population model for assessment of inter-individual variability in cardiotoxicity. | None | Burnett S, Grimm F, Anson B, Wright FA, Chiu W, Rusyn I | Burnett S, Grimm F, Anson B, Wright FA, Chiu W, Rusyn I. An in vitro human population model for assessment of inter-individual variability in cardiotoxicity. Lone Star SOT Annual Meeting, Austin, TX, 2018. |
R835802 (2018) R835802C001 (2018) |
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Presentation | Application of the WHO-IPCS dose-response framework to the human toxicity component of life cycle impact analysis. | None | Chiu W | Chiu W. Application of the WHO-IPCS dose-response framework to the human toxicity component of life cycle impact analysis. Society for Risk Analysis Annual Meeting. Arlington, VA, December 2018. |
R835802 (2018) R835802C001 (2018) |
not available |
Presentation | Beyond the RfD: Broad application of a probabilistic approach to improve chemical dose-response assessments for non-cancer effects. | None | Chiu W | Chiu W. Beyond the RfD: Broad application of a probabilistic approach to improve chemical dose-response assessments for non-cancer effects. UC-SF Program on Reproductive Health and the Environment (PRHE) Rapid Response Network Meeting, November 2018. |
R835802 (2018) R835802C001 (2018) |
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Presentation | Development and use of quantitative adverse outcome pathways: lessons learned from application to cardiotoxicity. | None | Chiu W | Chiu W. Development and use of quantitative adverse outcome pathways: lessons learned from application to cardiotoxicity. National Academies of Sciences Workshop: Strategies and tools for conducting systematic reviews of mechanistic data to support chemical assessments. Washington, DC, December 2018. |
R835802 (2018) R835802C001 (2018) |
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Presentation | Thorough QT/QTC in a dish: An in vitro human model that accurately predicts clinical concentration-QTC relationships. | None | Blanchette A, Grimm F, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS, Anson B, Rusyn I, Chiu WA | Blanchette A, Grimm F, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS, Anson B, Rusyn I, Chiu WA. Thorough QT/QTC in a dish: An in vitro human model that accurately predicts clinical concentration-QTC relationships. Presented at the Lone Star SOT Annual Meeting, Austin, TX, 2018. |
R835802 (2018) R835802C001 (2018) |
not available |
Presentation | Thorough QT/QTc in a dish: An in vitro human model that accurately predicts clinical concentration-QTc relationships. | None | Chiu W | Chiu W.Thorough QT/QTc in a dish: An in vitro human model that accurately predicts clinical concentration-QTc relationships. American Society for Cellular and Computational Toxicology webinar series, November 2018. |
R835802 (2018) R835802C001 (2018) |
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Presentation | Using ToxCast data in support of the key characteristics of carcinogens:opportunities and challenges. | None | Chiu W | Chiu W. Using ToxCast data in support of the key characteristics of carcinogens:opportunities and challenges. California EPA Cancer and Environmental Mixtures Meeting. Oakland, CA, August 2018. |
R835802 (2018) R835802C001 (2018) |
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Presentation | WHO/IPCS probabilistic approach to improve chemical dose-response assessments. | None | Chiu W | Chiu W. WHO/IPCS probabilistic approach to improve chemical dose-response assessments. Workshop on the Development of an Evidence Based Risk Assessment Framework. Ottawa, Canada, December 2018. |
R835802 (2018) R835802C001 (2018) |
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Presentation | A multi-tissue organotypic human in vitro model for rapid hazard identification of environmental chemicals and mixtures. | None | Chen Z, Yanagisawa L, Liu Y, Camargo K, Casillas G, McDonald T, Horney J, Chiu WA, Rusyn I | Chen Z, Yanagisawa L, Liu Y, Camargo K, Casillas G, McDonald T, Horney J, Chiu WA, Rusyn I. A multi-tissue organotypic human in vitro model for rapid hazard identification of environmental chemicals and mixtures. Society of Toxicology Annual Meeting, Baltimore, MD 2019. |
R835802 (2018) R835802C001 (2018) |
not available |
Presentation | Accurate clinical concentration-response predictions for cardiac arrhythmias using a population-based in vitro/in silico model. | None | Chiu W | Chiu W. Accurate clinical concentration-response predictions for cardiac arrhythmias using a population-based in vitro/in silico model. Department of Veterinary Physiology & Pharmacology Seminar. College Station, TX, February 2019. |
R835802 (2018) R835802C001 (2018) |
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Presentation | Enabling Assessment of Cardiotoxicity Hazard for Environmental Chemicals Using An In Vitro Human Population Model. | None | Burnett S, Blanchette A, Grimm F, Wright F, Chiu W, Rusyn I | Burnett S, Blanchette A, Grimm F, Wright F, Chiu W, Rusyn I. Enabling Assessment of Cardiotoxicity Hazard for Environmental Chemicals Using An In Vitro Human Population Model. Society of Toxicology Annual Meeting, Baltimore, MD 2019. |
R835802 (2018) R835802C001 (2018) |
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Presentation | POPKAT: A Framework for Bayesian Population PBPK Analysis. | None | Reisfeld B, Chiu W, Hsieh N, Ghosh S, Olschanowsky C, Bois F | Reisfeld B, Chiu W, Hsieh N, Ghosh S, Olschanowsky C, Bois F. POPKAT: A Framework for Bayesian Population PBPK Analysis. Society of Toxicology Annual Meeting, Baltimore, MD, 2019. |
R835802 (2018) R835802C001 (2018) |
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Presentation | Probabilistic Dose-Response Assessment Using the WHO/IPCS Framework. | None | Chiu W | Chiu W. Probabilistic Dose-Response Assessment Using the WHO/IPCS Framework. Training Workshop for California EPA/Department of Pesticide Regulation. Sacramento, CA, February 2019. |
R835802 (2018) R835802C001 (2018) |
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Presentation | The Utility of Informative Prior in Benchmark Dose Modeling for Animal Reduction. | None | Shao K, Chiu WA, Shapiro A | Shao K, Chiu WA, Shapiro A. The Utility of Informative Prior in Benchmark Dose Modeling for Animal Reduction. Society of Toxicology Annual Meeting, Baltimore, MD, 2019. |
R835802 (2018) R835802C001 (2018) |
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Presentation | Thorough QT/QTc in a dish:An in vitro human model that accurately predicts clinical concentration-QTc relationships. | None | Chiu W | Chiu W. Thorough QT/QTc in a dish:An in vitro human model that accurately predicts clinical concentration-QTc relationships. Food and Drug Administration, Center for Drug Evaluation and Research, Pharmacology and Toxicology Reviewer Cardiac Journal Club, March 2019. |
R835802 (2018) R835802C001 (2018) |
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Presentation | Initial Characterization of Hepatocytes Derived from Collaborative Cross Recombinant Inbred Mouse Strain iPSCs. | None | Botta D, Popp J, Farris L, Van Ness KP, White CC, Kelly EJ, Faustman EM, Rusyn I, Threadgill D Kavanagh TJ (2018) | Botta D, Popp J, Farris L, Van Ness KP, White CC, Kelly EJ, Faustman EM, Rusyn I, Threadgill D and Kavanagh TJ (2018). Initial Characterization of Hepatocytes Derived from Collaborative Cross Recombinant Inbred Mouse Strain iPSCs. Presented at the U.S EPA:3rd Annual STAR Organotypic Culture Models (OCM) Progress Review Meeting, Durham, NC. |
R835738C003 (2018) R835802 (2018) R835802C001 (2018) |
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Presentation | , Chiu, W. | None | Hsieh, N | Hsieh, N., Chiu, W., and Reisfeld, B. Pksensi:An R Package to Apply Sensitivity Analysis in Pharmacokinetic Modeling. Society of Toxicology Annual Meeting, Baltimore, MD. 2019. |
R835802C001 (2018) |
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Presentation | , Craft, E. | None | Danforth, C | Danforth, C., Craft, E., Bolden, A., Schultz, K., Kwiatkowski, C., Rusyn, I., and Chiu, W. Evidence integration across multiple toxicity endpoints to prioritize constituents of potential concern in oil and gas produced water. Society of Toxicology Annual Meeting, Baltimore, MD. 2019. |
R835802C001 (2018) |
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Presentation | S. | None | House, J | House, J.S., Grimm, F.A., Jima, D., Rusyn, I.,Wright, F.A. High-Throughput Concentration Response Modeling in iPSC-Cardiomyocytes. Organotypic culture models annual STAR grantee meeting. Durham, NC. 2018. |
R835802C001 (2018) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.