Publications Details for:

Organotypic Models of Mammalian Liver as a Platform for Adverse Outcomes Pathway Assessment of Engineered Nanomaterials
Grant Number R835738C003
RFA: Organotypic Culture Models for Predictive Toxicology Center (2013)
Abstract (2)
Journal Article (5)
Presentation (13)
Reference Type Citation Progress Report Year Document Sources
Abstract Altemeier WA, Haick A, Mittelsteadt KL, Kavanagh TJ. Primary mouse airway epithelial cells are resistant to silver nanoparticles. The Toxicologist 2016;150(Suppl 1):10. R835738C001 (2015)
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Abstract Chang S, Voellinger JL, White C, Kelly EJ, Eaton DL. A tissue-engineered rat/human liver microphysiological system for drug and chemical testing. The Toxicologist 2015;144(S-1):151. R835738 (2016)
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Journal Article Chang S-Y, Weber EJ, Van Ness KP, Eaton DL, Kelly EJ. Liver and kidney on chips: microphysiological models to understand transporter function. Clinical Pharmacology & Therapeutics 2016;100(5):464-478. R835738 (2016)
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Journal Article Chang S-Y, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL. Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. JCI Insight 2017;2(22):e95978 (15 pp.). R835738C003 (2017)
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Journal Article Chang S-Y, Voellinger JL, Van Ness KP, Chapron B, Shaffer RM, Neumann T, White CC, Kavanagh TJ, Kelly EJ, Eaton DL. Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity. Toxicology In Vitro 2017;40:170-183. R835738 (2016)
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Journal Article Melnikov F, Botta D, White CC, Schmuck SC, Schaupp CM, Gallagher EP, Brooks BW, Williams ES, Coish P, Anastas PT, Voutchkova-Kostal A, Kostal J and Kavanagh TJ. Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis. Chemical Research in Toxicology2019:32(3);421-436 R835738C001 (2018)
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Journal Article Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (15 pp.). R835736 (2015)
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Presentation Botta D, White CC, Melnikov F, Schaupp CM, Gallagher EG, Brooks BW, Kostal J, Voutchkova-Kostal, AM, Anastas PT and Kavanagh TJ. Using immortalized hepatocytes from wild-type and Gclm knock out mice to investigate the relative toxicity and Nrf2 activation of SN2 reactive electrophiles. Presented at the Society of Toxicology 57th Annual Meeting and ToxExpo, San Antonio, TX, March 11-15, 2018. R835738 (2017)
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Presentation Chang SY, Weber E, Kelly EJ, Eaton DL. Microphysiological systems to identify organ-organ interactions in toxicology: hepatic metabolism enhances nephrotoxicity of aristolochic acid. Presented at the Pacific Northwest Association of Toxicologists Annual Meeting, Woodinville, WA, September 17-18, 2015. R835738 (2016)
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Presentation Chang SY, Weber E, Neumann T, Kelly EJ, Eaton DL. Microphysiological Systems (MPS) to identify organ-organ interactions in tToxicology: hepatic metabolism enhances nephrotoxicity of aristolochic acid. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. R835738 (2016)
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Presentation Eaton D. New frontiers for linked microphysiological systems: integrated liver-kidney systems on a chip. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. R835738 (2017)
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Presentation Faustman E, French E, Eaton D, Kelly E, Kavanagh T. Using systems based approaches for refinement, integration and translation. Minicourse presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20, 2017. R835738 (2017)
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Presentation Kavanagh TJ, Schaupp CM, Botta D, Schmuck S, White CC, Chisholm C. Measuring chemically-induced oxidative stress in genetically modified cultured mammalian liver cells. Presented at the Northwest Green Chemistry Conference, Troutdale, OR, April 23-24, 2015. R835738 (2016)
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Presentation Kavanagh T. Educational tools for designing safer chemicals and predicting toxicity. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. R835738 (2017)
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Presentation Kavanagh T. Experiences with collaborative cross for assessing gene X environment interactions for engineered nanomaterials: can we capture human variability in vitro-lessons from the Predictive Toxicology Center. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. R835738 (2017)
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Presentation Kelly E. Bioengineered ex vivo models of human organs for predictive toxicity testing. Presented at the New England Drug Metabolism Discussion Group Meeting, Walkersville, MD, December 6, 2017 R835738 (2017)
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Presentation White CC, Botta D, Schaupp CM, Kavanagh TJ. Toxicological assessment of glutathione content, mitochondrial membrane potential and cardiolipin in an immortalized glutathione-deficient mouse hepatocyte cell line. Presented at the 32nd Congress of the International Society for Advancement of Cytometry, Boston, MA, June 10-14, 2017. R835738 (2016)
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Presentation Botta D, Popp J, Farris L, Van Ness KP, White CC, Kelly EJ, Faustman EM, Rusyn I, Threadgill D and Kavanagh TJ (2018). Initial Characterization of Hepatocytes Derived from Collaborative Cross Recombinant Inbred Mouse Strain iPSCs. Presented at the U.S EPA:3rd Annual STAR Organotypic Culture Models (OCM) Progress Review Meeting, Durham, NC. R835738C003 (2018)
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Presentation Botta D, Wang L, White CC, Popp J, Farris L, Lewis LA, Lynch RM, Bammler TK, Faustman EM, Rusyn I, Threadgill DW, Kavanagh TJ. Characterization of Hepatocytes Derived from Collaborative Cross Recombinant Inbred Mouse Strain Induced Pluripotent Stem Cells. Society of Toxicology Annual Meeting, Baltimore, MD (2019). R835738C003 (2018)
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Presentation Kavanagh TJ, Botta D, White CC, Ness KP, Eaton DL, Faustman EM, Kelly EJ, Melnikov F, Anastas P, Voutchkova-Kostal A, Kostal J, Popp J, Farris L, Rusyn I, Threadgill D (2018). Role of Interindividual and Genetic Differences in Response of Human and Mouse Hepatocytes to Chemical Stressors. Presented at the U.S EPA:3rd Annual STAR Organotypic Culture Models (OCM) Progress Review Meeting, Durham, NC. R835738C003 (2018)
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